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المؤلفون: Xiaotian Zhu, Dong Zou, Chester A. Metcalf, Raji Sundaramoorthi, Frank Wang, Feng Li, Jan Romero, John Iuliucci, Lois Commodore, Shuangying Liu, Wei-Sheng Huang, Lisi Cai, Qihong Xu, Jeff Keats, Tim Clackson, David C. Dalgarno, Joseph Snodgrass, Jiwei Qi, Yihan Wang, Victor M. Rivera, Mathew Thomas, Ingrid Chen, Tianjun Zhou, Yaoyu Ning, David Wen, Tomi K. Sawyer, Karin Russian, William C. Shakespeare, Marc I Broudy, Scott Wardwell
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3743-3748
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Mutant, Fusion Proteins, bcr-abl, Administration, Oral, Pharmaceutical Science, Carboxamide, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Drug Discovery, medicine, Animals, Molecular Biology, Aniline Compounds, Molecular Structure, biology, Chemistry, Organic Chemistry, Ponatinib, Biological activity, medicine.disease, In vitro, Rats, Disease Models, Animal, Cyclization, Enzyme inhibitor, Alkynes, Mutation, biology.protein, Molecular Medicine, Linker, Toluene, Chronic myelogenous leukemia
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المؤلفون: Yaoyu Ning, Chester A. Metcalf, Lois Commodore, Jan Romero, Scott Wardwell, Tomi K. Sawyer, Yihan Wang, Qurish K. Mohemmad, Scott Paul Lentini, Ingrid Chen, Victor M. Rivera, Karin Russian, Geetha Banda, Sasmita Das, Narayana I. Narasimhan, Xiaotian Zhu, Raji Sundaramoorthi, Lisi Cai, Tianjun Zhou, Jeff Keats, Frank Wang, Tim Clackson, Qihong Xu, Jiwei Qi, David Wen, Joseph Snodgrass, Shuangying Liu, William C. Shakespeare, R. Mathew Thomas, Marc I Broudy, John Iuliucci, Wei-Sheng Huang, David C. Dalgarno, Dong Zou
المصدر: Journal of Medicinal Chemistry. 53:4701-4719
مصطلحات موضوعية: Models, Molecular, Mutant, Fusion Proteins, bcr-abl, Administration, Oral, Antineoplastic Agents, Mice, SCID, Pharmacology, Crystallography, X-Ray, Mice, chemistry.chemical_compound, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Drug Discovery, medicine, Animals, Kinase activity, Benzamide, Protein Kinase Inhibitors, ADME, Kinase, Chemistry, Imidazoles, breakpoint cluster region, Myeloid leukemia, medicine.disease, Rats, Pyridazines, Leukemia, Blood-Brain Barrier, Mutation, Molecular Medicine, Drug Screening Assays, Antitumor
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المؤلفون: Jeff Keats, Marc I Broudy, John Iuliucci, Scott Wardwell, Karin Russian, Sasmita Das, Yaoyu Ning, Scott Paul Lentini, Yihan Wang, David Wen, William C. Shakespeare, Joseph Snodgrass, Tomi K. Sawyer, David C. Dalgarno, R. Mathew Thomas, Xiaotian Zhu, Mohammad Azam, Shuangying Liu, George Q. Daley, Wei-Sheng Huang, Raji Sundaramoorthi, Tim Clackson, Geetha Banda, Qihong Xu, Frank Wang
المصدر: Journal of Medicinal Chemistry. 52:4743-4756
مصطلحات موضوعية: Protein Conformation, Pharmacology, Mice, Structure-Activity Relationship, In vivo, hemic and lymphatic diseases, Drug Discovery, Animals, Humans, Proto-Oncogene Proteins c-abl, Protein Kinase Inhibitors, ABL, biology, Kinase, Chemistry, Wild type, Myeloid leukemia, Rats, src-Family Kinases, Purines, Enzyme inhibitor, Drug Design, NIH 3T3 Cells, biology.protein, Molecular Medicine, Female, K562 Cells, Proto-oncogene tyrosine-protein kinase Src, K562 cells
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المؤلفون: John C. L. Erve, Charles L. Crespi, Stephanie D. Turner, Andrew P. Blanchard, David M. Stresser, Christopher J. Patten, Raman Sharma, Catherine E. Cargill, Marc I. Broudy, Thuy Ho, Joseph J. Goodwin, Andre A. Dandeneau, Shangara S. Dehal
المصدر: Drug Metabolism and Disposition. 32:105-112
مصطلحات موضوعية: Bridged-Ring Compounds, Pharmaceutical Science, In Vitro Techniques, Pharmacology, Pleurotus, Substrate Specificity, Xenobiotics, CYP2J2, chemistry.chemical_compound, Non-competitive inhibition, Anti-Infective Agents, Cytochrome P-450 Enzyme System, Cytochrome P-450 Enzyme Inhibitors, Humans, Fluorometry, Enzyme Inhibitors, chemistry.chemical_classification, biology, Cytochrome P450, Triazoles, Ketoconazole, Enzyme, Solubility, chemistry, Biochemistry, Enzyme inhibitor, Steroid Hydroxylases, Microsomes, Liver, biology.protein, Microsome, Azole, Pleuromutilin, NADP
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3591095bd3827c7d53a82bd20d40b4
https://doi.org/10.1124/dmd.32.1.105 -
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المؤلفون: Daniel H. Fisher, L. Megan Fisher, Marc I. Broudy
المصدر: Biomedical Chromatography. 10:161-166
مصطلحات موضوعية: Pharmacology, Coefficient of determination, Chromatography, medicine.diagnostic_test, Chemistry, Clinical Biochemistry, Extraction (chemistry), General Medicine, Mass spectrometry, Biochemistry, High-performance liquid chromatography, Analytical Chemistry, Standard error, Linear range, Immunoassay, Drug Discovery, medicine, Gas chromatography, Molecular Biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c2d5d72759fe43fd0eaee7745f552e7f
https://doi.org/10.1002/(sici)1099-0801(199607)10:4<161::aid-bmc579>3.0.co;2-3 -
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المؤلفون: Marc I. Broudy, Daniel H. Fisher, L. Megan Fisher
المصدر: Journal of Liquid Chromatography. 18:3311-3327
مصطلحات موضوعية: Detection limit, Standard curve, Coulometry, Chromatography, Chemistry, Extraction (chemistry), Analytical chemistry, Molecular Medicine, Reversed-phase chromatography, Anaerobic exercise, Quantitative analysis (chemistry), Amperometry
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7دورية أكاديمية
المؤلفون: Wei-Sheng Huang, Xiaotian Zhu, Yihan Wang, Mohammad Azam, David Wen, Raji Sundaramoorthi, R. Mathew Thomas, Shuangying Liu, Geetha Banda, Scott P. Lentini, Sasmita Das, Qihong Xu, Jeff Keats, Frank Wang, Scott Wardwell, Yaoyu Ning, Joseph T. Snodgrass, Marc I. Broudy, Karin Russian, George Q. Daley
المصدر: Journal of Medicinal Chemistry; Aug2009, Vol. 52 Issue 15, p4743-4756, 14p
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