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المؤلفون: Andrew M. Piggott, Samantha J. Emery-Corbin, Daniel Vuong, Aaron R. Jex, Ernest Lacey, Alexander Y.F. Lam
المصدر: International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss, Pp 68-80 (2021)
International Journal for Parasitology: Drugs and Drug Resistanceمصطلحات موضوعية: Special issue articles on 'Anaerobic Protozoan Pathogens: Drugs, Resistance and New Developments', 0301 basic medicine, Sexually transmitted disease, Microbial metabolites, HTS, High-throughput screen, Trichomonas, Tritrichomonas foetus, Infectious and parasitic diseases, RC109-216, medicine.disease_cause, 0302 clinical medicine, MTS, Medium-throughput screen, Drug-discovery, Pharmacology (medical), MIC, Minimum inhibitory concentration, MetAP2, Methionine aminopeptidase 2, Tritrichomonas, Natural products, Trichomoniasis, biology, Mtz, Metronidazole, Infectious Diseases, HIV, Human immunodeficiency virus, BLAST, Basic local alignment search tool, STD, Sexually-transmitted disease, I-TASSER, Iterative threading assembly refinement algorithm, medicine.drug, NI, Nitroimidazole, 030231 tropical medicine, PBS, Phosphate buffered saline, Microbiology, 03 medical and health sciences, Entamoeba histolytica, Metronidazole, parasitic diseases, Trichomonas vaginalis, medicine, Animals, Fumagillin, MOA, Mode of action, ADT, AutoDockTools, Pharmacology, DMSO, Dimethyl sulfoxide, biology.organism_classification, medicine.disease, High-Throughput Screening Assays, 030104 developmental biology, PDB, Protein data bank, Parasitology, Giardia lamblia, TSA, Trichostatin A
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المؤلفون: Andreas Natsch, Heike Laue, Lu Hostettler, Tina Haupt
المصدر: Toxicology Reports, Vol 8, Iss, Pp 1002-1007 (2021)
Toxicology Reportsمصطلحات موضوعية: MCF7 proliferation assay, ER, estrogen receptor, OECD, Organisation of Economic Co-operation and Development, Health, Toxicology and Mutagenesis, CoRAP, Community Rolling Action Plan, NOAEL, no observed adverse effect level, Benzyl salicylate, Estrogen receptor, SCCS, European Scientific Committee for Consumer Safety: SRB, sulforhodamine B, YES, Yeast Estrogen screen, Reporter assay, BS, Benzyl salicylate, BPA, Bisphenol A, 010501 environmental sciences, Pharmacology, DMEM, Dulbecco's Modified Eagle Medium, Toxicology, 01 natural sciences, Partial agonist, HEPES, N-2-hydroxyethylpiperazine-N-ethanesulfonic acid, 03 medical and health sciences, chemistry.chemical_compound, HRPT, Human Relevant Potency Threshold, 0302 clinical medicine, In vivo, RA1190-1270, ERE, estrogen response element, Potency, TG, test guideline, CAT, chloramphenicol acetyl transferase gene, 0105 earth and related environmental sciences, 4−OHT, 4-hydroxy-tamoxifen, Reporter gene, MoA, Mode of action, ATCC, American Type Culture Collection, Cell growth, DMSO, Dimethyl sulfoxide, Regular Article, In vitro, Substance evaluation, chemistry, Toxicology. Poisons, FBS, foetal bovine serum, REACH, Registration, Evaluation, Authorisation and Restriction of Chemicals, E2, 17β-estradiol, 030217 neurology & neurosurgery
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المصدر: Toxicology Reports
Toxicology Reports, Vol 7, Iss, Pp 805-815 (2020)مصطلحات موضوعية: microRNAs: Potential biomarkers of toxicity, BMD, benchmark dose, Nrf2, nuclear receptor erythroid 2-like 2, Hepatocellular carcinoma, Health, Toxicology and Mutagenesis, AST, aspartate aminotransferase, 010501 environmental sciences, Pharmacology, Toxicology, TMM, trimmed mean of M-values, 01 natural sciences, DEmiRs, differentially expressed miRNAs, chemistry.chemical_compound, AOP, adverse outcome pathway, 0302 clinical medicine, tRNA, transfer RNA, Acox1, acyl-Coenzyme A oxidase 1, BMDA, apical-based benchmark dose, GEO, Gene Expression Omnibus, Benchmark dose (BMD), Receptor, Regulation of gene expression, Liver injury, PXR, pregnane X receptor, Phthalate, POD, point-of-departure, Peroxisome, AIC, Akaike Information Criterion, mRNA, messenger RNA, rRNA, ribosomal RNA, mtDNA, mitochondrial, AhR, aryl hydrocarbon receptor, smallRNA-seq, small RNA sequencing, CAR, constitutive androstane receptor, BBP, n-butyl benzyl phthalate, PROD, pentoxyresorufin O-depentylation, Liver toxicity, DEGs, differentially expressed genes, EPA, U.S. Environmental Protection Agency, BMDL, BMD lower confidence interval, Peroxisome proliferator-activated receptor alpha (PPARα), Biology, BROD, benzyloxyresorufin O-debenzylation, 03 medical and health sciences, lcsh:RA1190-1270, ALT, alanine aminotransferase, microRNA, medicine, miRNAs, microRNAs, Mode of action (MOA), Potency, BMR, benchmark response, ddPCR, droplet digital polymerase chain reaction, lcsh:Toxicology. Poisons, IPA, Ingenuity Pathway Analysis, 0105 earth and related environmental sciences, DEHP, di (2-thylhexyl) phthalate, PPARα, peroxisome proliferator-activated receptor alpha, Activator (genetics), MOA, mode of action, Adverse outcome pathway (AOP), medicine.disease, MicroRNAs, HCA, hepatocellular adenoma, chemistry, BMDT, transcriptional-based benchmark dose, EROD, ethoxyresorufin O-dealkylation, HCC, hepatocellular carcinoma, DNOP, di-n-octyl phthalate, SDH, sorbitol dehydrogenase, Biomarkers, 030217 neurology & neurosurgery
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المؤلفون: Carolyn J. Mattingly, Jolene Wiegers, Thomas C. Wiegers, Daniela Sciaky, Cynthia J. Grondin, Robin J. Johnson, Allan Peter Davis
المصدر: Current Research in Toxicology
Current Research in Toxicology, Vol 2, Iss, Pp 272-281 (2021)مصطلحات موضوعية: Health, Toxicology and Mutagenesis, Disease, Toxicology, computer.software_genre, medicine.disease_cause, Applied Microbiology and Biotechnology, Nicotine, RA1190-1270, Mn, manganese, Pb, lead, CGPD, chemical-gene-phenotype-disease, NAFP, nicotine, acetaldehyde, formaldehyde, particulate matter chemical mixture, P, pyruvaldehyde, Respiratory disease, Database, Vaping, Environmental exposure, Cr, chromium, Zn, zinc, Phenotype, N, nicotine, M, marker/mechanism relationship, E-cigarettes, medicine.anatomical_structure, CTD, Comparative Toxicogenomics Database, MOA, mode-of-action, Juul, medicine.drug, Biology, PM, particulate matter, MIE, molecular initiating event, Article, ROS, reactive oxygen species, medicine, F, formaldehyde, FR, free radicals, ComputingMethodologies_COMPUTERGRAPHICS, A, acetaldehyde, medicine.disease, AC, acetone, nAChR, nicotinic acetylcholine receptor, COPD, chronic obstructive pulmonary disease, Toxicology. Poisons, Ni, nickel, Toxicogenomics, computer, Oxidative stress, C, crotonaldehyde, NAFFCAPP, nicotine, acetaldehyde, formaldehyde, free radicals, crotonaldehyde, acetone, pyruvaldehyde, and particulate matter chemical mixture, Respiratory tract
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75832dd6fc32526c2e0de612d838996f
https://pubmed.ncbi.nlm.nih.gov/34458863 -
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المصدر: Ecotoxicology and Environmental Safety
مصطلحات موضوعية: PNEC, predicted no effect concentration, Aquatic Organisms, MITI, Ministry of International Trade and Industry, Japan, Biosolids, Health, Toxicology and Mutagenesis, Disinfectant, OECD, Organisation for Economic Co-operation and Development, 0211 other engineering and technologies, TEST, Toxicity Estimation Software Tool, U.S. EPA, Aquatic ecotoxicity, 02 engineering and technology, Wastewater treatment, SARS-CoV, SARS-associated coronavirus, 010501 environmental sciences, Wastewater, Ecotoxicology, 01 natural sciences, FFDCA, Federal Food, Drug and Cosmetic Act, PEC, predicted environmental concentration, Suspended solids, Ecology, ASTER, Assessment Tool for Evaluating Risk, U.S. EPA, ADBAC, alkyl dimethyl benzyl ammonium chloride, General Medicine, EPA, United States Environmental Protection Agency, Pollution, CASRN, Chemical Abstracts Service Registry Number, Biodegradation, Environmental, NICNAS, National Industrial Chemical Notification and Assessment Scheme, Australia, DDAC, dialkyl dimethyl ammonium chloride, Biodegradation, Sewage treatment, Quats, quaternary ammonium compounds, FDA, United States Food and Drug Administration, ECHA, European Chemicals Agency, Portable water purification, Risk Assessment, Article, Water Purification, Animals, Humans, COVID-19, 2019 novel coronavirus, SARS, severe acute respiratory syndrome, FIFRA, Federal Insecticide, Fungicide and Rodenticide Act, Effluent, Pandemics, 0105 earth and related environmental sciences, QSAR, quantitative structure activity relationship, 021110 strategic, defence & security studies, DTDMAC, ditallow dimethyl ammonium chloride, SARS-CoV-2, ecoTTC, ecotoxicological threshold of toxicological concern, Public Health, Environmental and Occupational Health, MOA, mode of action, COVID-19, RED, Reregistration Eligibility Decision, BPR, Biocidal Products Regulation, Europe, HESI, Health and Environmental Sciences Institute, PBT, persistent, bioaccumulative, and toxic, Quaternary Ammonium Compounds, Environmental science, BAC, benzalkonium chloride, Ecotoxicity, Water Pollutants, Chemical, Disinfectants
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المؤلفون: Bopp, Stephanie K, Barouki, Robert, Brack, Werner, Dalla Costa, Silvia, Dorne, Jean-Lou C M, Drakvik, Paula E, Faust, Michael, Karjalainen, Tuomo K, Kephalopoulos, Stylianos, van Klaveren, Jacob, Kolossa-Gehring, Marike, Kortenkamp, Andreas, Lebret, Erik, Lettieri, Teresa, Nørager, Sofie, Rüegg, Joëlle, Tarazona, Jose V, Trier, Xenia, van de Water, Bob, van Gils, Jos, Bergman, Åke, Sub RIVM, dIRAS RA-2
المساهمون: Sub RIVM, dIRAS RA-2
المصدر: Environment International
Environment International, Vol 120, Iss, Pp 544-562 (2018)
Environment international, 120, 544. Elsevier Limited
Environment International, 120, 544-562مصطلحات موضوعية: 0301 basic medicine, PNEC, predicted no effect concentration, SMRI, similar mixture risk indicator, 010501 environmental sciences, MoA, mode of action, 01 natural sciences, PBTK, physiologically based toxicokinetic (model), AOP, adverse outcome pathway, TTC, Threshold of Toxicological Concern, NAM, new approach methodology, Order (exchange), MCRA, Monte Carlo risk assessment tool, CMEP, chemical monitoring and emerging pollutants, lcsh:Environmental sciences, General Environmental Science, media_common, lcsh:GE1-350, IATA, integrated approach to testing and assessment, Legislature, Environmental exposure, CAG, cumulative assessment group, IPRA, integrated probabilistic risk assessment, DEB, dynamic energy budget, RDT, repeated dose systemic toxicity, Risk assessment, Exposure data, IA, independent action, DART, developmental and reproductive toxicity, EBT, effect-based tools, MSFD, Marine Strategy Framework Directive, TK, toxicokinetic, CRA, cumulative risk assessment, AO, adverse outcome, BMD, benchmark dose modelling, MCR, maximum cumulative ratio, MRA, mixture risk assessment, Complex Mixtures, PEC, predicted exposure concentration, Risk Assessment, SYRINA, systematic review and integrated assessment, Hazardous Substances, Article, 03 medical and health sciences, iPSC, induced pluripotent stem cells, EDC, endocrine disrupting chemical, LOE, lines of evidence, media_common.cataloged_instance, Animals, Humans, BQE, biological quality element, European Union, European union, Environmental planning, 0105 earth and related environmental sciences, Exposure assessment, QSAR, quantitative structure activity relationship, Research, EQS, environmental quality standard, Environmental Exposure, MEC, measured exposure concentration, Effect assessment, 030104 developmental biology, HBM, human biomonitoring, 13. Climate action, WFD, Water Framework Directive, CA, concentration addition
وصف الملف: image/pdf
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المصدر: The Science of the Total Environment
مصطلحات موضوعية: ECHA, European Chemicals Agency, Percentile, Environmental Engineering, 010504 meteorology & atmospheric sciences, CTD-TC, chemical toxicity distribution-threshold concentration, CY, Cyprus, MRA, mixture risk assessment, PNEC, predicted no-effect concentration, EFSA, European Food Safety Authority, SW, Sweden, 010501 environmental sciences, Ecotoxicological Threshold of Toxicological Concern, Combined exposure, 01 natural sciences, Article, AF, assessment factor, Aquatic toxicology, TTC, Threshold of Toxicological Concern, QSAR, quantitative structure–activity relationship, RQi, risk quotient for the individual substance, Statistics, Environmental Chemistry, Predicted no-effect concentration, FR, France, Aquatic toxicity, MLT, Malta, RQmix, risk quotient for a mixture, TU, toxic unit, Waste Management and Disposal, 0105 earth and related environmental sciences, Gap filling, ecoTTC, ecotoxicological Threshold of Toxicological Concern, Chemical toxicity, MOA, mode of action, PFOS, perfluorooctanesulfonic acid, STU, sum of toxic units, MEC, measured exposure concentration, Pollution, PFOA, perfluorooctanoic acid, Mode of action, CA, concentration addition, Monitoring data, REACH, Registration, Evaluation, Authorisation and Restriction of Chemicals, Environmental science, Ecotoxicity, Risk assessment
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8دورية أكاديمية
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المؤلفون: M.E. (Bette) Meek, Anna Bal-Price
المصدر: Pharmacology & Therapeutics
مصطلحات موضوعية: 0301 basic medicine, KE, key event, OECD, Organisation for Economic Co-operation and Development, Disease, PD, Parkinson's disease, Toxicology, DNT, developmental neurotoxicity, AOP, adverse outcome pathway, Adverse Outcome Pathway, MPTP, 1-methyl-4-phenyl-3104 1,2,3,6-tetrahydropyridine, Pharmacology (medical), Mechanistic understanding, B/H, Bradford-Hill, HTT, high-throughput toxicity testing, CNS, Central nervous system, TFHA, Task Force for Hazard Assessment, Late stage, Neurodegenerative Diseases, Weight of evidence, ADME, absorption, distribution, metabolism and excretion, CI, complex I of mitochondrial chain, Mechanism (philosophy), Environmental Pollutants, Neurotoxicity Syndromes, WNT, Working Group of the National Coordinators for the Test Guidelines Programme, KER, key event relationship, Neurotoxicity Syndrome, Adverse outcomes, AO, adverse outcome, BDNF, brain derived neurotrophic factor, Receptors, N-Methyl-D-Aspartate, MIE, molecular initiating event, Article, Quantitation, Economic cooperation, 03 medical and health sciences, NT, neurotoxicity, Key event relationship, Toxicity Tests, medicine, Neurotoxicity, Animals, Humans, PBPK, physiologically based pharmacokinetic, WOE, weight of evidence, Key event, QSAR, quantitative structure activity relationship, Pharmacology, Adverse Outcome Pathways, AD, Alzheimer disease, business.industry, MOA, mode of action, AOP-KB, adverse outcome pathway knowledge base, medicine.disease, IATA, integrated approaches to testing and assessment, 030104 developmental biology, business, Neuroscience
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المؤلفون: David A, Brott, Håkan A S, Andersson, Jane, Stewart, Lorna, Ewart, Greg, Christoph, Johannes, Harleman, Duncan, Armstrong, Lewis B, Kinter
المصدر: Toxicology Reports
مصطلحات موضوعية: ADP, adenosine-5′-diphosphate, Carcinogenicity, QWBA, quantitative whole body autoradiography, Dopamine transport inhibitor, LC-MS/MS, liquid chromatography-mass spectrometric, Translational, MOA, mode of action, IC50, inhibitory concentration fifty percent, MTD, maximum tolerated dose, NH, Hill coefficient, E2, estradiol, CHO, Chinese hamster ovary, Article, GLP, good laboratory practice, Prolactin, Uterine tumor, AUC, area under the curve, H&E, hematoxylin and eosin, LLOQ, lower limits of quantification, Cmax, maximal concentration, DAT, dopamine transport, Ki, inhibition concentration, TK, toxicokinetics
