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المؤلفون: Fournes, Florian, Niault, Theophile, Czarnecki, Jakub, Tissier-Visconti, Alvise, Mazel, Didier, Val, Marie-Eve
المساهمون: Plasticité du Génome Bactérien - Bacterial Genome Plasticity (PGB), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Sorbonne université - Faculté des Sciences et Ingénierie (SU FSI), Sorbonne Université (SU), Institute of Microbiology [Warsaw], Faculty of Biology [Warsaw], University of Warsaw (UW)-University of Warsaw (UW), Institut Pasteur, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique [CNRS-UMR 3525], French National Research Agency, Jeunes Chercheurs [ANR-19-CE12-0001], Laboratoires d’Excellence [ANR-10-LABX-62-IBEID], F.F. was supported by ANR-10-LABX-62-IBEID and ANR-19-CE12-0001, T.N. was supported by the Ministère de l’Enseignement Supérieur et de la Recherche, J.C. was supported by Institut Pasteur (Cantarini foundation) [ANR-19-CE12-0001, ANR-10-LABX-62-IBEID]. Funding for open access charge: French National Research Agency [ANR-19-CE12-0001]., ANR-19-CE12-0001,RepliChroms,Contrôle de la Réplication chez les Bactéries à Multiple Chromosomes(2019), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)
المصدر: Nucleic Acids Research
Nucleic Acids Research, 2021, 49 (19), pp.11119-11133. ⟨10.1093/nar/gkab903⟩
Nucleic Acids Research, Oxford University Press, 2021, 49 (19), pp.11119-11133. ⟨10.1093/nar/gkab903⟩مصطلحات موضوعية: MESH: Signal Transduction, Models, Molecular, Protein Conformation, alpha-Helical, MESH: Sequence Homology, Amino Acid, AcademicSubjects/SCI00010, MESH: DNA Replication, MESH: Amino Acid Sequence, MESH: Base Sequence, Genome Integrity, Repair and Replication, MESH: Recombinant Proteins, MESH: Genetic Vectors, MESH: Replication Origin, Cloning, Molecular, MESH: Bacterial Proteins, Vibrio cholerae, MESH: Gene Expression Regulation, Bacterial, MESH: Escherichia coli, Chromosomes, Bacterial, Recombinant Proteins, MESH: Protein Conformation, beta-Strand, MESH: Models, Molecular, Protein Binding, Signal Transduction, DNA Replication, DNA, Bacterial, MESH: Chromosomes, Bacterial, Genetic Vectors, MESH: Sequence Alignment, MESH: Binding, Competitive, Replication Origin, Binding, Competitive, Bacterial Proteins, Escherichia coli, MESH: Protein Binding, MESH: Cloning, Molecular, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Protein Interaction Domains and Motifs, Amino Acid Sequence, MESH: Protein Conformation, alpha-Helical, MESH: Protein Interaction Domains and Motifs, Binding Sites, Base Sequence, Sequence Homology, Amino Acid, fungi, Gene Expression Regulation, Bacterial, MESH: DNA, Bacterial, MESH: Binding Sites, nervous system, Protein Conformation, beta-Strand, Sequence Alignment, MESH: Vibrio cholerae
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::78989246a70ed6b9797197547822388d
http://europepmc.org/articles/PMC8565311 -
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المؤلفون: François Bulteau, Michel Thépaut, Maxime Henry, Amandine Hurbin, Laetitia Vanwonterghem, Corinne Vivès, Aline Le Roy, Christine Ebel, Olivier Renaudet, Franck Fieschi, Jean-Luc Coll
المساهمون: Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Département de Chimie Moléculaire (DCM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)
المصدر: Molecular Pharmaceutics
Molecular Pharmaceutics, 2022, 19 (1), pp.235-245. ⟨10.1021/acs.molpharmaceut.1c00744⟩مصطلحات موضوعية: MESH: HT29 Cells, Pharmaceutical Science, MESH: Spheroids, Cellular, Mice, Nude, MESH: Flow Cytometry, MESH: Recombinant Proteins, 03 medical and health sciences, Mice, 0302 clinical medicine, Spheroids, Cellular, Drug Discovery, Tn antigen, MESH: Mice, Nude, cancer, MESH: Microscopy, Confocal, Animals, Humans, MESH: Animals, Antigens, Tumor-Associated, Carbohydrate, Lectins, C-Type, MESH: Mice, 030304 developmental biology, 0303 health sciences, MESH: Humans, Microscopy, Confocal, MESH: Antigens, Tumor-Associated, Carbohydrate, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Surface Plasmon Resonance, Flow Cytometry, Recombinant Proteins, 3. Good health, MESH: Surface Plasmon Resonance, C-type lectin, A549 Cells, 030220 oncology & carcinogenesis, Molecular Medicine, Female, MESH: A549 Cells, MESH: Female, HT29 Cells, MESH: Neoplasm Transplantation, MESH: Lectins, C-Type, Neoplasm Transplantation
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المؤلفون: Jiho Kim, Bing-Mae Chen, Audrey Germond, Roffler Steve, Sucheol Gil, Laxman Savergave, Sanjay Singh, Hongjie Wang, Chang Li, Andre Lieber, Pascal Fender, Darrick Carter, Audrey Baldessari, Arjun Raghuwanshi, Charles W. Drescher, Swarnendu Kaviraj
المساهمون: PAI Life Sciences, Inc, Huazhong University of Science and Technology [Wuhan] (HUST), Complexe de recherche interprofessionnel en aérothermochimie (CORIA), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Gennova Biopharmaceuticals, Ltd, Division of Medical Genetics [Seattle], University of Washington [Seattle], Washington National Primate Research Center [Seattle], Institute of Biomedical Sciences [Taipei, Taiwan], Academia Sinica, Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Public Health Sciences Division, Fred Hutchinson Cancer Research Center [Seattle] (FHCRC)
المصدر: Scientific Reports
Scientific Reports, 2022, 12, pp.7753. ⟨10.1038/s41598-022-11843-z⟩مصطلحات موضوعية: Engineering, Technology, MESH: Tight Junctions, Tight Junctions, MESH: Recombinant Proteins, MESH: Doxorubicin, Mice, Antineoplastic Combined Chemotherapy Protocols, Animals, Humans, MESH: Animals, MESH: Mice, Cyclophosphamide, Ovarian Neoplasms, Multidisciplinary, MESH: Technology, MESH: Humans, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], business.industry, MESH: Cyclophosphamide, Recombinant Proteins, Cell biology, MESH: Antineoplastic Combined Chemotherapy Protocols, MESH: Ovarian Neoplasms, Doxorubicin, Female, business, MESH: Female
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المؤلفون: de Krijger, Inge, Föhr, Bastian, Pérez, Santiago Hernández, Vincendeau, Estelle, Serrat, Judit, Thouin, Alexander Marc, Susvirkar, Vivek, Lescale, Chloé, Paniagua, Inés, Hoekman, Liesbeth, Kaur, Simranjeet, Altelaar, Maarten, Deriano, Ludovic, Faesen, Alex C, Jacobs, Jacqueline J L, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics
المساهمون: Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Max Planck Institute for Biophysical Chemistry (MPI-BPC), Max-Planck-Gesellschaft, Université Paris Diderot, Sorbonne Paris Cité, Paris, France, Université Paris Diderot - Paris 7 (UPD7), Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie du système immunitaire (Inserm U1223), Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University [Utrecht], This work was supported by project grant 10999/2017-1 from the Dutch Cancer Society (KWF) to J.J.L.J., by the Institut Pasteur to L.D., by the Institut National Du Cancer (INCA_13852) to L.D., by the Ligue Nationale Contre le Cancer (Equipe labellisée 2019) to L.D. The Proteomics Facility of the Netherlands Cancer Institute was supported by the X-omics Initiative, partially funded by the Dutch Research Council (NWO)(project 184.034.019). E.V. received funding from Université de Paris, Sorbonne Paris Cité. A.C.F. is grateful for generous core funding by the Max Planck Society., Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Université Sorbonne Paris Cité (USPC), Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Institut Pasteur [Paris], Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris], Lescale, Chloé
المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.5421. ⟨10.1038/s41467-021-25724-y⟩
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, 12(1). Nature Publishing Group
Nature Communications, 2021, 12 (1), pp.5421. ⟨10.1038/s41467-021-25724-y⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-25724-y⟩مصطلحات موضوعية: DNA Repair, Chemistry(all), ATPase, MESH: DNA Breaks, Double-Stranded, Gene Expression, General Physics and Astronomy, Cell Cycle Proteins, [SDV.GEN] Life Sciences [q-bio]/Genetics, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Biochemistry, Piperazines, MESH: Recombinant Proteins, Mice, chemistry.chemical_compound, 0302 clinical medicine, DNA Breaks, Double-Stranded, MESH: Animals, 0303 health sciences, Multidisciplinary, biology, Chemistry, MESH: Protein Multimerization, DNA damage and repair, MESH: DNA, Recombinant Proteins, 3. Good health, Cell biology, DNA-Binding Proteins, MESH: ATPases Associated with Diverse Cellular Activities, MESH: HEK293 Cells, Mad2 Proteins, MESH: Phthalazines, MESH: Mad2 Proteins, Protein Binding, MESH: Cell Line, Tumor, MESH: Gene Expression, DNA repair, Science, Physics and Astronomy(all), Article, Chromosomes, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, MESH: Cell Cycle Proteins, Cell Line, Tumor, Animals, Humans, MESH: Protein Binding, Protein Interaction Domains and Motifs, MESH: Mice, 030304 developmental biology, MESH: Protein Interaction Domains and Motifs, [SDV.GEN]Life Sciences [q-bio]/Genetics, Binding Sites, MESH: Humans, TRIP13, Biochemistry, Genetics and Molecular Biology(all), [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, DNA, General Chemistry, DNA Repair Pathway, Fibroblasts, MESH: Cell Line, HEK293 Cells, MESH: Binding Sites, MESH: Cisplatin, MESH: Fibroblasts, MESH: HeLa Cells, biology.protein, ATPases Associated with Diverse Cellular Activities, Phthalazines, Cisplatin, Protein Multimerization, 030217 neurology & neurosurgery, Function (biology), MESH: DNA-Binding Proteins, HeLa Cells, Genetics and Molecular Biology(all)
وصف الملف: application/pdf
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المساهمون: Architecture et Dynamique des Macromolécules Biologiques - Architecture and Dynamics of Biological Macromolecules, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Collège doctoral [Sorbonne universités], Sorbonne Université (SU), Chimie biologique épigénétique - Epigenetic Chemical Biology (EpiCBio), Biologie des Bactéries pathogènes à Gram-positif - Biology of Gram-Positive Pathogens, The authors acknowledge a DIM1Health 2019 grant from the Région Ile de France to the project EpiK (coordinated by P.B. Arimondo) for the LCMS equipment., We thank the Crystallogenesis and Crystallography Platform (PF6) of Institut Pasteur for help in crystallization and preliminary crystallographic data collection. We thank Marcel Hollenstein and his group for the use of their HPLC system. We also thank staff from PROXIMA−1 and PROXIMA-2 beamlines for help in data collection and SOLEIL (Saint-Aubin, France) and for provision of synchrotron radiation facilities. We thank Pierre Legrand for discussions regarding the structural aspect of this work, as well as Laurent Debarbieux and his group for discussions regarding phages. We also thank Stéphane Decorps-Declere from the Hub de Bioinformatique et Biostatistique (C3BI, Institut Pasteur) for help with the S-2L genome mapping and its deposition., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Collège Doctoral, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4710. ⟨10.1038/s41467-021-25064-x⟩
Nature Communications, 2021, 12 (1), pp.4710. ⟨10.1038/s41467-021-25064-x⟩
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)مصطلحات موضوعية: DNA, Bacterial, Models, Molecular, Genes, Viral, Protein Conformation, Science, Static Electricity, MESH: Base Pairing, Genome, Viral, Siphoviridae, Crystallography, X-Ray, Article, MESH: Recombinant Proteins, Adenylosuccinate Synthase, Viral Proteins, MESH: Protein Conformation, Escherichia coli, DNA metabolism, MESH: 2-Aminopurine, Bacteriophages, MESH: Adenylosuccinate Synthase, MESH: Siphoviridae, MESH: Bacteriophages, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], 2-Aminopurine, Base Pairing, MESH: Static Electricity, X-ray crystallography, MESH: Genes, Viral, Deoxyadenosines, MESH: Escherichia coli, MESH: Podoviridae, MESH: Deoxyadenosines, Podoviridae, MESH: Crystallography, X-Ray, MESH: Viral Proteins, MESH: DNA, Bacterial, Phosphoric Monoester Hydrolases, Recombinant Proteins, MESH: DNA, Viral, MESH: Metabolic Networks and Pathways, DNA, Viral, MESH: Phosphoric Monoester Hydrolases, MESH: Genome, Viral, Structural biology, Metabolic Networks and Pathways, MESH: Models, Molecular
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المؤلفون: Nani Van Gerven, Rick R. M. Joosten, Wai Li Ling, Alexander E. S. Van Driessche, Nico A. J. M. Sommerdijk, Mike Sleutel, Maria Bacia
المساهمون: Institut des Sciences de la Terre (ISTerre), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de recherche pour le développement [IRD] : UR219-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel-Université Grenoble Alpes (UGA), VIB-VUB Center for Structural Biology [Bruxelles], VIB [Belgium], Department of Chemical Engineering and Chemistry [Eindhoven], Eindhoven University of Technology [Eindhoven] (TU/e), Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Department of Biochemistry, Department of Molecular Biology, Faculty of Science, Radboud University, Radboud Institute for Molecular Life Sciences (RIMLS), 6525GA Nijmegen, the Netherlands, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences (RIMLS), Oncode Institute, Radboud University, Nijmegen, the Netherland, Structural Biology Brussels (SBB), Vrije Universiteit Brussel (VUB), ANR-10-INBS-0005,FRISBI,Infrastructure Française pour la Biologie Structurale Intégrée(2010), ANR-17-EURE-0003,CBH-EUR-GS,CBH-EUR-GS(2017), Centre National de la Recherche Scientifique (CNRS)-PRES Université de Grenoble-Université Joseph Fourier - Grenoble 1 (UJF)-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de recherche pour le développement [IRD] : UR219-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de recherche pour le développement [IRD] : UR219-Université Grenoble Alpes (UGA)-Université Gustave Eiffel-Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institute for Complex Molecular Systems, Materials and Interface Chemistry, Physical Chemistry, Department of Bio-engineering Sciences, Structural Biology Brussels
المصدر: Nature Communications
Nature Communications, 2021, 12, pp.3902. ⟨10.1038/s41467-021-24171-z⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-24171-z⟩
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-24171-z⟩
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Nature Communications, 12
Nature Communications, 12, 1
Nature Communications, Nature Publishing Group, 2021, 12, pp.3902. ⟨10.1038/s41467-021-24171-z⟩
Nature Communications, 12(1):3902. Nature Publishing Groupمصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Chemistry(all), Nucleation, General Physics and Astronomy, Nanoparticle, Crystallography, X-Ray, 01 natural sciences, law.invention, MESH: Recombinant Proteins, law, Crystallization, Aldose-Ketose Isomerases, MESH: Crystallization, Multidisciplinary, MESH: Kinetics, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Self-assembly, Nanocrystalline material, Recombinant Proteins, MESH: Cryoelectron Microscopy, Protein crystallization, MESH: Models, Molecular, Materials science, Science, Nanotechnology, Physics and Astronomy(all), 010402 general chemistry, Molecular resolution, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, MESH: Nanostructures, Point Mutation, [CHIM]Chemical Sciences, MESH: Particle Size, Particle Size, MESH: Aldose-Ketose Isomerases, MESH: Point Mutation, Biochemistry, Genetics and Molecular Biology(all), Cryoelectron Microscopy, Proteins, General Chemistry, MESH: Crystallography, X-Ray, 0104 chemical sciences, Nanostructures, Kinetics, 030104 developmental biology, Phase transitions and critical phenomena, Nanocrystal, [SDU]Sciences of the Universe [physics], Nanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19]
وصف الملف: application/pdf
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المؤلفون: Veronica Vallejo, Laurent Camborde, Monique Berger, Jean Daydé, Eva Petit, Alban Jacques
المساهمون: Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Interactions Microbiennes dans la Rhizosphère et les Racines, Laboratoire de Recherche en Sciences Végétales (LRSV), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), PepsiCo, PepsiCo Global R&D
المصدر: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.15137. ⟨10.1038/s41598-020-71746-9⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Agroinfiltration, Glycosylation, MESH: Glycosyltransferases / metabolism, Nicotiana benthamiana, lcsh:Medicine, MESH: Glycosyltransferases / genetics, Steviol, MESH: Biosynthetic Pathways, MESH: Stevia / enzymology, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Glucosides, Stevia, lcsh:Science, MESH: Glucosides / metabolism, Plant Proteins, chemistry.chemical_classification, Multidisciplinary, Expression vector, biology, Chemistry, Biological techniques, MESH: Glycosylation, Recombinant Proteins, MESH: Plant Proteins / metabolism, Diterpenes, Kaurane, Biotechnology, digestive system, Article, Uridine Diphosphate, 03 medical and health sciences, Glycosyltransferase, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, MESH: Recombinant Proteins / isolation & purification, lcsh:R, fungi, Glycoside, Glycosyltransferases, biology.organism_classification, MESH: Plant Proteins / genetics, Biosynthetic Pathways, Stevia rebaudiana, MESH: Diterpenes, Kaurane / metabolism, 030104 developmental biology, MESH: Uridine Diphosphate / metabolism, biology.protein, lcsh:Q, MESH: Recombinant Proteins / metabolism, Plant sciences, MESH: Recombinant Proteins / genetics, 010606 plant biology & botany
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المؤلفون: Savva, Christos, Clark, Alice, Naylor, Claire, Popoff, Michel, Moss, David, Basak, Ajit, Titball, Richard, Bokori-Brown, Monika
المساهمون: Leicester Institute of Structural and Chemical Biology [Leicester] (LISCB), University of Leicester, University of Wolverhampton, Molecular Dimensions Ltd [Newmarket], Bactéries anaérobies et Toxines, Institut Pasteur [Paris], Birkbeck College [University of London], College of Life and Environmental Sciences [Exeter], University of Exeter, This work was supported by grants from the UK Medical Research Council (MC-A021-53019) and the Wellcome Trust (WT089618MA)., We thank Professor Nicholas Harmer and Alice Cross, University of Exeter, UK for assistance with the thermostability assay. We also wish to thank Dr. Shaoxia Chen, Dr. Giuseppe Cannone, Dr. Greg McMullan, MRC Laboratory of Molecular Biology, Cambridge, UK, Dr. Peter Moody, University of Leicester, UK, and Dr. Edmund Kunji, MRC Mitochondrial Biology Unit, Cambridge, UK for helpful discussions and advice., Institut Pasteur [Paris] (IP)
المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.2641. ⟨10.1038/s41467-019-10645-8⟩
Nature Communications, 2019, 10 (1), pp.2641. ⟨10.1038/s41467-019-10645-8⟩مصطلحات موضوعية: Models, Molecular, MESH: Clostridium Infections/prevention & control, MESH: Recombinant Proteins/metabolism, Bacterial toxins, MESH: Bacterial Toxins/genetics, Clostridium perfringens, [SDV]Life Sciences [q-bio], [SDV.BC]Life Sciences [q-bio]/Cellular Biology, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Article, Cell Line, MESH: Bacterial Toxins/chemistry, MESH: Clostridium perfringens/genetics, MESH: Dogs, MESH: Clostridium perfringens/pathogenicity, Dogs, Cryoelectron microscopy, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Animals, Nanotechnology, MESH: Animals, MESH: Recombinant Proteins/genetics, MESH: Bacterial Toxins/metabolism, MESH: Bacterial Toxins/isolation & purification, MESH: Recombinant Proteins/isolation & purification, MESH: Biotechnology/methods, MESH: Clostridium perfringens/ultrastructure, MESH: Protein Multimerization/genetics, MESH: Nanotechnology/methods, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Recombinant Proteins, MESH: Protein Conformation, beta-Strand/genetics, MESH: Cell Line, MESH: Clostridium Infections/microbiology, MESH: Mutagenesis, Site-Directed, MESH: Recombinant Proteins/chemistry, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, MESH: Enterotoxemia/prevention & control, Clostridium Infections, Mutagenesis, Site-Directed, Protein Conformation, beta-Strand, MESH: Enterotoxemia/microbiology, MESH: Cryoelectron Microscopy, Protein Multimerization, MESH: Clostridium perfringens/metabolism, MESH: Models, Molecular, Biotechnology, Enterotoxemia
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المؤلفون: Carlos Contreras-Martel, Leandro F. Estrozi, Daniel M. Trindade, Mayara M. Miyachiro, Fernanda Rodrigues-Costa, Ina Attrée, Guy Schoehn, Caíque C. Malospirito, Alexandre Martins, Viviana Job, Andréa Dessen, Lionel Imbert, Manon Janet-Maitre
المساهمون: Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Groupe Pathogenèse Bactérienne et Réponses Cellulaires / Bacterial Pathogenesis and Cellular Responses Group (IBS-PBRC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Brazilian Biosciences National Laboratory (LNBio), National Center for Research in Energy and Materials, Groupe de RMN biomoléculaire (IBS-NMR), ANR-18-CE11-0019,PSEUDO-WALL,Architecture et fonction de complexes de la biosynthèse de la paroi cellulaire de Pseudomonas aeruginosa(2018)
المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-22957-9⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.2987. ⟨10.1038/s41467-021-22957-9⟩
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, 2021, 12 (1), pp.2987. ⟨10.1038/s41467-021-22957-9⟩مصطلحات موضوعية: 0301 basic medicine, Science, General Physics and Astronomy, MESH: Amino Acid Sequence, MreB, General Biochemistry, Genetics and Molecular Biology, Bacterial cell structure, Article, MESH: Recombinant Proteins, 03 medical and health sciences, 0302 clinical medicine, Protein structure, MESH: Cell Wall, Phylogenetics, Cryoelectron microscopy, MESH: Phylogeny, MESH: Bacterial Proteins, MESH: Mutagenesis, X-ray crystallography, chemistry.chemical_classification, MESH: Protein Conformation, alpha-Helical, Bacterial structural biology, Multidisciplinary, MESH: Conserved Sequence, biology, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Chemistry, MESH: Protein Multimerization, Mutagenesis, General Chemistry, biology.organism_classification, MESH: Crystallography, X-Ray, Cell biology, 030104 developmental biology, Enzyme, MESH: Pseudomonas aeruginosa, MESH: Protein Domains, MESH: Protein Conformation, beta-Strand, MESH: Cryoelectron Microscopy, Elongation, 030217 neurology & neurosurgery, Bacteria
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المؤلفون: N. Kyle Tanner, Mourad Barhoumi, Emna Harigua-Souiai, Arnaud Blondel, Josette Banroques, Yosser Zina Abdelkrim, Ikram Guizani
المساهمون: Expression Génétique Microbienne (EGM (UMR_8261 / FRE_3630)), Institut de biologie physico-chimique (IBPC (FR_550)), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP), Faculté des Sciences de Bizerte [Université de Carthage], Université de Carthage - University of Carthage, Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), This work was supported by the Centre National de la Recherche Scientifique, France, by the HelicaRN [2010 BLAN 1503 01] and HeliDEAD grants [ANR-13-BSV8-0009-01] from the Agence Nationale de la Recherche, France, and by the Initiative d'Excellence program from the French State [Grant DYNAMO, ANR-11-LABX-0011-01] to NKT. This work received financial support from the Pasteur Institute Transversal Research Program (grant PTR426), France, and partially from the Ministry of Higher Education and Research in Tunisia (LR11IPT04 & LR16IPT04) to IG. EHS received support from the UNESCO-L'Oréal, 'For Women in Science,' international fellowship and the Institut Pasteur International Network (Calmette and Yersin programme)., We thank Patrick Linder, Centre Médical Universitaire, Geneva, Switzerland, for the eIF4AIMus clone. The 6-aminocholestanol was a gift from Dr. Leila el Kihel, Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), UFR des Sciences Pharmaceutiques, Université de Caen de Basse-Normandie, France, for the minimal costs of shipping fees. We thank Damien Monet for his assistance in the cavity generation and analyses., ANR-13-BSV8-0009,HeliDEAD,Les ARN hélicases à boite DEAD: quels sont leurs rôles, leurs partenaires, leurs substrats ARN et comment elles fonctionnent.(2013), ANR-11-LABX-0011,DYNAMO,Dynamique des membranes transductrices d'énergie : biogénèse et organisation supramoléculaire.(2011), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Faculté des Sciences de Bizerte, Bioinformatique structurale, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), ANR-11-LABX-0011/11-LABX-0011,DYNAMO,Dynamique des membranes transductrices d'énergie : biogénèse et organisation supramoléculaire.(2011), Institut de biologie physico-chimique (IBPC)
المصدر: Molecular and Biochemical Parasitology
Molecular and Biochemical Parasitology, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩
Molecular and Biochemical Parasitology, Elsevier, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩مصطلحات موضوعية: Hippuristanol, 0301 basic medicine, Antifungal Agents, MESH: Sequence Homology, Amino Acid, ATPase, Protozoan Proteins, Gene Expression, MESH: Protein Structure, Secondary, MESH: Amino Acid Sequence, Protein Structure, Secondary, MESH: Eukaryotic Initiation Factor-4A, MESH: Recombinant Proteins, Mice, chemistry.chemical_compound, Adenosine Triphosphate, MESH: Cholesterol, MESH: Genetic Vectors, MESH: Adenosine Triphosphate, MESH: Animals, MESH: Trypanocidal Agents, Cloning, Molecular, Leishmania infantum, MESH: Protozoan Proteins, Conserved Sequence, Ergosterol, MESH: Conserved Sequence, MESH: Kinetics, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], MESH: Escherichia coli, Trypanocidal Agents, RNA Helicase A, Recombinant Proteins, MESH: Leishmania infantum, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Cholesterol, Biochemistry, Translation-initiation factor, MESH: Drug Repositioning, Protein Binding, RNA helicase, MESH: Gene Expression, Genetic Vectors, MESH: Sequence Alignment, MESH: Binding, Competitive, Biology, Binding, Competitive, Drug design, 03 medical and health sciences, Escherichia coli, Animals, Humans, MESH: Protein Binding, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Protein Interaction Domains and Motifs, MESH: Cloning, Molecular, Amino Acid Sequence, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Binding site, MESH: Mice, Molecular Biology, MESH: Protein Interaction Domains and Motifs, Binding Sites, MESH: Humans, Sequence Homology, Amino Acid, MESH: RNA, Helminth, 030102 biochemistry & molecular biology, Drug Repositioning, RNA, Helicase, MESH: Antifungal Agents, Kinetics, 030104 developmental biology, MESH: Binding Sites, chemistry, eIF4A, Eukaryotic Initiation Factor-4A, Nucleic acid, biology.protein, Parasitology, RNA, Helminth, Sequence Alignment
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