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المؤلفون: Jian Liu, Qi Lv, Yinan Zhang, Yao Xing, Dong Dong, Yue Liu, Lihong Hu, Hongzhi Qiao
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2880-2899 (2021)مصطلحات موضوعية: PMSF, phenylmethanesulfonyl fluoride, MPO, myeloperoxidase, ATG7, autophagy-related protein 7, DMSO, dimethyl sulfoxide, CETSA, cellular thermal shift assay, 0302 clinical medicine, EZH2, enhancer of zeste homolog 2, General Pharmacology, Toxicology and Pharmaceutics, M-CSF, macrophage colony stimulating factor, 0303 health sciences, Chemistry, BMDMs, bone marrow-derived macrophages, EZH2, Inflammasome, ELISA, enzyme-linked immunosorbent assay, Colitis, PMA, phorbol myristate acetate, Ulcerative colitis, ChIP, chromatin immunoprecipitation, 030220 oncology & carcinogenesis, Histone methyltransferase, LPS, lipopolysaccharide, Original Article, DAI, disease activity index, medicine.drug, AIM2, absent in melanoma 2, ATP, adenosine triphosphate, ECL, enhanced chemiluminescent, 3-MC, 3-methylcholanthrene, ATG5, RM1-950, macromolecular substances, SIP, solvent-induced protein precipitation, Lonicerin, 03 medical and health sciences, CHX, cycloheximide, FBS, fetal bovine serum, PAMPs, pathogen-associated molecular patterns, DSS, dextran sulfate sodium, Autophagy, medicine, Epigenetics, TEM, transmission electron microscopy, 030304 developmental biology, EDTA, ethylenediaminetetraacetic acid, RMSF, root mean-square fluctuation, RMSD, root mean-square deviation, MDP, muramyldipeptide, medicine.disease, NLRP3 inflammasome, ATG5, autophagy-related protein 5, MSU, monosodium urate crystals, UC, ulcerative colitis, 5-ASA, 5-aminosalicylic acid, DTT, dithiothreitol, DAMPs, damage-associated molecular patterns, H&E, hematoxylin and eosin, Cancer research, Therapeutics. Pharmacology, NLRP3, nucleotide-binding domain-like receptors family pyrin domain containing 3, PRC2, polycomb repressive complex 2
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المؤلفون: Oksana Mykhailivna Tarasenko, Olena Myroslavivna Karmazina, Valentyn Valentinovich Taranchuk, V Kondratiuk
المصدر: Journal of Medicine and Life
مصطلحات موضوعية: Male, 0301 basic medicine, Gout, Synbiotics, Cytokine profile, medicine.medical_treatment, Interleukin-1beta, Gut flora, Gastroenterology, 0302 clinical medicine, synbiotic, TNF - tumor necrosis factor, biology, Arthritis, Gouty, MSU - monosodium urate, General Medicine, Middle Aged, C-Reactive Protein, Cytokine, Female, Original Article, Tumor necrosis factor alpha, medicine.symptom, medicine.drug, medicine.medical_specialty, BOS - bacterial overgrowth syndrome, Allopurinol, HU-hyperuricemia, Inflammation, ULT - urate-lowering therapy, Bacteria, Anaerobic, 03 medical and health sciences, Internal medicine, medicine, Humans, 030203 arthritis & rheumatology, therapy, fecal microbiota, Tumor Necrosis Factor-alpha, UA - uric acid, business.industry, medicine.disease, biology.organism_classification, cytokines, CFU - colony-forming unit, Gastrointestinal Microbiome, Uric Acid, 030104 developmental biology, GIT - gastrointestinal tract, Chronic Disease, NSAIDs - non-steroidal anti-inflammatory drugs, business, IL - interleukin
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3
المؤلفون: Andras Perl, Christian Geier
المصدر: Autoimmunity Reviews
مصطلحات موضوعية: ULK1, Unc-51 like autophagy activating kinase, p70S6K, P70-S6 kinase, DAMP, damage-associated molecular pattern, RA, rheumatoid arthritis, Autoimmunity, Review, Antiviral immunity, Raptor, regulatory-associated protein of mTOR, medicine.disease_cause, DEPTOR, DEP domain-containing mTOR-interacting protein, SLE, systemic lupus erythematosus, DC, dendritic cell, MOG, Myelin oligodendrocyte glycoprotein, Immunology and Allergy, Lupus Erythematosus, Systemic, ANA, antinuclear antibodies, COVID-19, coronavirus disease 2019, EAE, experimental autoimmune encephalomyelitis, TH, T helper cell, EBV, Epstein-Barr virus, TNF, tumor necrosis factor, biology, TCR, T cell receptor, TOR Serine-Threonine Kinases, mTOR, mechanistic target of rapamycin, Lc3b, microtubule-associated protein 1 light chain 3β, Rictor, rapamycin-insensitive companion of mTOR, CCR7, CC-chemokine receptor 7, Acquired immune system, medicine.anatomical_structure, 4E-BP2, eukaryotic translation initiation factor 4E-binding protein 2, mTORC, mTOR complex, G6PD, glucose-6-phosphate-dehydrogenase, mTOR, Lifespan extension, PRR5, Proline-rich protein 5, medicine.symptom, Rapa, rapamycin, Mechanistic target of rapamycin, PI3K, phosphoinositide 3-kinase, medicine.drug, IKK-β, inhibitor of nuclear factor kappa-B kinase subunit beta, TLR, Toll-like receptor, Rheb, ras homolog enriched in brain, T cell, Immunology, Longevity, SIN1, Stress-activated map kinase-interacting protein 1, Treg, regulatory T cell, Inflammation, ETV7, transcription factor ETV7, FKBP8, FKBP prolyl isomerase 8, Antiviral Agents, MSU, monosodium urate, PD-1, programmed cell death protein 1, Systemic lupus erythematosus, HHV-8, human herpesvirus-8, PRAS40, proline-rich Akt substrate of 40 kDa, medicine, Humans, eiF4E, Elongation initiation factor 4E, PI3K/AKT/mTOR pathway, Aged, Sirolimus, MHC, Major histocompatibility complex, Immune cell lineage specification, Innate immune system, IFN-γ, interferon gamma, business.industry, SARS-CoV-2, S1P1, sphingosine-1-phosphate receptor 1, COVID-19, iMCD, idiopathic multicentric Castleman disease, NAC, N-Acetylcysteine, AMPK, AMP-activated protein kinase, APC, antigen-presenting cell, KSHV, Kaposi's sarcoma-associated herpesvirus, 4E-BP1, eukaryotic translation initiation factor 4E-binding protein 1, biology.protein, business, mLST8, mammalian lethal with SEC13 protein 8, TSC, tuberous sclerosis complex, FAO, fatty acid oxidation
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المؤلفون: Byung-Cheol Han, Huijeong Ahn, Seung Ho Lee, Pyeung-Hyeun Kim, Seung Goo Kang, Geun-Shik Lee, Jeongeun Kim, Kyoung Hwa Jang, Seung Ho So
المصدر: Journal of Ginseng Research
Journal of Ginseng Research, Vol 43, Iss 2, Pp 291-299 (2019)مصطلحات موضوعية: 0301 basic medicine, NS, nonsaponin fraction, Lipopolysaccharide, medicine.medical_treatment, Lys, lysate, Peritonitis, LCCM, L929 cell-conditioned medium, NLRP3, (NOD)2-like receptor protein 3, Biochemistry, Genetics and Molecular Biology (miscellaneous), Sup, supernatant, NF-kB, nuclear factor kappa-light-chain-enhancer of activated B cells, LB, Luria-Bertani, 03 medical and health sciences, Ginseng, chemistry.chemical_compound, 0302 clinical medicine, Alum, aluminum potassium sulfate, Downregulation and upregulation, lcsh:Botany, HKST, heat-killed Salmonella typhimurium, medicine, Secretion, TLR4, Cytokine, Korean Red Ginseng extracts, NOD, nucleotide-binding and oligomerization domain, MSU, monosodium urate crystal, SF, saponin fraction, Interleukin, RGE, Korean Red Ginseng extracts, Molecular biology, lcsh:QK1-989, IL, interleukin, PECs, peritoneal exudate cells, 030104 developmental biology, Complementary and alternative medicine, chemistry, 030220 oncology & carcinogenesis, Nonsaponin fraction, LPS, lipopolysaccharide, Cytokine secretion, ip, intraperitoneally, TLRs, toll-like receptors, Non, nontreatment, Research Article, BMDMs, bone marrow–derived macrophages, Biotechnology
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المؤلفون: Shengbing Yang, Hanjun Li, Jingtian Mei, Han Qiao, Feng Zhou, Minqi Wang, Linyang Chu, Tingting Tang, Xiuguo Han
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 973-985 (2019)مصطلحات موضوعية: MAPK/ERK pathway, C/EBP β, CCAAT/enhancer-binding protein β, RA, rheumatoid arthritis, OARSI, Osteoarthritis Research Society International, TNF-α, tumor necrosis factor-α, chemistry.chemical_compound, 0302 clinical medicine, GA, gouty arthritis, Polarization, BV, bone volume, IFN-γ, interferon-γ, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, medicine.diagnostic_test, Chemistry, Kinase, S&F, safranin O-fast green, NSAIDs, non-steroidal anti-inflammatory drugs, Cell biology, Tb.Sp, trabecular separation, medicine.anatomical_structure, 030220 oncology & carcinogenesis, behavior and behavior mechanisms, iNOS, inducible nitric oxide synthase, Phosphorylation, OA, osteoarthritis, TLRs, toll-like receptors, AP-1, activator protein-1, Cell signaling, Original article, HUVECs, human umbilical vein endothelial cells, NF-κB, nuclear factor-κB, MSU, monosodium urate, Chondrocyte, 03 medical and health sciences, DMEM, Dulbecco׳s minimum essential medium, CM, conditioned medium, ROS, reactive oxygen species, Chondrocytes, Western blot, Osteoarthritis, medicine, otorhinolaryngologic diseases, IRF4, interferon regulatory factor 4, BV/TV, bone volume/total tissue volume, 030304 developmental biology, Macrophages, lcsh:RM1-950, Tb.N, trabecular number, Kin, kinsenoside, NF-κB, Tb.Th, trabecular thickness, H&E, hematoxylin & eosin, PPARγ, peroxisome proliferator-activated receptor γ, Kinsenoside, IκBα, lcsh:Therapeutics. Pharmacology, Arg-1, arginase-1, MAPK, mitogen-activated protein kinases, LPS, lipopolysaccharides
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6Extracellular cathepsin Z signals through the α5 integrin and augments NLRP3 inflammasome activation
المؤلفون: Justin A. MacDonald, Catherine J. Greene, Christina F. Sandall, Neil McKenna, Rhiannon I. Campden, Jose A. Chiriboga, Robin M. Yates, Devin Aggarwal, Amy L. Warren, Corey R. Arnold
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Inflammasomes, Interleukin-1beta, Integrin alpha5, Biochemistry, Mice, 0302 clinical medicine, 0303 health sciences, biology, Chemistry, interleukin-1 (IL-1), Inflammasome, Silicon Dioxide, PMA, phorbol myristate acetate, Cysteine protease, 3. Good health, Cell biology, silica, LPS, lipopolysaccharide, medicine.symptom, RGD, arginine-glycine-asparigine, Research Article, medicine.drug, integrin, Silicosis, Integrin, Inflammation, MSU, monosodium urate, MS, multiple sclerosis, EAE, encephalomyelitis, 03 medical and health sciences, NLRP3, FBS, fetal bovine serum, inflammasome, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Extracellular, Animals, APC, antigen-presenting cells, Molecular Biology, BMDC, bone marrow-derived dendritic cells, 030304 developmental biology, Cathepsin, Cathepsin Z, Cell Biology, arginine-glycine-aspartic acid (RGD) domain, Cell culture, biology.protein, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b27c210c61616d4955d5ffecfb0fa14
https://doi.org/10.1016/j.jbc.2021.101459 -
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المؤلفون: Chengyuan Tang, Xiaofen Xiong, Xiaoxuan Xu, Lin Sun, Shuguang Yuan, Yachun Han, Xianghui Chen, Shikun Yang, Yashpal S. Kanwar, Fuyou Liu, Xuejing Zhu, Ming Yang, Li Xiao, Peng Gao
المصدر: Redox Biology
Redox Biology, Vol 16, Iss, Pp 32-46 (2018)مصطلحات موضوعية: 0301 basic medicine, Mitochondrial ROS, MFI, median fluorescence intensity, BUN, blood urea nitrogen, Clinical Biochemistry, TPP, triphenylphosphonium, AST, aspartate aminotransferase, Diabetic nephropathy, Mitochondrion, ECL, enhanced chemiluminescence, Biochemistry, MitoQ, chemistry.chemical_compound, 0302 clinical medicine, LDL, low-density lipoprotein, TBARS, thiobarbituric acid reactive substances, lcsh:QH301-705.5, chemistry.chemical_classification, MtROS, mitochondria reactive oxygen species, lcsh:R5-920, TG, triglyceride, Chemistry, BW, body weight, TXNIP, thioredoxin-interacting protein, MMT, methyl methane-thiosulphonate, 3. Good health, Cell biology, UA, uric acid, Mitochondria, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end-labeling, TRX, thioredoxin, KW, kidney weight, 030220 oncology & carcinogenesis, DCFDA, dichlorodihydrofluorescein diacetate, medicine.symptom, Thioredoxin, lcsh:Medicine (General), EMT, epithelial–mesenchymal transition, TXNIP, IHC, immunohistochemistry, Scr, serum creatinine, Research Paper, HbA1C, hemoglobin A1c, Inflammation, MSU, monosodium urate, MMP, mitochondrial transmembrane potential, MPTP, mitochondrial permeability transition pore, 03 medical and health sciences, DN, diabetic nephropathy, HE, hematoxylin-eosin, ALT, alanine aminotransferase, medicine, IF, immunofluorescence, MDA, malondialdehyde, Reactive oxygen species, BG, blood glucose, EM, electron microscopy, Organic Chemistry, Reactive oxygen species (ROS), medicine.disease, NLRP3 inflammasome, TC, total cholesterol, PAS, periodic acid-Schiff, 8-OHdG, 8-oxo-deoxyguanosine, 030104 developmental biology, lcsh:Biology (General), TRX/TXNIP
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المؤلفون: Matthias Epple, Yana Dautova, Kevin Pappert, Alexander N. Kapustin, Martin D. Bootman, Hanneke Okkenhaug, Diane Proudfoot, Simon J. Cook, Catherine M. Shanahan
المصدر: Journal of Molecular and Cellular Cardiology
Dautova, Y, Kapustin, A, Pappert, K, Epple, M, Okkenhaug, H, Cook, S J, Shanahan, C M, Bootman, M D & Proudfoot, D 2017, ' Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells : A role for spleen tyrosine kinase and exosome release ', Journal of Molecular and Cellular Cardiology . https://doi.org/10.1016/j.yjmcc.2017.12.007مصطلحات موضوعية: 0301 basic medicine, Calcium Phosphates, Male, BM, basal culture medium, Vascular smooth muscle, Inflammasomes, Interleukin-1beta, Syk, Exosomes, Muscle, Smooth, Vascular, SYK, Phosphorylation, Cells, Cultured, Caspase 1, Inflammasome, Middle Aged, CaP, calcium phosphate, Cell biology, VSMC, vascular smooth muscle cells, Caspase-1, Cytokines, LPS, lipopolysaccharide, Female, Cardiology and Cardiovascular Medicine, medicine.drug, Adult, IL-1β, interleukin-1β, ATP, adenosine triphosphate, Myocytes, Smooth Muscle, Chemie, chemistry.chemical_element, Calcium, Exosome, MSU, monosodium urate, Article, SYK, spleen tyrosine kinase, 03 medical and health sciences, Young Adult, medicine, SFM, serum-free medium, Humans, Syk Kinase, Secretion, NLRP3: nucleotide-binding domain, leucine-rich repeat/pyrin domain-containing-3, Molecular Biology, Calcium phosphate particles, Enzyme Activation, 030104 developmental biology, chemistry
وصف الملف: application/pdf
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المؤلفون: Misha Zarbafian, Jan P. Dutz
المصدر: JAAD Case Reports, Vol 3, Iss 1, Pp 45-48 (2017)
JAAD Case Reportsمصطلحات موضوعية: tophus, 030203 arthritis & rheumatology, medicine.medical_specialty, business.industry, Tophus, Case Report, finger-tip, hyperuricemia, Dermatology, lcsh:RL1-803, medicine.disease, MSU, monosodium urate, Surgery, Raynaud phenomenon, 03 medical and health sciences, 0302 clinical medicine, ULT, urate-lowering therapy, Monosodium urate, lcsh:Dermatology, medicine, 030212 general & internal medicine, Hyperuricemia, business
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10دورية أكاديمية
المؤلفون: Fischer S; Institute for Immunology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany., Stegmann F; Institute for Immunology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany., Gnanapragassam VS; Institute for Immunology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany., Lepenies B; Institute for Immunology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
المصدر: Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2022 Oct 20; Vol. 20, pp. 5790-5812. Date of Electronic Publication: 2022 Oct 20 (Print Publication: 2022).
نوع المنشور: Journal Article; Review
بيانات الدورية: Publisher: Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology Country of Publication: Netherlands NLM ID: 101585369 Publication Model: eCollection Cited Medium: Print ISSN: 2001-0370 (Print) Linking ISSN: 20010370 NLM ISO Abbreviation: Comput Struct Biotechnol J Subsets: PubMed not MEDLINE
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