المؤلفون: Álvaro Otero-Sobrino, Johanne Le Coq, Pedro Aguilar-Garrido, Miguel Ángel Navarro Aguadero, María Hernández-Sánchez, María Isabel Albarrán, Javier Klett, Carmen Blanco, Rafael Fernández Leiro, Joaquín Martinez-Lopez, Maria Velasco Estevez, Miguel Gallardo

المصدر: HemaSphere, Vol 7, p e16620e5 (2023)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000970288.16620.e5; https://doaj.org/toc/2572-9241

URL الوصول: https://doaj.org/article/073b8e3fa8494bd0b0680734b0c1962f

المؤلفون: Timothy P. Cash, Sonia Alcalá, María del Rosario Rico-Ferreira, Elena Hernández-Encinas, Jennifer García, María Isabel Albarrán, Sandra Valle, Javier Muñoz, Sonia Martínez-González, Carmen Blanco-Aparicio, Joaquín Pastor, Manuel Serrano, Bruno Sainz

المصدر: Cancers, Vol 12, Iss 7, p 1790 (2020)

مصطلحات موضوعية: compound library, cancer stem cells, pancreatic ductal adenocarcinoma, lysosomal membrane permeabilization, patient-derived xenografts, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2072-6694/12/7/1790; https://doaj.org/toc/2072-6694

URL الوصول: https://doaj.org/article/2d0bdf7ec8ee4e87ac2f8f73c80218bf

المؤلفون: Maria Mitsi, Estela Vega, Yolanda Duran, Rafael Álvarez, Elena Garralda, María Isabel Albarrán, Sofia Perea, Antonio Cubillo, Manuel Hidalgo, Marta Camacho-Artacho, T. Sánchez-Pérez, Orlando Domínguez, Carmen Blanco-Aparicio, Álvaro Otero, Natalia Baños, Jorge Monsech, Alba de Martino, Jorge L. Martínez-Torrecuadrada, Tirso Pons, Francesca Sarno, Rodrigo A. Toledo, Victoria Bonilla, Daniel Lietha

المصدر: Clinical Cancer Research. 24:3550-3559

مصطلحات موضوعية: Vascular Endothelial Growth Factor A, 0301 basic medicine, Cancer Research, Class I Phosphatidylinositol 3-Kinases, Protein Conformation, Somatic cell, Colorectal cancer, Angiogenesis Inhibitors, Biology, medicine.disease_cause, Germline, Mice, 03 medical and health sciences, 0302 clinical medicine, Germline mutation, Cell Line, Tumor, Exome Sequencing, Biomarkers, Tumor, medicine, Animals, Humans, Anaplastic Lymphoma Kinase, Exome, Proto-Oncogene Proteins c-abl, Exome sequencing, Cell Proliferation, Mutation, Neovascularization, Pathologic, Kinase, Cancer, medicine.disease, Vascular Endothelial Growth Factor Receptor-2, ErbB Receptors, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, Heterografts, Female, Colorectal Neoplasms, Cell-Free Nucleic Acids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b581f7dbb5e9512c1c15212517406ff9
https://doi.org/10.1158/1078-0432.ccr-18-0103

المؤلفون: David Cebrián, Antonio Rodríguez, Ana Isabel Hernández, Jennifer García-Arocha, Francisco Ramos-Lima, María Isabel Albarrán, Rosa María Alvarez, James R. Bischoff, Antonio Cebriá, Carmen Blanco-Aparicio, Joaquín Pastor, Sonia Martínez González, Elena Hernández-Encinas

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:4794-4799

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Chemistry, Pharmaceutical, Chemical structure, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Scaffold hopping, Biochemistry, Inhibitory Concentration 50, Mice, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Animals, Protein Isoforms, Phosphorylation, Protein Kinase Inhibitors, Molecular Biology, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, Chemistry, TOR Serine-Threonine Kinases, Organic Chemistry, Imidazoles, Combinatorial chemistry, In vitro, 030104 developmental biology, Pyrazines, Molecular Medicine, Proto-Oncogene Proteins c-akt, Lead compound, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44321058fa3297031674b7a62a97be3c
https://doi.org/10.1016/j.bmcl.2017.09.059

المؤلفون: James R. Bischoff, Carmen Varela, Sonia Martínez-González, Julen Oyarzabal, Beatriz García-Serelde, Ana Isabel Hernández, Javier Klett, Ana Belén García, Manuel Cuadrado-Urbano, Joaquín Pastor, María Isabel Albarrán, Carmen Blanco-Aparicio, Obdulia Rabal, Antonio Cebriá, Sonsoles Rodriguez-Aristegui, Cristina Ana Gomez De La Oliva, David Cebrián, Elena Gómez-Casero, Nuria Ajenjo, Esther González Cantalapiedra

المصدر: European journal of medicinal chemistry. 168

مصطلحات موضوعية: Drug, Protein family, media_common.quotation_subject, Cell, hERG, Antineoplastic Agents, 01 natural sciences, Pyridazine, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, Cell Line, Tumor, Drug Discovery, medicine, Humans, Protein Kinase Inhibitors, 030304 developmental biology, media_common, Cell Proliferation, Pharmacology, 0303 health sciences, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Quinoline, General Medicine, Triazoles, Small molecule, Combinatorial chemistry, 0104 chemical sciences, Pyridazines, medicine.anatomical_structure, chemistry, biology.protein, Quinolines, Phosphorylation, Drug Screening Assays, Antitumor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7808abcde1b56bf005eed1f90086c4e5
https://pubmed.ncbi.nlm.nih.gov/30802730

المؤلفون: Joaquín Pastor, Sandra Valle, Sonia Martínez-González, Manuel Serrano, Javier Muñoz, María Isabel Albarrán, Jennifer García, Carmen Blanco-Aparicio, Bruno Sainz, María del Rosario Rico-Ferreira, Timothy P. Cash, Sonia Alcalá, Elena Hernández-Encinas

المساهمون: Fero Foundation, Fundacion Asociacion Espanola Contra el Cancer (AECC), European Regional Development Fund, CNIO, European Union (EU), European Research Council (ERC), Secretaria d'Universitats i Recerca del Departament d'Empresa i Coneixement of Catalonia (Grup de Recerca consolidat), UAM. Departamento de Bioquímica, Instituto de Investigaciones Biomédicas 'Alberto Sols' (IIBM), Ministerio de Economía y Competitividad (España), Fundación Fero, Fundación Científica Asociación Española Contra el Cáncer, European Commission, Centro de Investigación Biomédica en Red Cáncer (España), Fundación 'la Caixa', European Research Council, Generalitat de Catalunya, European Regional Development Fund (ERDF/FEDER)

المصدر: Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Dipòsit Digital de la UB
Universidad de Barcelona
Cancers
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Digital.CSIC. Repositorio Institucional del CSIC
Repisalud
Instituto de Salud Carlos III (ISCIII)
Cancers, Vol 12, Iss 1790, p 1790 (2020)
Volume 12
Issue 7

مصطلحات موضوعية: cancer stem cells, DISRUPTION, 0301 basic medicine, Cancer Research, endocrine system diseases, Stem cells, medicine.disease_cause, Metastasis, Pancreatic ductal adenocarcinoma, PATHWAY, 0302 clinical medicine, lysosomal membrane permeabilization, Pancreas cancer, education.field_of_study, Cancer stem cells, Chemistry, DEATH, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, Patient-derived xenografts, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, SURVIVAL, patient-derived xenografts, Stem cell, Cèl·lules mare, medicine.drug, Medicina, Population, compound library, pancreatic ductal adenocarcinoma, METABOLISM, lcsh:RC254-282, Article, SIRAMESINE, 03 medical and health sciences, Cancer stem cell, Pancreatic cancer, Lysosome, medicine, education, Càncer de pàncrees, Lysosomal membrane permeabilization, Compound library, Siramesine, medicine.disease, 030104 developmental biology, Cancer research, INHIBITORS, Carcinogenesis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d421fdee33c90cee459616d0b83414
https://doi.org/10.3390/cancers12071790

المؤلفون: Joaquín Pastor, Carmen Varela, David Cebrián, Rosa María Alvarez, Patricia Alfonso, Antonio Cebriá, María Isabel Albarrán, Sonsoles Rodriguez-Aristegui, Esther González Cantalapiedra, James R. Bischoff, Antonio Rodríguez Hergueta, Sonia Martínez González, Ana Isabel Hernández, Elena Cendón

المصدر: Bioorganicmedicinal chemistry letters. 27(11)

مصطلحات موضوعية: 0301 basic medicine, Pyrazine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Protein Isoforms, Molecular Biology, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, chemistry.chemical_classification, Chemistry, Organic Chemistry, Imidazoles, Combinatorial chemistry, Cancer treatment, 030104 developmental biology, Pyrazines, Microsomes, Liver, Molecular Medicine, Tricyclic, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7835af028ce0ed6db63bf87366ca9b3a
https://pubmed.ncbi.nlm.nih.gov/28404374

المؤلفون: María Isabel Albarrán, Obdulia Rabal, Jesús Fominaya, Joaquín Pastor, Isabel Reymundo, Natasha Zarich, Irene Palacios, Julen Oyarzabal, Genoveva Mateos, James R. Bischoff, Manuel Urbano-Cuadrado, Antonio Salgado, Ana Corrionero

المصدر: Journal of Medicinal Chemistry. 53:6618-6628

مصطلحات موضوعية: Models, Molecular, Databases, Factual, Protein Conformation, Quantitative Structure-Activity Relationship, Antineoplastic Agents, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Serine, Cell Line, Tumor, Drug Discovery, Humans, IC50, Cell Proliferation, Virtual screening, Ligand efficiency, biology, Kinase, Chemistry, EIF4E, Intracellular Signaling Peptides and Proteins, Biochemistry, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Phosphorylation, Drug Screening Assays, Antitumor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3790ae859fa008087b354e462db63357
https://doi.org/10.1021/jm1005513

المؤلفون: Guido Kurz, James R. Bischoff, Miguel Angel Ortega, Joaquín Pastor, Julen Oyarzabal, Carmen Blanco, María Isabel Albarrán, Antonio Salgado, Paolo Pevarello, Obdulia Rabal, Rosa María Alvarez, Gustavo Saluste

المصدر: PLoS ONE
PLoS ONE, Vol 7, Iss 10, p e45964 (2012)

مصطلحات موضوعية: Models, Molecular, Drugs and Devices, Drug Research and Development, Databases, Pharmaceutical, In silico, Cancer Treatment, lcsh:Medicine, Computational biology, Pharmacology, Biochemistry, Proto-Oncogene Mas, chemistry.chemical_compound, Inhibitory Concentration 50, Fragment (logic), Proto-Oncogene Proteins c-pim-1, Drug Discovery, Chemogenomics, Molecule, Humans, Pharmacokinetics, lcsh:Science, Biology, Protein Kinase Inhibitors, ADME, Virtual screening, Multidisciplinary, Oncogene, Molecular Structure, Drug discovery, lcsh:R, Chemistry, chemistry, Oncology, Microsomes, Liver, Medicine, lcsh:Q, Medicinal Chemistry, Research Article, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695da6466de38b333cf5b8c938ba0c24
http://europepmc.org/articles/PMC3480357

المؤلفون: Joaquín Pastor, Antonio Cebriá, Oliver Renner, Borja Barrera, Carmen Blanco Aparicio, Manuel Urbano, Rosario Concepcion Riesco, María Isabel Albarrán, Sonia Martínez González, Cristina Ana Gomez De La Oliva, Ana Isabel Hernández, Elena Gómez-Casero, Virginia Elena Rivero, Maria del Carmen Rodriguez de Miguel, Enara Aguirre

المصدر: Cancer Research. 76:4337-4337

مصطلحات موضوعية: Cancer Research, biology, Kinase, RNA polymerase II, medicine.disease_cause, Oncology, Biochemistry, biology.protein, Cancer research, medicine, Cyclin-dependent kinase 8, Cyclin-dependent kinase 9, STAT1, Cyclin-dependent kinase 7, Carcinogenesis, Transcription factor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ea96105653180d0ad7daf6fe2745f046
https://doi.org/10.1158/1538-7445.am2016-4337