المؤلفون: Gozgit JM; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA. Electronic address: jgozgit@ribontx.com., Vasbinder MM; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Abo RP; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Kunii K; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Kuplast-Barr KG; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Gui B; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Lu AZ; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Molina JR; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Minissale E; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Swinger KK; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Wigle TJ; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Blackwell DJ; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Majer CR; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Ren Y; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Niepel M; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Varsamis ZA; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Nayak SP; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Bamberg E; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Mo JR; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Church WD; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Mady ASA; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Song J; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Utley L; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Rao PE; Patricia E. Rao Consulting, Acton, MA 01720, USA., Mitchison TJ; Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Warren Alpert 536, Boston, MA 02115, USA., Kuntz KW; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Richon VM; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA., Keilhack H; Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA. Electronic address: hkeilhack@ribontx.com.

المصدر: Cancer cell [Cancer Cell] 2021 Sep 13; Vol. 39 (9), pp. 1214-1226.e10. Date of Electronic Publication: 2021 Jul 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Drug Resistance, Neoplasm/*drug effects , Interferon Type I/*metabolism , Neoplasms/*drug therapy , Nucleoside Transport Proteins/*genetics , Nucleoside Transport Proteins/*metabolism , Small Molecule Libraries/*administration & dosage, Adaptive Immunity/drug effects ; Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; HEK293 Cells ; HeLa Cells ; Humans ; Mice ; Neoplasms/genetics ; Neoplasms/metabolism ; Signal Transduction/drug effects ; Small Molecule Libraries/pharmacology ; Tumor Escape/drug effects ; Xenograft Model Antitumor Assays

المؤلفون: Kump KJ, Miao L, Mady ASA, Ansari NH, Shrestha UK, Yang Y, Pal M, Liao C, Perdih A; National Institute of Chemistry, Ljubljana 1000, Slovenia., Abulwerdi FA, Chinnaswamy K, Meagher JL, Carlson JM; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, United States.; Center for Innovation in Brain Science, Tucson, Arizona 85721, United States., Khanna M; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, United States.; Center for Innovation in Brain Science, Tucson, Arizona 85721, United States., Stuckey JA, Nikolovska-Coleska Z

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Mar 12; Vol. 63 (5), pp. 2489-2510. Date of Electronic Publication: 2020 Feb 14.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Benzoic Acid/*pharmacology , Myeloid Cell Leukemia Sequence 1 Protein/*antagonists & inhibitors , Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors, Animals ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Benzoic Acid/chemistry ; Cell Line, Tumor ; Humans ; Lymphoma/drug therapy ; Lymphoma/metabolism ; Mice ; Mice, Transgenic ; Minor Histocompatibility Antigens/metabolism ; Molecular Docking Simulation ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism

المؤلفون: Zhang Q; Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Mady ASA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Ma Y; Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Ryan C; Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Lawrence TS; Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Nikolovska-Coleska Z; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Sun Y; Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310029, Zhejiang, China., Morgan MA; Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

المصدر: Nucleic acids research [Nucleic Acids Res] 2019 May 07; Vol. 47 (8), pp. 4039-4053.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: DNA End-Joining Repair*, F-Box-WD Repeat-Containing Protein 7/*genetics , Poly (ADP-Ribose) Polymerase-1/*genetics , Poly Adenosine Diphosphate Ribose/*metabolism , Stem Cell Factor/*genetics, Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Binding Sites ; Cell Line ; Cell Line, Tumor ; Cell Survival/radiation effects ; DNA Damage ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; F-Box-WD Repeat-Containing Protein 7/chemistry ; F-Box-WD Repeat-Containing Protein 7/metabolism ; Fibroblasts/metabolism ; Fibroblasts/radiation effects ; Fibroblasts/ultrastructure ; Gamma Rays ; HCT116 Cells ; Humans ; Insulin-Secreting Cells/metabolism ; Insulin-Secreting Cells/radiation effects ; Insulin-Secreting Cells/ultrastructure ; Models, Molecular ; Mutation ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly Adenosine Diphosphate Ribose/chemistry ; Protein Binding ; Protein Domains ; Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Stem Cell Factor/metabolism ; Ubiquitination/radiation effects

المؤلفون: Mady ASA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.; Interdepartmental Graduate Program in Medicinal Chemistry, University of Michigan, College of Pharmacy, Ann Arbor, MI, USA., Liao C; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.; School of Medical Engineering, Hefei University of Technology, Hefei, Anhui, 230009, China., Bajwa N; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.; Pfizer Inc, Lake Forest, IL, 60045, USA., Kump KJ; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.; Program in Chemical Biology, University of Michigan, Ann Arbor, MI, USA., Abulwerdi FA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.; Interdepartmental Graduate Program in Medicinal Chemistry, University of Michigan, College of Pharmacy, Ann Arbor, MI, USA.; Basic Research Laboratory, National Cancer Institute, Frederick, MD, 21702, USA., Lev KL; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA., Miao L; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA., Grigsby SM; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.; Molecular and Cellular Pathology Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA., Perdih A; National Institute of Chemistry, Ljubljana, Slovenia., Stuckey JA; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Du Y; Department of Pharmacology, Emory University, Atlanta, GA, USA., Fu H; Department of Pharmacology, Emory University, Atlanta, GA, USA., Nikolovska-Coleska Z; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA. zanetan@med.umich.edu.; Molecular and Cellular Pathology Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA. zanetan@med.umich.edu.; Interdepartmental Graduate Program in Medicinal Chemistry, University of Michigan, College of Pharmacy, Ann Arbor, MI, USA. zanetan@med.umich.edu.; Program in Chemical Biology, University of Michigan, Ann Arbor, MI, USA. zanetan@med.umich.edu.

المصدر: Scientific reports [Sci Rep] 2018 Jul 05; Vol. 8 (1), pp. 10210. Date of Electronic Publication: 2018 Jul 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Myeloid Cell Leukemia Sequence 1 Protein/*antagonists & inhibitors , Small Molecule Libraries/*chemical synthesis , Small Molecule Libraries/*pharmacology, Cell Line, Tumor ; Cell Survival/drug effects ; Computer Simulation ; Drug Screening Assays, Antitumor ; High-Throughput Screening Assays ; Humans ; Models, Molecular ; Molecular Docking Simulation ; Molecular Structure ; Myeloid Cell Leukemia Sequence 1 Protein/chemistry ; Small Molecule Libraries/chemistry ; Structure-Activity Relationship