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1دورية أكاديمية
المؤلفون: Sabine Sewing, Marcel Gubler, Régine Gérard, Blandine Avignon, Yasmin Mueller, Annamaria Braendli-Baiocco, Marielle Odin, Annie Moisan
المصدر: Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 67-79 (2019)
مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Annie Moisan, Marcel Gubler, Jitao David Zhang, Yann Tessier, Kamille Dumong Erichsen, Sabine Sewing, Régine Gérard, Blandine Avignon, Sylwia Huber, Fethallah Benmansour, Xing Chen, Roberto Villaseñor, Annamaria Braendli-Baiocco, Matthias Festag, Andreas Maunz, Thomas Singer, Franz Schuler, Adrian B. Roth
المصدر: Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 89-105 (2017)
مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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3
المؤلفون: Marcel Gubler, Kamille Dumong Erichsen, Adrian Roth, Régine Gérard, Fethallah Benmansour, Xing Chen, Jitao David Zhang, Sylwia Huber, Matthias Festag, Yann Tessier, Roberto Villaseñor, Sabine Sewing, Blandine Avignon, Thomas Singer, Andreas Maunz, Franz Schuler, Annie Moisan, Annamaria Braendli-Baiocco
المصدر: Molecular Therapy: Nucleic Acids, Vol 6, Iss, Pp 89-105 (2017)
Molecular Therapy. Nucleic Acidsمصطلحات موضوعية: oligonucleotide, safety, 0301 basic medicine, Drug, kidney, EGFR, antisense, media_common.quotation_subject, Biology, Pharmacology, 03 medical and health sciences, 0302 clinical medicine, Epidermal growth factor, Drug Discovery, preclinical, Extracellular, medicine, PTEC, Cytotoxicity, Receptor, EGF, media_common, Kidney, Oligonucleotide, nephrotoxicity, lcsh:RM1-950, In vitro, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Molecular Medicine, Original Article
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4
المؤلفون: Tim Tetaz, Marcel Gubler, Armin Ruf, Dragana Cubrilovic, Wolfgang Haap, Konstantin Barylyuk, Jörg Benz, Martin Badertscher, Renato Zenobi, Catherine Joseph
المصدر: ACS chemical biology
مصطلحات موضوعية: Models, Molecular, Spectrometry, Mass, Electrospray Ionization, genetic structures, Stereochemistry, Electrospray ionization, Allosteric regulation, Cooperativity, Crystallography, X-Ray, Ligands, 01 natural sciences, Biochemistry, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Allosteric Regulation, Drug Discovery, TetR, Enzyme Inhibitors, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, 010401 analytical chemistry, Cooperative binding, General Medicine, Fructose-Bisphosphatase, 0104 chemical sciences, Dissociation constant, Enzyme, chemistry, Molecular Medicine, Protein Multimerization, Protein Binding, Protein ligand
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbb6eba56b434bf247997c43324ac90
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5
المؤلفون: Stephan Kirchner, Paul Hebeisen, Eric A. Kitas, Effie Tozzo, Bernd Kuhn, Marcel Gubler, Armin Ruf, Hans Peter Wessel, Ulrich Zutter, Wolfgang Haap, Catherine Joseph, Peter Mohr, Rubén Alvarez-Sánchez, Jörg Benz, Agnès Bénardeau, Brigitte Schott
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3237-3242
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Allosteric regulation, Fructose 1,6-bisphosphatase, Administration, Oral, Aminopyridines, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Inhibitory Concentration 50, Mice, Enzyme activator, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Binding site, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Glycogen, Organic Chemistry, Fructose-Bisphosphatase, Enzyme Activation, Disease Models, Animal, Enzyme, Diabetes Mellitus, Type 2, Liver, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Allosteric Site
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6
المؤلفون: Axel Paehler, Hans Peter Wessel, Armin Ruf, Jörg Benz, Catherine Joseph, Marcel Gubler, Eric A. Kitas, Brigitte Schott, Bernd Kuhn, Peter Mohr, Effie Tozzo, Agnès Bénardeau, Paul Hebeisen, Walter Huber, Ruben Alvarez Sanchez, Wolfgang Haap
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:594-599
مصطلحات موضوعية: Molecular model, Metabolite, Clinical Biochemistry, Fructose 1,6-bisphosphatase, Pharmaceutical Science, Type 2 diabetes, Crystallography, X-Ray, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Diabetes mellitus, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Structure–activity relationship, Molecular Biology, ADME, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, medicine.disease, Fructose-Bisphosphatase, High-Throughput Screening Assays, Disease Models, Animal, Thiazoles, Sulfonylurea Compounds, Enzyme, Diabetes Mellitus, Type 2, chemistry, biology.protein, Molecular Medicine
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7
المؤلفون: Brigitte Schott, Bernd Kuhn, Eric A. Kitas, Paul Hebeisen, Kohler Philipp Christoph, Marcel Gubler, Armin Ruf, Jörg Benz, Walter Huber, Catherine Joseph
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:4708-4712
مصطلحات موضوعية: Phosphoric monoester hydrolases, Chemistry, Pharmaceutical, Clinical Biochemistry, Allosteric regulation, Molecular Conformation, Fructose 1,6-bisphosphatase, Administration, Oral, Pharmaceutical Science, Cooperativity, Biochemistry, Drug Discovery, Hydrolase, Humans, Molecular Biology, chemistry.chemical_classification, Binding Sites, Molecular Structure, biology, Chemistry, Organic Chemistry, Adenosine Monophosphate, Fructose-Bisphosphatase, Kinetics, Glucose, Sulfonylurea Compounds, Enzyme, Liver, Models, Chemical, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Allosteric Site, Homotetramer
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8
المؤلفون: Abdul G. Dulloo, Sandro Rusconi, Marcel Gubler, Giovanni Solinas, Serge Summermatter, Josiane Seydoux, Jean-Pierre Montani, Davide Mainieri, Matthias P. Wymann, Luciano Pirola
المصدر: FEBS Letters. 577:539-544
مصطلحات موضوعية: Leptin, Male, medicine.medical_specialty, Substrate Cycling, Biophysics, Models, Biological, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, AMP-activated protein kinase, Lipid oxidation, Structural Biology, Internal medicine, Genetics, medicine, Animals, Obesity, Muscle, Skeletal, Molecular Biology, Mice, Inbred BALB C, biology, Diabetes, Adenylate Kinase, AMPK, Skeletal muscle, Insulin resistance, Thermogenesis, Cell Biology, Lipid Metabolism, Sterol regulatory element binding protein-1c, Glucose, Endocrinology, medicine.anatomical_structure, Lipotoxicity, Lipogenesis, biology.protein, Gluco-lipotoxicity, Oxidation-Reduction, Phosphatidylinositol 3-kinase, Signal Transduction
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9
المؤلفون: Krzysztof Wrzesinski, Maria Bobadilla, Stephen J. Fey, Tobias Bergauer, Line Visby Hansen, Signe Marie Andersen, Kira Joensen, Jacques Mizrahi, Marcel Gubler, Ove B. Schaffalitzky de Muckadell, Jacob Bastholm Olesen, Christina Møller Andreasen, Kelan Zhang, Maria Chiara Magnone, Marianne Ehrhorn Kruse
المصدر: Wrzesinski, K, Magnone, M C, Hansen, L V, Ehrhorn Kruse, M, Bergauer, T, Bobadilla, M, Gubler, M, Mizrahi, J, Zhang, K, Andreasen, C M, Joensen, K, Andersen, S M, Olesen, J B, Schaffalitzky de Muckadell, O B & Fey, S J 2013, ' HepG2/C3A 3D spheroids exhibit stable physiological functionality for at least 24 days after recovering from trypsinisation ', Toxicology Research, vol. 2, no. 3, pp. 163-172 . https://doi.org/10.1039/c3tx20086h
مصطلحات موضوعية: 3D culture, HepG2-C3A cells, Cholesterol, Physiology, Health, Toxicology and Mutagenesis, Systems biology, Spheroid, Biology, Toxicology, Cell biology, chemistry.chemical_compound, chemistry, Glycogenesis, Toxicity, Spheroids, Mode of action, Drug metabolism, Homeostasis, toxicology
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4053ffb15294539a9dc44f05c77ffa7f
https://findresearcher.sdu.dk:8443/ws/files/118365785/c3tx20086h_3.pdf -
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المؤلفون: Davide Mainieri, Jean-Pierre Montani, Marcel Gubler, Giovanni Solinas, Serge Summermatter, Abdul G. Dulloo, Steven R. Smith, Josiane Seydoux
مصطلحات موضوعية: Male, medicine.medical_specialty, endocrine system, Corticotropin-Releasing Hormone, Biology, Corticotropin-releasing hormone, Mice, Phosphatidylinositol 3-Kinases, Endocrinology, Lipid oxidation, Internal medicine, medicine, Animals, Protein kinase A, Muscle, Skeletal, Urocortin, Mice, Inbred BALB C, Adenylate Kinase, Skeletal muscle, Lipids, medicine.anatomical_structure, Lipotoxicity, Lipogenesis, Models, Animal, Thermogenesis, Glycolysis, hormones, hormone substitutes, and hormone antagonists, Body Temperature Regulation
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ed6a2100ab79fad1fa487b835d754f
http://doc.rero.ch/record/5827/files/dulloo_crh.pdf