المؤلفون: Shu Y; Departments of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA., Diamond TL; Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA., Hershey JC; Neuroscience Biology Discovery, Merck & Co., Inc., West Point, PA 19486, USA., Huang S; Departments of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA., Magliaro BC; Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA., O'Brien JA; Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA., Schlegel KS; Departments of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA., Puri V; Neuroscience Biology Discovery, Merck & Co., Inc., West Point, PA 19486, USA., Uebele VN; Neuroscience Biology Discovery, Merck & Co., Inc., West Point, PA 19486, USA., Uslaner JM; Neuroscience Biology Discovery, Merck & Co., Inc., West Point, PA 19486, USA., Wang C; Departments of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA., Converso A; Departments of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA. Electronic address: antonella_converso@merck.com.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 May 01; Vol. 30 (9), pp. 127066. Date of Electronic Publication: 2020 Feb 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Receptors, Metabotropic Glutamate/*antagonists & inhibitors, Adjuvants, Anesthesia/toxicity ; Amino Acids/pharmacology ; Amphetamines/pharmacology ; Animals ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Glutamic Acid/metabolism ; High-Throughput Screening Assays ; Mice ; Molecular Structure ; Scopolamine/toxicity ; Structure-Activity Relationship

المؤلفون: Tong L; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Li W; Translational Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Lo MM; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Gao X; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Wai JM; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Rudd M; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Tellers D; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Joshi A; Translational Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Zeng Z; Translational Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Miller P; Translational Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Salinas C; Translational Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Riffel K; Translational Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Haley H; Translational Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Purcell M; Translational Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Holahan M; Translational Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Gantert L; Translational Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Schubert JW; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Jones K; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Mulhearn J; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Egbertson M; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Meng Z; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Hanney B; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Gomez R; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Harrison ST; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., McQuade P; Translational Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Bueters T; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Uslaner J; Discovery Biology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Morrow J; Discovery Biology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Thomson F; Discovery Biology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Kong J; Department of Process Research and Development, Merck & Co., Inc., 126 East Lincoln Avenue Rahway, New Jersey 07065, United States., Liao J; Department of Process Research and Development, Merck & Co., Inc., 126 East Lincoln Avenue Rahway, New Jersey 07065, United States., Selyutin O; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Bao J; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Hastings NB; Discovery Biology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Agrawal S; Discovery Biology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Magliaro BC; Discovery Biology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Monsma FJ Jr; Discovery Biology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Smith MD; Discovery Biology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Risso S; Discovery Biology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Hesk D; Department of Process Research and Development, Merck & Co., Inc., 126 East Lincoln Avenue Rahway, New Jersey 07065, United States., Hostetler E; Translational Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Mazzola R; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Mar 12; Vol. 63 (5), pp. 2411-2425. Date of Electronic Publication: 2020 Mar 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Allosteric Regulation/*drug effects , Muscarinic Agonists/*pharmacology , Pyridines/*pharmacology , Receptor, Muscarinic M4/*agonists, Animals ; CHO Cells ; Carbon Radioisotopes/chemistry ; Carbon Radioisotopes/pharmacology ; Cricetulus ; Humans ; Macaca mulatta ; Muscarinic Agonists/chemistry ; Neurodegenerative Diseases/diagnostic imaging ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/metabolism ; Positron-Emission Tomography ; Pyridines/chemistry ; Receptor, Muscarinic M4/metabolism

المؤلفون: Kutchukian PS; Modeling and Informatics, Merck & Co., Inc., MRL , Boston, Massachusetts, United States., Warren L; Neuroscience, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States., Magliaro BC; Pharmacology, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States., Amoss A; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States., Cassaday JA; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States., O'Donnell G; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States., Squadroni B; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States., Zuck P; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States., Pascarella D; Pharmacology, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States., Culberson JC; Modeling and Informatics, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States., Cooke AJ; Chemistry, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States., Hurzy D; Chemistry, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States., Schlegel KS; Chemistry, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States., Thomson F; Neuroscience, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States., Johnson EN; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States., Uebele VN; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States., Hermes JD; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States., Parmentier-Batteur S; Neuroscience, Merck & Co., Inc., MRL , West Point, Pennsylvania, United States., Finley M; Screening and Protein Sciences, Merck & Co., Inc., MRL , North Wales, Pennsylvania, United States.

المصدر: ACS chemical biology [ACS Chem Biol] 2017 Feb 17; Vol. 12 (2), pp. 519-527. Date of Electronic Publication: 2017 Jan 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: High-Throughput Screening Assays*, Amino Acid Transport System y+/*antagonists & inhibitors, Animals ; Bayes Theorem ; CHO Cells ; Cricetinae ; Cricetulus ; Humans ; Machine Learning

المؤلفون: Layton ME; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Reif AJ; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Hartingh TJ; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Rodzinak K; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Dudkin V; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Wang C; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Arrington K; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Kelly MJ 3rd; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Garbaccio RM; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., O'Brien JA; Department of In Vitro Sciences, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Magliaro BC; Department of Psychiatry Research, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Uslaner JM; Department of Central Pharmacology, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Huszar SL; Department of Central Pharmacology, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Fillgrove KL; Department of Drug Metabolism, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Tang C; Department of Drug Metabolism, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Kuo Y; Department of Drug Metabolism, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States., Jacobson MA; Department of Psychiatry Research, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Feb 15; Vol. 26 (4), pp. 1260-4. Date of Electronic Publication: 2016 Jan 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Imidazoles/*chemistry , Pyridines/*chemistry , Pyridones/*chemistry , Receptors, Metabotropic Glutamate/*chemistry, Allosteric Regulation ; Animals ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Imidazoles/blood ; Imidazoles/pharmacology ; Imidazoles/therapeutic use ; Locomotion/drug effects ; Protein Binding ; Psychotic Disorders/drug therapy ; Psychotic Disorders/pathology ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Pyridones/blood ; Pyridones/pharmacology ; Rats ; Receptors, Metabotropic Glutamate/metabolism ; Structure-Activity Relationship

المؤلفون: Pero JE; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., Rossi MA; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., Kelly MJ 3rd; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., Lehman HD; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., Layton ME; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., Garbaccio RM; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., O'Brien JA; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., Magliaro BC; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., Uslaner JM; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., Huszar SL; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., Fillgrove KL; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., Tang C; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., Kuo Y; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., Joyce LA; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., Sherer EC; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States., Jacobson MA; Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2016 Jan 10; Vol. 7 (3), pp. 312-7. Date of Electronic Publication: 2016 Jan 10 (Print Publication: 2016).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Parmentier-Batteur S; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA. Electronic address: sophie_parmentier_batteur@merck.com., Hutson PH; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Menzel K; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Uslaner JM; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Mattson BA; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., O'Brien JA; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Magliaro BC; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Forest T; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Stump CA; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Tynebor RM; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Anthony NJ; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Tucker TJ; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Zhang XF; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Gomez R; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Huszar SL; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Lambeng N; Addex Therapeutics, 12, chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland., Fauré H; Addex Therapeutics, 12, chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland., Le Poul E; Addex Therapeutics, 12, chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland., Poli S; Addex Therapeutics, 12, chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland., Rosahl TW; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Rocher JP; Addex Therapeutics, 12, chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland., Hargreaves R; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA., Williams TM; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.

المصدر: Neuropharmacology [Neuropharmacology] 2014 Jul; Vol. 82, pp. 161-73. Date of Electronic Publication: 2013 Jan 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

مواضيع طبية MeSH: Antipsychotic Agents/*toxicity , Benzamides/*toxicity , Brain/*drug effects , Cell Death/*drug effects , Excitatory Amino Acid Agents/*toxicity , Oxadiazoles/*toxicity , Receptor, Metabotropic Glutamate 5/*metabolism, Allosteric Regulation ; Animals ; Antipsychotic Agents/chemistry ; Antipsychotic Agents/pharmacokinetics ; Benzamides/chemistry ; Benzamides/pharmacokinetics ; Brain/pathology ; Brain/physiopathology ; CHO Cells ; Cell Death/physiology ; Cells, Cultured ; Cricetulus ; Excitatory Amino Acid Agents/chemistry ; Excitatory Amino Acid Agents/pharmacokinetics ; Female ; Humans ; Male ; Mice, 129 Strain ; Mice, Knockout ; Necrosis/pathology ; Necrosis/physiopathology ; Neurons/drug effects ; Neurons/pathology ; Neurons/physiology ; Neurotoxicity Syndromes/pathology ; Neurotoxicity Syndromes/physiopathology ; Oxadiazoles/chemistry ; Oxadiazoles/pharmacokinetics ; Rats, Sprague-Dawley ; Rats, Wistar ; Receptor, Metabotropic Glutamate 5/genetics

المؤلفون: Hutson PH; Merck & Co., Inc., Department of Neuroscience, West Point, PA 19486, USA. Peter_Hutson@merck.com, Finger EN, Magliaro BC, Smith SM, Converso A, Sanderson PE, Mullins D, Hyde LA, Eschle BK, Turnbull Z, Sloan H, Guzzi M, Zhang X, Wang A, Rindgen D, Mazzola R, Vivian JA, Eddins D, Uslaner JM, Bednar R, Gambone C, Le-Mair W, Marino MJ, Sachs N, Xu G, Parmentier-Batteur S

المصدر: Neuropharmacology [Neuropharmacology] 2011 Sep; Vol. 61 (4), pp. 665-76. Date of Electronic Publication: 2011 May 19.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

مواضيع طبية MeSH: 3',5'-Cyclic-AMP Phosphodiesterases/*antagonists & inhibitors , Cognition/*drug effects , Neuronal Plasticity/*drug effects , Phosphodiesterase Inhibitors/*pharmacology , Pyrazoles/*pharmacology , Pyrimidinones/*pharmacology , Synapses/*drug effects , Synapses/*enzymology, 3',5'-Cyclic-AMP Phosphodiesterases/metabolism ; Animals ; CHO Cells ; Cognition/physiology ; Cricetinae ; Cricetulus ; Dose-Response Relationship, Drug ; Female ; HEK293 Cells ; Hippocampus/drug effects ; Hippocampus/enzymology ; Humans ; Macaca mulatta ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Neuronal Plasticity/physiology ; Phosphodiesterase Inhibitors/metabolism ; Pyrazoles/metabolism ; Pyrimidinones/metabolism ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar

المؤلفون: Garbaccio RM; Departments of Medicinal Chemistry., Brnardic EJ; Departments of Medicinal Chemistry., Fraley ME; Departments of Medicinal Chemistry., Hartman GD; Departments of Medicinal Chemistry., Hutson PH; Psychiatry Research., O'Brien JA; In Vitro Sciences., Magliaro BC; Psychiatry Research., Uslaner JM; Central Pharmacology., Huszar SL; Central Pharmacology., Fillgrove KL; Drug Metabolism., Small JH; Drug Metabolism., Tang C; Drug Metabolism., Kuo Y; Drug Metabolism., Jacobson MA; Psychiatry Research.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2010 Jul 12; Vol. 1 (8), pp. 406-10. Date of Electronic Publication: 2010 Jul 12 (Print Publication: 2010).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Brnardic EJ; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. edward_brnardic@merck.com, Fraley ME, Garbaccio RM, Layton ME, Sanders JM, Culberson C, Jacobson MA, Magliaro BC, Hutson PH, O'Brien JA, Huszar SL, Uslaner JM, Fillgrove KL, Tang C, Kuo Y, Sur SM, Hartman GD

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 May 15; Vol. 20 (10), pp. 3129-33. Date of Electronic Publication: 2010 Mar 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Oxazolidinones/*chemistry , Receptors, Metabotropic Glutamate/*metabolism , Schizophrenia/*drug therapy, Allosteric Regulation ; Animals ; Antipsychotic Agents ; Ketamine/toxicity ; Oxazolidinones/chemical synthesis ; Oxazolidinones/pharmacology ; Rats ; Receptors, Metabotropic Glutamate/agonists ; Structure-Activity Relationship

المؤلفون: Magliaro BC; Department of Schizophrenia Research, Merck Research Laboratories, Merck & Co, Inc, West Point, PA 19486-0004, USA. brian_magliaro@merck.com, Saldanha CJ

المصدر: Brain research [Brain Res] 2009 Aug 04; Vol. 1283, pp. 14-24. Date of Electronic Publication: 2009 Jun 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE

مواضيع طبية MeSH: Clozapine/*pharmacology , Extracellular Signal-Regulated MAP Kinases/*drug effects , Hydrogen Peroxide/*antagonists & inhibitors , Neurons/*drug effects , Neuroprotective Agents/*pharmacology , Oxidative Stress/*drug effects, Animals ; Antipsychotic Agents/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/physiology ; Clozapine/analogs & derivatives ; Enzyme Activation/drug effects ; Enzyme Activation/physiology ; Enzyme Inhibitors/pharmacology ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Hydrogen Peroxide/toxicity ; Indicators and Reagents ; Neurons/metabolism ; Oxidative Stress/physiology ; PC12 Cells ; Phosphorylation/drug effects ; Rats ; Superoxide Dismutase/antagonists & inhibitors ; Superoxide Dismutase/metabolism ; Superoxide Dismutase-1