المؤلفون: Sabine Sewing, Marcel Gubler, Régine Gérard, Blandine Avignon, Yasmin Mueller, Annamaria Braendli-Baiocco, Marielle Odin, Annie Moisan

المصدر: Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 67-79 (2019)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253118302993; https://doaj.org/toc/2162-2531

URL الوصول: https://doaj.org/article/2372d539f88947098a3a24ddd5408f46

المؤلفون: Annie Moisan, Marcel Gubler, Jitao David Zhang, Yann Tessier, Kamille Dumong Erichsen, Sabine Sewing, Régine Gérard, Blandine Avignon, Sylwia Huber, Fethallah Benmansour, Xing Chen, Roberto Villaseñor, Annamaria Braendli-Baiocco, Matthias Festag, Andreas Maunz, Thomas Singer, Franz Schuler, Adrian B. Roth

المصدر: Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 89-105 (2017)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S216225311630364X; https://doaj.org/toc/2162-2531

URL الوصول: https://doaj.org/article/6a19a17eb817471d91d25a02041685db

المؤلفون: Marcel Gubler, Kamille Dumong Erichsen, Adrian Roth, Régine Gérard, Fethallah Benmansour, Xing Chen, Jitao David Zhang, Sylwia Huber, Matthias Festag, Yann Tessier, Roberto Villaseñor, Sabine Sewing, Blandine Avignon, Thomas Singer, Andreas Maunz, Franz Schuler, Annie Moisan, Annamaria Braendli-Baiocco

المصدر: Molecular Therapy: Nucleic Acids, Vol 6, Iss, Pp 89-105 (2017)
Molecular Therapy. Nucleic Acids

مصطلحات موضوعية: oligonucleotide, safety, 0301 basic medicine, Drug, kidney, EGFR, antisense, media_common.quotation_subject, Biology, Pharmacology, 03 medical and health sciences, 0302 clinical medicine, Epidermal growth factor, Drug Discovery, preclinical, Extracellular, medicine, PTEC, Cytotoxicity, Receptor, EGF, media_common, Kidney, Oligonucleotide, nephrotoxicity, lcsh:RM1-950, In vitro, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Molecular Medicine, Original Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b94950840f7bc75e2af78fbe25415b4
https://doi.org/10.1016/j.omtn.2016.11.006

المؤلفون: Tim Tetaz, Marcel Gubler, Armin Ruf, Dragana Cubrilovic, Wolfgang Haap, Konstantin Barylyuk, Jörg Benz, Martin Badertscher, Renato Zenobi, Catherine Joseph

المصدر: ACS chemical biology

مصطلحات موضوعية: Models, Molecular, Spectrometry, Mass, Electrospray Ionization, genetic structures, Stereochemistry, Electrospray ionization, Allosteric regulation, Cooperativity, Crystallography, X-Ray, Ligands, 01 natural sciences, Biochemistry, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Allosteric Regulation, Drug Discovery, TetR, Enzyme Inhibitors, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, 010401 analytical chemistry, Cooperative binding, General Medicine, Fructose-Bisphosphatase, 0104 chemical sciences, Dissociation constant, Enzyme, chemistry, Molecular Medicine, Protein Multimerization, Protein Binding, Protein ligand

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbb6eba56b434bf247997c43324ac90

المؤلفون: Stephan Kirchner, Paul Hebeisen, Eric A. Kitas, Effie Tozzo, Bernd Kuhn, Marcel Gubler, Armin Ruf, Hans Peter Wessel, Ulrich Zutter, Wolfgang Haap, Catherine Joseph, Peter Mohr, Rubén Alvarez-Sánchez, Jörg Benz, Agnès Bénardeau, Brigitte Schott

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3237-3242

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Allosteric regulation, Fructose 1,6-bisphosphatase, Administration, Oral, Aminopyridines, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Inhibitory Concentration 50, Mice, Enzyme activator, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Binding site, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Glycogen, Organic Chemistry, Fructose-Bisphosphatase, Enzyme Activation, Disease Models, Animal, Enzyme, Diabetes Mellitus, Type 2, Liver, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Allosteric Site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4388584265f0ac68a801ab2793b185c3
https://doi.org/10.1016/j.bmcl.2011.04.044

المؤلفون: Axel Paehler, Hans Peter Wessel, Armin Ruf, Jörg Benz, Catherine Joseph, Marcel Gubler, Eric A. Kitas, Brigitte Schott, Bernd Kuhn, Peter Mohr, Effie Tozzo, Agnès Bénardeau, Paul Hebeisen, Walter Huber, Ruben Alvarez Sanchez, Wolfgang Haap

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:594-599

مصطلحات موضوعية: Molecular model, Metabolite, Clinical Biochemistry, Fructose 1,6-bisphosphatase, Pharmaceutical Science, Type 2 diabetes, Crystallography, X-Ray, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Diabetes mellitus, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Structure–activity relationship, Molecular Biology, ADME, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, medicine.disease, Fructose-Bisphosphatase, High-Throughput Screening Assays, Disease Models, Animal, Thiazoles, Sulfonylurea Compounds, Enzyme, Diabetes Mellitus, Type 2, chemistry, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba14e44d2fe82d84bf408ab6efc043d4
https://doi.org/10.1016/j.bmcl.2009.11.093

المؤلفون: Brigitte Schott, Bernd Kuhn, Eric A. Kitas, Paul Hebeisen, Kohler Philipp Christoph, Marcel Gubler, Armin Ruf, Jörg Benz, Walter Huber, Catherine Joseph

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:4708-4712

مصطلحات موضوعية: Phosphoric monoester hydrolases, Chemistry, Pharmaceutical, Clinical Biochemistry, Allosteric regulation, Molecular Conformation, Fructose 1,6-bisphosphatase, Administration, Oral, Pharmaceutical Science, Cooperativity, Biochemistry, Drug Discovery, Hydrolase, Humans, Molecular Biology, chemistry.chemical_classification, Binding Sites, Molecular Structure, biology, Chemistry, Organic Chemistry, Adenosine Monophosphate, Fructose-Bisphosphatase, Kinetics, Glucose, Sulfonylurea Compounds, Enzyme, Liver, Models, Chemical, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Allosteric Site, Homotetramer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6975f1f1f7b7b2839502166d90ce4a1a
https://doi.org/10.1016/j.bmcl.2008.06.103

المؤلفون: Abdul G. Dulloo, Sandro Rusconi, Marcel Gubler, Giovanni Solinas, Serge Summermatter, Josiane Seydoux, Jean-Pierre Montani, Davide Mainieri, Matthias P. Wymann, Luciano Pirola

المصدر: FEBS Letters. 577:539-544

مصطلحات موضوعية: Leptin, Male, medicine.medical_specialty, Substrate Cycling, Biophysics, Models, Biological, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, AMP-activated protein kinase, Lipid oxidation, Structural Biology, Internal medicine, Genetics, medicine, Animals, Obesity, Muscle, Skeletal, Molecular Biology, Mice, Inbred BALB C, biology, Diabetes, Adenylate Kinase, AMPK, Skeletal muscle, Insulin resistance, Thermogenesis, Cell Biology, Lipid Metabolism, Sterol regulatory element binding protein-1c, Glucose, Endocrinology, medicine.anatomical_structure, Lipotoxicity, Lipogenesis, biology.protein, Gluco-lipotoxicity, Oxidation-Reduction, Phosphatidylinositol 3-kinase, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd0d164ec2b82d9c68bc36a646cc646
https://doi.org/10.1016/j.febslet.2004.10.066

المؤلفون: Krzysztof Wrzesinski, Maria Bobadilla, Stephen J. Fey, Tobias Bergauer, Line Visby Hansen, Signe Marie Andersen, Kira Joensen, Jacques Mizrahi, Marcel Gubler, Ove B. Schaffalitzky de Muckadell, Jacob Bastholm Olesen, Christina Møller Andreasen, Kelan Zhang, Maria Chiara Magnone, Marianne Ehrhorn Kruse

المصدر: Wrzesinski, K, Magnone, M C, Hansen, L V, Ehrhorn Kruse, M, Bergauer, T, Bobadilla, M, Gubler, M, Mizrahi, J, Zhang, K, Andreasen, C M, Joensen, K, Andersen, S M, Olesen, J B, Schaffalitzky de Muckadell, O B & Fey, S J 2013, ' HepG2/C3A 3D spheroids exhibit stable physiological functionality for at least 24 days after recovering from trypsinisation ', Toxicology Research, vol. 2, no. 3, pp. 163-172 . https://doi.org/10.1039/c3tx20086h

مصطلحات موضوعية: 3D culture, HepG2-C3A cells, Cholesterol, Physiology, Health, Toxicology and Mutagenesis, Systems biology, Spheroid, Biology, Toxicology, Cell biology, chemistry.chemical_compound, chemistry, Glycogenesis, Toxicity, Spheroids, Mode of action, Drug metabolism, Homeostasis, toxicology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4053ffb15294539a9dc44f05c77ffa7f
https://findresearcher.sdu.dk:8443/ws/files/118365785/c3tx20086h_3.pdf

المؤلفون: Davide Mainieri, Jean-Pierre Montani, Marcel Gubler, Giovanni Solinas, Serge Summermatter, Abdul G. Dulloo, Steven R. Smith, Josiane Seydoux

مصطلحات موضوعية: Male, medicine.medical_specialty, endocrine system, Corticotropin-Releasing Hormone, Biology, Corticotropin-releasing hormone, Mice, Phosphatidylinositol 3-Kinases, Endocrinology, Lipid oxidation, Internal medicine, medicine, Animals, Protein kinase A, Muscle, Skeletal, Urocortin, Mice, Inbred BALB C, Adenylate Kinase, Skeletal muscle, Lipids, medicine.anatomical_structure, Lipotoxicity, Lipogenesis, Models, Animal, Thermogenesis, Glycolysis, hormones, hormone substitutes, and hormone antagonists, Body Temperature Regulation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ed6a2100ab79fad1fa487b835d754f
http://doc.rero.ch/record/5827/files/dulloo_crh.pdf