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1
المؤلفون: Peter B. McGarvey, Joshua Orvis, Jiahao Huang, Subha Madhavan, Yael Katsir, Malcolm J. Kavarana, Richard C. Peet, Nitzan Lotringer, Iris Nesher, Matthew McCoy, David Meiri, Mingyang Sun
المصدر: Gene. 762
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Sequence assembly, Biology, Genome, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Genetics, medicine, ORFS, Blast2GO, Gene, Intramolecular Transferases, Cannabis, Plant Proteins, Cannabinoids, food and beverages, Molecular Sequence Annotation, General Medicine, Gene Annotation, 030104 developmental biology, 030220 oncology & carcinogenesis, Cannabinoid
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2
المؤلفون: Malcolm L. Gefter, Alexander L. Satz, Matthew C Oliff, Cecil E Rise, Sibongile Mataruse, Fan Li, Cynthia H. Chiu, John W. Cuozzo, Steven R. Skinner, Matthew A. Clark, Gang Yao, Kurt D Franzen, Paul Myers, Heather O’Keefe, Lujia Tang, Christopher S. Kollmann, Christopher P. Davie, Nils Jakob Vest Hansen, Neil R Carlson, Paolo A. Centrella, Michael Kelley, Patricia F Medeiros, Steven P Hale, Richard W. Wagner, Christopher C. Arico-Muendel, Dennis Benjamin, David I. Israel, Kurt van Vloten, G Joseph Franklin, Svetlana L. Belyanskaya, Jennifer L Svendsen, Kenneth E Lind, Raksha A. Acharya, Barry A. Morgan, Baoguang Zhao, Steffen Phillip Creaser, Malcolm J. Kavarana, Jinwei Jiang, Jeffrey A. Messer, Yun Ding
المصدر: Nature Chemical Biology. 5:647-654
مصطلحات موضوعية: Models, Molecular, Materials science, Phage display, Combinatorial Chemistry Techniques, Oligonucleotide, DNA-encoded chemical library, Drug discovery, Aptamer, Small Molecule Libraries, DNA, Cell Biology, Computational biology, Protein Serine-Threonine Kinases, p38 Mitogen-Activated Protein Kinases, Small molecule, Aurora Kinases, Drug Design, Animals, Protein Kinase Inhibitors, Molecular Biology
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3
المؤلفون: Ghotas Evindar, Amy Hutchings, Jeanine Lorusso, Albion D. Wright, Michael Kelley, Sylvie G. Bernier, Keith Halley, Barry A. Morgan, William F. Westlin, Elisabeth Doyle, Nazbeh Taghizadeh, Gerhard Hannig, Alexander L. Satz, Malcolm J. Kavarana, Ashis K. Saha
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:2315-2319
مصطلحات موضوعية: Agonist, medicine.drug_class, Sphingosine-1-phosphate receptor, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Biochemistry, Chemical synthesis, Mice, chemistry.chemical_compound, Sphingosine, In vivo, Drug Discovery, medicine, Animals, Potency, Sphingosine-1-phosphate, Receptor, Molecular Biology, Dose-Response Relationship, Drug, Fingolimod Hydrochloride, Chemistry, Organic Chemistry, Imidazoles, Amides, In vitro, Protein Subunits, Receptors, Lysosphingolipid, Propylene Glycols, Molecular Medicine
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4
المؤلفون: Avinash Kalsi, Malcolm J. Kavarana, Tianfen Lu, Diana S. Hamilton, Donald J. Creighton, Dale L. Whalen
المصدر: Journal of Medicinal Chemistry. 43:3981-3986
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Molecular Conformation, Antineoplastic Agents, Tripeptide, Hydrophobic effect, chemistry.chemical_compound, Lactoylglutathione lyase, Catalytic Domain, Drug Discovery, Enzyme Inhibitors, Alkyl, chemistry.chemical_classification, biology, Aryl, Lactoylglutathione Lyase, Active site, Stereoisomerism, Glutathione, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Carbamates, Protein Binding
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5
المؤلفون: Donald J. Creighton, Bengt Mannervik, B. Olin, Marianne Ridderström, Alexander D. Cameron, Malcolm J. Kavarana
المصدر: Biochemistry. 38:13480-13490
مصطلحات موضوعية: Models, Molecular, Reaction mechanism, Macromolecular Substances, Protein Conformation, Stereochemistry, Glutamine, Glutamic Acid, Crystallography, X-Ray, Ligands, Binding, Competitive, Biochemistry, Catalysis, Triosephosphate isomerase, chemistry.chemical_compound, Lactoylglutathione lyase, Transition state analog, Humans, Molecule, biology, Chemistry, Lactoylglutathione Lyase, Active site, Glutathione, Lyase, Zinc, Crystallography, biology.protein
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6
المؤلفون: Elisabeth Doyle, Sylvie G. Bernier, Jeanine Lorusso, Barry A. Morgan, Gerhard Hannig, Ashis K. Saha, Ghotas Evindar, Malcolm J. Kavarana, William F. Westlin, Heather S. Blanchette, Alexander L. Satz
المصدر: Bioorganicmedicinal chemistry letters. 20(8)
مصطلحات موضوعية: Chemistry, Sphingosine-1-phosphate receptor, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Pharmacology, Biochemistry, Amino Alcohols, Mice, Receptors, Lysosphingolipid, Structure-Activity Relationship, In vivo, Oral administration, Drug Discovery, Molecular Medicine, Moiety, Potency, Animals, Pharmacophore, Selectivity, Receptor, Molecular Biology
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7
المؤلفون: Albion D. Wright, Ashis K. Saha, Jeanine Lorusso, Michael Kelley, Ghotas Evindar, Barry A. Morgan, Elisabeth Doyle, Amy Hutchings, Malcolm J. Kavarana, William F. Westlin, Gerhard Hannig, Sylvie G. Bernier, Keith Halley
المصدر: Bioorganicmedicinal chemistry letters. 19(2)
مصطلحات موضوعية: Stereochemistry, Sphingosine-1-phosphate receptor, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Molecule, Animals, Humans, Sphingosine-1-phosphate, Receptor, Molecular Biology, Dose-Response Relationship, Drug, Chemistry, Organic Chemistry, Imidazoles, Amides, Receptors, Lysosphingolipid, Alkoxy group, Molecular Medicine, Selectivity
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8
المؤلفون: Dorothy L. Sentz, Julie L. Eiseman, Ellyn M. Sharkey, Malcolm J. Kavarana, Haibo Wang, Hugh B. O'Neill, Donald J. Creighton
المصدر: Cancer chemotherapy and pharmacology. 46(2)
مصطلحات موضوعية: Male, Cancer Research, medicine.medical_specialty, Melanoma, Experimental, Mice, Nude, Antineoplastic Agents, Adenocarcinoma, Toxicology, chemistry.chemical_compound, Lactoylglutathione lyase, Mice, Bolus (medicine), Pharmacokinetics, In vivo, Internal medicine, Medicine, Animals, Humans, Pharmacology (medical), Tissue Distribution, Pharmacology, Mice, Knockout, biology, business.industry, Methylglyoxal, Esterases, Lactoylglutathione Lyase, Prostatic Neoplasms, Glutathione, Prodrug, Endocrinology, Oncology, chemistry, Enzyme inhibitor, Area Under Curve, Colonic Neoplasms, Injections, Intravenous, biology.protein, Female, business, Injections, Intraperitoneal, Half-Life
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9
المؤلفون: Malcolm J. Kavarana, Julie L. Eiseman, Ellyn M. Sharkey, Diana S. Hamilton, Donald J. Creighton
المصدر: Journal of medicinal chemistry. 42(10)
مصطلحات موضوعية: Cell Membrane Permeability, Stereochemistry, Placenta, Antineoplastic Agents, Lactoylglutathione lyase, chemistry.chemical_compound, Mice, Blood serum, Drug Stability, Drug Discovery, Tumor Cells, Cultured, Animals, Humans, Prodrugs, Enzyme Inhibitors, Leukemia L1210, Glutathione Transferase, biology, Lactoylglutathione Lyase, Sulfoxide, Glutathione, Prodrug, Kinetics, chemistry, Biochemistry, Enzyme inhibitor, Mice, Inbred DBA, biology.protein, Molecular Medicine, L1210 cells, Drug Screening Assays, Antitumor, Intracellular
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10
المؤلفون: Elena G. Kovaleva, Julie L. Eiseman, Megan B. Wollman, Donald J. Creighton, Malcolm J. Kavarana
المصدر: Journal of medicinal chemistry. 42(2)
مصطلحات موضوعية: Cell Membrane Permeability, Antineoplastic Agents, Binding, Competitive, Lactoylglutathione lyase, chemistry.chemical_compound, Mice, Blood serum, Non-competitive inhibition, Drug Stability, Drug Discovery, Tumor Cells, Cultured, Animals, Humans, Enzyme Inhibitors, Cells, Cultured, biology, Methylglyoxal, Lactoylglutathione Lyase, Glutathione, chemistry, Biochemistry, Cell culture, biology.protein, Molecular Medicine, L1210 cells, Growth inhibition, Cell Division