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المؤلفون: Patrice E. Fort, Mandy K. Losiewicz, Lynda Elghazi, Dejuan Kong, Corentin Cras-Méneur, Diane C. Fingar, Scot R. Kimball, Raju V.S. Rajala, Alexander J. Smith, Robin R. Ali, Steven F. Abcouwer, Thomas W. Gardner
المصدر: The Journal of biological chemistry. 298(6)
مصطلحات موضوعية: Retinal Ganglion Cells, Mice, Animals, Glaucoma, Cell Biology, Mechanistic Target of Rapamycin Complex 1, Molecular Biology, Biochemistry, Retina
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72e56c86d0cfd71cc78e0799efc3085
https://pubmed.ncbi.nlm.nih.gov/35447116 -
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المؤلفون: Patrice Fort, Raju V. S. Rajala, Thomas W. Gardner, Steven F. Abcouwer, Mandy K. Losiewicz, Lynda Elghazi, Stephen I. Lentz, Diane C. Fingar
المصدر: Exp Eye Res
مصطلحات موضوعية: Male, Retinal Ganglion Cells, genetic structures, Immunoblotting, P70-S6 Kinase 1, mTORC1, Mechanistic Target of Rapamycin Complex 2, Mechanistic Target of Rapamycin Complex 1, Retinal ganglion, mTORC2, Article, Rats, Sprague-Dawley, Cellular and Molecular Neuroscience, Mice, Retinal Diseases, medicine, Animals, Humans, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, Retina, biology, Sensory Systems, eye diseases, Cell biology, Rats, Mice, Inbred C57BL, Ophthalmology, Disease Models, Animal, medicine.anatomical_structure, Gene Expression Regulation, Ribosomal protein s6, biology.protein, RNA, sense organs, Signal Transduction
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3دورية أكاديمية
المؤلفون: Patrice E Fort, Mandy K Losiewicz, Chad E N Reiter, Ravi S J Singh, Makoto Nakamura, Steven F Abcouwer, Alistair J Barber, Thomas W Gardner
المصدر: PLoS ONE, Vol 6, Iss 10, p e26498 (2011)
وصف الملف: electronic resource
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المؤلفون: Patrice Fort, Thomas W. Gardner, Ravi S.J. Singh, Hisanori Imai, Sergey N. Zolov, Mandy K. Losiewicz
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, insulin, retina, medicine.medical_specialty, medicine.medical_treatment, IGF-1, Insulin-like growth factor-1, IR, Insulin receptor, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Insulin-Like Growth Factor II, Internal medicine, Diabetes mellitus, medicine, Animals, Phosphorylation, insulin receptor, Kinase activity, Molecular Biology, PY, phosphorylation, Insulin-like growth factor 1 receptor, IGF-2, Insulin-like growth factor-2, Retina, IGFBP, Insulin-like growth factor binding protein, diabetes, 030102 biochemistry & molecular biology, biology, Insulin, IGF1R, Insulin-like growth factor-1 receptor, HRP, horseradish peroxidase, Retinal, Cell Biology, medicine.disease, Receptor, Insulin, insulin-like growth factor-2, Rats, Insulin receptor, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Insulin-like growth factor 2, biology.protein, Proto-Oncogene Proteins c-akt, Signal Transduction, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e18ff3674ad867c227822fb391102c
https://doi.org/10.1016/j.jbc.2021.100712 -
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المؤلفون: Leonard S. Jefferson, Subramaniam Pennathur, Patrice Fort, Scot R. Kimball, Mandy K. Losiewicz, Steven F. Abcouwer, Thomas W. Gardner
المصدر: Diabetes
مصطلحات موضوعية: Blood Glucose, Male, Complications, Endocrinology, Diabetes and Metabolism, mTORC1, mTORC2, Mice, chemistry.chemical_compound, 0302 clinical medicine, beta-Crystallin B Chain, Insulin, 0303 health sciences, TOR Serine-Threonine Kinases, Intracellular Signaling Peptides and Proteins, medicine.anatomical_structure, medicine.medical_specialty, P70-S6 Kinase 1, Mechanistic Target of Rapamycin Complex 2, Biology, Protein degradation, alpha-Crystallin A Chain, Retina, Diabetes Mellitus, Experimental, 03 medical and health sciences, Internal medicine, Internal Medicine, medicine, Animals, Eye Proteins, Protein kinase B, 030304 developmental biology, Protein turnover, Skeletal muscle, Retinal, Regulatory-Associated Protein of mTOR, Phosphoproteins, Receptor, Insulin, Rats, Diabetes Mellitus, Type 1, Phlorhizin, Rapamycin-Insensitive Companion of mTOR Protein, Endocrinology, chemistry, RNA, Ribosomal, Hyperglycemia, Multiprotein Complexes, Protein Biosynthesis, 030221 ophthalmology & optometry, Carrier Proteins, Proto-Oncogene Proteins c-akt
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c73480949dbdeea316d905389b22b3c
https://doi.org/10.2337/db14-0235 -
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المصدر: Molecular & Cellular Proteomics. 8:767-779
مصطلحات موضوعية: medicine.medical_specialty, Insulin, medicine.medical_treatment, Retinal, Diabetic retinopathy, Biology, medicine.disease, Proteomics, Bioinformatics, Biochemistry, eye diseases, Analytical Chemistry, chemistry.chemical_compound, Endocrinology, chemistry, Downregulation and upregulation, Crystallin, Diabetes mellitus, Internal medicine, medicine, sense organs, Molecular Biology, Protein kinase B
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0761324aefa140bda6dcb8c4c9dee31c
https://doi.org/10.1074/mcp.m800326-mcp200 -
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المؤلفون: Patrice Fort, Mandy K. Losiewicz, Thomas W. Gardner, Steve F. Abcouwer
مصطلحات موضوعية: Male, Physiology, Endocrinology, Diabetes and Metabolism, Eukaryotic Initiation Factor-2, Biology, AMP-Activated Protein Kinases, Mechanistic Target of Rapamycin Complex 1, Retina, Dephosphorylation, chemistry.chemical_compound, Peptide Elongation Factor 2, Physiology (medical), Protein Phosphatase 1, Animals, Lactic Acid, Protein Phosphatase 2, Phosphorylation, Protein kinase B, Ribosomal Protein S6, TOR Serine-Threonine Kinases, Intracellular Signaling Peptides and Proteins, Protein phosphatase 1, Okadaic acid, Protein phosphatase 2, Articles, Phosphoproteins, Cell biology, Rats, Biochemistry, chemistry, Anaerobic glycolysis, Ribosomal protein s6, Multiprotein Complexes, Protein Biosynthesis, Carrier Proteins, Glycolysis, Proto-Oncogene Proteins c-akt, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3162fd12eb530479a271fee0c6da97ea
https://europepmc.org/articles/PMC4572451/ -
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المؤلفون: Cuong Q. Diep, T. Eric Blank, Vepkhia Pilauri, James E. Hopper, Mandy K. Losiewicz, Xiaorong Tao
مصطلحات موضوعية: Saccharomyces cerevisiae Proteins, DNA Repair, Genotype, Transcription, Genetic, DNA repair, Saccharomyces cerevisiae, Mutation, Missense, Repressor, Biology, Investigations, Polymerase Chain Reaction, Transcription (biology), Genetics, Binding site, DNA, Fungal, Gene, Transcription factor, DNA Primers, Binding Sites, Galactose, biology.organism_classification, Repressor Proteins, Amino Acid Substitution, Mutation, Trans-Activators, Sequence motif, Cell Division, Genes, Switch, Transcription Factors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ac98af2df208086e3b5d00fa7d6b65
https://europepmc.org/articles/PMC2248352/ -
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المؤلفون: Mandy K. Losiewicz, Christopher C. Norbury, Keri B. Donohue, Wei Jin, Minying Zhang, William Reiley, Shao Cong Sun
المصدر: Nature immunology. 7(4)
مصطلحات موضوعية: Male, T cell, T-Lymphocytes, Immunology, Regulator, Receptors, Antigen, T-Cell, Biology, Deubiquitinating Enzyme CYLD, Mice, medicine, Immunology and Allergy, Cytotoxic T cell, Animals, Crosses, Genetic, Mice, Knockout, ZAP-70 Protein-Tyrosine Kinase, Ubiquitin, ZAP70, Tumor Suppressor Proteins, CD28, T lymphocyte, Immunity, Innate, Cell biology, Specific Pathogen-Free Organisms, Mice, Inbred C57BL, medicine.anatomical_structure, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Mice, Inbred DBA, Cancer research, CD8, Signal Transduction
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المؤلفون: Mandy K. Losiewicz, Patrice Fort
المصدر: Investigative Opthalmology & Visual Science. 52:5034
مصطلحات موضوعية: Down-Regulation, Apoptosis, Neuroprotection, Retina, Diabetes Mellitus, Experimental, Mice, chemistry.chemical_compound, Downregulation and upregulation, Crystallin, Diabetes mellitus, medicine, Animals, alpha-Crystallins, gamma-Crystallins, Cells, Cultured, bcl-2-Associated X Protein, Diabetic Retinopathy, biology, Chemistry, Retinal, Diabetic retinopathy, medicine.disease, beta-Crystallins, Mice, Mutant Strains, eye diseases, Up-Regulation, Cell biology, Mice, Inbred C57BL, Disease Models, Animal, Diabetes Mellitus, Type 1, medicine.anatomical_structure, Chaperone (protein), biology.protein, sense organs, Photoreceptor Cells, Vertebrate
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994f4042f0ff2ca1a65bb412fc320f6e
https://doi.org/10.1167/iovs.10-6931