المؤلفون: Kathrin Jäger, Juliane Mensch, Maria Elisabeth Grimmig, Bruno Neuner, Kerstin Gorzelniak, Seval Türkmen, Ilja Demuth, Alexander Hartmann, Christiane Hartmann, Felix Wittig, Anje Sporbert, Andreas Hermann, Georg Fuellen, Steffen Möller, Michael Walter

المصدر: Science Advances
Science advances 8(33), eabk2814 (2022). doi:10.1126/sciadv.abk2814

مصطلحات موضوعية: MTOR protein, human, Aging, Multidisciplinary, TOR Serine-Threonine Kinases, Fibroblasts, Telomere, genetics [TOR Serine-Threonine Kinases], Humans, genetics [Telomere], ddc:500, Gene Silencing, Technology Platforms, Aged

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26523e7f771fa6ddb74fc2317303f2d1
https://pubmed.ncbi.nlm.nih.gov/35977016

المؤلفون: Silvia Cases-Cunillera, Karen M J van Loo, Julika Pitsch, Anne Quatraccioni, Sugirthan Sivalingam, Paolo Salomoni, Valeri Borger, Dirk Dietrich, Susanne Schoch, Albert J Becker

المصدر: Neuro-Oncology 24(5), 741-754 (2022). doi:10.1093/neuonc/noab268

مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Cancer Research, MTOR protein, human, genetics [Proto-Oncogene Proteins B-raf], metabolism [TOR Serine-Threonine Kinases], epileptogenicity, Mice, metabolism [Proto-Oncogene Proteins B-raf], physiology [Signal Transduction], Animals, Humans, ddc:610, pediatric tumor, Ganglioglioma, dysplastic neuron, Brain Neoplasms, TOR Serine-Threonine Kinases, genetics [TOR Serine-Threonine Kinases], metabolism [Brain Neoplasms], genetics [Brain Neoplasms], Oncology, Mutation, metabolism [Proto-Oncogene Proteins c-akt], genetics [Ganglioglioma], genetics [Proto-Oncogene Proteins c-akt], Neurology (clinical), neoplastic astroglia, Proto-Oncogene Proteins c-akt, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c084401789e468e8a20d91d828e5463a

المؤلفون: Ian Casci, Angelo Poletti, Julia Japtok, Claudia Moebius, Karl Hackmann, Marc Bickle, Udai Bhan Pandey, Barbara Klink, Ellen Koerner, Lydia Reinhardt, Antje Janosch, Anthony A. Hyman, Andreas Hermann, Simon Alberti, Lara Marrone, Cordula Andree, Jared Sterneckert, Peter Reinhardt, Ina Poser, Hyun O. Lee, Maria Elena Cicardi

المصدر: Stem Cell Reports
Stem Cell Reports, Vol 10, Iss 2, Pp 375-389 (2018)
Stem cell reports 10(2), 375-389 (2018). doi:10.1016/j.stemcr.2017.12.018

مصطلحات موضوعية: 0301 basic medicine, amyotrophic lateral sclerosis, Drug Evaluation, Preclinical, FUS protein, Drosophila, Biochemistry, Green fluorescent protein, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, genetics [Drosophila Proteins], Drosophila Proteins, Amyotrophic lateral sclerosis, Induced pluripotent stem cell, lcsh:QH301-705.5, Motor Neurons, lcsh:R5-920, pharmacology [Antipyretics], gene editing, TOR Serine-Threonine Kinases, genetics [TOR Serine-Threonine Kinases], Phenotype, Antidepressive Agents, 3. Good health, Cell biology, metabolism [Induced Pluripotent Stem Cells], genetics [Amyotrophic Lateral Sclerosis], pharmacology [Antidepressive Agents], Drosophila, lcsh:Medicine (General), CRISPR/Cas9n, Signal Transduction, drug effects [Signal Transduction], MTOR protein, human, stress granules, autophagy, Antipyretics, genetics [Autophagy], pathology [Motor Neurons], induced pluripotent stem cells, genetics [Heterogeneous-Nuclear Ribonucleoprotein Group F-H], Green Fluorescent Proteins, Biology, Article, 03 medical and health sciences, Stress granule, Genetics, medicine, genetics [Green Fluorescent Proteins], Animals, Humans, ddc:610, pathology [Amyotrophic Lateral Sclerosis], Protein kinase B, PI3K/AKT/mTOR pathway, FUS, Heterogeneous-Nuclear Ribonucleoprotein Group F-H, metabolism [Amyotrophic Lateral Sclerosis], Autophagy, metabolism [Motor Neurons], Cell Biology, FUS protein, human, medicine.disease, 030104 developmental biology, lcsh:Biology (General), Mutation, RNA-Binding Protein FUS, genetics [Proto-Oncogene Proteins c-akt], CRISPR-Cas Systems, genetics [Phosphatidylinositol 3-Kinases], genetics [RNA-Binding Protein FUS], Proto-Oncogene Proteins c-akt, 030217 neurology & neurosurgery, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367a59d6fc57ca1ec0aeef1d84ed53ba
https://doi.org/10.1016/j.stemcr.2017.12.018

المؤلفون: Sevinc Inan, Ece Onur, Gulperi Oktem, Gülçin Ekizceli, Kemal Ozbilgin

المساهمون: Department of Histology and Embryology, Uludag University Faculty of Medicine, Bursa, Turkey, Department of Histology and Embryology, Izmir University of Economics, Faculty of Medicine, Izmir, Turkey, Department of Histology and Embryology, Ege University, Faculty of Medicine, Izmir, Turkey, Department of Medical Biochemistry, Celal Bayar University, Faculty of Medicine, Manisa, Turkey, Department of Histology and Embryology, Celal Bayar University, Faculty of Medicine, Manisa, Turkey, Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı., Ekizceli, Gülçin, AAZ-2915-2020, AAP-3523-2020

المصدر: Biotechnic & Histochemistry. 92:450-458

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Physiology, Angiogenesis, Expression, mTORC1, mTORC2, ERK1, Western blotting, 0302 clinical medicine, Pregnancy, Nidation, Decidual cells, Phosphorylation, 030219 obstetrics & reproductive medicine, Biotechnology & applied microbiology, Signaling pathway, TOR Serine-Threonine Kinases, Target of rapamycin kinase, General Medicine, Select nutrients, Immunohistochemistry, Implantation, Stem-cells, Medical Laboratory Technology, Animals, 3 Phosphoinositide Dependent Protein Kinase, Phosphatidylinositols, Female, Signal Transduction, Cell biology, MTOR protein, human, Cell signaling, medicine.medical_specialty, Histology, Blotting, Western, Biology, 03 medical and health sciences, Complex, Internal medicine, medicine, Embryo Implantation, Protein kinase B, PI3K/AKT/mTOR pathway, MTORC1, PAKT1/2/3, Vaginal Smears, P70 s6 kinase, MTORC2, Vagina smear, Animal, Uterus, Rats, Glucose, Metabolism, 030104 developmental biology, Endocrinology, Cancer research, Rat, Growth-factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e540d73c9de6174a33e8cdaf57ee32c
https://doi.org/10.1080/10520295.2017.1350749

المؤلفون: Fernandez-Santiago, R., Martin-Flores, N., Antonelli, F., Cerquera, C., Moreno, V., Bandres-Ciga, S., Manduchi, E., Tolosa, E., Singleton, A.B., Moore, J.H., Noyce, A.J., Kaiyrzhanov, R., Middlehurst, B., Kia, D.A., Tan, M., Houlden, H., Morris, H.R., Plun-Favreau, H., Holmans, P., Hardy, J., Trabzuni, D., Bras, J., Quinn, J., Mok, K.Y., Kinghorn, K.J., Billingsley, K., Wood, N.W., Lewis, P., Schreglmann, S., Guerreiro, R., Lovering, R., R'Bibo, L., Manzoni, C., Rizig, M., Ryten, M., Guelfi, S., Escott-Price, V., Chelban, V., Foltynie, T., Williams, N., Morrison, K.E., Clarke, C., Brice, A., Danjou, F., Lesage, S., Corvol, J.C., Martinez, M., Schulte, C., Brockmann, K., Simoon-Saanchez, J., Heutink, P., Rizzu, P., Sharma, M., Gasser, T., Nicolas, A., Cookson, M.R., Blauwendraat, C., Craig, D.W., Faghri, F., Gibbs, J.R., Hernandez, D.G., Keuren-Jensen, K. van, Shulman, J.M., Iwaki, H., Leonard, H.L., Nalls, M.A., Robak, L., Lubbe, S., Finkbeiner, S., Mencacci, N.E., Lungu, C., Scholz, S.W., Reed, X., Alcalay, R.N., Gan-Or, Z., Rouleau, G.A., Krohn, L., Hilten, J.J. van, Marinus, J., Adarmes-Goomez, A.D., Aguilar, I., Alvarez, I., Alvarez, V., Barrero, F.J., Yarza, J.A.B., Bernal-Bernal, I., Blazquez, M., Bonilla-Toribio, M., Botia, J.A., Boungiorno, M.T., Buiza-Rueda, D., Camara, A., Carrillo, F., Carrion-Claro, M., Cerdan, D., Clarimon, J., Compta, Y., Casa, B. de la, Diez-Fairen, M., Dols-Icardo, O., Duarte, J., Duran, R., Escamilla-Sevilla, F., Ezquerra, M., Feliz, C., Fernandez, M., Garcia, C., Garcia-Ruiz, P., Gomez-Garre, P., Heredia, M.J.G., Gonzalez-Aramburu, I., Pagola, A.G., Hoenicka, J., Infante, J., Jesus, S., Jimenez-Escrig, A., Kulisevsky, J., Labrador-Espinosa, M.A., Lopez-Sendon, J.L., Arregui, A.L.D., Macias, D., Torres, I.M., Marin, J., Marti, M.J., Martinez-Castrillo, C., Mendez-del-Barrio, C., Gonzalez, M.M., Mata, M., Minguez, A., Mir, P., Rezola, E.M., Munoz, E., Pagonabarraga, J., Pascual-Sedano, B., Pastor, P., Errazquin, F.P., Perinan-Tocino, T., Ruiz-Martinez, J., Ruz, C., Rodriguez, A.S., Sierra, M., Suarez-Sanmartin, E., Tabernero, C., Tartari, J.P., Tejera-Parrado, C., Valldeoriola, F., Vargas-Gonzalez, L., Vela, L., Vives, F., Zimprich, A., Pihlstrom, L., Toft, M., Koks, S., Taba, P., Hassin-Baer, S., Malagelada, C., Int Parkinson's Dis Genomics Conso

المساهمون: Fundació La Marató de TV3, Michael J. Fox Foundation for Parkinson's Research, National Institutes of Health (US), Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España)

المصدر: Mov Disord
Movement disorders 34(9), 1333-1344 (2019). doi:10.1002/mds.27770
Digital.CSIC. Repositorio Institucional del CSIC
instname
Movement Disorders, 34(9), 1333-1344
MOVEMENT DISORDERS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau

مصطلحات موضوعية: 0301 basic medicine, epistasis, Male, Parkinson's disease, very elderly, alpha-synuclein, Alpha‐synuclein, regulatory associated protein of mTOR, Cohort Studies, 0302 clinical medicine, single nucleotide polymorphism, genetics, Age of Onset, Genetics, Aged, 80 and over, Polymorphism, Single Nucleoti, biology, TOR Serine-Threonine Kinases, target of rapamycin kinase, fchsd1 gene, Age at onset, Chromosome Mapping, glycogen synthase kinase 3beta, Parkinson Disease, Middle Aged, cohort analysis, LRRK2, priority journal, Neurology, chromosomal mapping, neuromodulation, mTOR, alpha-Synuclein, Female, age at onset, Signal Transduction, onset age, Adult, MTOR protein, human, protein kinase LKB1, gene locus, Genotype, multifactor dimensionality reduction, SNP, Single-nucleotide polymorphism, rps6ka2 gene, Polymorphism, Single Nucleotide, Risk Assessment, Article, brain function, 03 medical and health sciences, alpha synuclein, medicine, Humans, controlled study, Genetic Predisposition to Disease, human, ddc:610, SNCA protein, human, gene, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, mammalian target of rapamycin, Aged, RPTOR, Epistasis, Genetic, Odds ratio, medicine.disease, major clinical study, nervous system diseases, 030104 developmental biology, mTOR signaling, biology.protein, Epistasis, pathology, Neurology (clinical), genetic predisposition, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fab7d934f1f6ea0784330ea889bec1
https://pubmed.ncbi.nlm.nih.gov/31234232

المؤلفون: Nigel Mackman, K. Matiash, Carol A. Mercer, Xiaoyang Qi, Fred V. Lucas, Clayton S. Lewis, Aniruddha Karve, Vladimir Y. Bogdanov, R. E. Boody, H. Elnakat Thomas, Bruce J. Aronow, Melissa A. Orr-Asman, Henri H. Versteeg, H. W. Davis, Yohei Hisada, L. C. Green

المصدر: Journal of Thrombosis and Haemostasis, 17(1), 169-182. WILEY

مصطلحات موضوعية: mTOR protein, Mice, Nude, Antineoplastic Agents, mTORC1, Mechanistic Target of Rapamycin Complex 2, 030204 cardiovascular system & hematology, carcinoma, Mechanistic Target of Rapamycin Complex 1, MLN0128, Article, Thromboplastin, Small hairpin RNA, 03 medical and health sciences, Tissue factor, 0302 clinical medicine, Cell Line, Tumor, neuroendocrine, Animals, Humans, human, Promoter Regions, Genetic, Sapanisertib, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Gene knockdown, Kinase, Chemistry, TOR Serine-Threonine Kinases, Hematology, carcinoma, neuroendocrine, tissue factor, mTOR protein, human, Xenograft Model Antitumor Assays, Tumor Burden, Pancreatic Neoplasms, Neuroendocrine Tumors, Pyrimidines, Cell culture, Cancer research, Pyrazoles, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ad5073d76a74c15f4a2831fc5d915a
https://europepmc.org/articles/PMC6345540/

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Angela Ingrassia, Annemieke J.M. Rozemuller, Wilma D.J. van de Berg, Peter Heutink, Renee X. de Menezes, Anke A. Dijkstra, Ronald E. van Kesteren

المساهمون: Anatomy and neurosciences, Epidemiology and Data Science, Pathology, Human genetics, NCA - neurodegeneration, Molecular and Cellular Neurobiology, Neuroscience Campus Amsterdam - Neurodegeneration

المصدر: Dijkstra, A A, Ingrassia, A, Menezes, R X, van Kesteren, R E, Rozemuller, A J, Heutink, P & van de Berg, W D J 2015, ' Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson's Disease. ', PLoS ONE, vol. 10, no. 6, e0128651 . https://doi.org/10.1371/journal.pone.0128651
PLoS ONE, 10(6):e0128651. Public Library of Science
PLoS ONE, Vol 10, Iss 6, p e0128651 (2015)
PLoS ONE
PLOS ONE 10(6), e0128651 (2015). doi:10.1371/journal.pone.0128651

مصطلحات موضوعية: Male, Parkinson's disease, Eukaryotic Initiation Factor-2, lcsh:Medicine, physiology [Eukaryotic Initiation Factor-2], physiology [TOR Serine-Threonine Kinases], Transcriptome, lcsh:Science, In Situ Hybridization, Oligonucleotide Array Sequence Analysis, Multidisciplinary, physiopathology [Lewy Body Disease], TOR Serine-Threonine Kinases, Dopaminergic, Parkinson Disease, Endocytosis, Cell biology, Substantia Nigra, Disease Progression, Female, physiopathology [Parkinson Disease], Signal transduction, Research Article, Signal Transduction, Lewy Body Disease, physiology [Endocytosis], MTOR protein, human, immunology [Substantia Nigra], Substantia nigra, Biology, immunology [Parkinson Disease], Immune system, SDG 3 - Good Health and Well-being, physiology [Signal Transduction], medicine, Humans, ddc:610, PI3K/AKT/mTOR pathway, physiopathology [Substantia Nigra], Aged, physiology [Axons], lcsh:R, medicine.disease, Axons, nervous system, Case-Control Studies, lcsh:Q, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d51b10100b72eb0b95aee2d23911022
https://doi.org/10.1371/journal.pone.0128651

المؤلفون: C Rotermund, Philipp J. Kahle, A Ciociaro, B I Pérez-Revuelta, M M Hettich, Donato A. Di Monte, S Krauss

المصدر: Cell death & disease 5(5), e1209-e1209 (2014). doi:10.1038/cddis.2014.175
Cell Death & Disease

مصطلحات موضوعية: Cancer Research, pharmacology [Protein Kinase Inhibitors], drug effects [Hippocampus], Time Factors, animal diseases, AMP-Activated Protein Kinases, Hippocampus, Mice, metabolism [AMP-Activated Protein Kinases], Serine, pathology [Neurons], Parkinson, metabolism [alpha-Synuclein], Protein Phosphatase 2, Phosphorylation, Neurons, enzymology [Neurons], TOR Serine-Threonine Kinases, Metformin, PP2A, mTOR, genetics [alpha-Synuclein], alpha-Synuclein, Original Article, embryology [Hippocampus], medicine.drug, Signal Transduction, medicine.medical_specialty, drug effects [Signal Transduction], MTOR protein, human, mice, Immunology, Phosphatase, pharmacology [Hypoglycemic Agents], Primary Cell Culture, Down-Regulation, Gestational Age, mTOR protein, mouse, Biology, metabolism [TOR Serine-Threonine Kinases], Transfection, Cellular and Molecular Neuroscience, enzymology [Hippocampus], Internal medicine, ddc:570, medicine, Animals, Humans, drug effects [Neurons], Hypoglycemic Agents, Protein kinase A, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Dose-Response Relationship, Drug, rapamycin, RPTOR, metabolism [Protein Phosphatase 2], Cell Biology, Protein phosphatase 2, nervous system diseases, Enzyme Activation, Mice, Inbred C57BL, Endocrinology, pathology [Hippocampus], nervous system, pharmacology [Metformin], antagonists & inhibitors [TOR Serine-Threonine Kinases], HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736688cea10e29d69ece6608f1cc9e70

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.