يعرض 1 - 10 نتائج من 29 نتيجة بحث عن '"Marcus B. Noyes"', وقت الاستعلام: 1.22s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Engineered dual selection for directed evolution of SpCas9 PAM specificity

    المؤلفون: Gregory W. Goldberg, Jeffrey M. Spencer, David O. Giganti, Brendan R. Camellato, Neta Agmon, David M. Ichikawa, Jef D. Boeke, Marcus B. Noyes

    المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

    مصطلحات موضوعية: Science

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/2041-1723

    URL الوصول: https://doaj.org/article/3e675de09c284972a7413a9b4147d955

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  2. 2
    دورية أكاديمية
    Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing

    المؤلفون: Benjamin L. Oakes, Danny F. Xia, Elizabeth F. Rowland, Denise J. Xu, Irina Ankoudinova, Jennifer S. Borchardt, Lei Zhang, Patrick Li, Jeffrey C. Miller, Edward J. Rebar, Marcus B. Noyes

    المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

    مصطلحات موضوعية: Science

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/2041-1723

    URL الوصول: https://doaj.org/article/e66bba0eeef149b0809ce032052bdf58

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  3. 3
    A universal deep-learning model for zinc finger design enables transcription factor reprogramming

    المؤلفون: David M. Ichikawa, Osama Abdin, Nader Alerasool, Manjunatha Kogenaru, April L. Mueller, Han Wen, David O. Giganti, Gregory W. Goldberg, Samantha Adams, Jeffrey M. Spencer, Rozita Razavi, Satra Nim, Hong Zheng, Courtney Gionco, Finnegan T. Clark, Alexey Strokach, Timothy R. Hughes, Timothee Lionnet, Mikko Taipale, Philip M. Kim, Marcus B. Noyes

    المصدر: Nature Biotechnology.

    مصطلحات موضوعية: Biomedical Engineering, Molecular Medicine, Bioengineering, Applied Microbiology and Biotechnology, Biotechnology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::078da30df1b51cdd076e7daf23ffe8ec
    https://doi.org/10.1038/s41587-022-01624-4

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  4. 4
    Engineered dual selection for directed evolution of SpCas9 PAM specificity

    المؤلفون: Jef D. Boeke, Marcus B. Noyes, Brendan Camellato, David M. Ichikawa, Gregory W. Goldberg, Neta Agmon, Jeffrey M. Spencer, David Giganti

    المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
    Nature Communications

    مصطلحات موضوعية: 0301 basic medicine, CRISPR-Cas9 genome editing, Streptococcus pyogenes, Science, General Physics and Astronomy, Computational biology, Biology, Protein Engineering, General Biochemistry, Genetics and Molecular Biology, Article, Substrate Specificity, 03 medical and health sciences, Negative selection, 0302 clinical medicine, stomatognathic system, CRISPR-Associated Protein 9, Cell Line, Tumor, mental disorders, parasitic diseases, Humans, Guide RNA, Amino Acid Sequence, Nucleotide Motifs, Selection (genetic algorithm), Synthetic biology, reproductive and urinary physiology, Zinc finger, Gene Editing, Multidisciplinary, Cas9, General Chemistry, Protein engineering, DNA, Directed evolution, Protospacer adjacent motif, 030104 developmental biology, Experimental evolution, Mutation, embryonic structures, Nucleic Acid Conformation, CRISPR-Cas Systems, Directed Molecular Evolution, 030217 neurology & neurosurgery, RNA, Guide, Kinetoplastida

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25762a6571ede1ec0d9d9c2b6abd77b8
    https://doaj.org/article/3e675de09c284972a7413a9b4147d955

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  5. 5
    دورية أكاديمية
    Rapid Synthesis and Screening of Chemically Activated Transcription Factors with GFP-based Reporters

    المؤلفون: R. Scott McIsaac, author1, 3, Benjamin L. Oakes, author1, David Botstein, author1, 2, Marcus B. Noyes, author1

    المصدر: Journal of Visualized Experiments. (81)

    الإتاحة: http://www.jove.com/video/51153

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  6. 6
    A physics-based energy function allows the computational redesign of a PDZ domain

    المؤلفون: Young Joo Sun, Carlos Corbi-Verge, Nicolas Panel, Vaitea Opuu, Philip M. Kim, Titus Hou, Thomas Simonson, Marcus B. Noyes, David M. Ichikawa, Ernesto J. Fuentes

    المساهمون: Laboratoire de Biologie Structurale de la Cellule (BIOC), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Carver College of Medicine [Iowa City], University of Iowa [Iowa City]

    المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
    Scientific Reports
    Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.11150. ⟨10.1038/s41598-020-67972-w⟩

    مصطلحات موضوعية: Thermal denaturation, Fold (higher-order function), Computer science, Monte Carlo method, Protein design, PDZ domain, lcsh:Medicine, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, 010402 general chemistry, Molecular mechanics, 01 natural sciences, Article, Inverse folding, Protein sequencing, Protein structure, Experimental testing, Animal disease models, 0103 physical sciences, Statistical physics, lcsh:Science, Peptide ligand, Biological models, chemistry.chemical_classification, Physics, Multidisciplinary, 010304 chemical physics, Ligand, lcsh:R, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Physics based, Circular dichroism spectra, Amino acid, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], 0104 chemical sciences, chemistry, lcsh:Q, Biological system

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c547ce2f6433948eaa712562e8d22676
    http://link.springer.com/article/10.1038/s41598-020-67972-w

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  7. 7
    A yeast optogenetic toolkit (yOTK) for gene expression control in Saccharomyces cerevisiae

    المؤلفون: Megan N. McClean, Justin Melendez, Michael T Patel, Cameron J. Stewart, Marcus B. Noyes, Jidapas My An-Adirekkun, Stephanie H. Geller, Benjamin L. Oakes

    المصدر: Biotechnol Bioeng

    مصطلحات موضوعية: Saccharomyces cerevisiae Proteins, Computer science, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Bioengineering, Computational biology, Optogenetics, Applied Microbiology and Biotechnology, Article, 03 medical and health sciences, 0302 clinical medicine, Gene Expression Regulation, Fungal, Gene expression, Basic Helix-Loop-Helix Transcription Factors, Cloning, Molecular, Promoter Regions, Genetic, Transcription factor, 030304 developmental biology, 0303 health sciences, biology, Arabidopsis Proteins, 030302 biochemistry & molecular biology, Zinc Fingers, Promoter, biology.organism_classification, Yeast, Cryptochromes, 030217 neurology & neurosurgery, Function (biology), Biological network, Transcription Factors, Biotechnology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2b434031836b9359acab53e81ec1c6
    https://doi.org/10.1002/bit.27234

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  8. 8
    A Multireporter Bacterial 2-Hybrid Assay for the High-Throughput and Dynamic Assay of PDZ Domain–Peptide Interactions

    المؤلفون: Marcus B. Noyes, David M. Ichikawa, Jamie Snider, Michael J Shen, Igor Stagljar, Philip M. Kim, Carles Corbi-Verge, Victoria Wong

    مصطلحات موضوعية: 0106 biological sciences, bacteria hybrid assay, PDZ domain, protein-protein interactions, Biomedical Engineering, PDZ Domains, Peptide, Nerve Tissue Proteins, Computational biology, 01 natural sciences, Biochemistry, Genetics and Molecular Biology (miscellaneous), Article, 03 medical and health sciences, Synthetic biology, Genes, Reporter, Peptide Library, 010608 biotechnology, Escherichia coli, Humans, Amino Acid Sequence, Throughput (business), 030304 developmental biology, Adaptor Proteins, Signal Transducing, chemistry.chemical_classification, 0303 health sciences, Chemistry, liniear motifs, screening, Sorting, General Medicine, Limiting, High-Throughput Screening Assays, Peptides, Protein Binding

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d002501242e837e58bb70fc3ead9530
    https://europepmc.org/articles/PMC6818413/

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  9. 9
    A multi-reporter bacterial 2-hybrid assay for the fast, simple, and dynamic assay of PDZ domain – peptide interactions

    المؤلفون: David M. Ichikawa, Igor Stagljar, Jamie Snider, Shen Mj, Carles Corbi-Verge, Philip M. Kim, Marcus B. Noyes, Wong

    مصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, 03 medical and health sciences, chemistry, Computer science, 030302 biochemistry & molecular biology, PDZ domain, Peptide, Sensitivity (control systems), Computational biology, 030304 developmental biology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ed42850c490daae48a85ecc60ce45914
    https://doi.org/10.1101/512566

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  10. 10
    Lineage context switches the function of aC. elegansPax6 homolog in determining a neuronal fate

    المؤلفون: Marcus B. Noyes, David M. Ichikawa, Niels Ringstad, Kristopher M. Barnes, Zhirong Bao, Julia P. Brandt, Zhuo Du, Mary Rossillo, Allison Chen

    المصدر: Development.

    مصطلحات موضوعية: Gene isoform, 0303 health sciences, animal structures, Locus (genetics), Biology, Homology (biology), Cell biology, 03 medical and health sciences, 0302 clinical medicine, Gene expression, Homeobox, PAX6, Molecular Biology, Transcription factor, Psychological repression, 030217 neurology & neurosurgery, 030304 developmental biology, Developmental Biology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::069ce10505b65c7a907d3f7eac043d0a
    https://doi.org/10.1242/dev.168153

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