المؤلفون: Bertron JL; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Duvernay MT; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Mitchell SG; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Smith ST; Chemical and Physical Biology Program, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, United States., Maeng JG; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Blobaum AL; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Davis DC; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Meiler J; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.; Institute for Drug Discovery, Leipzig University, Saxony 04109, Germany., Hamm HE; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Lindsley CW; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.

المصدر: ACS chemical neuroscience [ACS Chem Neurosci] 2021 Dec 15; Vol. 12 (24), pp. 4524-4534. Date of Electronic Publication: 2021 Dec 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Central Nervous System*/metabolism , Receptors, Thrombin*/metabolism, Animals ; Brain/metabolism ; Mice ; Rats

المؤلفون: Werfel TA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Department of Chemical Engineering, University of Mississippi, Oxford, Mississippi., Hicks DJ; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Rahman B; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Bendeman WE; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Duvernay MT; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee., Maeng JG; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee., Hamm H; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee., Lavieri RR; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Joly MM; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Pulley JM; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Elion DL; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Brantley-Sieders DM; Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Cook RS; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee. rebecca.cook@vanderbilt.edu.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, Tennessee.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2020 Dec; Vol. 19 (12), pp. 2454-2464. Date of Electronic Publication: 2020 Oct 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Drug Repositioning*, Antineoplastic Agents/*pharmacology , Genome-Wide Association Study/*methods , Receptors, Thromboxane/*antagonists & inhibitors , Receptors, Thromboxane/*genetics, Cell Line, Tumor ; Drug Screening Assays, Antitumor/methods ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Neoplasm Metastasis ; Phenotype ; Polymorphism, Single Nucleotide ; Receptors, Thromboxane/metabolism

المؤلفون: Duvernay MT; Department of Pharmacology (M.T.D., K.J.T., J.G.M., A.L.B., S.R.S., C.W.L., H.E.H.) and Vanderbilt Center for Neuroscience Drug Discovery (K.J.T., A.L.B., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Department of Chemistry, Vanderbilt University, Nashville, Tennessee (S.R.S., C.W.L.)., Temple KJ; Department of Pharmacology (M.T.D., K.J.T., J.G.M., A.L.B., S.R.S., C.W.L., H.E.H.) and Vanderbilt Center for Neuroscience Drug Discovery (K.J.T., A.L.B., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Department of Chemistry, Vanderbilt University, Nashville, Tennessee (S.R.S., C.W.L.)., Maeng JG; Department of Pharmacology (M.T.D., K.J.T., J.G.M., A.L.B., S.R.S., C.W.L., H.E.H.) and Vanderbilt Center for Neuroscience Drug Discovery (K.J.T., A.L.B., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Department of Chemistry, Vanderbilt University, Nashville, Tennessee (S.R.S., C.W.L.)., Blobaum AL; Department of Pharmacology (M.T.D., K.J.T., J.G.M., A.L.B., S.R.S., C.W.L., H.E.H.) and Vanderbilt Center for Neuroscience Drug Discovery (K.J.T., A.L.B., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Department of Chemistry, Vanderbilt University, Nashville, Tennessee (S.R.S., C.W.L.)., Stauffer SR; Department of Pharmacology (M.T.D., K.J.T., J.G.M., A.L.B., S.R.S., C.W.L., H.E.H.) and Vanderbilt Center for Neuroscience Drug Discovery (K.J.T., A.L.B., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Department of Chemistry, Vanderbilt University, Nashville, Tennessee (S.R.S., C.W.L.)., Lindsley CW; Department of Pharmacology (M.T.D., K.J.T., J.G.M., A.L.B., S.R.S., C.W.L., H.E.H.) and Vanderbilt Center for Neuroscience Drug Discovery (K.J.T., A.L.B., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Department of Chemistry, Vanderbilt University, Nashville, Tennessee (S.R.S., C.W.L.)., Hamm HE; Department of Pharmacology (M.T.D., K.J.T., J.G.M., A.L.B., S.R.S., C.W.L., H.E.H.) and Vanderbilt Center for Neuroscience Drug Discovery (K.J.T., A.L.B., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Department of Chemistry, Vanderbilt University, Nashville, Tennessee (S.R.S., C.W.L.) heidi.hamm@vanderbilt.edu.

المصدر: Molecular pharmacology [Mol Pharmacol] 2017 Jan; Vol. 91 (1), pp. 39-47. Date of Electronic Publication: 2016 Oct 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Blood Platelets/*metabolism , Integrin beta3/*metabolism , Platelet Glycoprotein GPIb-IX Complex/*metabolism , Receptor, PAR-1/*metabolism , Receptors, Thrombin/*metabolism , Thrombin/*pharmacology, Blood Platelets/drug effects ; Humans ; Ligands ; Receptor, PAR-1/antagonists & inhibitors ; Receptors, Thrombin/antagonists & inhibitors ; Signal Transduction/drug effects

المؤلفون: Temple KJ; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Duvernay MT; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Maeng JG; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Blobaum AL; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Stauffer SR; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA., Hamm HE; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Lindsley CW; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Nov 15; Vol. 26 (22), pp. 5481-5486. Date of Electronic Publication: 2016 Oct 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Platelet Aggregation/*drug effects , Receptors, Thrombin/*antagonists & inhibitors , Thiadiazoles/*chemistry , Thiadiazoles/*pharmacology, Blood Platelets/cytology ; Blood Platelets/drug effects ; Blood Platelets/metabolism ; Humans ; Platelet Aggregation Inhibitors/chemistry ; Platelet Aggregation Inhibitors/pharmacology ; Receptors, Thrombin/metabolism ; Thrombin/metabolism

المؤلفون: Temple KJ, Duvernay MT, Young SE, Wen W; College of Science, Northwest Agriculture & Forestry University , Yangling, Shaanxi 712100, China., Wu W; College of Science, Northwest Agriculture & Forestry University , Yangling, Shaanxi 712100, China., Maeng JG, Blobaum AL, Stauffer SR; Department of Chemistry, Vanderbilt University , Nashville, Tennessee 37232, United States., Hamm HE, Lindsley CW; Department of Chemistry, Vanderbilt University , Nashville, Tennessee 37232, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2016 Aug 25; Vol. 59 (16), pp. 7690-5. Date of Electronic Publication: 2016 Aug 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*pharmacology , Indoles/*pharmacology , Pyrimidines/*pharmacology , Receptors, Thrombin/*antagonists & inhibitors , Thrombin/*antagonists & inhibitors, Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Indoles/chemical synthesis ; Indoles/chemistry ; Molecular Structure ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Structure-Activity Relationship ; Thrombin/metabolism