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1
المؤلفون: Richard Jiao, Pasquale P. Vicario, Gabor Butora, Shankaran Kothandaraman, Stephen D. Goble, Mary Struthers, Gregori J. Morriello, Julie A. DeMartino, Sander G. Mills, Malcolm MacCoss, Julia M. Ayala, Margaret A. Cascieri, Karla L. Donnely, Changyou Zhou, Lihu Yang, Alexander Pasternak
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:1830-1834
مصطلحات موضوعية: CCR2, Receptors, CCR2, Stereochemistry, medicine.drug_class, Chemistry, Pharmaceutical, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Receptor, Molecular Biology, Amination, Molecular Structure, Chemotaxis, Organic Chemistry, Tetrahydropyran, Macaca mulatta, Rats, Models, Chemical, chemistry, Design synthesis, Drug Design, Molecular Medicine
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2
المؤلفون: Margaret A. Cascieri, Sander G. Mills, Malcolm MacCoss, Pasquale P. Vicario, H J Zweerink, William H. Parsons, Lihu Yang, Martin S. Springer, Liangqin Guo, Changyou Zhou
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:309-314
مصطلحات موضوعية: CCR2, Receptors, CCR2, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, CHO Cells, In Vitro Techniques, Biochemistry, Monocytes, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Cricetulus, Dogs, Neurokinin-1 Receptor Antagonists, Aminothiazole, Cricetinae, Drug Discovery, medicine, Animals, Humans, Receptor, Molecular Biology, IC50, Chemokine CCL2, Chromatography, High Pressure Liquid, Membranes, Trifluoromethyl, Chemotaxis, Monocyte, Organic Chemistry, Stereoisomerism, Small molecule, Rats, medicine.anatomical_structure, chemistry, Drug Design, Molecular Medicine, Indicators and Reagents, Receptors, Chemokine
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3
المؤلفون: Deodialsingh Guiadeen, William H. Parsons, Pasquale P. Vicario, Gregori J. Morriello, Malcolm MacCoss, Margaret A. Cascieri, Shankaran Kothandaraman, Alexander Pasternak, Lihu Yang, Gabor Butora
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:4715-4722
مصطلحات موضوعية: CCR2, Alkylation, Receptors, CCR2, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Alicyclic compound, Cricetinae, Drug Discovery, Animals, Humans, Receptor, Molecular Biology, Cells, Cultured, Alkyl, Amination, chemistry.chemical_classification, Trifluoromethyl, Molecular Structure, Organic Chemistry, Amides, Small molecule, Rats, chemistry, Molecular Medicine, Receptors, Chemokine, Selectivity, Lead compound
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4
المؤلفون: Gary G. Chicchi, Paul E. Finke, Joseph M. Metzger, Dorothy Levorse, Malcolm MacCoss, Margaret A. Cascieri, D. Euan MacIntyre, Laura C. Meurer, Kwei-Lan Tsao, Sharon Sadowski, Sander G. Mills
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:4497-4503
مصطلحات موضوعية: Molecular Structure, Tertiary amine, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Ether, Cyclopentanes, Receptors, Neurokinin-1, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Neurokinin-1 Receptor Antagonists, Solubility, chemistry, Morpholine, Drug Discovery, Humans, Molecular Medicine, Molecule, Structure–activity relationship, Cyclopentane, Molecular Biology
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5
المؤلفون: Margaret A. Cascieri, Salvatore J. Siciliano, Karen Holmes, Sandra L. Gould, Kevin T. Chapman, William A. Schleif, J. J. Hale, Richard J. Budhu, Renee Danzeisen, Joseph Kessler, Anthony Carella, Julie A. DeMartino, Christopher A. Willoughby, Daria J. Hazuda, Sander G. Mills, Malcolm MacCoss, Michael W. Miller, Janet Lineberger, Emilio A. Emini, Lorraine Malkowitz, Keith G. Rosauer, Martin S. Springer, Gwen Carver
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:427-431
مصطلحات موضوعية: Pyrrolidines, Anti-HIV Agents, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, CHO Cells, CCR5 receptor antagonist, Biochemistry, Chemical synthesis, Pyrrolidine, chemistry.chemical_compound, Piperidines, In vivo, Cricetinae, Drug Discovery, Side chain, Animals, Humans, Chemokine CCL4, Molecular Biology, Organic Chemistry, Antagonist, Hydrogen Bonding, Macrophage Inflammatory Proteins, In vitro, Rats, chemistry, CCR5 Receptor Antagonists, Molecular Medicine, Piperidine, Half-Life, HeLa Cells
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6
المؤلفون: Emilio A. Emini, Julie A. DeMartino, Salvatore J. Siciliano, Karen Holmes, Gwen Carver, Sandra L. Gould, Kevin T. Chapman, Anthony Carella, Renee Danzeisen, Michael W. Miller, Joseph Kessler, Malcolm MacCoss, Christopher L. Lynch, Daria J. Hazuda, Sander G. Mills, Janet Lineberger, Lorraine Malkowitz, Amy Gentry, Richard J. Budhu, Jeffrey J. Hale, William A. Schleif, Margaret A. Cascieri, Martin S. Springer
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:3001-3004
مصطلحات موضوعية: Cell Membrane Permeability, Pyrrolidines, Chemical Phenomena, Anti-HIV Agents, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, CHO Cells, CCR5 receptor antagonist, Biochemistry, Chemical synthesis, Pyrrolidine, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Cricetinae, Drug Discovery, Animals, Humans, Structure–activity relationship, Chemokine CCL4, Molecular Biology, Chemistry, Physical, Chemistry, Chinese hamster ovary cell, Organic Chemistry, Antagonist, Macrophage Inflammatory Proteins, In vitro, Rats, CCR5 Receptor Antagonists, HIV-1, Molecular Medicine, Indicators and Reagents, HeLa Cells
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7
المؤلفون: Gary G. Chicchi, Barry R. Cunningham, Michelle K. Clements, Marc M. Kurtz, Ruiping Wang, Qingyun Liu, Christopher P. Austin, Margaret A. Cascieri
المصدر: Gene. 296:205-212
مصطلحات موضوعية: Male, Molecular Sequence Data, Peptide, Substance P, CHO Cells, Biology, Cleavage (embryo), Binding, Competitive, Mice, Radioligand Assay, chemistry.chemical_compound, Cricetinae, Tachykinins, Databases, Genetic, Genetics, medicine, Animals, Humans, heterocyclic compounds, Amino Acid Sequence, Protein Precursors, Receptor, Gene, Receptors, Tachykinin, B cell, chemistry.chemical_classification, Dose-Response Relationship, Drug, Sequence Homology, Amino Acid, Gene Expression Profiling, Receptors, Neurokinin-3, Receptors, Neurokinin-2, General Medicine, Receptors, Neurokinin-1, Peptide Fragments, Rats, Gene expression profiling, medicine.anatomical_structure, chemistry, Biochemistry, Female, Tachykinin receptor, Sequence Alignment
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8
المؤلفون: Margaret A. Cascieri
المصدر: Nature Reviews Drug Discovery. 1:122-130
مصطلحات موضوعية: medicine.medical_specialty, Arteriosclerosis, medicine.drug_class, Anti-Inflammatory Agents, Coronary Disease, Disease, Bioinformatics, Anti-inflammatory, Coronary artery disease, chemistry.chemical_compound, Cell Movement, Internal medicine, Drug Discovery, Leukocytes, medicine, Humans, Cause of death, Pharmacology, Cholesterol, business.industry, Macrophages, General Medicine, Cell movement, medicine.disease, Disease Models, Animal, chemistry, Cardiology, Lipid lowering, Inflammation Mediators, business, Foam Cells
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9
المؤلفون: Jerry Di Salvo, Allan D. Blake, Martin S. Springer, Julie A. DeMartino, Anna Sirotina-Meisher, Bruce L. Daugherty, Margaret A. Cascieri, Greg E. Koch, Kathleen A. Sullivan, Kristine E. Johnson, Yong Liu
المصدر: European Journal of Pharmacology. 409:143-154
مصطلحات موضوعية: Receptors, CXCR4, T-Lymphocytes, Gene Expression, CHO Cells, GTP-Binding Protein alpha Subunits, Gi-Go, Biology, Binding, Competitive, Jurkat cells, Jurkat Cells, Chemokine receptor, Cricetinae, Cyclic AMP, Animals, Humans, Virulence Factors, Bordetella, Binding site, Receptor, Pharmacology, Dose-Response Relationship, Drug, Ligand binding assay, Chinese hamster ovary cell, Colforsin, Ligand (biochemistry), Virology, Chemokine CXCL12, Cell biology, Pertussis Toxin, Guanosine 5'-O-(3-Thiotriphosphate), Leukocytes, Mononuclear, Signal transduction, Chemokines, CXC, Signal Transduction
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10
المؤلفون: Linda Brockunier, Ann E. Weber, Suresh B. Singh, Michael H. Fisher, Mari R. Candelore, Yong Liu, Liping Deng, Laurie Tota, Margaret A. Cascieri, Jiafang He, Emma R. Parmee, Matthew J. Wyvratt
المصدر: Bioorganic & Medicinal Chemistry Letters. 10:2283-2286
مصطلحات موضوعية: Models, Molecular, Agonist, Adrenergic receptor, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Adrenergic, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Structure–activity relationship, Moiety, Receptor, Molecular Biology, Bicyclic molecule, Chemistry, Organic Chemistry, Adrenergic beta-Agonists, Isoquinolines, Amides, Recombinant Proteins, Drug Design, Receptors, Adrenergic, beta-3, Molecular Medicine, Adrenergic beta-3 Receptor Antagonists, Receptors, Adrenergic, beta-2, Receptors, Adrenergic, beta-1, Peptides
