المؤلفون: Cm, Lindgren, Im, Heid, Jc, Randall, Lamina C, Steinthorsdottir V, Qi L, Ek, Speliotes, Thorleifsson G, Cj, Willer, Bm, Herrera, Au, Jackson, Lim N, Scheet P, Soranzo N, Amin N, Ys, Aulchenko, Jc, Chambers, Drong A, Luan J, Hn, Lyon, Rivadeneira F, Sanna S, Nj, Timpson, Mc, Zillikens, Jh, Zhao, Almgren P, Bandinelli S, Aj, Bennett, Rn, Bergman, Ll, Bonnycastle, Sj, Bumpstead, Sj, Chanock, Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Asf, Doney, Ebrahim S, Elliott P, Erdos MR, Estrada K, Ferrucci L, Fischer G, Ng, Forouhi, Gieger C, Grallert H, Cj, Groves, Grundy S, Guiducci C, Hadley D, Hamsten A, As, Havulinna, Hofman A, Holle R, Jw, Holloway, Illig T, Isomaa B, Lc, Jacobs, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Gm, Lathrop, Da, Lawlor, Mangino M, Wl, Mcardle, Meitinger T, Ma, Morken, Ap, Morris, Munroe P, Narisu N, Nordström A, Nordström P, Ba, Oostra, Cna, Palmer, Payne F, Jf, Peden, Inga Prokopenko, Renström F, Ruokonen A, Salomaa V, Ms, Sandhu, Lj, Scott, Scuteri A, Silander K, Song K, Yuan X, Hm, Stringham, Aj, Swift, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Gb, Walters, Mn, Weedon, Jcm, Witteman, Zhang C, Zhang W, Mj, Caulfield, Fs, Collins, Davey Smith G, Inm, Day, Pw, Franks, At, Hattersley, Fb, Hu, Jarvelin M, Kong A, Js, Kooner, Laakso M, Lakatta E, Mooser V, Ad, Morris, Peltonen L, Nj, Samani, Td, Spector, Dp, Strachan, Tanaka T, Tuomilehto J, Ag, Uitterlinden, Cm, Duijn, Nj, Wareham, Procardis, Watkins For The Consortia H., Dm, Waterworth, Boehnke M, Deloukas P, Groop L, Dj, Hunter, Thorsteinsdottir U, Schlessinger D, H-, Wichmann, Tm, Frayling, Gr, Abecasis, Jn, Hirschhorn, Rjf, Loos, Stefansson K, Kl, Mohlke, Barroso I, Giant Mi, Mccarthy For The Consortium

المصدر: Europe PubMed Central
PLoS Genetics
PLoS Genetics, Vol 5, Iss 7 (2009)

مصطلحات موضوعية: lcsh:Genetics, 0303 health sciences, 03 medical and health sciences, Cancer Research, 0302 clinical medicine, lcsh:QH426-470, Genetics, Correction, 030209 endocrinology & metabolism, Molecular Biology, Genetics (clinical), Ecology, Evolution, Behavior and Systematics, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4aa71e313de404e331242e6d0f0e4f
http://europepmc.org/abstract/PMC/PMC2722420

المؤلفون: Roman TS; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Cannon ME; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Vadlamudi S; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Buchkovich ML; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Wolford BN; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Welch RP; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Morken MA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Kwon GJ; The Jackson Laboratory for Genomic Medicine, Farmington, CT.; Department of Genetics and Genome Sciences, University of Connecticut Health, Farmington, CT., Varshney A; Department of Human Genetics, University of Michigan, Ann Arbor, MI., Kursawe R; The Jackson Laboratory for Genomic Medicine, Farmington, CT., Wu Y; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Erdos MR; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Kuusisto J; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Collins FS; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Parker SCJ; Department of Human Genetics, University of Michigan, Ann Arbor, MI.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI., Stitzel ML; The Jackson Laboratory for Genomic Medicine, Farmington, CT.; Institute for Systems Genomics, University of Connecticut, Farmington, CT., Mohlke KL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC mohlke@med.unc.edu.

مؤلفون مشاركون: National Institutes of Health Intramural Sequencing Center (NISC) Comparative Sequencing Program

المصدر: Diabetes [Diabetes] 2017 Sep; Vol. 66 (9), pp. 2521-2530. Date of Electronic Publication: 2017 Jul 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Variation* , Genome-Wide Association Study*, Adenylyl Cyclases/*metabolism , Diabetes Mellitus, Type 2/*metabolism , Gene Expression Regulation/*physiology , Islets of Langerhans/*metabolism, Adenylyl Cyclases/genetics ; Diabetes Mellitus, Type 2/genetics ; Humans ; Insulin/metabolism ; Insulin Secretion

المؤلفون: Locke AE; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Kahali B; Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Justice AE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Pers TH; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark., Day FR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Powell C; Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Vedantam S; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA., Buchkovich ML; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Yang J; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.; The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia., Croteau-Chonka DC; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Esko T; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Fall T; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Gustafsson S; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Kutalik Z; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland.; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.; Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Mägi R; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Randall JC; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Winkler TW; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Workalemahu T; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA., Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA., Chen J; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA., Fehrmann R; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Hedman ÅK; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Karjalainen J; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Schmidt EM; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Absher D; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA., Amin N; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands., Anderson D; Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia 6008, Australia., Beekman M; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Bolton JL; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Bragg-Gresham JL; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, Michigan 48109, USA., Buyske S; Department of Statistics & Biostatistics, Rutgers University, Piscataway, New Jersey 08854, USA.; Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA., Demirkan A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands., Deng G; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Gastroenterology and Hepatology, Imperial College London, London W2 1PG, UK.; Institute of infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China., Ehret GB; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark., Feitosa MF; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Fischer K; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Goel A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Gong J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Jackson AU; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.; Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany., Kristiansson K; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Lim U; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA., Lotay V; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Leach IM; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Medina-Gomez C; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA., Palmer CD; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA., Pasko D; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Pechlivanis S; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany., Peters MJ; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Prokopenko I; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK., Shungin D; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.; Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden.; Department of Odontology, Umeå University, Umeå 901 85, Sweden., Stančáková A; University of Eastern Finland, FI-70210 Kuopio, Finland., Strawbridge RJ; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Sung YJ; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Tanaka T; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA., Teumer A; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany., Trompet S; Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., van der Laan SW; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van Setten J; Department of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Van Vliet-Ostaptchouk JV; Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands., Wang Z; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.; Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA., Yengo L; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Zhang W; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Center for Medical Sytems Biology, 2300 RC Leiden, The Netherlands., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Ärnlöv J; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.; School of Health and Social Studies, Dalarna University, SE-791 88 Falun, Sweden., Arscott GM; PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia., Attwood AP; Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.; NHS Blood and Transplant, Cambridge CB2 0PT, UK., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), 50125 Florence, Italy., Barrett A; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Bas IN; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines., Bellis C; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA.; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4001, Australia., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Berne C; Department of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala 75185, Sweden., Blagieva R; Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany., Blüher M; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Böhringer S; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Böttcher Y; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany., Boyd HA; Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark., Bruinenberg M; LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Caspersen IH; Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway., Chen YI; Department of Pediatrics, University of California Los Angeles, Torrance, California 90502, USA.; Transgenomics Institute, Los Angeles Biomedical Research Institute, Torrance, California 90502, USA., Clarke R; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Daw EW; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., de Craen AJM; Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Delgado G; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany., Dimitriou M; Department of Dietetics-Nutrition, Harokopio University, 17671 Athens, Greece., Doney ASF; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Eklund N; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland., Estrada K; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA., Eury E; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Folkersen L; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Fraser RM; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA., Geller F; Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala 75185, Sweden., Gigante B; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., Go AS; Kaiser Permanente, Division of Research, Oakland, California 94612, USA., Golay A; Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva CH-1211, Switzerland., Goodall AH; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Gordon SD; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Gorski M; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.; Department of Nephrology, University Hospital Regensburg, D-93053 Regensburg, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, D-17475 Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, D-17475 Greifswald, Germany., Grallert H; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Grammer TB; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany., Gräßler J; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany., Grönberg H; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Gusto G; Institut inter Régional pour la Santé, Synergies, F-37520 La Riche, France., Haessler J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Hall P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Haller T; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Hallmans G; Department of Public Health and Clinical Medicine, Unit of Nutritional Research, Umeå University, Umeå 90187, Sweden., Hartman CA; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands., Hassinen M; Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK., Heard-Costa NL; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA., Helmer Q; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Faculty of Psychology and Education, VU University Amsterdam, 1081BT Amsterdam, The Netherlands., Hengstenberg C; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Deutsches Herzzentrum München, Technische Universität München, D-80636 Munich, Germany., Holmen O; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway., Hottenga JJ; Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands., James AL; Department of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia 6009, Australia.; School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia., Jeff JM; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Johansson Å; Uppsala University, Department of Immunology, Genetics, Pathology, SciLifeLab, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden., Jolley J; Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.; NHS Blood and Transplant, Cambridge CB2 0PT, UK., Juliusdottir T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Kinnunen L; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Koenig W; Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany., Koskenvuo M; Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland., Kratzer W; Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany., Laitinen J; Finnish Institute of Occupational Health, FI-90100 Oulu, Finland., Lamina C; Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria., Leander K; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., Lee NR; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines., Lichtner P; Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Lind L; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Lindström J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Lo KS; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada., Lobbens S; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Lorbeer R; Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany., Lu Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Mach F; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., McArdle WL; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK., McLachlan S; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Merger S; Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany., Mihailov E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., Milani L; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Moayyeri A; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.; Farr Institute of Health Informatics Research, University College London, London NW1 2DA, UK., Monda KL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; The Center for Observational Research, Amgen, Inc., Thousand Oaks, California 91320, USA., Morken MA; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Mulas A; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy., Müller G; Center for Evidence-based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, D-81377 Munich, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany., Musk AW; Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia., Nagaraja R; Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA., Nöthen MM; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany.; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany., Nolte IM; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Pilz S; Department of Epidemiology and Biostatistics, Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University Medical Center, 1081BT Amsterdam, The Netherlands.; Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, 8036 Graz, Austria., Rayner NW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Renstrom F; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden., Rettig R; Institute of Physiology, University Medicine Greifswald, D-17495 Karlsburg, Germany., Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Ripke S; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., Robertson NR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA., Sanna S; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy., Scharnagl H; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria., Scholtens S; LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Schumacher FR; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Scott WR; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., Seufferlein T; Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany., Shi J; National Cancer Institute, Bethesda, Maryland 20892, USA., Smith AV; Icelandic Heart Association, Kopavogur 201, Iceland.; University of Iceland, Reykjavik 101, Iceland., Smolonska J; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Stanton AV; Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland., Steinthorsdottir V; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland., Stirrups K; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Stringham HM; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Sundström J; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Swertz MA; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Swift AJ; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Syvänen AC; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75144, Sweden., Tan ST; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Tayo BO; Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 61053, USA., Thorand B; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany., Thorleifsson G; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland., Tyrer JP; Department of Oncology, University of Cambridge, Cambridge CB2 0QQ, UK., Uh HW; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Vandenput L; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., Verhulst FC; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Centre, 3000 CB Rotterdam, The Netherlands., Vermeulen SH; Department for Health Evidence, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.; Department of Genetics, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Vonk JM; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Waite LL; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA., Warren HR; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Waterworth D; Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA., Weedon MN; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Wilkens LR; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA., Willenborg C; German Center for Cardiovascular Research, partner site Hamburg/Lubeck/Kiel, 23562 Lubeck, Germany.; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, D-23562 Lübeck, Germany., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway., Wojczynski MK; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Wong A; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Wright AF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK., Zhang Q; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Brennan EP; Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland., Choi M; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea., Dastani Z; Lady Davis Institute, Departments of Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal, Québec H3T1E2, Canada., Drong AW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Eriksson P; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Franco-Cereceda A; Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden., Gådin JR; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Gharavi AG; Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10032, USA., Goddard ME; Biosciences Research Division, Department of Primary Industries, Victoria 3083, Australia.; Department of Food and Agricultural Systems, University of Melbourne, Victoria 3010, Australia., Handsaker RE; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Huang J; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.; NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford OX3 7LE, UK., Kathiresan S; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Keildson S; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Kiryluk K; Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10032, USA., Kubo M; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Lee JY; Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Chungbuk 363-951, Republic of Korea., Liang L; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Harvard School of Public Health, Department of Biostatistics, Harvard University, Boston, Massachusetts 2115, USA., Lifton RP; Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, New Haven, Connecticut 06520, USA., Ma B; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning 116026, China., McCarroll SA; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., McKnight AJ; Nephrology Research, Centre for Public Health, Queen's University of Belfast, Belfast, County Down BT9 7AB, UK., Min JL; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK., Moffatt MF; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Montgomery GW; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Murabito JM; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA., Nicholson G; Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.; MRC Harwell, Harwell Science and Innovation Campus, Harwell OX11 0QG, UK., Nyholt DR; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia., Okada Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan., Perry JRB; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, 138672 Singapore., Reinmaa E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Salem RM; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Sandholm N; Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Helsinki FI-00076, Finland.; Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, FI-00290 Helsinki, Finland.; Folkhälsan Institute of Genetics, Folkhälsan Research Center, FI-00290 Helsinki, Finland., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Stolk L; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Takahashi A; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Tanaka T; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan.; Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Division of Disease Diversity, Bioresource Research Center, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan., van 't Hooft FM; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Vinkhuyzen AAE; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia., Westra HJ; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Zheng W; Division of Epidemiology, Department of Medicine; Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37075, USA., Zondervan KT; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford OX3 7BN, UK., Heath AC; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Arveiler D; Department of Epidemiology and Public Health, EA3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France., Bakker SJL; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Beilby J; PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.; Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia., Bergman RN; Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California 90048, USA., Blangero J; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA., Bovet P; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1010 Lausanne, Switzerland.; Ministry of Health, Victoria, Republic of Seychelles., Campbell H; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Caulfield MJ; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Cesana G; University of Milano, Bicocca, 20126, Italy., Chakravarti A; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA., Chines PS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Crawford DC; Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA., Cupples LA; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA., Cusi D; Department of Health Sciences, University of Milano, I 20142, Italy.; Fondazione Filarete, Milano I 20139, Italy., Danesh J; Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., de Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., den Ruijter HM; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Dominiczak AF; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Erbel R; Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, 45147 Essen, Germany., Erdmann J; German Center for Cardiovascular Research, partner site Hamburg/Lubeck/Kiel, 23562 Lubeck, Germany.; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, D-23562 Lübeck, Germany., Eriksson JG; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, FI-00290 Helsinki, Finland.; Unit of General Practice, Helsinki University Central Hospital, Helsinki 00290, Finland., Farrall M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Felix SB; Department of Internal Medicine B, University Medicine Greifswald, D-17475 Greifswald, Germany.; DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany., Ferrannini E; Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy.; National Research Council Institute of Clinical Physiology, University of Pisa, 56124 Pisa, Italy., Ferrières J; Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, 31400 Toulouse, France., Ford I; Robertson Center for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK., Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Forrester T; UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica., Franco OH; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Gansevoort RT; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Gejman PV; NorthShore University HealthSystem, Evanston, IL 60201, University of Chicago, Chicago, Illinois, USA., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Gottesman O; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Gudnason V; Icelandic Heart Association, Kopavogur 201, Iceland.; University of Iceland, Reykjavik 101, Iceland., Gyllensten U; Uppsala University, Department of Immunology, Genetics, Pathology, SciLifeLab, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden., Hall AS; Leeds MRC Medical Bioinformatics Centre, University of Leeds, Leeds LS2 9LU, UK., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA., Hattersley AT; Institute of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK., Hicks AA; Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated institute of the University of Lübeck, D-23562 Lübeck, Germany)., Hindorff LA; Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Hingorani AD; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK., Hofman A; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany., Hovingh GK; Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands., Humphries SE; Centre for Cardiovascular Genetics, Institute Cardiovascular Sciences, University College London, London WC1E 6JJ, UK., Hunt SC; Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA., Hyppönen E; Sansom Institute for Health Research, University of South Australia, Adelaide 5000, South Australia, Australia.; School of Population Health, University of South Australia, Adelaide 5000, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia 5000, Australia.; Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK., Illig T; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover, D-30625 Hannover, Germany., Jacobs KB; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.; Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA., Jarvelin MR; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; National Institute for Health and Welfare, FI-90101 Oulu, Finland.; MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.; Unit of Primary Care, Oulu University Hospital, FI-90220 Oulu, Finland.; Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland.; Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany., Johansen B; Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway., Jousilahti P; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Jukema JW; Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands (ICIN), 3501 DG Utrecht, The Netherlands.; Interuniversity Cardiology Institute of the Netherlands (ICIN), 3501 DG Utrecht, The Netherlands., Jula AM; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kaprio J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.; Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland., Kastelein JJP; Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands., Keinanen-Kiukaanniemi SM; Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland.; Unit of Primary Health Care/General Practice, Oulu University Hospital, FI-90220 Oulu, Finland., Kiemeney LA; Department for Health Evidence, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.; Department of Urology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands., Knekt P; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kooner JS; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Kovacs P; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Kraja AT; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Kumari M; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.; Department of Biological and Social Epidemiology, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK., Kuusisto J; Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Lakka TA; Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.; Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, FI-70211 Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK., Marchand LL; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, FI-33520 Tampere, Finland., Lyssenko V; Steno Diabetes Center A/S, Gentofte DK-2820, Denmark.; Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden., Männistö S; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Marette A; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada.; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada., Matise TC; Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA., McKenzie CA; UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica., McKnight B; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA., Moll FL; Department of Surgery, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Morris AD; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Morris AP; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK., Murray JC; Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA., Nelis M; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands., Ong KK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Madden PAF; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Pasterkamp G; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Peden JF; Illumina, Inc, Little Chesterford, Cambridge CB10 1XL, UK., Peters A; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany., Postma DS; University of Groningen, University Medical Center Groningen, Department of Pulmonary Medicine and Tuberculosis, Groningen, The Netherlands., Pramstaller PP; Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated institute of the University of Lübeck, D-23562 Lübeck, Germany).; Department of Neurology, General Central Hospital, Bolzano 39100, Italy., Price JF; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Qi L; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20521 Turku, Finland., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA., Rao DC; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Rice TK; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA., Rioux JD; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.; Université de Montréal, Montreal, Quebec H1T 1C8, Canada., Ritchie MD; Center for Systems Genomics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA., Rudan I; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.; Croatian Centre for Global Health, Faculty of Medicine, University of Split, 21000 Split, Croatia., Salomaa V; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Saramies J; South Carelia Central Hospital, 53130 Lappeenranta, Finland., Sarzynski MA; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA., Schunkert H; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Deutsches Herzzentrum München, Technische Universität München, D-80636 Munich, Germany., Schwarz PEH; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.; Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), 01307 Dresden, Germany., Sever P; International Centre for Circulatory Health, Imperial College London, London W2 1PG, UK., Shuldiner AR; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland 21201, USA., Sinisalo J; Helsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, FI-00290 Helsinki, Finland., Stolk RP; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany., Tönjes A; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Trégouët DA; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1166, F-75013 Paris, France.; INSERM, UMR S 1166, Team Genomics and Physiopathology of Cardiovascular Diseases, F-75013 Paris, France.; Institute for Cardiometabolism And Nutrition (ICAN), F-75013 Paris, France., Tremblay A; Department of Kinesiology, Laval University, Quebec QC G1V 0A6, Canada., Tremoli E; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano & Centro Cardiologico Monzino, Instituto di Ricovero e Cura a Carattere Scientifico, Milan 20133, Italy., Virtamo J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Vohl MC; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.; Department of Food Science and Nutrition, Laval University, Quebec QC G1V 0A6, Canada., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.; DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany., Waeber G; Department of Internal Medicine, University Hospital (CHUV) and University of Lausanne, Lausanne 1011, Switzerland., Willemsen G; Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands., Witteman JC; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Zillikens MC; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Amouyel P; Institut Pasteur de Lille; INSERM, U744; Université de Lille 2; F-59000 Lille, France., Asselbergs FW; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands (ICIN), 3501 DG Utrecht, The Netherlands.; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Assimes TL; 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CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Chambers JC; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Cooper RS; Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 61053, USA., de Bakker PIW; Department of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Epidemiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Dedoussis G; Department of Dietetics-Nutrition, Harokopio University, 17671 Athens, Greece., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA., Franks PW; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.; Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden., Froguel P; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Groop LC; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.; Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden., Haiman CA; 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Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Belfer 1306, New York 10461, USA., Kivimaki M; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK., Kuh D; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Laakso M; Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Liu Y; Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., März W; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.; Synlab Academy, Synlab Services GmbH, 68163 Mannheim, Germany., Melbye M; Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA.; Department of Clinical Medicine, Copenhagen University, 2200 Copenhagen, Denmark., Metspalu A; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany., Munroe PB; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Njølstad I; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway., Oostra BA; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Center for Medical Sytems Biology, 2300 RC Leiden, The Netherlands.; Department of Clinical Genetics, Erasmus MC University Medical Center, 3000 CA Rotterdam, The Netherlands., Palmer CNA; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Perola M; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland., Pérusse L; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.; Department of Kinesiology, Laval University, Quebec QC G1V 0A6, Canada., Peters U; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Power C; Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK., Quertermous T; Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA., Rauramaa R; Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Rivadeneira F; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Saaristo TE; Finnish Diabetes Association, Kirjoniementie 15, FI-33680 Tampere, Finland.; Pirkanmaa Hospital District, FI-33521 Tampere, Finland., Saleheen D; Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; Center for Non-Communicable Diseases, Karatchi, Pakistan.; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Sattar N; BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK., Schadt EE; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10580, USA., Schlessinger D; Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA., Slagboom PE; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Snieder H; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Thorsteinsdottir U; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., Stumvoll M; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Tuomilehto J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Health Research, University Hospital of La Paz (IdiPaz), 28046 Madrid, Spain.; Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.; Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria., Uitterlinden AG; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.; Research Unit, Kuopio University Hospital, FI-70210 Kuopio, Finland., van der Harst P; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands (ICIN), 3501 DG Utrecht, The Netherlands., Walker M; Institute of Cellular Medicine, Newcastle University, Newcastle NE1 7RU, UK., Wallaschofski H; DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Watkins H; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA., Wichmann HE; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-85764 Munich, Germany.; Klinikum Grosshadern, D-81377 Munich, Germany.; Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany., Wilson JF; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Zanen P; Department of Pulmonology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Borecki IB; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Deloukas P; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, 21589 Jeddah, Saudi Arabia., Fox CS; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA., Heid IM; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., O'Connell JR; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA., Strachan DP; Division of Population Health Sciences & Education, St George's, University of London, London SW17 0RE, UK., Stefansson K; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Center for Medical Sytems Biology, 2300 RC Leiden, The Netherlands., Abecasis GR; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Franke L; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford OX3 7LJ, UK., Visscher PM; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.; The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia., Scherag A; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany.; Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, 07743 Jena, Germany., Willer CJ; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Boehnke M; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Lindgren CM; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Beckmann JS; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.; Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland.; Service of Medical Genetics, CHUV University Hospital, 1011 Lausanne, Switzerland., Barroso I; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 OQQ, UK.; NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 OQQ, UK., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Ingelsson E; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Hirschhorn JN; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Loos RJF; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Speliotes EK; Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.

مؤلفون مشاركون: LifeLines Cohort Study, ADIPOGen Consortium, AGEN-BMI Working Group, CARDIOGRAMplusC4D Consortium, CKDGen Consortium, GLGC, ICBP, MAGIC Investigators, MuTHER Consortium, MIGen Consortium, PAGE Consortium, ReproGen Consortium, GENIE Consortium, International Endogene Consortium

المصدر: Nature [Nature] 2015 Feb 12; Vol. 518 (7538), pp. 197-206.

نوع المنشور: Journal Article; Meta-Analysis

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Body Mass Index* , Genome-Wide Association Study*, Obesity/*genetics , Obesity/*metabolism, Adipogenesis/genetics ; Adiposity/genetics ; Age Factors ; Energy Metabolism/genetics ; Europe/ethnology ; Female ; Genetic Predisposition to Disease/genetics ; Glutamic Acid/metabolism ; Humans ; Insulin/metabolism ; Insulin Secretion ; Male ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/genetics ; Racial Groups/genetics ; Synapses/metabolism

المؤلفون: Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Esko T; 1] Estonian Genome Center, University of Tartu, Tartu, Estonia. [2] Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. [3] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. [4] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA., Yang J; 1] Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. [2] University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, Queensland, Australia., Vedantam S; 1] Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA., Pers TH; 1] Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. [3] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [4] Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark., Gustafsson S; 1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden., Chu AY; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Estrada K; 1] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. [2] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. [3] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Luan J; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Kutalik Z; 1] Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. [2] Swiss Institute of Bioinformatics, Lausanne, Switzerland. [3] Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland., Amin N; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Buchkovich ML; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA., Croteau-Chonka DC; 1] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Day FR; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Duan Y; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA., Fall T; 1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden. [3] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Fehrmann R; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Jackson AU; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA., Karjalainen J; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Lo KS; Montreal Heart Institute, Montreal, Quebec, Canada., Locke AE; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA., Mägi R; 1] Estonian Genome Center, University of Tartu, Tartu, Estonia. [2] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Mihailov E; 1] Estonian Genome Center, University of Tartu, Tartu, Estonia. [2] Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia., Porcu E; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Italy., Randall JC; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Wellcome Trust Sanger Institute, Hinxton, UK., Scherag A; 1] Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany. [2] Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany., Vinkhuyzen AA; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Westra HJ; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Winkler TW; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany., Workalemahu T; Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA., Zhao JH; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Absher D; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Anderson D; Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia., Baron J; Section on Growth and Development, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, US National Institutes of Health, Bethesda, Maryland, USA., Beekman M; 1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Demirkan A; 1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. [2] Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Ehret GB; 1] Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [2] Department of Specialties of Internal Medicine, Division of Cardiology, Geneva University Hospital, Geneva, Switzerland., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Feitosa MF; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA., Fischer K; Estonian Genome Center, University of Tartu, Tartu, Estonia., Fraser RM; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK., Goel A; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UK., Gong J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Justice AE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Kleber ME; 1] Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany. [2] Department of Internal Medicine II, Ulm University Medical Centre, Ulm, Germany., Kristiansson K; National Institute for Health and Welfare, Helsinki, Finland., Lim U; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA., Lotay V; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Lui JC; Section on Growth and Development, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, US National Institutes of Health, Bethesda, Maryland, USA., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Mateo Leach I; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Medina-Gomez C; 1] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. [3] Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA., Nyholt DR; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Palmer CD; 1] Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA., Pasko D; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Pechlivanis S; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany., Prokopenko I; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. [3] Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK., Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Ripke S; 1] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA., Shungin D; 1] Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hospital, Malmö, Sweden. [2] Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden. [3] Department of Odontology, Umeå University, Umeå, Sweden., Stancáková A; Department of Medicine, University of Eastern Finland, Kuopio, Finland., Strawbridge RJ; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Sung YJ; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA., Tanaka T; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA., Teumer A; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Trompet S; 1] Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., van der Laan SW; Experimental Cardiology Laboratory, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., van Setten J; Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands., Van Vliet-Ostaptchouk JV; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Wang Z; 1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. [2] Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. [3] Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA. [4] Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA., Yengo L; 1] CNRS UMR 8199, Lille, France. [2] European Genomic Institute for Diabetes, Lille, France. [3] Université de Lille 2, Lille, France., Zhang W; 1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. [2] Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Afzal U; 1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. [2] Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Arnlöv J; 1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden. [3] School of Health and Social Studies, Dalarna University, Falun, Sweden., Arscott GM; PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia, Australia., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy., Barrett A; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Bellis C; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Berne C; Department of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala, Sweden., Blüher M; 1] Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany. [2] Department of Medicine, University of Leipzig, Leipzig, Germany., Bolton JL; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK., Böttcher Y; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany., Boyd HA; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Bruinenberg M; LifeLines, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Buckley BM; Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland., Buyske S; 1] Department of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersy, USA. [2] Department of Genetics, Rutgers University, Piscataway, New Jersey, USA., Caspersen IH; Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway., Chines PS; Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA., Clarke R; Clinical Trial Service Unit, Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Claudi-Boehm S; Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, Ulm, Germany., Cooper M; Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia., Daw EW; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA., De Jong PA; Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands., Deelen J; 1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Delgado G; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany., Denny JC; Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, USA., Dhonukshe-Rutten R; Department of Human Nutrition, Wageningen University, Wageningen, the Netherlands., Dimitriou M; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Doney AS; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Dörr M; 1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. [2] Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany., Eklund N; 1] National Institute for Health and Welfare, Helsinki, Finland. [2] Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland., Eury E; 1] CNRS UMR 8199, Lille, France. [2] European Genomic Institute for Diabetes, Lille, France. [3] Université de Lille 2, Lille, France., Folkersen L; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA., Geller F; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Go AS; Kaiser Permanente, Division of Research, Oakland, California, USA., Grallert H; 1] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [3] German Center for Diabetes Research (DZD), Neuherberg, Germany., Grammer TB; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany., Gräßler J; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Grönberg H; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., de Groot LC; Department of Human Nutrition, Wageningen University, Wageningen, the Netherlands., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Haessler J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Hall P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Haller T; Estonian Genome Center, University of Tartu, Tartu, Estonia., Hallmans G; Unit of Nutritional Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Hannemann A; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Hartman CA; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Hassinen M; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Heard-Costa NL; 1] National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, USA. [2] Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA., Helmer Q; 1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands. [3] Faculty of Psychology and Education, VU University Amsterdam, Amsterdam, the Netherlands., Hemani G; 1] Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. [2] University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, Queensland, Australia., Henders AK; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Hillege HL; 1] Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. [2] Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Hlatky MA; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA., Hoffmann W; 1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. [2] Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Hoffmann P; 1] Department of Biomedicine, Division of Medical Genetics, University of Basel, Basel, Switzerland. [2] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. [3] Institute of Human Genetics, University of Bonn, Bonn, Germany., Holmen O; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway., Houwing-Duistermaat JJ; 1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands., Illig T; 1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Hannover Unified Biobank, Hannover Medical School, Hannover, Germany., Isaacs A; 1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. [2] Center for Medical Systems Biology, Leiden, the Netherlands., James AL; 1] Department of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia, Australia. [2] School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia., Jeff J; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Johansen B; Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway., Johansson Å; Department of Immunology, Genetics and Pathology, SciLifeLab, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden., Jolley J; 1] Department of Haematology, University of Cambridge, Cambridge, UK. [2] NHS Blood and Transplant, Cambridge, UK., Juliusdottir T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Junttila J; Department of Medicine, University of Oulu, Oulu, Finland., Kho AN; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Kinnunen L; National Institute for Health and Welfare, Helsinki, Finland., Klopp N; 1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Hannover Unified Biobank, Hannover Medical School, Hannover, Germany., Kocher T; Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Greifswald, Germany., Kratzer W; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Lichtner P; Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Lind L; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden., Lindström J; National Institute for Health and Welfare, Helsinki, Finland., Lobbens S; 1] CNRS UMR 8199, Lille, France. [2] European Genomic Institute for Diabetes, Lille, France. [3] Université de Lille 2, Lille, France., Lorentzon M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Lu Y; 1] Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Lyssenko V; Steno Diabetes Center A/S, Gentofte Denmark., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Maillard M; Service of Nephrology, Department of Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland., McArdle WL; School of Social and Community Medicine, University of Bristol, Bristol, UK., McKenzie CA; Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica., McLachlan S; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK., McLaren PJ; 1] Global Health Institute, Department of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. [2] Institute of Microbiology, University Hospital and University of Lausanne, Lausanne, Switzerland., Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Merger S; Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, Ulm, Germany., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Moayyeri A; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Monda KL; 1] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Center for Observational Research, Amgen, Inc., Thousand Oaks, California, USA., Morken MA; Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA., Müller G; Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Müller-Nurasyid M; 1] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Department of Medicine I, University Hospital Großhadern, Ludwig Maximilians Universität, Munich, Germany. [3] Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians Universität, Neuherberg, Germany. [4] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany., Musk AW; Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia., Narisu N; Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA., Nauck M; 1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. [2] Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Nolte IM; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Nöthen MM; 1] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. [2] Institute of Human Genetics, University of Bonn, Bonn, Germany., Oozageer L; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK., Pilz S; 1] Department of Epidemiology and Biostatistics, Institute for Research in Extramural Medicine (EMGO) Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands. [2] Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria., Rayner NW; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Wellcome Trust Sanger Institute, Hinxton, UK. [3] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Renstrom F; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hospital, Malmö, Sweden., Robertson NR; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Roussel R; 1] Diabetology-Endocrinology-Nutrition, Public Hospital System of the City of Paris (AP-HP), Bichat Hospital, Paris, France. [2] INSERM U872, Centre de Recherche des Cordeliers, Paris, France. [3] Paris Diderot University, Paris, France., Sanna S; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Italy., Scharnagl H; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., Scholtens S; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Schumacher FR; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Schunkert H; 1] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany. [2] Deutsches Herzzentrum München, Technische Universität München, Munich, Germany., Scott RA; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Sehmi J; 1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. [2] Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Seufferlein T; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Shi J; National Cancer Institute, Bethesda, Maryland, USA., Silventoinen K; Department of Sociology, University of Helsinki, Helsinki, Finland., Smit JH; 1] EMGO Institute for Health and Care Research, VU University, Amsterdam, the Netherlands. [2] Department of Psychiatry, Neuroscience Campus, VU University Amsterdam, Amsterdam, the Netherlands., Smith AV; 1] Icelandic Heart Association, Kopavogur, Iceland. [2] University of Iceland, Reykjavik, Iceland., Smolonska J; 1] Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. [2] Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Stanton AV; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland., Stirrups K; 1] Wellcome Trust Sanger Institute, Hinxton, UK. [2] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Stott DJ; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK., Stringham HM; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA., Sundström J; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden., Swertz MA; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Syvänen AC; 1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala, Sweden., Tayo BO; Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois, USA., Thorleifsson G; deCODE Genetics, Amgen, Inc., Reykjavik, Iceland., Tyrer JP; Department of Oncology, University of Cambridge, Cambridge, UK., van Dijk S; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., van Schoor NM; Department of Epidemiology and Biostatistics, Institute for Research in Extramural Medicine (EMGO) Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands., van der Velde N; 1] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. [2] Section of Geriatrics, Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands., van Heemst D; 1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., van Oort FV; Department of Child and Adolescent Psychiatry, Psychology, Erasmus University Medical Center, Rotterdam, the Netherlands., Vermeulen SH; 1] Department for Health Evidence, Radboud University Medical Centre, Nijmegen, the Netherlands. [2] Department of Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Vonk JM; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Waite LL; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA., Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Wennauer R; Department of Clinical Chemistry, Ulm University Medical Centre, Ulm, Germany., Wilkens LR; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA., Willenborg C; 1] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), partner site Hamburg-Lubeck-Kiel, Lubeck, Germany. [2] Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Tromsø, Tromsø, Norway., Wojczynski MK; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA., Wong A; MRC Unit for Lifelong Health and Ageing at University College London, London, UK., Wright AF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Zhang Q; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA., Arveiler D; Department of Epidemiology and Public Health, University of Strasbourg, Faculty of Medicine, Strasbourg, France., Bakker SJ; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Beilby J; 1] PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia, Australia. [2] Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia., Bergman RN; Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California, USA., Bergmann S; 1] Swiss Institute of Bioinformatics, Lausanne, Switzerland. [2] Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland., Biffar R; Department of Prosthetic Dentistry, Gerostomatology and Dental Materials, University Medicine Greifswald, Greifswald, Germany., Blangero J; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Boomsma DI; Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands., Bornstein SR; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Bovet P; 1] Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland. [2] Ministry of Health, Victoria, Republic of Seychelles., Brambilla P; Laboratory Medicine, Hospital of Desio, Department of Health Sciences, University of Milano, Bicocca, Italy., Brown MJ; Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Campbell H; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK., Caulfield MJ; 1] Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. [2] Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Chakravarti A; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Collins R; Clinical Trial Service Unit, Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Collins FS; Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA., Crawford DC; 1] Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA. [2] Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Cupples LA; 1] National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, USA. [2] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Danesh J; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., de Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., den Ruijter HM; 1] Experimental Cardiology Laboratory, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands., Erbel R; Clinic of Cardiology, West German Heart Centre, University Hospital Essen, Essen, Germany., Erdmann J; 1] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), partner site Hamburg-Lubeck-Kiel, Lubeck, Germany. [2] Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany., Eriksson JG; 1] National Institute for Health and Welfare, Helsinki, Finland. [2] Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland. [3] Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland., Farrall M; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UK., Ferrannini E; 1] Department of Internal Medicine, University of Pisa, Pisa, Italy. [2] National Research Council (CNR) Institute of Clinical Physiology, University of Pisa, Pisa, Italy., Ferrières J; Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France., Ford I; Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK., Forouhi NG; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Forrester T; Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica., Gansevoort RT; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Gejman PV; NorthShore University HealthSystem, University of Chicago, Evanston, Illinois, USA., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Golay A; Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva, Switzerland., Gottesman O; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Gudnason V; 1] Icelandic Heart Association, Kopavogur, Iceland. [2] University of Iceland, Reykjavik, Iceland., Gyllensten U; Department of Immunology, Genetics and Pathology, SciLifeLab, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden., Haas DW; Department of Medicine, Pharmacology, Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Hall AS; Leeds MRC Medical Bioinformatics Centre, University of Leeds, Leeds, UK., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA., Hattersley AT; Institute of Biomedical and Clinical Science, University of Exeter, Exeter, UK., Heath AC; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA., Hengstenberg C; 1] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany. [2] Deutsches Herzzentrum München, Technische Universität München, Munich, Germany., Hicks AA; Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck, Lübeck, Germany)., Hindorff LA; Division of Genomic Medicine, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA., Hingorani AD; Institute of Cardiovascular Science, University College London, London, UK., Hofman A; 1] Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. [2] Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Hovingh GK; Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands., Humphries SE; Centre for Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London, UK., Hunt SC; Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA., Hypponen E; 1] School of Population Health, University of South Australia, Adelaide, South Australia, Australia. [2] Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia. [3] South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia. [4] Centre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, London, UK., Jacobs KB; 1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA. [2] Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA., Jarvelin MR; 1] Department of Epidemiology and Biostatistics, Imperial College London, London, UK. [2] National Institute for Health and Welfare, Oulu, Finland. [3] MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. [4] Unit of Primary Care, Oulu University Hospital, Oulu, Finland. [5] Biocenter Oulu, University of Oulu, Oulu, Finland. [6] Institute of Health Sciences, University of Oulu, Oulu, Finland., Jousilahti P; National Institute for Health and Welfare, Helsinki, Finland., Jula AM; National Institute for Health and Welfare, Helsinki, Finland., Kaprio J; 1] National Institute for Health and Welfare, Helsinki, Finland. [2] Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland. [3] Hjelt Institute Department of Public Health, University of Helsinki, Helsinki, Finland., Kastelein JJ; Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands., Kayser M; 1] Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. [2] Department of Forensic Molecular Biology, Erasmus Medical Center, Rotterdam, the Netherlands., Kee F; UK Clinical Research Collaboration Centre of Excellence for Public Health (Northern Ireland), Queens University of Belfast, Belfast, UK., Keinanen-Kiukaanniemi SM; 1] Faculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland. [2] Unit of General Practice, Oulu University Hospital, Oulu, Finland., Kiemeney LA; 1] Department for Health Evidence, Radboud University Medical Centre, Nijmegen, the Netherlands. [2] Department of Urology, Radboud University Medical Centre, Nijmegen, the Netherlands., Kooner JS; 1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. [2] Imperial College Healthcare NHS Trust, London, UK. [3] National Heart and Lung Institute, Imperial College London, London, UK., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Koskinen S; National Institute for Health and Welfare, Helsinki, Finland., Kovacs P; 1] Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany. [2] Department of Medicine, University of Leipzig, Leipzig, Germany., Kraja AT; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA., Kumari M; Department of Epidemiology and Public Health, University College London, London, UK., Kuusisto J; Department of Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland., Lakka TA; 1] Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. [2] Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. [3] Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland., Langenberg C; 1] Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. [2] Department of Epidemiology and Public Health, University College London, London, UK., Le Marchand L; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland., Lupoli S; 1] Department of Health Sciences, University of Milano, Milan, Italy. [2] Fondazione Filarete, Milan, Italy., Madden PA; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA., Männistö S; National Institute for Health and Welfare, Helsinki, Finland., Manunta P; 1] Division of Nephrology and Dialysis, San Raffaele Scientific Institute, Milan, Italy. [2] Università Vita-Salute San Raffaele, Milan, Italy., Marette A; 1] Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada. [2] Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada., Matise TC; Department of Genetics, Rutgers University, Piscataway, New Jersey, USA., McKnight B; Department of Biostatistics, University of Washington, Seattle, Washington, USA., Meitinger T; DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany., Moll FL; Department of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands., Montgomery GW; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Morris AD; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Morris AP; 1] Estonian Genome Center, University of Tartu, Tartu, Estonia. [2] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [3] Department of Biostatistics, University of Liverpool, Liverpool, UK., Murray JC; Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA., Nelis M; Estonian Genome Center, University of Tartu, Tartu, Estonia., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Ong KK; 1] Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. [2] MRC Unit for Lifelong Health and Ageing at University College London, London, UK., Ouwehand WH; 1] Department of Haematology, University of Cambridge, Cambridge, UK. [2] NHS Blood and Transplant, Cambridge, UK., Pasterkamp G; Experimental Cardiology Laboratory, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., Peters A; 1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany. [3] Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Pramstaller PP; 1] Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck, Lübeck, Germany). [2] Department of Neurology, General Central Hospital, Bolzano, Italy., Price JF; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK., Qi L; 1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA., Raitakari OT; 1] Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. [2] Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA., Rao DC; 1] Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA. [2] Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA. [3] Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA., Rice TK; 1] Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA. [2] Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA., Ritchie M; Center for Systems Genomics, Pennsylvania State University, University Park, Pennsylvania, USA., Rudan I; 1] Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK. [2] Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia., Salomaa V; National Institute for Health and Welfare, Helsinki, Finland., Samani NJ; 1] Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK. [2] National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK., Saramies J; South Carelia Central Hospital, Lappeenranta, Finland., Sarzynski MA; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA., Schwarz PE; 1] Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. [2] Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany., Sebert S; Institute of Health Sciences, University of Oulu, Oulu, Finland., Sever P; International Centre for Circulatory Health, Imperial College London, London, UK., Shuldiner AR; 1] Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. [2] Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA. [3] Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland, USA., Sinisalo J; Helsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland., Steinthorsdottir V; deCODE Genetics, Amgen, Inc., Reykjavik, Iceland., Stolk RP; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Tardif JC; 1] Montreal Heart Institute, Montreal, Quebec, Canada. [2] Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada., Tönjes A; 1] Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany. [2] Department of Medicine, University of Leipzig, Leipzig, Germany., Tremblay A; Department of Kinesiology, Laval University, Quebec City, Quebec, Canada., Tremoli E; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano and Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy., Virtamo J; National Institute for Health and Welfare, Helsinki, Finland., Vohl MC; 1] Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada. [2] Department of Food Science and Nutrition, Laval University, Quebec City, Quebec, Canada., Amouyel P; Institut Pasteur de Lille, INSERM U744, Université de Lille 2, Lille, France., Asselbergs FW; 1] Institute of Cardiovascular Science, University College London, London, UK. [2] Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands. [3] Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, the Netherlands., Assimes TL; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA., Bochud M; 1] Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland. [2] Ministry of Health, Victoria, Republic of Seychelles., Boehm BO; 1] Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, Ulm, Germany. [2] Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore., Boerwinkle E; Health Science Center at Houston, University of Texas, Houston, Texas, USA., Bottinger EP; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA., Cauchi S; 1] CNRS UMR 8199, Lille, France. [2] European Genomic Institute for Diabetes, Lille, France. [3] Université de Lille 2, Lille, France., Chambers JC; 1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. [2] Department of Epidemiology and Biostatistics, Imperial College London, London, UK. [3] Imperial College Healthcare NHS Trust, London, UK., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA., Cooper RS; Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois, USA., de Bakker PI; 1] Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Epidemiology, University Medical Center Utrecht, Utrecht, the Netherlands., Dedoussis G; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA., Franks PW; 1] Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA. [2] Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hospital, Malmö, Sweden. [3] Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden., Froguel P; 1] Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK. [2] CNRS UMR 8199, Lille, France. [3] European Genomic Institute for Diabetes, Lille, France. [4] Université de Lille 2, Lille, France., Groop LC; 1] Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland. [2] Lund University Diabetes Centre, Lund University, Malmö, Sweden. [3] Diabetes and Endocrinology Unit, Department of Clinical Science, Lund University, Malmö, Sweden., Haiman CA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Hamsten A; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Hayes MG; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Hui J; 1] PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia, Australia. [2] Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia. [3] School of Population Health, University of South Australia, Adelaide, South Australia, Australia. [4] Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia., Hunter DJ; 1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA. [3] Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA., Hveem K; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway., Jukema JW; 1] Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. [2] Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, the Netherlands. [3] Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, the Netherlands., Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine. Belfer, New York, USA., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK., Kuh D; MRC Unit for Lifelong Health and Ageing at University College London, London, UK., Laakso M; Department of Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland., Liu Y; Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., März W; 1] Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany. [2] Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. [3] Synlab Academy, Synlab Services, Mannheim, Germany., Melbye M; 1] Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. [2] Department of Medicine, Stanford University School of Medicine, Stanford, California, USA., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany., Munroe PB; 1] Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. [2] Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Njølstad I; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Tromsø, Tromsø, Norway., Oostra BA; 1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. [2] Center for Medical Systems Biology, Leiden, the Netherlands. [3] Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands., Palmer CN; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Perola M; 1] Estonian Genome Center, University of Tartu, Tartu, Estonia. [2] National Institute for Health and Welfare, Helsinki, Finland. [3] Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland., Pérusse L; 1] Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada. [2] Department of Kinesiology, Laval University, Quebec City, Quebec, Canada., Peters U; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Powell JE; 1] Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. [2] University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, Queensland, Australia., Power C; Centre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, London, UK., Quertermous T; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA., Rauramaa R; 1] Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. [2] Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland., Reinmaa E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Ridker PM; 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA., Rivadeneira F; 1] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. [3] Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, California, USA., Saaristo TE; 1] Finnish Diabetes Association, Tampere, Finland. [2] Pirkanmaa Hospital District, Tampere, Finland., Saleheen D; 1] Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [2] Center for Non-Communicable Diseases, Karatchi, Pakistan. [3] Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Schlessinger D; Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA., Slagboom PE; 1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Snieder H; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Strauch K; 1] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians Universität, Neuherberg, Germany., Stumvoll M; 1] Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany. [2] Department of Medicine, University of Leipzig, Leipzig, Germany., Tuomilehto J; 1] National Institute for Health and Welfare, Helsinki, Finland. [2] Instituto de Investigacion Sanitaria del Hospital Universario La Paz (IdiPAZ), Madrid, Spain. [3] Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia. [4] Centre for Vascular Prevention, Danube University Krems, Krems, Austria., Uusitupa M; 1] Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. [2] Research Unit, Kuopio University Hospital, Kuopio, Finland., van der Harst P; 1] Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. [2] Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. [3] Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, the Netherlands., Völzke H; 1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. [2] Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Walker M; Institute of Cellular Medicine, Newcastle University, Newcastle, UK., Wareham NJ; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Watkins H; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UK., Wichmann HE; 1] Chair of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians Universität, Munich, Germany. [2] Klinikum Großhadern, Munich, Germany. [3] Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Wilson JF; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK., Zanen P; Department of Pulmonology, University Medical Center Utrecht, Utrecht, the Netherlands., Deloukas P; 1] Wellcome Trust Sanger Institute, Hinxton, UK. [2] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. [3] King Abdulaziz University, Jeddah, Saudi Arabia., Heid IM; 1] Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany. [2] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Lindgren CM; 1] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. [2] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA., Speliotes EK; 1] Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA. [2] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA., Thorsteinsdottir U; 1] deCODE Genetics, Amgen, Inc., Reykjavik, Iceland. [2] Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Barroso I; 1] Wellcome Trust Sanger Institute, Hinxton, UK. [2] University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. [3] NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Fox CS; National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, USA., North KE; 1] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Strachan DP; Division of Population Health Sciences and Education, St George's, University of London, London, UK., Beckmann JS; 1] Swiss Institute of Bioinformatics, Lausanne, Switzerland. [2] Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. [3] Service of Medical Genetics, CHUV University Hospital, Lausanne, Switzerland., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA., Boehnke M; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA., Borecki IB; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA., McCarthy MI; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. [3] Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, UK., Metspalu A; 1] Estonian Genome Center, University of Tartu, Tartu, Estonia. [2] Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia., Stefansson K; 1] deCODE Genetics, Amgen, Inc., Reykjavik, Iceland. [2] Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Uitterlinden AG; 1] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. [3] Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., van Duijn CM; 1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. [3] Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. [4] Center for Medical Systems Biology, Leiden, the Netherlands., Franke L; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Willer CJ; 1] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. [2] Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA. [3] Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Price AL; 1] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. [2] Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA. [3] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA., Lettre G; 1] Montreal Heart Institute, Montreal, Quebec, Canada. [2] Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada., Loos RJ; 1] Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. [2] Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [3] Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [4] Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Weedon MN; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Ingelsson E; 1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden. [3] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., O'Connell JR; 1] Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. [2] Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA., Abecasis GR; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA., Chasman DI; 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA., Goddard ME; 1] Biosciences Research Division, Department of Primary Industries, Melbourne, Victoria, Australia. [2] Department of Food and Agricultural Systems, University of Melbourne, Melbourne, Victoria, Australia., Visscher PM; 1] Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. [2] University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, Queensland, Australia., Hirschhorn JN; 1] Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. [3] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.

مؤلفون مشاركون: Electronic Medical Records and Genomics (eMEMERGEGE) Consortium, MIGen Consortium, PAGEGE Consortium, LifeLines Cohort Study

المصدر: Nature genetics [Nat Genet] 2014 Nov; Vol. 46 (11), pp. 1173-86. Date of Electronic Publication: 2014 Oct 05.

نوع المنشور: Journal Article; Meta-Analysis

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Body Height/*genetics , Genetic Variation/*genetics , Polymorphism, Single Nucleotide/*genetics , White People/*genetics, Adult ; Analysis of Variance ; Genetics, Population ; Genome-Wide Association Study/methods ; Humans ; Oligonucleotide Array Sequence Analysis

المؤلفون: Dimas AS; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.Alexander Fleming, Biomedical Sciences Research Center, Vari, Athens, Greece., Lagou V; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, U.K., Barker A; Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K., Knowles JW; Department of Medicine and Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA., Mägi R; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, U.K.Estonian Genome Center, University of Tartu, Tartu, Estonia., Hivert MF; Department of Medicine, Université de Sherbrooke, Sherbrooke, Québec, CanadaGeneral Medicine Division, Massachusetts General Hospital, Boston, MA., Benazzo A; Department of Biology and Evolution, University of Ferrara, Ferrara, Italy., Rybin D; Boston University Data Coordinating Center, Boston, MA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI., Song C; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Fischer-Rosinsky A; Charité-Universitätsmedizin Berlin, Department of Endocrinology and Metabolism, Berlin, Germany., Boesgaard TW; Steno Diabetes Center, Gentofte, Denmark., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Abbasi FA; Department of Medicine and Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA., Assimes TL; Department of Medicine and Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA., Hao K; Department of Genetics and Genomic Sciences, Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY., Yang X; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA., Lecoeur C; CNRS UMR8199-Institute of Biology, Pasteur Institute, Lille 2-Droit et Santé University, Lille, France., Barroso I; Wellcome Trust Sanger Institute, Hinxton, U.K.University of Cambridge Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K., Bonnycastle LL; Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD., Böttcher Y; IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany., Bumpstead S; Wellcome Trust Sanger Institute, Hinxton, U.K., Chines PS; Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD., Erdos MR; Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD., Graessler J; Department of Medicine III, Division of Prevention and Care of Diabetes, University of Dresden, Dresden, Germany., Kovacs P; Interdisciplinary Center for Clinical Research Leipzig, Leipzig, Germany., Morken MA; Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD., Narisu N; Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD., Payne F; Wellcome Trust Sanger Institute, Hinxton, U.K., Stancakova A; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Swift AJ; Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD., Tönjes A; IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, GermanyDepartment of Medicine, University of Leipzig, Leipzig, Germany., Bornstein SR; Department of Medicine III, Division of Prevention and Care of Diabetes, University of Dresden, Dresden, Germany., Cauchi S; CNRS UMR8199-Institute of Biology, Pasteur Institute, Lille 2-Droit et Santé University, Lille, France., Froguel P; CNRS UMR8199-Institute of Biology, Pasteur Institute, Lille 2-Droit et Santé University, Lille, FranceDepartment of Genomics of Common Disease, Imperial College London, London, U.K., Meyre D; CNRS UMR8199-Institute of Biology, Pasteur Institute, Lille 2-Droit et Santé University, Lille, FranceDepartment of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada., Schwarz PE; Department of Medicine III, Division of Prevention and Care of Diabetes, University of Dresden, Dresden, Germany., Häring HU; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany., Smith U; Lundberg Laboratory for Diabetes Research, Center of Excellence for Metabolic and Cardiovascular Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI., Bergman RN; Department of Physiology & Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA., Collins FS; Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD., Mohlke KL; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Tuomilehto J; Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, FinlandCentre for Vascular Prevention, Danube University Krems, Krems, AustriaKing Abdulaziz University, Jeddah, Saudi Arabia., Quertemous T; Department of Medicine and Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA., Lind L; Department of Medical Sciences, Akademiska Sjukhuset, Uppsala University, Uppsala, Sweden., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkFaculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkHagedorn Research Institute, Copenhagen, DenmarkInstitute of Biomedical Science, Faculty of Health Sciences, University of Copenhagen, Copenhagen, DenmarkFaculty of Health Sciences, University of Aarhus, Aarhus, Denmark., Walker M; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, U.K., Pfeiffer AF; Charité-Universitätsmedizin Berlin, Department of Endocrinology and Metabolism, Berlin, GermanyDepartment of Clinical Nutrition, German Institute of Human Nutrition, Nuthetal, Germany., Spranger J; Charité-Universitätsmedizin Berlin, Department of Endocrinology and Metabolism, Berlin, Germany., Stumvoll M; IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, GermanyDepartment of Medicine, University of Leipzig, Leipzig, Germany., Meigs JB; General Medicine Division, Massachusetts General Hospital, Boston, MADepartment of Medicine, Harvard Medical School, Boston, MA., Wareham NJ; Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Langenberg C; Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MAThe National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA., Watanabe RM; Departments of Preventive Medicine and Physiology & Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA., Florez JC; Department of Medicine, Harvard Medical School, Boston, MACenter for Human Genetic Research and Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MAProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA., Ingelsson E; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, U.K.Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, U.K., Prokopenko I; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, U.K.Department of Genomics of Common Disease, Imperial College London, London, U.K.

مؤلفون مشاركون: MAGIC Investigators

المصدر: Diabetes [Diabetes] 2014 Jun; Vol. 63 (6), pp. 2158-71. Date of Electronic Publication: 2013 Dec 02.

نوع المنشور: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review

بيانات الدورية: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Predisposition to Disease*, Diabetes Mellitus, Type 2/*genetics , Insulin/*metabolism , Insulin Resistance/*genetics , Insulin-Secreting Cells/*metabolism , Quantitative Trait Loci/*genetics, Alleles ; Cluster Analysis ; Female ; Gene Frequency ; Genetic Variation ; Genome-Wide Association Study ; Humans ; Insulin Secretion ; Male ; Polymorphism, Single Nucleotide ; Risk Factors ; Transcription Factors/metabolism

المؤلفون: Kulzer JR; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Stitzel ML; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA., Morken MA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Huyghe JR; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Collins FS; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Mohlke KL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: mohlke@med.unc.edu.

المصدر: American journal of human genetics [Am J Hum Genet] 2014 Feb 06; Vol. 94 (2), pp. 186-97. Date of Electronic Publication: 2014 Jan 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0370475 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6605 (Electronic) Linking ISSN: 00029297 NLM ISO Abbreviation: Am J Hum Genet Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Loci* , Up-Regulation*, Adaptor Proteins, Signal Transducing/*genetics , Diabetes Mellitus, Type 2/*genetics , Insulin-Secreting Cells/*metabolism, Adaptor Proteins, Signal Transducing/metabolism ; Aged ; Alleles ; Animals ; Cell Line ; Diabetes Mellitus, Type 2/metabolism ; Eye Proteins/genetics ; Eye Proteins/metabolism ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Insulin-Secreting Cells/cytology ; Male ; Mice ; Middle Aged ; PAX6 Transcription Factor ; Paired Box Transcription Factors/genetics ; Paired Box Transcription Factors/metabolism ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Repressor Proteins/genetics ; Repressor Proteins/metabolism

المؤلفون: Mahendran Y; Department of Medicine, University of Eastern Finland, Kuopio, Finland., Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M

المصدر: Diabetes [Diabetes] 2013 Oct; Vol. 62 (10), pp. 3618-26. Date of Electronic Publication: 2013 Apr 04.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE

مواضيع طبية MeSH: Polymorphism, Single Nucleotide*, Blood Glucose/*metabolism , Diabetes Mellitus, Type 2/*blood , Hyperglycemia/*blood , Ketone Bodies/*blood, 3-Hydroxybutyric Acid/blood ; Acetoacetates/blood ; Area Under Curve ; Biomarkers/blood ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Fasting ; Finland/epidemiology ; Genome-Wide Association Study ; Glucose Tolerance Test ; Humans ; Hyperglycemia/epidemiology ; Hyperglycemia/genetics ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/epidemiology ; Middle Aged ; Predictive Value of Tests ; Risk Factors ; White People/genetics

المؤلفون: Gartner JJ; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Parker SC, Prickett TD, Dutton-Regester K, Stitzel ML, Lin JC, Davis S, Simhadri VL, Jha S, Katagiri N, Gotea V, Teer JK, Wei X, Morken MA, Bhanot UK, Chen G, Elnitski LL, Davies MA, Gershenwald JE, Carter H, Karchin R, Robinson W, Robinson S, Rosenberg SA, Collins FS, Parmigiani G, Komar AA, Kimchi-Sarfaty C, Hayward NK, Margulies EH, Samuels Y

مؤلفون مشاركون: NISC Comparative Sequencing Program

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Aug 13; Vol. 110 (33), pp. 13481-6. Date of Electronic Publication: 2013 Jul 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*genetics , Gene Expression Regulation/*genetics , Genome, Human/*genetics , Melanoma/*genetics , Muscle Proteins/*genetics , Proto-Oncogene Proteins c-bcl-2/*genetics, Base Sequence ; Blotting, Western ; DNA Primers/genetics ; Exome/genetics ; Genetic Vectors/genetics ; HEK293 Cells ; Humans ; Immunoprecipitation ; Lentivirus ; MicroRNAs/genetics ; Molecular Sequence Data ; Muscle Proteins/metabolism ; Mutation/genetics ; Polymorphism, Single Nucleotide/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Small Interfering/genetics ; Real-Time Polymerase Chain Reaction ; Sequence Analysis, DNA ; Tumor Suppressor Protein p53/metabolism

المؤلفون: Stancáková A; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Civelek M, Saleem NK, Soininen P, Kangas AJ, Cederberg H, Paananen J, Pihlajamäki J, Bonnycastle LL, Morken MA, Boehnke M, Pajukanta P, Lusis AJ, Collins FS, Kuusisto J, Ala-Korpela M, Laakso M

المصدر: Diabetes [Diabetes] 2012 Jul; Vol. 61 (7), pp. 1895-902. Date of Electronic Publication: 2012 May 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE

مواضيع طبية MeSH: Adaptor Proteins, Signal Transducing/*genetics , Amino Acids/*blood , Hyperglycemia/*genetics, Adipose Tissue/metabolism ; Aged ; Blood Glucose/analysis ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/genetics ; Finland ; Gene Expression Regulation/genetics ; Genetic Predisposition to Disease ; Humans ; Insulin Resistance/genetics ; Male ; Middle Aged

المؤلفون: Manning AK; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, Amin N, Barnes D, Cadby G, Hottenga JJ, Ingelsson E, Jackson AU, Johnson T, Kanoni S, Ladenvall C, Lagou V, Lahti J, Lecoeur C, Liu Y, Martinez-Larrad MT, Montasser ME, Navarro P, Perry JR, Rasmussen-Torvik LJ, Salo P, Sattar N, Shungin D, Strawbridge RJ, Tanaka T, van Duijn CM, An P, de Andrade M, Andrews JS, Aspelund T, Atalay M, Aulchenko Y, Balkau B, Bandinelli S, Beckmann JS, Beilby JP, Bellis C, Bergman RN, Blangero J, Boban M, Boehnke M, Boerwinkle E, Bonnycastle LL, Boomsma DI, Borecki IB, Böttcher Y, Bouchard C, Brunner E, Budimir D, Campbell H, Carlson O, Chines PS, Clarke R, Collins FS, Corbatón-Anchuelo A, Couper D, de Faire U, Dedoussis GV, Deloukas P, Dimitriou M, Egan JM, Eiriksdottir G, Erdos MR, Eriksson JG, Eury E, Ferrucci L, Ford I, Forouhi NG, Fox CS, Franzosi MG, Franks PW, Frayling TM, Froguel P, Galan P, de Geus E, Gigante B, Glazer NL, Goel A, Groop L, Gudnason V, Hallmans G, Hamsten A, Hansson O, Harris TB, Hayward C, Heath S, Hercberg S, Hicks AA, Hingorani A, Hofman A, Hui J, Hung J, Jarvelin MR, Jhun MA, Johnson PC, Jukema JW, Jula A, Kao WH, Kaprio J, Kardia SL, Keinanen-Kiukaanniemi S, Kivimaki M, Kolcic I, Kovacs P, Kumari M, Kuusisto J, Kyvik KO, Laakso M, Lakka T, Lannfelt L, Lathrop GM, Launer LJ, Leander K, Li G, Lind L, Lindstrom J, Lobbens S, Loos RJ, Luan J, Lyssenko V, Mägi R, Magnusson PK, Marmot M, Meneton P, Mohlke KL, Mooser V, Morken MA, Miljkovic I, Narisu N, O'Connell J, Ong KK, Oostra BA, Palmer LJ, Palotie A, Pankow JS, Peden JF, Pedersen NL, Pehlic M, Peltonen L, Penninx B, Pericic M, Perola M, Perusse L, Peyser PA, Polasek O, Pramstaller PP, Province MA, Räikkönen K, Rauramaa R, Rehnberg E, Rice K, Rotter JI, Rudan I, Ruokonen A, Saaristo T, Sabater-Lleal M, Salomaa V, Savage DB, Saxena R, Schwarz P, Seedorf U, Sennblad B, Serrano-Rios M, Shuldiner AR, Sijbrands EJ, Siscovick DS, Smit JH, Small KS, Smith NL, Smith AV, Stančáková A, Stirrups K, Stumvoll M, Sun YV, Swift AJ, Tönjes A, Tuomilehto J, Trompet S, Uitterlinden AG, Uusitupa M, Vikström M, Vitart V, Vohl MC, Voight BF, Vollenweider P, Waeber G, Waterworth DM, Watkins H, Wheeler E, Widen E, Wild SH, Willems SM, Willemsen G, Wilson JF, Witteman JC, Wright AF, Yaghootkar H, Zelenika D, Zemunik T, Zgaga L, Wareham NJ, McCarthy MI, Barroso I, Watanabe RM, Florez JC, Dupuis J, Meigs JB, Langenberg C

مؤلفون مشاركون: DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Multiple Tissue Human Expression Resource (MUTHER) Consortium

المصدر: Nature genetics [Nat Genet] 2012 May 13; Vol. 44 (6), pp. 659-69. Date of Electronic Publication: 2012 May 13.

نوع المنشور: Journal Article; Meta-Analysis

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Body Mass Index* , Polymorphism, Single Nucleotide*, Blood Glucose/*metabolism , Insulin/*metabolism , Insulin Resistance/*genetics, Cholesterol, HDL/metabolism ; Diabetes Mellitus, Type 2/genetics ; Genome-Wide Association Study ; Humans