المؤلفون: Moure CJ; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey., Vara B; Department of Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey., Cheng MM; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey., Sondey C; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey., Muise E; Department of Data and Genome Sciences, Merck & Co., Inc., Rahway, New Jersey., Park E; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey., Vela Ramirez JE; Department of Discovery Pharmaceutical Sciences, Merck & Co., Inc., Rahway, New Jersey., Su D; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey., D'Souza S; Department of Discovery Oncology, Merck & Co., Inc., Rahway, New Jersey., Yan Q; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey., Yeung CS; Department of Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey., Zhang M; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey., Mansueto MS; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey., Linn D; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey., Buchanan M; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey., Foti R; Department of PPDM, Merck & Co., Inc., Rahway, New Jersey., DiMauro E; Department of Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey., Long B; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey., Simov V; Department of Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey., Barry ER; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2024 Aug 01; Vol. 23 (8), pp. 1095-1108.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Hepatocyte Growth Factor*/metabolism , Transcription Factors*/metabolism , Transcription Factors*/antagonists & inhibitors , Proto-Oncogene Proteins c-met*/antagonists & inhibitors , Proto-Oncogene Proteins c-met*/metabolism , Signal Transduction*/drug effects , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/antagonists & inhibitors , YAP-Signaling Proteins* , Drug Resistance, Neoplasm*/drug effects, Humans ; Animals ; Mice ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Small Molecule Libraries/pharmacology ; TEA Domain Transcription Factors ; Cell Proliferation/drug effects

المؤلفون: Wen X; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Liu C; SCIEX, Concord, Ontario L4K 4V8, Canada., Tovar K; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Curran P; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Richards M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Agrawal S; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Johnstone R; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Loy RE; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Methot JL; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Mansueto MS; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Koglin M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wildey MJ; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Burton L; SCIEX, Concord, Ontario L4K 4V8, Canada., Covey TR; SCIEX, Concord, Ontario L4K 4V8, Canada., Bateman KP; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Kavana M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., McLaren DG; Merck & Co., Inc., Rahway, New Jersey 07065, United States.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2024 Jul 24; Vol. 146 (29), pp. 19792-19799. Date of Electronic Publication: 2024 Jul 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Mass Spectrometry*/methods , High-Throughput Screening Assays*/methods, Small Molecule Libraries/chemistry ; Humans ; Acoustics ; Drug Discovery/methods ; Ligands

المؤلفون: Makarov AA; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA. Electronic address: alexey.makarov@merck.com., Jiang Y; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Sondey C; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Zhang M; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Mansueto MS; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Pirrone GF; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Huang C; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Biswas K; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Duggal R; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Al-Sayah MA; Merck & Co. Inc., MRL, 213 E. Grand Avenue, So. San Francisco, CA, 94080, USA., Regalado EL; Merck & Co. Inc., MRL, 126 E. Lincoln Avenue, Rahway, NJ, 07065, USA., Mangion I; Merck & Co. Inc., MRL, 126 E. Lincoln Avenue, Rahway, NJ, 07065, USA.

المصدر: Analytica chimica acta [Anal Chim Acta] 2022 Sep 08; Vol. 1225, pp. 340234. Date of Electronic Publication: 2022 Aug 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE

مواضيع طبية MeSH: Deuterium Exchange Measurement*/methods , Hydrogen Deuterium Exchange-Mass Spectrometry*, Cell Membrane Permeability ; Deuterium/chemistry ; Hydrogen/chemistry ; Peptides ; Permeability ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods

المؤلفون: Kawamura S; Discovery Chemistry, Merck & Co., Inc., Boston, MA 02115, United States. Electronic address: shuhei.kawamura@merck.com., Palte RL; Computational and Structural Chemistry, Merck & Co., Inc., Boston, MA 02115, United States., Kim HY; NMR Structure Elucidation, Process and Analytical Chemistry, Merck & Co., Inc., Boston, MA 02115, United States., Saurí J; NMR Structure Elucidation, Process and Analytical Chemistry, Merck & Co., Inc., Boston, MA 02115, United States., Sondey C; Quantitative Biosciences, Merck & Co., Inc., Boston, MA 02115, United States., Mansueto MS; Quantitative Biosciences, Merck & Co., Inc., Boston, MA 02115, United States., Altman MD; Computational and Structural Chemistry, Merck & Co., Inc., Boston, MA 02115, United States., Machacek MR; Discovery Chemistry, Merck & Co., Inc., Boston, MA 02115, United States.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Jul 15; Vol. 66, pp. 116820. Date of Electronic Publication: 2022 May 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Adaptor Proteins, Signal Transducing*/metabolism , Protein-Arginine N-Methyltransferases*/chemistry

المؤلفون: Simov V; Merck & Co., Inc., Chemistry, 33 Avenue Louis Pasteur, Boston, MA 02127, USA. Electronic address: vladimir_simov@merck.com., Altman MD; Merck & Co., Inc., Chemistry, 33 Avenue Louis Pasteur, Boston, MA 02127, USA., Bianchi E; Peptides and Small Molecules R&D, IRBM, Via Pontina, 30,600, 00071 Pomezia RM, Italy., DelRizzo S; Peptides and Small Molecules R&D, IRBM, Via Pontina, 30,600, 00071 Pomezia RM, Italy., DiNunzio EN; Merck & Co., Inc., Chemistry, 2000 Galloping Hill Road, K-15, Kenilworth, NJ 07033, USA., Feng G; Merck & Co., Inc., Quantitative Biosciences, 33 Avenue Louis Pasteur, Boston, MA 02127, USA., Goldenblatt P; Merck & Co., Inc., Quantitative Biosciences, 33 Avenue Louis Pasteur, Boston, MA 02127, USA., Ingenito R; Peptides and Small Molecules R&D, IRBM, Via Pontina, 30,600, 00071 Pomezia RM, Italy., Johnson SA; Merck & Co., Inc., Chemistry, 33 Avenue Louis Pasteur, Boston, MA 02127, USA., Mansueto MS; Merck & Co., Inc., Quantitative Biosciences, 33 Avenue Louis Pasteur, Boston, MA 02127, USA., Mayhood T; Merck & Co., Inc., Chemistry, 2000 Galloping Hill Road, K-15, Kenilworth, NJ 07033, USA., Mortison JD; Merck & Co., Inc., Chemistry, 33 Avenue Louis Pasteur, Boston, MA 02127, USA., Serebrov V; Merck & Co., Inc., Quantitative Biosciences, 33 Avenue Louis Pasteur, Boston, MA 02127, USA., Sondey C; Merck & Co., Inc., Quantitative Biosciences, 33 Avenue Louis Pasteur, Boston, MA 02127, USA., Sriraman V; Merck & Co., Inc., Quantitative Biosciences, 33 Avenue Louis Pasteur, Boston, MA 02127, USA., Tucker TJ; Merck & Co., Inc., Chemistry, 770 Sumneytown Pike, West Point, PA 19486, USA., Walji A; Merck & Co., Inc., Chemistry, 770 Sumneytown Pike, West Point, PA 19486, USA., Wan H; Merck & Co., Inc., PPDM, 126 East Lincoln Avenue, Rahway, NJ 07065, USA., Yue Y; Merck & Co., Inc., Biology, 33 Avenue Louis Pasteur, Boston, MA 02127, USA., Stoeck A; Merck & Co., Inc., Biology, 33 Avenue Louis Pasteur, Boston, MA 02127, USA., DiMauro EF; Merck & Co., Inc., Chemistry, 33 Avenue Louis Pasteur, Boston, MA 02127, USA.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 15; Vol. 224, pp. 113686. Date of Electronic Publication: 2021 Jul 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: DNA/*chemistry , MafG Transcription Factor/*antagonists & inhibitors , NF-E2-Related Factor 2/*antagonists & inhibitors , Peptides/*chemistry, Antioxidant Response Elements/drug effects ; DNA/metabolism ; Drug Design ; Drug Stability ; Electrophoretic Mobility Shift Assay ; Half-Life ; HeLa Cells ; Humans ; MafG Transcription Factor/metabolism ; NF-E2-Related Factor 2/metabolism ; Neoplasms/drug therapy ; Neoplasms/pathology ; Peptides/metabolism ; Peptides/pharmacology ; Peptides/therapeutic use ; Structure-Activity Relationship

المؤلفون: Quiroz RV; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Reutershan MH; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Schneider SE; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Sloman D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Lacey BM; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Swalm BM; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Yeung CS; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Gibeau C; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Spellman DS; Merck & Co., Inc., 770 Sumneytown Pike, Lansdale, Pennsylvania 19446, United States., Rankic DA; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Chen D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Witter D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Linn D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Munsell E; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Feng G; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Xu H; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Hughes JME; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States., Lim J; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Saurí J; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Geddes K; Merck & Co., Inc., 770 Sumneytown Pike, Lansdale, Pennsylvania 19446, United States., Wan M; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Mansueto MS; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Follmer NE; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Fier PS; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States., Siliphaivanh P; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Daublain P; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Palte RL; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Hayes RP; Merck & Co., Inc., 770 Sumneytown Pike, Lansdale, Pennsylvania 19446, United States., Lee S; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States., Kawamura S; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Silverman S; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States., Sanyal S; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Henderson TJ; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Ye Y; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Gao Y; Merck & Co., Inc., 770 Sumneytown Pike, Lansdale, Pennsylvania 19446, United States., Nicholson B; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Machacek MR; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 3911-3939. Date of Electronic Publication: 2021 Mar 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Aminoquinolines/*therapeutic use , Antineoplastic Agents/*therapeutic use , Enzyme Inhibitors/*therapeutic use , Neoplasms/*drug therapy , Nucleosides/*therapeutic use , Protein-Arginine N-Methyltransferases/*antagonists & inhibitors, Aminoquinolines/chemical synthesis ; Aminoquinolines/metabolism ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Cell Proliferation/drug effects ; Drug Design ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/metabolism ; Female ; Humans ; Mice, SCID ; Molecular Docking Simulation ; Molecular Structure ; Nucleosides/chemical synthesis ; Nucleosides/metabolism ; Protein Binding ; Protein-Arginine N-Methyltransferases/metabolism ; Structure-Activity Relationship ; Mice

المؤلفون: Palte RL; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Schneider SE; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Altman MD; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Hayes RP; Computational and Structural Chemistry, West Point, Pennsylvania 19486, United States., Kawamura S; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Lacey BM; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Mansueto MS; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Reutershan M; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Siliphaivanh P; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Sondey C; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Xu H; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Xu Z; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Ye Y; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Machacek MR; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Aug 07; Vol. 11 (9), pp. 1688-1693. Date of Electronic Publication: 2020 Aug 07 (Print Publication: 2020).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Xu H; Department of Pharmacology, Merck & Co., Inc., Boston, MA, USA., Muise ES; Department of Genetics and Pharmacogenomics, Merck & Co., Inc., Boston, MA, USA., Javaid S; Department of Genetics and Pharmacogenomics, Merck & Co., Inc., Boston, MA, USA., Chen L; Department of Strategic Planning & Research Informatics, Merck & Co., Inc., Beijing, China., Cristescu R; Department of Precision Oncology Biomarkers, Merck & Co., Inc., Boston, MA, USA., Mansueto MS; Department of Pharmacology, Merck & Co., Inc., Boston, MA, USA., Follmer N; Department of Oncology Early Discovery, Merck & Co., Inc., Boston, MA, USA., Cho J; Department of Genetics and Pharmacogenomics, Merck & Co., Inc., Boston, MA, USA., Kerr K; Department of Genetics and Pharmacogenomics, Merck & Co., Inc., Boston, MA, USA., Altura R; Department of Oncology Early Development, Merck & Co., Inc., Rahway, NJ, USA., Machacek M; Department of Discovery Chemistry, Merck & Co., Inc., Boston, MA, USA., Nicholson B; Department of Oncology Early Discovery, Merck & Co., Inc., Boston, MA, USA., Addona G; Department of Pharmacology, Merck & Co., Inc., Boston, MA, USA., Kariv I; Department of Pharmacology, Merck & Co., Inc., Boston, MA, USA., Chen H; Department of Pharmacology, Merck & Co., Inc., Boston, MA, USA.

المصدر: Journal of cellular and molecular medicine [J Cell Mol Med] 2019 Oct; Vol. 23 (10), pp. 7063-7077. Date of Electronic Publication: 2019 Aug 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE

مواضيع طبية MeSH: Models, Biological*, Cytarabine/*therapeutic use , Leukemia, Myeloid, Acute/*drug therapy , Leukemia, Myeloid, Acute/*genetics, Adult ; Aged ; Aged, 80 and over ; Bone Marrow Cells/metabolism ; Cell Line, Tumor ; Cytarabine/pharmacology ; Female ; Gene Expression Regulation, Leukemic/drug effects ; Humans ; Inhibitory Concentration 50 ; Male ; Middle Aged ; Mutation/genetics ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Treatment Outcome

المؤلفون: Mansueto MS; From the Departments of Pharmacology and., Reens A; From the Departments of Pharmacology and., Rakhilina L; From the Departments of Pharmacology and., Chi A; Chemical Biology, Merck & Co., Inc., Boston, Massachusetts 02115., Pan BS; From the Departments of Pharmacology and., Miller JR; From the Departments of Pharmacology and james.miller2@merck.com.

المصدر: The Journal of biological chemistry [J Biol Chem] 2019 May 10; Vol. 294 (19), pp. 7658-7668. Date of Electronic Publication: 2019 Mar 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Models, Chemical*, Syk Kinase/*chemistry, Amino Acid Motifs ; Enzyme Activation ; Humans ; Phosphorylation ; Proto-Oncogene Mas ; Syk Kinase/metabolism ; src Homology Domains ; src-Family Kinases/chemistry ; src-Family Kinases/metabolism

المؤلفون: Chen H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , 250 Longwood Avenue, Boston, Massachusetts 02115, United States., Coseno M; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , 250 Longwood Avenue, Boston, Massachusetts 02115, United States., Ficarro SB; Department of Cancer Biology and Blais Proteomics Center, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, Massachusetts 02215, United States., Mansueto MS; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , 250 Longwood Avenue, Boston, Massachusetts 02115, United States., Komazin-Meredith G; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , 250 Longwood Avenue, Boston, Massachusetts 02115, United States., Boissel S; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , 250 Longwood Avenue, Boston, Massachusetts 02115, United States., Filman DJ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , 250 Longwood Avenue, Boston, Massachusetts 02115, United States., Marto JA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , 250 Longwood Avenue, Boston, Massachusetts 02115, United States.; Department of Cancer Biology and Blais Proteomics Center, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, Massachusetts 02215, United States., Hogle JM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , 250 Longwood Avenue, Boston, Massachusetts 02115, United States., Coen DM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , 250 Longwood Avenue, Boston, Massachusetts 02115, United States.

المصدر: ACS infectious diseases [ACS Infect Dis] 2017 Feb 10; Vol. 3 (2), pp. 112-118. Date of Electronic Publication: 2016 Dec 06.

نوع المنشور: Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents/*pharmacology , Cytomegalovirus/*enzymology , DNA-Binding Proteins/*metabolism , DNA-Directed DNA Polymerase/*metabolism , Small Molecule Libraries/*pharmacology , Viral Proteins/*metabolism, Allosteric Regulation ; Allosteric Site ; Antiviral Agents/chemistry ; Crystallography, X-Ray ; DNA-Binding Proteins/chemistry ; DNA-Directed DNA Polymerase/chemistry ; High-Throughput Screening Assays ; Humans ; Lysine/metabolism ; Models, Molecular ; Protein Binding/drug effects ; Protein Conformation ; Small Molecule Libraries/chemistry ; Viral Proteins/chemistry