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المؤلفون: Belov AM, Kozole J, Bean MF, Machutta CA, Zhang G, Gao EN, Ghislain L; Beckman Coulter Life Sciences, 170 Rose Orchard Way, San Jose, California 95134, United States., Datwani SS; Beckman Coulter Life Sciences, 170 Rose Orchard Way, San Jose, California 95134, United States., Leveridge M, Annan RS

المصدر: Analytical chemistry [Anal Chem] 2020 Oct 20; Vol. 92 (20), pp. 13847-13854. Date of Electronic Publication: 2020 Oct 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE

مواضيع طبية MeSH: High-Throughput Screening Assays*, Enzyme Inhibitors/*analysis , Mass Spectrometry/*methods, Acoustics ; Histone Acetyltransferases/antagonists & inhibitors ; Histone Acetyltransferases/metabolism ; Kinetics

المؤلفون: Machutta CA, Kollmann CS, Lind KE, Bai X, Chan PF, Huang J, Ballell L, Belyanskaya S, Besra GS, Barros-Aguirre D, Bates RH, Centrella PA, Chang SS, Chai J, Choudhry AE, Coffin A, Davie CP, Deng H, Deng J, Ding Y, Dodson JW, Fosbenner DT, Gao EN, Graham TL, Graybill TL, Ingraham K, Johnson WP, King BW, Kwiatkowski CR, Lelièvre J, Li Y, Liu X, Lu Q, Lehr R, Mendoza-Losana A, Martin J, McCloskey L, McCormick P, O'Keefe HP, O'Keeffe T, Pao C, Phelps CB, Qi H, Rafferty K, Scavello GS, Steiginga MS, Sundersingh FS, Sweitzer SM, Szewczuk LM, Taylor A, Fern Toh M, Wang J, Wang M, Wilkins DJ, Xia B, Yao G, Zhang J, Zhou J, Donahue CP, Messer JA, Holmes D, Arico-Muendel CC, Pope AJ, Gross JW, Evindar G

المصدر: Nature communications [Nat Commun] 2018 Jul 13; Vol. 9, pp. 16227. Date of Electronic Publication: 2018 Jul 13.

نوع المنشور: Journal Article; Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: PubMed not MEDLINE

المؤلفون: Machutta CA; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Kollmann CS; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Lind KE; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Bai X; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Chan PF; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Huang J; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Ballell L; GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Belyanskaya S; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Besra GS; University of Birmingham, School of Biosciences, Edgbaston, Birmingham B15 2TT, UK., Barros-Aguirre D; GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Bates RH; GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Centrella PA; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Chang SS; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Chai J; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Choudhry AE; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Coffin A; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Davie CP; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Deng H; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Deng J; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Ding Y; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Dodson JW; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Fosbenner DT; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Gao EN; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Graham TL; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Graybill TL; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Ingraham K; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Johnson WP; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., King BW; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Kwiatkowski CR; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Lelièvre J; GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Li Y; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Liu X; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Lu Q; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Lehr R; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Mendoza-Losana A; GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Martin J; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., McCloskey L; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., McCormick P; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., O'Keefe HP; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., O'Keeffe T; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Pao C; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Phelps CB; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Qi H; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Rafferty K; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Scavello GS; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Steiginga MS; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Sundersingh FS; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Sweitzer SM; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Szewczuk LM; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Taylor A; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Toh MF; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Wang J; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Wang M; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Wilkins DJ; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Xia B; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Yao G; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Zhang J; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Zhou J; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Donahue CP; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Messer JA; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Holmes D; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Arico-Muendel CC; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Pope AJ; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Gross JW; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Evindar G; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA.

المصدر: Nature communications [Nat Commun] 2017 Jul 17; Vol. 8, pp. 16081. Date of Electronic Publication: 2017 Jul 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Gene Library* , Small Molecule Libraries*, Acinetobacter baumannii/*drug effects , Anti-Bacterial Agents/*pharmacology , Drug Discovery/*methods , Mycobacterium tuberculosis/*drug effects , Staphylococcus aureus/*drug effects, Acinetobacter baumannii/metabolism ; Drug Evaluation, Preclinical ; Molecular Targeted Therapy ; Mycobacterium tuberculosis/metabolism ; Staphylococcus aureus/metabolism

المؤلفون: Kapilashrami K; Department of Chemistry, Institute for Chemical Biology & Drug Discovery, Stony Brook University, Stony Brook, New York 11794, USA., Bommineni GR, Machutta CA, Kim P, Lai CT, Simmerling C, Picart F, Tonge PJ

المصدر: The Journal of biological chemistry [J Biol Chem] 2013 Mar 01; Vol. 288 (9), pp. 6045-52. Date of Electronic Publication: 2013 Jan 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/*antagonists & inhibitors , Bacterial Proteins/*antagonists & inhibitors , Enzyme Inhibitors/*chemistry , Mycobacterium tuberculosis/*enzymology, 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/genetics ; 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Enzyme Inhibitors/chemical synthesis ; Mycobacterium smegmatis/enzymology ; Mycobacterium smegmatis/genetics ; Mycobacterium tuberculosis/genetics ; Protein Binding ; Structure-Activity Relationship ; Thiophenes/chemical synthesis ; Thiophenes/chemistry

المؤلفون: Diaz E; Platform Technology and Science, GlaxoSmithKline, Collegeville, PA 19426, USA., Machutta CA, Chen S, Jiang Y, Nixon C, Hofmann G, Key D, Sweitzer S, Patel M, Wu Z, Creasy CL, Kruger RG, LaFrance L, Verma SK, Pappalardi MB, Le B, Van Aller GS, McCabe MT, Tummino PJ, Pope AJ, Thrall SH, Schwartz B, Brandt M

المصدر: Journal of biomolecular screening [J Biomol Screen] 2012 Dec; Vol. 17 (10), pp. 1279-92. Date of Electronic Publication: 2012 Aug 17.

نوع المنشور: Journal Article; Validation Study

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9612112 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-454X (Electronic) Linking ISSN: 10870571 NLM ISO Abbreviation: J Biomol Screen Subsets: MEDLINE

مواضيع طبية MeSH: High-Throughput Screening Assays/*methods , Nucleosomes/*metabolism , Peptides/*metabolism , Polycomb Repressive Complex 2/*metabolism, Drug Screening Assays, Antitumor/methods ; Enhancer of Zeste Homolog 2 Protein ; Humans ; Indicators and Reagents ; Kinetics ; Peptides/antagonists & inhibitors ; Polycomb Repressive Complex 2/antagonists & inhibitors ; Polycomb Repressive Complex 2/chemistry ; Reproducibility of Results

المؤلفون: Verma SK; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Tian X; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., LaFrance LV; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Duquenne C; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Suarez DP; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Newlander KA; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Romeril SP; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Burgess JL; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Grant SW; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Brackley JA; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Graves AP; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Scherzer DA; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Shu A; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Thompson C; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Ott HM; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Aller GS; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Machutta CA; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Diaz E; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Jiang Y; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Johnson NW; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Knight SD; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Kruger RG; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., McCabe MT; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Dhanak D; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Tummino PJ; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Creasy CL; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Miller WH; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2012 Oct 19; Vol. 3 (12), pp. 1091-6. Date of Electronic Publication: 2012 Oct 19 (Print Publication: 2012).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Borgaro JG; Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States., Chang A, Machutta CA, Zhang X, Tonge PJ

المصدر: Biochemistry [Biochemistry] 2011 Dec 13; Vol. 50 (49), pp. 10678-86. Date of Electronic Publication: 2011 Nov 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/*metabolism , Escherichia coli/*enzymology , Mycobacterium tuberculosis/*enzymology, 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/antagonists & inhibitors ; 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/chemistry ; Acetyltransferases/chemistry ; Acetyltransferases/genetics ; Acetyltransferases/metabolism ; Amino Acid Sequence ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Binding Sites ; Coenzyme A/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Fatty Acid Synthase, Type II/chemistry ; Fatty Acid Synthase, Type II/genetics ; Fatty Acid Synthase, Type II/metabolism ; Kinetics ; Molecular Sequence Data ; Mutation ; Palmitoyl Coenzyme A/metabolism ; Pantetheine/analogs & derivatives ; Pantetheine/chemistry ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Substrate Specificity

المؤلفون: Machutta CA; Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA., Bommineni GR, Luckner SR, Kapilashrami K, Ruzsicska B, Simmerling C, Kisker C, Tonge PJ

المصدر: The Journal of biological chemistry [J Biol Chem] 2010 Feb 26; Vol. 285 (9), pp. 6161-9. Date of Electronic Publication: 2009 Dec 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/*antagonists & inhibitors, 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/chemistry ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/antagonists & inhibitors ; Catalytic Domain/genetics ; Enzyme Inhibitors/pharmacology ; Escherichia coli/enzymology ; Kinetics ; Mycobacterium tuberculosis/enzymology ; Protein Binding ; Protein Conformation ; Substrate Specificity ; Thiophenes/pharmacology

المؤلفون: Luckner SR; Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, Würzburg, Germany., Machutta CA, Tonge PJ, Kisker C

المصدر: Structure (London, England : 1993) [Structure] 2009 Jul 15; Vol. 17 (7), pp. 1004-13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

مواضيع طبية MeSH: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/*chemistry , Antitubercular Agents/*pharmacology , Cell Wall/*metabolism , Mycobacterium tuberculosis/*enzymology, 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/metabolism ; Binding Sites ; Crystallography, X-Ray ; Fatty Acids/biosynthesis ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Mycobacterium tuberculosis/metabolism ; Mycolic Acids/metabolism ; Protein Binding ; Protein Conformation ; Protein Structure, Secondary ; Substrate Specificity ; Thiophenes/pharmacology