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المؤلفون: Rachel Deplus, Martine Duterque-Coquillaud, Anne Flourens, Edith Bonnelye, Nathalie Vanpouille, Tian V. Tian, Philippe Clézardin, Anais Fradet, Carine Delliaux, Xavier Leroy, Yvan de Launoit, Mathilde Bouchet, Arnauld Villers
المساهمون: Mécanismes de tumorigenèse et thérapies ciblées, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal (UdeM), Universitat Pompeu Fabra [Barcelona] (UPF), Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Pôle de Biologie Pathologie Génétique [CHU Lille], This work was in part supported by the Centre national de la recherche scientifique (CNRS), Ligue nationale contre le Cancer (Comité du Pas-de-Calais), Institut national du cancer (INCa_4419), Institut Pasteur de Lille, Conseil Régional du Nord-Pas-de-Calais and Fondation pour la Recherche Médicale (FRM), Conseil Régional du Nord-Pas-de-Calais, Association pour la Recherche sur le Cancer (ARC), MINECO (Juan de la Cierva Postdoctoral Fellowship FJCI-2014-22946), ARTP (Association de Recherche sur les tumeurs de prostate)., Mécanismes de la Tumorigénèse et Thérapies Ciblées (M3T) - UMR 8161 (M3T), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Center for Genomic Regulation (CRG-UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Service d'urologie, Hôpital Huriez-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), We would like to thank M. Tardivel, A. Bongiovanni and E. Werkmeister from the BioImaging Center Lille Nord de France (BICeL) for their technical assistance, M. Canouil for his statistics advice, and M. Vernier for his bioinformatic advice and stimulating discussions. We would also like to thank the local Tumor Tissue Bank (Tumorothèque), Regional Reference Oncology Center (CRRC) (Head, Pr. M.C. Copin) in Lille, France.
المصدر: Cancer Letters
Cancer Letters, Elsevier, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩
Cancer Letters, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Oncogene Proteins, Fusion, [SDV]Life Sciences [q-bio], MESH: Gene Expression Regulation, Neoplastic, Mice, SCID, urologic and male genital diseases, Fusion gene, MESH: Oncogene Proteins, Fusion/metabolism, Metastasis, Prostate cancer, 0302 clinical medicine, MESH: Animals, MESH: Mice, SCID, MESH: Osteoblasts/pathology, ComputingMilieux_MISCELLANEOUS, MESH: Prostatic Neoplasms/genetics, Endothelin-1, Bone metastasis, MESH: Prostatic Neoplasms/pathology, Tumor Burden, 3. Good health, Gene Expression Regulation, Neoplastic, Phenotype, Osteoblastic lesions, Oncology, 030220 oncology & carcinogenesis, PC-3 Cells, MESH: Bone Neoplasms/metabolism, MESH: Bone Neoplasms/secondary, MESH: PC-3 Cells, MESH: Endothelin-1/metabolism, Erg, MESH: Alkaline Phosphatase/metabolism, MESH: Cell Line, Tumor, Transplantation, Heterologous, MESH: Biomarkers, Tumor/genetics, MESH: Tumor Burden/genetics, Bone Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, MESH: Phenotype, TMPRSS2, MESH: Oncogene Proteins, Fusion/genetics, 03 medical and health sciences, Transcriptional regulation, Cell Line, Tumor, Biomarkers, Tumor, medicine, Animals, Humans, MESH: Transplantation, Heterologous, MESH: Biomarkers, Tumor/metabolism, Osteoblasts, MESH: Alkaline Phosphatase/genetics, MESH: Humans, MESH: Prostatic Neoplasms/metabolism, Prostatic Neoplasms, Gene rearrangement, Alkaline Phosphatase, MESH: Bone Neoplasms/genetics, MESH: Osteoblasts/metabolism, medicine.disease, MESH: Male, Collagen Type I, alpha 1 Chain, TMPRSS2:ERG, 030104 developmental biology, MESH: Endothelin-1/genetics, Cancer research, Ectopic expression
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المؤلفون: Anne Flourens, Carine Delliaux, Yvan de Launoit, Xavier Leroy, Rachel Deplus, Martine Duterque-Coquillaud, Nathalie Marchand, Nathalie Vanpouille
المساهمون: Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 (M3T), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), This work was supported by grants from the Centre national de la recherche scientifique (CNRS), La Ligue contre le Cancer (Comité du Pas-de-Calais) and the Institut national du cancer (INCa_4419). CD is a recipient of Ph.D. fellowships from the Institut Pasteur of Lille/Nord-Pas-de-Calais Regional Council (Région Nord-Pas-de Calais) and the FRM (Fondation pour la Recheche Médicale)., We thank Tian V. Tian, Edith Bonnelye and Olivier Morales for help and advices in mouse experiments. We thank the Microscopy-Imaging-Cytometry Facility of the BioImaging Center Lille Nord-de-France for access to instruments and technical advice. We thank also Francois Fuks for his helpful advices in manuscript redaction., de Launoit, Yvan
المصدر: Oncotarget
Oncotarget, Impact journals, 2017, 8 (7), pp.11827-11840. ⟨10.18632/oncotarget.14399⟩
Oncotarget, 2017, 8 (7), pp.11827-11840. ⟨10.18632/oncotarget.14399⟩
Oncotarget, 8 (7مصطلحات موضوعية: 0301 basic medicine, Male, Pathology, Oncogene Proteins, Fusion, TMPRSS2-ERG, MESH: Cell Movement/physiology, [SDV]Life Sciences [q-bio], Mice, SCID, urologic and male genital diseases, Metastasis, Transcriptome, Cell Proliferation -- physiology, Prostate cancer, Cell Movement -- physiology, Mice, 0302 clinical medicine, Cell Movement, MESH: Animals, MESH: Oncogene Proteins, Fusion/genetics, Neoplasm Metastasis, MESH: Mice, SCID, bone metastasis, Prostatic Neoplasms -- genetics -- metabolism -- pathology, Bone metastasis, Cell migration, Sciences bio-médicales et agricoles, MESH: Prostatic Neoplasms/pathology, prostate cancer, bone tropism, [SDV] Life Sciences [q-bio], Oncogene Proteins, Fusion -- biosynthesis -- genetics, Oncology, 030220 oncology & carcinogenesis, MESH: Bone Neoplasms/metabolism, Heterografts, MESH: Bone Neoplasms/secondary, MESH: Bone Neoplasms/genetics, Research Paper, medicine.medical_specialty, MESH: Cell Line, Tumor, Bone Neoplasms, Transfection, TMPRSS2, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, MESH: Mice, Tropism, Cell Proliferation, MESH: Prostatic Neoplasms/genetics, Bone Neoplasms -- genetics -- metabolism -- secondary, MESH: Humans, MESH: Oncogene Proteins, Fusion/biosynthesis, business.industry, MESH: Transfection, MESH: Prostatic Neoplasms/metabolism, Prostatic Neoplasms, MESH: Cell Proliferation/physiology, medicine.disease, MESH: Neoplasm Metastasis, MESH: Male, 030104 developmental biology, Cancer cell, MESH: Heterografts, business
وصف الملف: application/pdf; 1 full-text file(s): application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6842a4a21bd05145fce04e57a3617d
https://hal.archives-ouvertes.fr/hal-02391621/file/TMPRSS2-ERG_fusion_promotes_prostate.pdf -
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