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1دورية أكاديمية
المؤلفون: Alastair J King, Marc R Arnone, Maureen R Bleam, Katherine G Moss, Jingsong Yang, Kelly E Fedorowicz, Kimberly N Smitheman, Joseph A Erhardt, Angela Hughes-Earle, Laurie S Kane-Carson, Robert H Sinnamon, Hongwei Qi, Tara R Rheault, David E Uehling, Sylvie G Laquerre
المصدر: PLoS ONE, Vol 8, Iss 7, p e67583 (2013)
وصف الملف: electronic resource
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المؤلفون: Tara Renae Rheault, Kimberly N. Smitheman, Kimberly G. Petrov, Chao Han, George Adjabeng, Alex G. Waterson, Marc R. Arnone, Alastair J. King, David E. Uehling, Olivia W. Rossanese, Keith R. Hornberger, Scott Howard Dickerson, John Stellwagen, Cynthia M. Rominger, Robert A. Mook
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:4436-4440
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Catalytic Domain, Drug Discovery, Animals, Thiazole, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Binding Sites, Kinase, Chemistry, Organic Chemistry, Fluorine, Rats, Bioavailability, Sulfonamide, Amino Acid Substitution, Microsomes, Liver, Molecular Medicine
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المؤلفون: Robert A. Copeland, Zhihong Lai, Tia Lewis, Kang Yan, Peter J. Tummino, Lata T. Gooljarsingh, John J. Kerrigan, Robert H. Sinnamon, Kyung O. Johanson, Christine Fernandes, Marc R. Arnone, Michael Grooms, Hong Zhang, Alastair J. King, Robert B. Kirkpatrick
المصدر: Proceedings of the National Academy of Sciences. 103:7625-7630
مصطلحات موضوعية: Boron Compounds, Lactams, Macrocyclic, Context (language use), Plasma protein binding, Hsp90 inhibitor, chemistry.chemical_compound, In vivo, Heat shock protein, polycyclic compounds, Benzoquinones, Animals, Humans, Potency, HSP90 Heat-Shock Proteins, Cells, Cultured, Fluorescent Dyes, Antibiotics, Antineoplastic, Multidisciplinary, biology, Quinones, Biological Sciences, Geldanamycin, Hsp90, Recombinant Proteins, Biochemistry, chemistry, biology.protein, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf9463212847a9e81115d757c99e1fd
https://doi.org/10.1073/pnas.0602650103 -
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المؤلفون: Robert H. Grafstrom, Charles F. Albright, Steven P. Seitz, Marvin Kendall, Zelda R. Wasserman, Weijun Pan, Marc R. Arnone
المصدر: Journal of Biological Chemistry. 278:27820-27827
مصطلحات موضوعية: Models, Molecular, Phage display, Matrix Metalloproteinases, Membrane-Associated, Proline, Genetic Vectors, Peptide, Plasma protein binding, Biology, Crystallography, X-Ray, Biochemistry, Substrate Specificity, Protein structure, Matrix Metalloproteinase 11, Peptide Library, Neoplasms, Cleave, Consensus sequence, Humans, Binding site, Peptide library, Molecular Biology, chemistry.chemical_classification, Binding Sites, Dose-Response Relationship, Drug, Metalloendopeptidases, Cell Biology, Molecular biology, Extracellular Matrix, Protein Structure, Tertiary, Kinetics, chemistry, Peptides, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289d527b7822fb0059c081d485b6dde8
https://doi.org/10.1074/jbc.m304436200 -
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المؤلفون: Marc R. Arnone, Ronald D. Snyder
المصدر: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 503:21-35
مصطلحات موضوعية: Imipramine, Health, Toxicology and Mutagenesis, Catalysis, Cell Line, chemistry.chemical_compound, Cricetulus, Cricetinae, Genetics, Animals, Topoisomerase II Inhibitors, Molecular Biology, Proflavine, Anthracenes, chemistry.chemical_classification, Micronucleus Tests, biology, Topoisomerase, Molecular biology, DNA Intercalating Agent, Intercalating Agents, Enzyme, chemistry, Quinacrine, Micronucleus test, biology.protein, Topoisomerase-II Inhibitor, Ethidium bromide, DNA, Mutagens
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd829e695ccab4f1d989d77a29986e0
https://doi.org/10.1016/s0027-5107(02)00028-3 -
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المؤلفون: Kelly E. Fedorowicz, Hongwei Qi, Angela Hughes-Earle, Joseph A. Erhardt, Robert H. Sinnamon, Marc R. Arnone, Tara Renae Rheault, Katherine G. Moss, Alastair J. King, Sylvie Laquerre, Jingsong Yang, David E. Uehling, Laurie S. Kane-Carson, Maureen R. Bleam, Kimberly N. Smitheman
المصدر: PLoS ONE
PLoS ONE, Vol 8, Iss 7, p e67583 (2013)مصطلحات موضوعية: MAPK/ERK pathway, endocrine system diseases, Drug Evaluation, Preclinical, Cancer Treatment, lcsh:Medicine, Signal transduction, Biochemistry, Metastasis, Mice, Molecular cell biology, Antineoplastic Combined Chemotherapy Protocols, Oximes, Drug Discovery, Basic Cancer Research, Biomacromolecule-Ligand Interactions, lcsh:Science, Melanoma, Skin Tumors, Trametinib, Multidisciplinary, Cell Death, Chemistry, MEK inhibitor, Clinical Pharmacology, Drug Information, Imidazoles, Signaling cascades, Tumor Burden, Enzymes, Oncology, Medicine, Female, Oncology Agents, Mitogen-Activated Protein Kinases, Cell Division, medicine.drug, Research Article, Proto-Oncogene Proteins B-raf, Drugs and Devices, MAPK signaling cascades, Drug Research and Development, Pyridones, Pyrimidinones, Cell Growth, Cell Line, Tumor, Chemical Biology, medicine, Animals, Humans, Kinase activity, neoplasms, Biology, Enzyme Kinetics, Cell growth, lcsh:R, Cancers and Neoplasms, Dabrafenib, Chemotherapy and Drug Treatment, medicine.disease, Xenograft Model Antitumor Assays, digestive system diseases, Enzyme Activation, Small Molecules, Mutation, Cancer research, lcsh:Q, Medicinal Chemistry, Ovarian cancer
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المؤلفون: Laurie S. Kane-Carson, Kimberly N. Smitheman, Chao Han, Alex G. Waterson, Marc R. Arnone, Olivia W. Rossanese, David E. Uehling, John Stellwagen, Keith R. Hornberger, Robert A. Mook, Scott Howard Dickerson, Katherine G. Moss, Alastair J. King, Kimberly G. Petrov, Sylvie Laquerre, Ganesh S. Moorthy, George Adjabeng, Tara Renae Rheault
مصطلحات موضوعية: MAPK/ERK pathway, biology, business.industry, Colorectal cancer, Melanoma, Organic Chemistry, Mutant, Dabrafenib, Pharmacology, medicine.disease, Biochemistry, In vitro, In vivo, Mitogen-activated protein kinase, Drug Discovery, biology.protein, Medicine, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ece1513b9365faece7d7d536bde0c1
https://europepmc.org/articles/PMC4027516/ -
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المؤلفون: Sarah Cox, Michael D. Boisclair, Charity L. Dean, Philip M. Czerniak, Pieter F. W. Stouten, David A. Nugiel, Steven P. Seitz, Chong-Hwan Chang, Catherine R. Burton, Marc R. Arnone, Lisa M. Sisk, Robert F. Kaltenbach, Barbara A. Harrison, Pamela A. Benfield, Robert H. Grafstrom, Jay A. Markwalder, Susan R. Sherk, Karen A. Rossi, Deborah Doleniak, Peter Worland, George L. Trainor
المصدر: Journal of medicinal chemistry. 47(24)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Transplantation, Heterologous, Antineoplastic Agents, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Cyclin-dependent kinase, Cell Line, Tumor, Proto-Oncogene Proteins, Drug Discovery, Structure–activity relationship, Animals, Humans, Cyclin D1, Binding site, Phosphorylation, Cells, Cultured, Binding Sites, biology, Molecular Structure, Cyclin-dependent kinase 4, Kinase, Chemistry, Cyclin-dependent kinase 2, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinases, Transplantation, Pyrimidines, Enzyme inhibitor, biology.protein, Molecular Medicine, Pyrazoles, Drug Screening Assays, Antitumor
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المؤلفون: Elisabeth A. Minthorn, Peter F. Lebowitz, Maureen R. Bleam, Marc R. Arnone, Sylvie Laquerre, Daniele Ouellet, Katherine G. Moss, Qi Liu
المصدر: Cancer Research. 71:5035-5035
مصطلحات موضوعية: MAPK/ERK pathway, Cancer Research, biology, business.industry, Cell growth, Melanoma, Cancer, Pharmacology, medicine.disease, biology.organism_classification, Effective dose (pharmacology), Nude mouse, Oncology, Medicine, Biomarker (medicine), business, IC50
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::620a0cf0541de393f1f480524ab68bc8
https://doi.org/10.1158/1538-7445.am2011-5035 -
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المؤلفون: Laurie S. Kane-Carson, John Stellwagen, George Adjabeng, David E. Uehling, Katherine G. Moss, Tara Renae Rheault, Bradley Heidrich, Robert A. Mook, Marc R. Arnone, Jessica Ward, Jingsong Yang, Keith R. Hornberger, Alex G. Waterson, Alastair J. King, Kimberly N. Smitheman, Chao Han, Sylvie Laquerre, Kelly E. Fisher
المصدر: Molecular Cancer Therapeutics. 8:B88-B88
مصطلحات موضوعية: MAPK/ERK pathway, Cancer Research, Oncology, Growth factor receptor, Cell growth, Kinase, Raf Kinase Inhibitor, c-Raf, Signal transduction, Kinase activity, Biology, Molecular biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::77cc92b0afa190ff680cb6dfde684263
https://doi.org/10.1158/1535-7163.targ-09-b88