المؤلفون: Gan SH; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada.; Department of Ecology, Evolution & Environmental Biology, Columbia University, New York, New York, USA., Sage RF; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada.

المصدر: Plant, cell & environment [Plant Cell Environ] 2024 Sep; Vol. 47 (9), pp. 3466-3477. Date of Electronic Publication: 2024 May 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 9309004 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-3040 (Electronic) Linking ISSN: 01407791 NLM ISO Abbreviation: Plant Cell Environ Subsets: MEDLINE

مواضيع طبية MeSH: Plant Stomata*/physiology , Carbon Dioxide*/metabolism , Photosynthesis*/physiology , Malate Dehydrogenase*/metabolism , Vapor Pressure*, Malate Dehydrogenase (NADP+)/metabolism ; Plant Leaves/physiology ; Plant Leaves/metabolism ; Plant Transpiration/physiology

المؤلفون: Wang R; Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China., Hao J; Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China., Cao C; Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China., Li J; Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China., Zhang X; Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 13; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Phylogeny* , Spirometra*/genetics , Spirometra*/enzymology , Malate Dehydrogenase*/genetics , Malate Dehydrogenase*/metabolism , Malate Dehydrogenase*/chemistry, Animals ; Helminth Proteins/genetics ; Helminth Proteins/chemistry ; Helminth Proteins/metabolism ; Multigene Family ; Amino Acid Sequence

المؤلفون: Gao M; State Key Laboratory for Crop Stress Resistance and High-Efficiency Production/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling 712100, Shaanxi, China., Yang N; State Key Laboratory for Crop Stress Resistance and High-Efficiency Production/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling 712100, Shaanxi, China., Shao Y; State Key Laboratory for Crop Stress Resistance and High-Efficiency Production/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling 712100, Shaanxi, China., Shen T; State Key Laboratory for Crop Stress Resistance and High-Efficiency Production/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling 712100, Shaanxi, China., Li W; State Key Laboratory for Crop Stress Resistance and High-Efficiency Production/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling 712100, Shaanxi, China., Ma B; State Key Laboratory for Crop Stress Resistance and High-Efficiency Production/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling 712100, Shaanxi, China., Wei X; State Key Laboratory for Crop Stress Resistance and High-Efficiency Production/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling 712100, Shaanxi, China., Ruan YL; State Key Laboratory for Crop Stress Resistance and High-Efficiency Production/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling 712100, Shaanxi, China., Ma F; State Key Laboratory for Crop Stress Resistance and High-Efficiency Production/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling 712100, Shaanxi, China., Li M; State Key Laboratory for Crop Stress Resistance and High-Efficiency Production/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling 712100, Shaanxi, China.

المصدر: Plant physiology [Plant Physiol] 2024 Sep 02; Vol. 196 (1), pp. 432-445.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society of Plant Biologists Country of Publication: United States NLM ID: 0401224 Publication Model: Print Cited Medium: Internet ISSN: 1532-2548 (Electronic) Linking ISSN: 00320889 NLM ISO Abbreviation: Plant Physiol Subsets: MEDLINE

مواضيع طبية MeSH: Malus*/genetics , Malus*/metabolism , Malates*/metabolism , Fruit*/genetics , Fruit*/metabolism , Malate Dehydrogenase*/genetics , Malate Dehydrogenase*/metabolism , Promoter Regions, Genetic*/genetics , Gene Expression Regulation, Plant* , Plant Proteins*/genetics , Plant Proteins*/metabolism, Quantitative Trait Loci/genetics ; Mutagenesis, Insertional/genetics ; Plants, Genetically Modified ; Genes, Plant

المؤلفون: Wang H; Department of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, No.44 Xiaoheyan Road, Dadong District, Shenyang, 110042, Liaoning Province, PR China. Electronic address: wanghuan2@cancerhosp-ln-cmu.com., Cui W; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, Liaoning Province, PR China; Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation, Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, 110122, Liaoning Province, PR China. Electronic address: cwl530@163.com., Yue S; Department of Ophthalmology, The First Hospital of China Medical University, Shenyang, Liaoning Province, PR China. Electronic address: yuesong567@163.com., Zhu X; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, Liaoning Province, PR China; Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation, Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, 110122, Liaoning Province, PR China., Li X; Department of Pathology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, No.44 Xiaoheyan Road, Dadong District, Shenyang, 110042, Liaoning Province, PR China., He L; Department of Pathology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, No.44 Xiaoheyan Road, Dadong District, Shenyang, 110042, Liaoning Province, PR China., Zhang M; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, Liaoning Province, PR China; Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation, Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, 110122, Liaoning Province, PR China., Yang Y; Department of Gastroenterology, The Fourth Affiliated Hospital of China Medical University, No.4, Chongshan Road, Huanggu District, Shenyang, Liaoning Province, PR China., Wei M; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, Liaoning Province, PR China; Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation, Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, 110122, Liaoning Province, PR China; Shenyang Kangwei Medical Laboratory Analysis Co. LTD, Shenyang City, Liaoning Province, PR China. Electronic address: wangshuo@cancerhosp-ln-cmu.com., Wu H; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, Liaoning Province, PR China; Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation, Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, 110122, Liaoning Province, PR China. Electronic address: wuhz@cmu.edu.cn., Wang S; Department of Gynecology Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, No.44 Xiaoheyan Road, Dadong District, Shenyang, 110042, Liaoning Province, PR China. Electronic address: mjwei@cmu.edu.cn.

المصدر: Redox biology [Redox Biol] 2024 Sep; Vol. 75, pp. 103273. Date of Electronic Publication: 2024 Jul 19.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/drug therapy , Neoplasms*/metabolism , Neoplasms*/genetics , Malate Dehydrogenase*/metabolism , Malate Dehydrogenase*/antagonists & inhibitors , Malate Dehydrogenase*/genetics , Energy Metabolism*, Humans ; Gene Expression Regulation, Neoplastic/drug effects ; Tumor Microenvironment ; Animals ; Protein Processing, Post-Translational ; Oxidation-Reduction

المؤلفون: Huang Y; Department of Oncological Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.; Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Gynecology, Guangzhou First People's Hospital, Guangzhou, China., Yang Y; Department of Oncological Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Chen X; Department of Oncological Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Zeng S; Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Chen Y; Department of Oncological Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Wang H; Department of Oncological Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Lv X; Department of Oncological Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Hu X; Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Teng L; Department of Oncological Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. lsteng@zju.edu.cn.

المصدر: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2024 Aug 30; Vol. 81 (1), pp. 375. Date of Electronic Publication: 2024 Aug 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE

مواضيع طبية MeSH: Stomach Neoplasms*/pathology , Stomach Neoplasms*/genetics , Stomach Neoplasms*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/genetics , Malate Dehydrogenase*/metabolism , Malate Dehydrogenase*/genetics , Oxidative Stress* , Down-Regulation* , Cell Proliferation*/genetics, Humans ; Animals ; Female ; Male ; Mice ; Middle Aged ; Cell Line, Tumor ; Mice, Nude ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Mice, Inbred BALB C ; Prognosis ; Aged ; Cell Movement/genetics

المؤلفون: Arioka M; Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: arioka@med.uoeh-u.ac.jp., Miura K; Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan., Han R; Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan., Igawa K; Department of Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan. Electronic address: igawa@kumamoto-u.ac.jp., Takahashi-Yanaga F; Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. Electronic address: ftakahashi@med.uoeh-u.ac.jp., Sasaguri T; Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: sasaguri.toshiyuki.922@m.kyushu-u.ac.jp.

المصدر: Life sciences [Life Sci] 2024 Aug 15; Vol. 351, pp. 122807. Date of Electronic Publication: 2024 Jun 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

مواضيع طبية MeSH: AMP-Activated Protein Kinases*/metabolism , Mitochondrial Dynamics*/drug effects , Mitochondrial Dynamics*/physiology , Malate Dehydrogenase*/metabolism , Mitochondria*/metabolism, Humans ; HeLa Cells ; Animals ; Hexanones/pharmacology ; Hexanones/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Enzyme Activation ; Hydrocarbons, Chlorinated

المؤلفون: Kang S; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA., Antoniewicz MR; Chemical Engineering Department, University of Michigan, Ann Arbor, MI, USA., Hay N; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA. nhay@uic.edu.; Research and Development Section, Jesse Brown VA Medical Center, Chicago, IL, USA. nhay@uic.edu.

المصدر: Nature communications [Nat Commun] 2024 Aug 08; Vol. 15 (1), pp. 6777. Date of Electronic Publication: 2024 Aug 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: YAP-Signaling Proteins*/metabolism , Citric Acid Cycle* , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/genetics , Fibroblasts*/metabolism , Malate Dehydrogenase*/metabolism , Malate Dehydrogenase*/genetics , Glycolysis* , Mitochondria*/metabolism , Transcriptome* , Contact Inhibition*, Animals ; Mice ; Malates/metabolism ; Cell Proliferation ; Pyruvic Acid/metabolism ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/genetics ; Phosphoproteins/metabolism ; Phosphoproteins/genetics

المؤلفون: Koch J; Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Broeks MH; Department of Genetics, Section Metabolic Diagnostics, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, the Netherlands., Gautschi M; Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Jans J; Department of Genetics, Section Metabolic Diagnostics, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, the Netherlands., Laemmle A; Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address: alexander.laemmle@insel.ch.

المصدر: Molecular genetics and metabolism [Mol Genet Metab] 2024 Aug; Vol. 142 (4), pp. 108520. Date of Electronic Publication: 2024 Jun 24.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9805456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-7206 (Electronic) Linking ISSN: 10967192 NLM ISO Abbreviation: Mol Genet Metab Subsets: MEDLINE

مواضيع طبية MeSH: Malates*/metabolism , Malate Dehydrogenase*/metabolism , Malate Dehydrogenase*/genetics , Mitochondria*/metabolism , Mitochondria*/genetics , Mitochondria*/pathology , Aspartic Acid*/metabolism, Humans ; Metabolism, Inborn Errors/genetics ; Metabolism, Inborn Errors/pathology ; Metabolism, Inborn Errors/metabolism ; Metabolism, Inborn Errors/diagnosis ; Amino Acid Transport Systems, Acidic/genetics ; Amino Acid Transport Systems, Acidic/deficiency ; Amino Acid Transport Systems, Acidic/metabolism ; Oxidative Phosphorylation ; Antiporters

المؤلفون: Shi J; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116023, Liaoning, China. Electronic address: 18537026803@163.com., Fan Y; College of Light Industry and Food, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, Guangdong, China. Electronic address: 1984631766@qq.com., Jiang X; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116023, Liaoning, China. Electronic address: jiangxinshan0214@163.com., Li X; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116023, Liaoning, China. Electronic address: lixianglong@mail.dlut.edu.cn., Li S; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116023, Liaoning, China. Electronic address: 1449912964@qq.com., Feng Y; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116023, Liaoning, China. Electronic address: afyb@dlut.edu.cn., Xue S; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116023, Liaoning, China. Electronic address: xuesong@dlut.edu.cn.

المصدر: Bioresource technology [Bioresour Technol] 2024 Jul; Vol. 403, pp. 130843. Date of Electronic Publication: 2024 May 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Applied Science Country of Publication: England NLM ID: 9889523 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2976 (Electronic) Linking ISSN: 09608524 NLM ISO Abbreviation: Bioresour Technol Subsets: MEDLINE

مواضيع طبية MeSH: Malates*/metabolism , Carbon Dioxide*/metabolism , Malate Dehydrogenase*/metabolism , Biocatalysis* , Pyruvic Acid*/metabolism, NAD/metabolism ; Decarboxylation ; Kinetics ; Mutation

المؤلفون: Pissas G; Department of Nephrology, Faculty of Medicine, University of Thessaly, Larissa, Greece., Tziastoudi M; Department of Nephrology, Faculty of Medicine, University of Thessaly, Larissa, Greece., Divani M; Department of Nephrology, Faculty of Medicine, University of Thessaly, Larissa, Greece., Poulianiti C; Department of Nephrology, Faculty of Medicine, University of Thessaly, Larissa, Greece., Konsta MAP; Department of Nephrology, Faculty of Medicine, University of Thessaly, Larissa, Greece., Lykotsetas E; Department of Nephrology, Faculty of Medicine, University of Thessaly, Larissa, Greece., Liakopoulos V; Department of Nephrology, Faculty of Medicine, University of Thessaly, Larissa, Greece., Stefanidis I; Department of Nephrology, Faculty of Medicine, University of Thessaly, Larissa, Greece., Eleftheriadis T; Department of Nephrology, Faculty of Medicine, University of Thessaly, Larissa, Greece.

المصدر: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2024 Oct; Vol. 38 (10), pp. e23854.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Reactive Oxygen Species*/metabolism , Epithelial Cells*/metabolism , Epithelial Cells*/pathology , Epithelial Cells*/drug effects , Malate Dehydrogenase*/metabolism, Humans ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/pathology ; Kidney Tubules, Proximal/cytology ; Cell Hypoxia/drug effects ; Mitochondria/metabolism ; Mitochondria/drug effects ; DNA Damage ; Apoptosis/drug effects