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المؤلفون: N. Kyle Tanner, Mourad Barhoumi, Emna Harigua-Souiai, Arnaud Blondel, Josette Banroques, Yosser Zina Abdelkrim, Ikram Guizani
المساهمون: Expression Génétique Microbienne (EGM (UMR_8261 / FRE_3630)), Institut de biologie physico-chimique (IBPC (FR_550)), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP), Faculté des Sciences de Bizerte [Université de Carthage], Université de Carthage - University of Carthage, Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), This work was supported by the Centre National de la Recherche Scientifique, France, by the HelicaRN [2010 BLAN 1503 01] and HeliDEAD grants [ANR-13-BSV8-0009-01] from the Agence Nationale de la Recherche, France, and by the Initiative d'Excellence program from the French State [Grant DYNAMO, ANR-11-LABX-0011-01] to NKT. This work received financial support from the Pasteur Institute Transversal Research Program (grant PTR426), France, and partially from the Ministry of Higher Education and Research in Tunisia (LR11IPT04 & LR16IPT04) to IG. EHS received support from the UNESCO-L'Oréal, 'For Women in Science,' international fellowship and the Institut Pasteur International Network (Calmette and Yersin programme)., We thank Patrick Linder, Centre Médical Universitaire, Geneva, Switzerland, for the eIF4AIMus clone. The 6-aminocholestanol was a gift from Dr. Leila el Kihel, Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), UFR des Sciences Pharmaceutiques, Université de Caen de Basse-Normandie, France, for the minimal costs of shipping fees. We thank Damien Monet for his assistance in the cavity generation and analyses., ANR-13-BSV8-0009,HeliDEAD,Les ARN hélicases à boite DEAD: quels sont leurs rôles, leurs partenaires, leurs substrats ARN et comment elles fonctionnent.(2013), ANR-11-LABX-0011,DYNAMO,Dynamique des membranes transductrices d'énergie : biogénèse et organisation supramoléculaire.(2011), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Faculté des Sciences de Bizerte, Bioinformatique structurale, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), ANR-11-LABX-0011/11-LABX-0011,DYNAMO,Dynamique des membranes transductrices d'énergie : biogénèse et organisation supramoléculaire.(2011), Institut de biologie physico-chimique (IBPC)
المصدر: Molecular and Biochemical Parasitology
Molecular and Biochemical Parasitology, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩
Molecular and Biochemical Parasitology, Elsevier, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩مصطلحات موضوعية: Hippuristanol, 0301 basic medicine, Antifungal Agents, MESH: Sequence Homology, Amino Acid, ATPase, Protozoan Proteins, Gene Expression, MESH: Protein Structure, Secondary, MESH: Amino Acid Sequence, Protein Structure, Secondary, MESH: Eukaryotic Initiation Factor-4A, MESH: Recombinant Proteins, Mice, chemistry.chemical_compound, Adenosine Triphosphate, MESH: Cholesterol, MESH: Genetic Vectors, MESH: Adenosine Triphosphate, MESH: Animals, MESH: Trypanocidal Agents, Cloning, Molecular, Leishmania infantum, MESH: Protozoan Proteins, Conserved Sequence, Ergosterol, MESH: Conserved Sequence, MESH: Kinetics, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], MESH: Escherichia coli, Trypanocidal Agents, RNA Helicase A, Recombinant Proteins, MESH: Leishmania infantum, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Cholesterol, Biochemistry, Translation-initiation factor, MESH: Drug Repositioning, Protein Binding, RNA helicase, MESH: Gene Expression, Genetic Vectors, MESH: Sequence Alignment, MESH: Binding, Competitive, Biology, Binding, Competitive, Drug design, 03 medical and health sciences, Escherichia coli, Animals, Humans, MESH: Protein Binding, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Protein Interaction Domains and Motifs, MESH: Cloning, Molecular, Amino Acid Sequence, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Binding site, MESH: Mice, Molecular Biology, MESH: Protein Interaction Domains and Motifs, Binding Sites, MESH: Humans, Sequence Homology, Amino Acid, MESH: RNA, Helminth, 030102 biochemistry & molecular biology, Drug Repositioning, RNA, Helicase, MESH: Antifungal Agents, Kinetics, 030104 developmental biology, MESH: Binding Sites, chemistry, eIF4A, Eukaryotic Initiation Factor-4A, Nucleic acid, biology.protein, Parasitology, RNA, Helminth, Sequence Alignment
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المؤلفون: Andrew G. Watts, A. Carlos Frasch, Ricardo Resende, Jean M. H. van den Elsen, Susan J. Crennell, Patricia Marcé, Pedro M. Alzari, Zexin Chen
المساهمون: University of Bath [Bath], Microbiologie structurale - Structural Microbiology (Microb. Struc. (UMR_3528 / U-Pasteur_5)), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Instituto de Investigaciones Biotecnológicas [San Martín] (IIB-INTECH), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Universidad Nacional de San Martin (UNSAM), RR was supported by a University Research Scholarship from the University of Bath., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 158, pp.25-33. ⟨10.1016/j.ejmech.2018.08.089⟩
Chen, Z, Marce Villa, P, Resende, R, Alzari, P M, Frasch, A C, Van Den Elsen, J, Crennell, S & Watts, A 2018, ' The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase ', European Journal of Medicinal Chemistry, vol. 158, pp. 25-33 . https://doi.org/10.1016/j.ejmech.2018.08.089
European Journal of Medicinal Chemistry, 2018, 158, pp.25-33. ⟨10.1016/j.ejmech.2018.08.089⟩مصطلحات موضوعية: 0301 basic medicine, Trans-sialidase, chemistry.chemical_compound, Drug Discovery, MESH: Trypanocidal Agents, Enzyme Inhibitors, Amination, Binding affinities, chemistry.chemical_classification, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], biology, MESH: Neuraminidase, General Medicine, Trypanocidal Agents, 3. Good health, Molecular Docking Simulation, T cruzi trans-sialidase, Biochemistry, MESH: Enzyme Inhibitors, Non competitive, MESH: Organophosphonates, MESH: Trypanosoma cruzi, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], Trypanosoma cruzi, Kinetic analysis, MESH: Glycoproteins, Organophosphonates, Neuraminidase, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, 03 medical and health sciences, SDG 3 - Good Health and Well-being, MESH: Molecular Docking Simulation, [CHIM.CRIS]Chemical Sciences/Cristallography, Humans, MESH: Chagas Disease, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Chagas Disease, MESH: Amination, Glycoproteins, Pharmacology, MESH: Humans, 030102 biochemistry & molecular biology, Inhibitors, Aryl, Organic Chemistry, biology.organism_classification, 030104 developmental biology, Enzyme, chemistry, Non-competitive, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], α-aminophosphonates
وصف الملف: application/pdf
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المؤلفون: Thomas, James A., Baker, Nicola, Hutchinson, Sebastian, Dominicus, Caia, Trenaman, Anna, Glover, Lucy, Alsford, Sam, Horn, David
المساهمون: London School of Hygiene and Tropical Medicine (LSHTM), University of York [York, UK], Institut Pasteur [Paris], The Francis Crick Institute [London], University of Dundee, We thank Philippa Radley for assistance with assembly of tagging constructs, Richard Wheeler (Uni. of Oxford) for advice on ImageJ analysis and Achim Schnaufer (Uni. of Edinburgh) for the ATP-synthase antibody, Institut Pasteur [Paris] (IP)
المصدر: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2018, 12 (11), pp.e0006980. ⟨10.1371/journal.pntd.0006980⟩
PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006980 (2018)
PLoS Neglected Tropical Diseases, 2018, 12 (11), pp.e0006980. ⟨10.1371/journal.pntd.0006980⟩مصطلحات موضوعية: Physiology, [SDV]Life Sciences [q-bio], RC955-962, Melarsoprol, MESH: Melarsoprol, Biochemistry, Arctic medicine. Tropical medicine, Medicine and Health Sciences, Cell Cycle and Cell Division, MESH: Trypanocidal Agents, Energy-Producing Organelles, Protozoans, Chromosome Biology, Pharmaceutics, Eukaryota, MESH: Mitochondrial Proteins, Trypanocidal Agents, Mitochondria, Electrophysiology, Nucleic acids, Cell Processes, MESH: Pentamidine, Cellular Structures and Organelles, Public aspects of medicine, RA1-1270, Research Article, Trypanosoma, MESH: Mitochondria, Trypanosoma brucei brucei, Mitosis, Suramin, Bioenergetics, DNA replication, Membrane Potential, MESH: Cell Biology, Mitochondrial Proteins, Drug Therapy, parasitic diseases, Trypanosoma Brucei, Genetics, Humans, MESH: Suramin, Pentamidine, MESH: Humans, MESH: Nifurtimox, Organisms, Biology and Life Sciences, MESH: Trypanosoma brucei brucei, Cell Biology, DNA, MESH: Mitosis, Parasitic Protozoans, Kinetoplasts, Trypanosomiasis, African, MESH: Trypanosomiasis, African, Nifurtimox, Lysosomes, Trypanosoma Brucei Gambiense, MESH: Lysosomes
وصف الملف: application/pdf
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المؤلفون: Mahin Abad Dar, Franziska Maiwald, Diego Benítez, Laurent Meijer, Nadège Loaëc, Conrad Kunick, Lutz Preu, Hanna Erdmann, Marcelo A. Comini, Oliver Koch, Diego Charquero, Christoph Hölscher
المساهمون: Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Institut Pasteur de Montevideo, Réseau International des Instituts Pasteur (RIIP), Forschungszentrum Borstel - Research Center Borstel, Technische Universität Dortmund [Dortmund] (TU), ManRos Therapeutics, This project was funded by the German 'Bundesministerium für Bildung und Forschung' (KMU-innovativ 5, Förderkennzeichen 0315814, to F. M., M. A. D., O. K., C. H., and C. K.). The support of FOCEM (MERCOSUR Structural Convergence Fund, COF 03/11) and ANII (grant Innova Uruguay, agreement DCI-ALA/2007/19.040 between Uruguay and the European Commission, INI_X_2011_1_4077 and POS_NAC_2013_1_114477) is acknowledged by M. A. C., D. B. and D. C.. L. M. was supported by a grant from the ‘Agence Nationale de la Recherche’ (ANR- 11-RPIB-0016 grant, Transleish).
المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2014, 83, pp.274-283. ⟨10.1016/j.ejmech.2014.06.020⟩مصطلحات موضوعية: MESH: Trypanocidal Agents/chemical synthesis, MESH: Benzazepines/toxicity, Nagana, Mice, Chalcones, MESH: Structure-Activity Relationship, MESH: Cell Proliferation/drug effects, Human trypanosomiasis, Drug Discovery, MESH: Animals, MESH: Benzazepines/chemistry, biology, MESH: Trypanosoma brucei brucei/physiology, Chemistry, MESH: Macrophages/drug effects, General Medicine, Trypanocidal Agents, 3. Good health, MESH: Trypanocidal Agents/pharmacology, Biochemistry, Paullones, MESH: Trypanocidal Agents/toxicity, MESH: Trypanosomiasis, African/parasitology, Trypanosoma brucei brucei, Cell Line, Structure-Activity Relationship, Heck reaction, parasitic diseases, medicine, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Trypanosoma brucei brucei/drug effects, MESH: Drug Design, MESH: Mice, Cell Proliferation, Pharmacology, MESH: Humans, MESH: Benzazepines/chemical synthesis, MESH: Trypanocidal Agents/chemistry, Macrophages, Organic Chemistry, MESH: Benzazepines/pharmacology, Benzazepines, biology.organism_classification, medicine.disease, Antiparasitic agent, Cinnamides, MESH: Cell Line, Trypanosomiasis, African, Drug Design, Trypanosoma
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المؤلفون: Maxime D. Crozet, Alan H. Fairlamb, Geneviève Pratviel, Alexis Valentin, Pascal Rathelot, Alix Sournia-Saquet, Clotilde Boudot, Anita Cohen, Patrice Vanelle, Julien Pedron, Jean-Luc Stigliani, Sandra Bourgeade-Delmas, Susan Wyllie, Pierre Verhaeghe, Nadine Azas, Caroline Castera-Ducros, Cyril Fersing, Alain Moreau, Sébastien Hutter, Nicolas Primas, Bertrand Courtioux
المساهمون: Institut de Chimie Radicalaire (ICR), Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques (IP-TPT), Service de Santé des Armées-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD), Aix-Marseille Université - Faculté de pharmacie (AMU PHARM), Aix Marseille Université (AMU), Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut de Recherche pour le Développement (IRD), Department of Biochemistry, Medical Sciences Institute, Dundee University, Dundee, Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Service de Santé des Armées, Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT), Université de Toulouse (UT)
المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 157, pp.115-126. ⟨10.1016/j.ejmech.2018.07.064⟩
European Journal of Medicinal Chemistry, 2018, 157, pp.115-126. ⟨10.1016/j.ejmech.2018.07.064⟩مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, SARs, Redox potentials, HepG2 cytotoxicity, Crystallography, X-Ray, MESH: Parasitic Sensitivity Tests, MESH: Dose-Response Relationship, Drug, chemistry.chemical_compound, MESH: Structure-Activity Relationship, Parasitic Sensitivity Tests, In vitro activity, Drug Discovery, Nitroheterocycles, Moiety, MESH: Trypanocidal Agents, Imidazo[1, Leishmania, 2-a]pyridine, Molecular Structure, MESH: Drug Screening Assays, Antitumor, Hep G2 Cells, General Medicine, Trypanocidal Agents, 3. Good health, MESH: Nitroreductases, MESH: Cell Survival, Imidazo[1,2-a]pyridine, Pharmacophore, MESH: Models, Molecular, Trypanosoma, MESH: Cell Line, Tumor, Cell Survival, Stereochemistry, Antiparasitic, medicine.drug_class, Trypanosoma brucei brucei, 030106 microbiology, MESH: Molecular Structure, Substituent, Antineoplastic Agents, MESH: Hep G2 Cells, Article, Structure-Activity Relationship, 03 medical and health sciences, Cell Line, Tumor, MESH: Cell Proliferation, medicine, Humans, Amastigote, Cell Proliferation, Pharmacology, MESH: Humans, MESH: Leishmania donovani, Dose-Response Relationship, Drug, Aryl, Organic Chemistry, MESH: Trypanosoma brucei brucei, Nitroreductases, MESH: Crystallography, X-Ray, 030104 developmental biology, chemistry, Nitro, Suzuki-Miyaura cross-coupling reaction, MESH: Antineoplastic Agents, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Drug Screening Assays, Antitumor, Leishmania donovani, Fexinidazole
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المؤلفون: Andrea Medeiros, Francesca Moraca, Marcelo A. Comini, Maurizio Botta, Cecilia Ortíz, Niall M. Hamilton
المساهمون: Institut Pasteur de Montevideo, Réseau International des Instituts Pasteur (RIIP), Università degli Studi di Siena = University of Siena (UNISI), Universidad de la República [Montevideo] (UCUR), Drug Discovery Unit, Cancer Research, UK Manchester Institute, Wilmslow Road, Manchester, CO acknowledges support from ANII (Agencia Nacional de Investigación e Innovación, Uruguay, doctoral fellowship POS_NAC_2012_1_8803) and CSIC (Comisión Sectorial de Investigaciones Científicas, Universidad de la República Uruguay). CSIC and the Coimbra Group is acknowledged, the last for supporting a research traineeship at the Università degli Studi di Siena, is acknowledged by AM. MAC acknowledges the financial support of FOCEM (MERCOSUR Structural Convergence Fund) COF 03/11 and grant INNOVA Uruguay (agreement No. DCI-ALA/2007/19.040 between Uruguay and the European Commision). We acknowledge Cameron F. Abrams (Drexel University, Philadelphia, PA, USA) for the computational resourcesand help
المصدر: Molecules
Molecules, MDPI, 2016, 21 (3), pp.368. ⟨10.3390/molecules21030368⟩
Molecules, Vol 21, Iss 3, p 368 (2016)
Molecules; Volume 21; Issue 3; Pages: 368مصطلحات موضوعية: 0301 basic medicine, Chagas disease, [SDV]Life Sciences [q-bio], Pharmaceutical Science, Dehydrogenase, Epiandrosterone, Analytical Chemistry, Drug Discovery, MESH: Trypanocidal Agents, chemistry.chemical_classification, Leishmania, biology, structure activity relationship, Trypanocidal Agents, Molecular Docking Simulation, epiandrosterone, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Biochemistry, Chemistry (miscellaneous), Molecular Medicine, Steroids, Ribosemonophosphates, MESH: Trypanosoma cruzi, Stereochemistry, Trypanosoma cruzi, MESH: Glucosephosphate Dehydrogenase, pentose phosphate pathway, Glucosephosphate Dehydrogenase, Androsterone, Article, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, MESH: Androsterone, MESH: Molecular Docking Simulation, Structure–activity relationship, Humans, MESH: Chagas Disease, Physical and Theoretical Chemistry, Binding site, inhibition by steroids, Binding Sites, MESH: Humans, Organic Chemistry, Active site, biology.organism_classification, MESH: Steroids, 030104 developmental biology, Enzyme, chemistry, MESH: Binding Sites, biology.protein, Uncompetitive inhibitor, MESH: Ribosemonophosphates
وصف الملف: application/pdf
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المؤلفون: François Xavier N'Siesi, Simon Van Nieuwenhove, Sylvie Bisser, Constantin Miaka Mia Bilenge, Veerle Lejon, Pierre-Marie Preux, Philippe Büscher
المساهمون: Neuroépidémiologie Tropicale et Comparée (NETEC), Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Université de Limoges (UNILIM), Institut de Médecine Tropicale (IMT), Institut de Médecine Tropicale d'Anvers, Centre de Développement Intégral, République Démocratique du Congo, Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Unité Fonctionnelle de Recherche Clinique et de Biostatistique (UFRCB), CHU Limoges, World Health Organization, Democratic Republic of Congo
المصدر: Scopus-Elsevier
Journal of Infectious Diseases
Journal of Infectious Diseases, Oxford University Press (OUP), 2007, 195 (3), pp.322-9. ⟨10.1086/510534⟩مصطلحات موضوعية: Male, Trypanosoma brucei gambiense, MESH: Brain Diseases, Administration, Oral, Melarsoprol, MESH: Melarsoprol, Gastroenterology, MESH: Trypanosoma brucei gambiense, law.invention, 0302 clinical medicine, Randomized controlled trial, Recurrence, law, Immunology and Allergy, MESH: Animals, African trypanosomiasis, MESH: Trypanocidal Agents, MESH: Treatment Outcome, Brain Diseases, 0303 health sciences, Protozoal diseases, Trypanocidal Agents, 3. Good health, Congo-Kinshasa, Treatment Outcome, Infectious Diseases, Injections, Intravenous, MESH: Administration, Oral, Drug Therapy, Combination, Female, Drug therapy, Randomized clinical trials, medicine.drug, Adult, medicine.medical_specialty, Combination therapy, 030231 tropical medicine, MESH: Drug Administration Schedule, Biology, Drug Administration Schedule, 03 medical and health sciences, Internal medicine, parasitic diseases, medicine, Animals, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Africa, Central, Nifurtimox, Adverse effect, MESH: Humans, MESH: Nifurtimox, 030306 microbiology, MESH: Adult, Monotherapy, medicine.disease, MESH: Injections, Intravenous, MESH: Male, MESH: Recurrence, Surgery, MESH: Drug Therapy, Combination, Regimen, MESH: Trypanosomiasis, African, Trypanosomiasis, African, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Female, Trypanosomiasis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbd3805533ce5a7b8454f9cd2983e3a
https://doi.org/10.1086/510534 -
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المؤلفون: Munday, Jane C., Eze, Anthonius A., Baker, Nicola, Glover, Lucy, Clucas, Caroline, Aguinaga Andres, David, Natto, Manal J., Teka, Ibrahim A., McDonald, Jennifer, Lee, Rebecca S., Graf, Fabrice E., Ludin, Philipp, Burchmore, Richard J. S., Turner, C. Michael R., Tait, Andy, MacLeod, Annette, Mäser, Pascal, Barrett, Michael P., Horn, David, De Koning, Harry P.
المساهمون: University of Glasgow, University of Nigeria, London School of Hygiene and Tropical Medicine (LSHTM), Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), This work was supported by the Wellcome Trust. The Wellcome Trust Centre for Molecular Parasitology is supported by core funding from the Wellcome Trust (085349).
المصدر: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2014, 69 (3), pp.651-663. ⟨10.1093/jac/dkt442⟩مصطلحات موضوعية: drug transport, MESH: Sequence Analysis, DNA, MESH: Aquaglyceroporins, MESH: Biological Transport, [SDV]Life Sciences [q-bio], Genes, Protozoan, Trypanosoma brucei brucei, Drug Resistance, Melarsoprol, resistance mutation, MESH: Melarsoprol, parasitic diseases, MESH: Trypanocidal Agents, Alleles, Pentamidine, Original Research, protozoan, MESH: Alleles, MESH: Trypanosoma brucei brucei, Biological Transport, Sequence Analysis, DNA, Trypanocidal Agents, aquaporin, MESH: Genes, Protozoan, parasite, MESH: Drug Resistance, MESH: Pentamidine, Aquaglyceroporins
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::61002478b01320a5ea5dac41a2b03c61
https://hal-pasteur.archives-ouvertes.fr/pasteur-03107152/file/dkt442.pdf -
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المؤلفون: David Horn, Michael P. Barrett, Lucy Glover, Nicola Baker, Harry P. de Koning, David Aguinaga Andrés, Jane C. Munday
المساهمون: London School of Hygiene and Tropical Medicine (LSHTM), University of Glasgow, This work was funded by Grant 093010/Z/10/Z (to D.H.) from The Wellcome Trust and Grant 84733 (to H.P.d.K. and M.P.B.) from the Medical Research Council. N.B. was supported by a Bloomsbury Colleges doctoral studentship.
المصدر: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (27), pp.10996-11001. ⟨10.1073/pnas.1202885109⟩مصطلحات موضوعية: [SDV]Life Sciences [q-bio], Drug Resistance, Melarsoprol, Drug resistance, urologic and male genital diseases, MESH: Melarsoprol, Flagellar pocket, Diminazene aceturate, MESH: Animals, MESH: Trypanocidal Agents, MESH: Tsetse Flies, 0303 health sciences, Multidisciplinary, biology, Biological Sciences, Trypanocidal Agents, 3. Good health, Flagella, MESH: Pentamidine, MESH: Drug Resistance, MESH: Trypanosomiasis, medicine.drug, MESH: High-Throughput Screening Assays, Tsetse Flies, Molecular Sequence Data, Trypanosoma brucei brucei, Trypanosoma brucei, MESH: Flagella, Cell Line, 03 medical and health sciences, Trypanosomiasis, medicine, Animals, Humans, Pentamidine, Gene knockout, 030304 developmental biology, Aquaporin 3, Aquaporin 2, MESH: Aquaporin 2, MESH: Humans, MESH: Molecular Sequence Data, MESH: Aquaporin 3, 030306 microbiology, urogenital system, MESH: Trypanosoma brucei brucei, biology.organism_classification, medicine.disease, Virology, High-Throughput Screening Assays, MESH: Cell Line
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9ce7c29a0ef3ade746acd2bf72720e
https://hal-pasteur.archives-ouvertes.fr/pasteur-03107134 -
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المؤلفون: Bébène Bandzouzi, Ghislain Mpandzou, Alain Buguet, Philippe Vincendeau, Raymond Cespuglio, Stéphane Ngampo, Bernard Bouteille
المساهمون: Radicaux libres, substrats énergétiques et physeopathologie cérébrale, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Neuroépidémiologie Tropicale et Comparée (NETEC), Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Université de Limoges (UNILIM), Service de Parasitologie Mycologie [CHU Limoges], CHU Limoges, Université de Limoges (UNILIM)
المصدر: Journal of the Neurological Sciences
Journal of the Neurological Sciences, Elsevier, 2011, 305 (1-2), pp.112-5. ⟨10.1016/j.jns.2011.03.002⟩مصطلحات موضوعية: Sleep Wake Disorders, medicine.medical_specialty, Pediatrics, Every Six Months, Polysomnography, Trypanosoma brucei gambiense, 030231 tropical medicine, Encephalopathy, Melarsoprol, MESH: Melarsoprol, MESH: Trypanosoma brucei gambiense, 03 medical and health sciences, 0302 clinical medicine, Arsenic Poisoning, parasitic diseases, MESH: Congo, medicine, Humans, African trypanosomiasis, MESH: Trypanocidal Agents, MESH: Sleep Disorders, MESH: Humans, medicine.diagnostic_test, Lumbar puncture, business.industry, MESH: Child, Preschool, medicine.disease, Trypanocidal Agents, 3. Good health, Surgery, Trypanosomiasis, African, MESH: Trypanosomiasis, African, Congo, Neurology, MESH: Polysomnography, Child, Preschool, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), business, Trypanosomiasis, MESH: Arsenic Poisoning, MESH: Female, 030217 neurology & neurosurgery, medicine.drug, Pentamidine
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