نتائج البحث - "Marc Grenley"

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دورية أكاديمية

Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironment

المصدر: Frontiers in Pharmacology, Vol 15 (2024)

مصطلحات موضوعية: phase 0, intratumoral microdosing, spatial profiling, multidrug analyses, pharmacodynamics, tumor microenvironment, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1367581/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/df356ddd88154387999a5c867f337370

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دورية أكاديمية

722 Evaluation of the effects of pembrolizumab alone and in combination(s) with MDSC-targeting agents MK-0482 and MK-4830 on the native cancer patient TME via functional spatial profiling (CIVO®)

المصدر: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2051-1426

URL الوصول: https://doaj.org/article/2626a56932aa4490b7e1fa8b5af9b7d9

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دورية أكاديمية

ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance

المصدر: Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2399-3642

URL الوصول: https://doaj.org/article/d6164d29cedd4b8db922002838b3e600

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569 A CIVO intratumor microdose Phase 0 Trial of subasumstat (TAK-981) in combination with cetuximab or avelumab reveals Type 1 Interferon induction and immune activation in head and neck cancer patients

المؤلفون: Jeffrey Houlton, Daniel Clayburgh, Ryan Li, Nathan Schauer, Marc Grenley, Connor Burns, Angela Merrell, Jason Frazier, Jonathan Derry, Emily Beirne, Wendy Jenkins, Allison Berger, Richard Klinghoffer

المصدر: Regular and Young Investigator Award Abstracts.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e0e3704a0b760f166b475d28f7ef8a3e
https://doi.org/10.1136/jitc-2022-sitc2022.0569

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Abstract 3476: TAK-243 increases tumor immunogenicity enhancing systemic anti-tumor immune response and tumor regression in combination with immune checkpoint inhibition in a syngeneic model of lymphoma

المؤلفون: Richard Klinghoffer, Connor Burns, Angela Merrell, Marc Grenley

المصدر: Cancer Research. 83:3476-3476

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3766e1f250514d8edbf10f3805bf0a7e
https://doi.org/10.1158/1538-7445.am2023-3476

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Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma

المؤلفون: Jessica A. Bertout, Kimberly H.W. Sottero, Richard A. Klinghoffer, Jason Frazier, Howard J. Goodman, Matthew J. Thompson, Gary B. Deutsch, Daniel C. Ramirez, Joyoti Dey, Marc Grenley, Mee Young Lee, Kenneth R. Gundle, William S. Kerwin, Micah Ellison, Jessica L. Davis, Robert G. Maki, Seth M. Pollack, Emily Beirne

المصدر: Clinical Cancer Research. 26:3958-3968

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0c1d6980abd02bcb1b9f58a80547b972
https://doi.org/10.1158/1078-0432.ccr-20-0614

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ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance

المصدر: Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)

مصطلحات موضوعية: 0301 basic medicine, QH301-705.5, Medicine (miscellaneous), Cancer immunotherapy, Systemic inflammation, Article, General Biochemistry, Genetics and Molecular Biology, Proinflammatory cytokine, Extracellular Vesicles, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Tumor Microenvironment, medicine, Animals, Biology (General), Antigen-presenting cell, Immunologic Surveillance, Mice, Inbred BALB C, Tumor microenvironment, Extracellular vesicle, Extravasation, Mice, Inbred C57BL, 030104 developmental biology, 030220 oncology & carcinogenesis, Stimulator of interferon genes, Cancer research, Nanoparticles, Female, medicine.symptom, General Agricultural and Biological Sciences

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b76e65940414bd13ef06ef91b2232ab
https://doi.org/10.1038/s42003-021-02004-5

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8

Abstract 620: Intratumoral microdosing via the CIVO® Platform reveals anti-tumor immune responses induced by the STING Agonist TAK-676 alone and in combination with chemotherapies

المؤلفون: Beryl A. Hatton, Marc Grenley, Sally Ditzler, Richard A. Klinghoffer, Allison J. Berger, Karim S. Malek, Richard C. Gregory, Neil B. Lineberry

المصدر: Cancer Research. 82:620-620

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b2448dc7272998f714f3d5417d81e2d7
https://doi.org/10.1158/1538-7445.am2022-620

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Abstract 3424: Deep mechanistic profiling of immune oncology (I-O) drug combinations in cancer patients with CIVO® intratumoral microdosing and NanoString GeoMx DSP

المؤلفون: Jason P. Frazier, Kenneth R. Gundle, Marc Grenley, Gloria Kung, Kimberly Sottero, Kirsten Anderson, Richard Klinghoffer, Jonathan M. Derry

المصدر: Cancer Research. 82:3424-3424

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f1eece298badad8e5dff09d5df1b7a3c
https://doi.org/10.1158/1538-7445.am2022-3424

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Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition

المؤلفون: Kate C. Gillespie, Thomas L. Deckwerth, Richard A. Klinghoffer, Joseph Casalini, Joyoti Dey, Edward F. Kleinman, Sally Ditzler, Marc Grenley, Emily Beirne, Chantel P. Dixon, Angela Merrell, Connor Burns, William S. Kerwin

المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Combination therapy, medicine.medical_treatment, lcsh:Medicine, Antineoplastic Agents, Apoptosis, Article, Targeted therapy, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, immune system diseases, Cell Line, Tumor, hemic and lymphatic diseases, medicine, Animals, Humans, Benzopyrans, lcsh:Science, Chemotherapy, Sulfonamides, Multidisciplinary, business.industry, Venetoclax, lcsh:R, Germinal center, Drug Synergism, medicine.disease, Bridged Bicyclo Compounds, Heterocyclic, Lymphoma, 030104 developmental biology, chemistry, Gene Expression Regulation, Proto-Oncogene Proteins c-bcl-2, 030220 oncology & carcinogenesis, Imino Furanoses, Cancer research, Myeloid Cell Leukemia Sequence 1 Protein, lcsh:Q, Lymphoma, Large B-Cell, Diffuse, business, Diffuse large B-cell lymphoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46350778d35faa88995b3d2c527bb77d
http://link.springer.com/article/10.1038/s41598-017-18368-w

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