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المؤلفون: Silvia Corrochano, Abigail Harris, Hans Clevers, Caroline Eozenou, Isabelle Stévant, Joelle Bignon-Topalovic, Nick Warr, Neila Belguith, Sara Wells, Bochra Ben Rhouma, Pam Siggers, Serge Nef, Daniel T. Grimes, Ken McElreavey, Rebecca D. Burdine, Feng Cong, Makoto Suzuki, Andy Greenfield, Danielle Sagar, Anu Bashamboo, Bon-Kyoung Koo, Raja Brauner
المساهمون: Medical Research Coucil Harwell [Oxford, UK] (MRC Harwell), MRC Harwell, Department of Molecular Biology [Princeton], Princeton University, Novartis Institutes for BioMedical Research (NIBR), Hubrecht Institute [Utrecht, Netherlands], University Medical Center [Utrecht]-Royal Netherlands Academy of Arts and Sciences (KNAW), Université de Genève = University of Geneva (UNIGE), Fondation Ophtalmologique Adolphe de Rothschild [Paris], Université Paris Descartes - Paris 5 (UPD5), Faculté de médecine - Faculty of Medicine [Sfax, Tunisie] (FMS), Université de Sfax - University of Sfax, Génétique du Développement humain - Human developmental genetics, Institut Pasteur [Paris] (IP), This work was supported by the Medical Research Council by core funding Grant MC_U142684167 (to A.G.) at the Harwell Institute, and the Agence Nationale de la Recherche Grant ANR-10-LABX-73 (to K.M.). S.N. acknowledges support from Swiss National Science Foundation Grant 31003A_173070. M.S. was a visiting scientist supported by the Strategic International Research Exchange Program between Princeton University and National Institutes of Natural Sciences, Japan. D.T.G. was supported by National Institute of Arthritis and Mucoskeletal and Skin Diseases Pathway to Independence Award 1K99AR070905. Work in the R.D.B. laboratory is supported by the National Institute of Child Health and Development Grant 2R01HD048584., We thank the husbandry team in Ward 5 of the Mary Lyon Centre at Harwell and the Frozen Embryo and Sperm Archive (FESA) and histology teams. We thank Dagmar Wilhelm for the kind gift of anti-FOXL2 antibody. We thank Phil Johnson for zebrafish husbandry. We acknowledge European Cooperation in Science & Technology (COST) Action BM1303 (DSDnet)., ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010), Université de Genève (UNIGE), Génétique du développement humain, Institut Pasteur [Paris], Hubrecht Institute for Developmental Biology and Stem Cell Research
المصدر: Proceedings of the National Academy of Sciences, Vol. 115, No 21 (2018) pp. 5474-5479
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (21), pp.5474-5479. ⟨10.1073/pnas.1801223115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (21), pp.5474-5479. ⟨10.1073/pnas.1801223115⟩
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5474
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5474-5479. National Academy of Sciencesمصطلحات موضوعية: 0301 basic medicine, Male, Embryo, Nonmammalian, Sex Differentiation, Organogenesis, Wnt Proteins/antagonists & inhibitors, Disorders of Sex Development, DSD, MESH: Wnt Proteins / metabolism, MESH: Testis / metabolism, MESH: Disorders of Sex Development / genetics, MESH: Testis / pathology, MESH: Embryo, Nonmammalian / cytology, Mice, Embryo, Nonmammalian/cytology, MESH: Gene Expression Regulation, Developmental, Testis, Missense mutation, MESH: Animals, ddc:576.5, Developmental, Disorders of sex development, 10. No inequality, MESH: Ubiquitin-Protein Ligases / genetics, Exome sequencing, Cells, Cultured, beta Catenin, Zebrafish, Multidisciplinary, Cultured, MESH: Thrombospondins / genetics, MESH: SOX9 Transcription Factor / metabolism, Wnt signaling pathway, Gene Expression Regulation, Developmental, SOX9 Transcription Factor, beta Catenin/antagonists & inhibitors, MESH: beta Catenin / metabolism, Sex reversal, MESH: Gonads / pathology, Cell biology, MESH: Young Adult, Embryo, MESH: Gonads / metabolism, Female, MESH: Cells, Cultured, Adult, Adolescent, Ubiquitin-Protein Ligases, Cells, Thrombospondins/genetics, Mutation, Missense, MESH: beta Catenin / antagonists & inhibitors, SOX9, Biology, Gonads/metabolism, MESH: Embryo, Nonmammalian / metabolism, 03 medical and health sciences, Young Adult, MESH: Wnt Proteins / genetics, WNT signaling, medicine, Animals, Humans, Ubiquitin-Protein Ligases/genetics, MESH: SOX9 Transcription Factor / genetics, MESH: Zebrafish, RSPO1, Gonads, General, MESH: Mice, Nonmammalian/cytology, MESH: Disorders of Sex Development / pathology, MESH: Adolescent, MESH: Wnt Proteins / antagonists & inhibitors, MESH: Mutation, Missense, MESH: Humans, MESH: beta Catenin / genetics, ZNRF3, MESH: Adult, Sex determination, medicine.disease, MESH: Male, MESH: Ubiquitin-Protein Ligases / physiology, SOX9 Transcription Factor/genetics, Wnt Proteins, 030104 developmental biology, MESH: Thrombospondins / metabolism, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Gene Expression Regulation, Mutation, Testis/metabolism, Missense, Thrombospondins, MESH: Female, Function (biology), Disorders of Sex Development/genetics, MESH: Sex Differentiation
وصف الملف: image/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f785b7c346bbb98027161ca7382405e7
https://hdl.handle.net/20.500.11755/a85a814a-a5a7-4064-9ca8-516f15a8bb58 -
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المؤلفون: Annette Martin, Brigitte Blumen, Stephanie Aicher, Eliane F. Meurs, Penelope Mavromara, Athanasios Kakkanas, Lisette Cohen, Richard Njouom, Gabriela Oprişan
المساهمون: Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut Pasteur Hellénique, Réseau International des Instituts Pasteur (RIIP), University of Patras, School of Medicine, Cantacuzino National Medico-Military Institute for Research Development [Bucharest], Cantacuzino Institute [Romania], Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Titu Maiorescu University = Universitatea Titu Maiorescu [Buchares] (UTM), Centre Pasteur du Cameroun, Hépacivirus et Immunité innée, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Democritus University of Thrace (DUTH), This work was supported in part by an ACIP grant (#A23/2013) from the Institut Pasteur, Paris, France and by the Hellenic Pasteur Institute, Athens, Greece. SA, a PhD student of the University of Patras, School of Health Sciences, Department of Pharmacy, Greece was the recipient of doctoral fellowships from the Calmette and Yersin program and the Virology Department of the Institut Pasteur, and of a young researcher prize from the Fondation des Treilles., The authors gratefully acknowledge: Christine Neuveut (IP Paris) for helpful discussions and for sharing pFOP and pTOP plasmids, Alberto L. Epstein (Université Claude Bernard, Lyon) for sharing pA-EUA2 + lacZ plasmid, Amadou Sall (IP Cambodia) for sharing HCV 1aC isolate, Takaji Wakita (NIID, Tokyo, Japan), Ralf Bartenschlager (Univ. Heidelberg, Germany) and Charles Rice (Rockefeller Univ., New York, USA) for their respective generous gifts of pJFH1, cell-culture adapted pJFH1-2EI3-adapt cDNA, Huh7.5 cells and 1aH77 cDNA, Stephanie Dabo and Matthieu Fritz (IP Paris) for sharing experimental expertise, Sousana Kotanidou and Ksenia Rybkina for technical assistance, Pascal Roux and Anne Danckaert at the Imagopole core facility (IP Paris) for their help in the acquisition and processing of the immunofluorescence images, Sylvie van der Werf (Head of the Unit of Molecular Genetics of RNA Viruses) for her continuous support., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.11185. ⟨10.1038/s41598-018-29078-2⟩
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports, 2018, 8 (1), pp.11185. ⟨10.1038/s41598-018-29078-2⟩مصطلحات موضوعية: 0301 basic medicine, MESH: Active Transport, Cell Nucleus / genetics, Viral pathogenesis, [SDV]Life Sciences [q-bio], lcsh:Medicine, Hepacivirus, medicine.disease_cause, Malignant transformation, MESH: Genotype, MESH: Wnt Signaling Pathway / genetics, MESH: Hepatitis C / genetics, Transcription (biology), T Cell Transcription Factor 1, MESH: Liver Neoplasms / genetics, lcsh:Science, Wnt Signaling Pathway, beta Catenin, MESH: Cell Proliferation / genetics, Multidisciplinary, Hepatitis C virus, Liver Neoplasms, Wnt signaling pathway, MESH: Carcinoma, Hepatocellular / pathology, MESH: Gene Expression Regulation, Neoplastic, Hepatitis C, 3. Good health, MESH: Hepacivirus / genetics, Gene Expression Regulation, Neoplastic, Cell Transformation, Neoplastic, MESH: HEK293 Cells, Cell signalling, Carcinoma, Hepatocellular, Genotype, Active Transport, Cell Nucleus, MESH: Liver Neoplasms / virology, Biology, Article, 03 medical and health sciences, Downregulation and upregulation, medicine, Humans, Gene, Cell Proliferation, MESH: beta Catenin / genetics, MESH: Liver Neoplasms / pathology, MESH: Humans, lcsh:R, MESH: Carcinoma, Hepatocellular / genetics, MESH: Cell Transformation, Neoplastic / genetics, Molecular biology, MESH: Carcinoma, Hepatocellular / virology, MESH: T Cell Transcription Factor 1 / genetics, 030104 developmental biology, HEK293 Cells, MESH: Hepacivirus / pathogenicity, Catenin, MESH: Hepatitis C / virology, MESH: Hepatitis C / pathology, lcsh:Q
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المؤلفون: Rocio Lopez, Pierre Hainaut, Iris Suarez M, Germán Osorio, Pascal Pineau, Diego Uribe, Sergio Hoyos, Juan Camilo Pérez, Maria-C Navas, Carlos Mario Jaramillo
المساهمون: Grupo de Gastrohepatologia [Medellin, Colombia], Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Departamento de Patologia [Medellin, Colombia], Facultad de Psicología, Valencia, Hospital Pablo Tobón Uribe [Medellín, Colombie], Fundacion Santa Fe de Bogota [Colombia], International Prevention Research Institute (IPRI), Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), This study was funded by Departamento Nacional de Ciencia, Innovación y Tecnologia Colciencias (Grant 111540820471) and Proyecto de Sostenibilidad, Vicerrectoría de Investigación, Universidad de Antioquia., We thank Dr. Anne Lise Haenni from the Institut Jacques Monod for critical reading of the manuscript and Dr. Andres Arias from Universidad de Antioquia for discussion of the results. We also thank Ghyslaine Martel from International Agency for Research on Cancer (IARC) and Beatriz Vieco from Departamento de Patología, Universidad de Antioquia, for technical assistance., Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)
المصدر: Annals of hepatology : official journal of the Mexican Association of Hepatology
Annals of hepatology : official journal of the Mexican Association of Hepatology, Elsevier, 2015, 14 (1), pp.64-74. ⟨10.1016/S1665-2681(19)30802-6⟩
Annals of Hepatology, Vol 14, Iss 1, Pp 64-74 (2015)
Annals of hepatology : official journal of the Mexican Association of Hepatology, 2015, 14 (1), pp.64-74. ⟨10.1016/S1665-2681(19)30802-6⟩مصطلحات موضوعية: Pathology, MESH: Wnt Signaling Pathway / genetics, Specialties of internal medicine, MESH: Neoplasm Grading, MESH: Colombia, medicine.disease_cause, Exon, MESH: Aged, 80 and over, MESH: Liver Neoplasms / genetics, CTNNB1, HCC, MESH: Cohort Studies, HBV infection, MESH: Aged, Mutation, MESH: Middle Aged, Subcellular localization, MESH: Hepatitis B, Chronic / complications, Wnt signaling pathway, MESH: Carcinoma, Hepatocellular / pathology, General Medicine, MESH: beta Catenin / metabolism, Hepatitis B, 3. Good health, RC581-951, Hepatocellular carcinoma, Immunohistochemistry, MESH: Liver Neoplasms / etiology, medicine.medical_specialty, MESH: Carcinoma, Hepatocellular / etiology, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], medicine, Carcinoma, neoplasms, Gene, MESH: Age Factors, MESH: beta Catenin / genetics, MESH: Liver Neoplasms / pathology, MESH: Humans, Hepatology, MESH: Carcinoma, Hepatocellular / genetics, MESH: Retrospective Studies, MESH: Immunohistochemistry, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, β-catenin, medicine.disease, MESH: Male, digestive system diseases, MESH: Mutation, Cancer research, MESH: Exons, MESH: Female
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المؤلفون: Suarez, Iris, Uribe, Diego, Jaramillo, Carlos, Osorio, German, Pérez, Juan, Lopez, Rocio, Hoyos, Sergio, Hainaut, Pierre, Pineau, Pascal, Navas, Maria-C
المساهمون: Grupo de Gastrohepatologia [Medellin, Colombia], Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Departamento de Patologia [Medellin, Colombia], Facultad de Psicología, Valencia, Hospital Pablo Tobón Uribe [Medellín, Colombie], Fundacion Santa Fe de Bogota [Colombia], International Prevention Research Institute (IPRI), Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), This study was funded by Departamento Nacional de Ciencia, Innovación y Tecnologia Colciencias (Grant 111540820471) and Proyecto de Sostenibilidad, Vicerrectoría de Investigación, Universidad de Antioquia., We thank Dr. Anne Lise Haenni from the Institut Jacques Monod for critical reading of the manuscript and Dr. Andres Arias from Universidad de Antioquia for discussion of the results. We also thank Ghyslaine Martel from International Agency for Research on Cancer (IARC) and Beatriz Vieco from Departamento de Patología, Universidad de Antioquia, for technical assistance., Pineau, Pascal
المصدر: Annals of hepatology : official journal of the Mexican Association of Hepatology
Annals of hepatology : official journal of the Mexican Association of Hepatology, 2015, 14 (1), pp.64-74. ⟨10.1016/S1665-2681(19)30802-6⟩مصطلحات موضوعية: MESH: Wnt Signaling Pathway / genetics, MESH: Neoplasm Grading, MESH: Carcinoma, Hepatocellular / etiology, MESH: Colombia, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Aged, 80 and over, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], MESH: Liver Neoplasms / genetics, CTNNB1, HCC, neoplasms, MESH: Cohort Studies, HBV infection, MESH: Age Factors, MESH: Aged, MESH: beta Catenin / genetics, MESH: Liver Neoplasms / pathology, MESH: Humans, MESH: Middle Aged, Subcellular localization, MESH: Hepatitis B, Chronic / complications, MESH: Carcinoma, Hepatocellular / genetics, MESH: Carcinoma, Hepatocellular / pathology, MESH: Retrospective Studies, MESH: Immunohistochemistry, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, β-catenin, MESH: beta Catenin / metabolism, digestive system diseases, MESH: Male, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Mutation, MESH: Mutation, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], MESH: Liver Neoplasms / etiology, MESH: Exons, MESH: Female
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