لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Acker BA; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Badescu VO; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Berkenpas MB; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Groppi VE; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Hajós M; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Higdon NR; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Hurst RS; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Jon Jacobsen E; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Margolis BJ; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., McWhorter WW; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Myers JK; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Piotrowski DW; Pfizer Worldwide Research & Development, Groton, CT 06340, USA. Electronic address: david.w.piotrowski@comcast.net., Rogers BN; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Sarapa D; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Vetman TN; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Walker DP; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Wall TM; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Wilhite DM; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Wishka DG; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Xu W; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Yates KM; Pfizer Worldwide Research & Development, Groton, CT 06340, USA.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Sep 01; Vol. 93, pp. 129433. Date of Electronic Publication: 2023 Aug 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: alpha7 Nicotinic Acetylcholine Receptor* , Receptors, Nicotinic*, Rats ; Animals ; Hippocampus ; Phenylurea Compounds/chemistry ; Isoxazoles/pharmacology ; Isoxazoles/chemistry ; Allosteric Regulation

المؤلفون: Vidler LR; Research and Development, Eli Lilly and Company, Ltd., Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom., Watson IA; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Margolis BJ; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Cummins DJ; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Brunavs M; Research and Development, Eli Lilly and Company, Ltd., Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Jul 10; Vol. 9 (8), pp. 792-796. Date of Electronic Publication: 2018 Jul 10 (Print Publication: 2018).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Fales KR; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Njoroge FG; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Brooks HB; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Thibodeaux S; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Torrado A; Centro de Investigación Lilly , S. A., Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain., Si C; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Toth JL; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Mc Cowan JR; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Roth KD; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Thrasher KJ; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Frimpong K; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Lee MR; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Dally RD; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Shepherd TA; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Durham TB; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Margolis BJ; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Wu Z; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Wang Y; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Atwell S; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Wang J; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Hui YH; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Meier TI; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Konicek SA; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Geeganage S; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2017 Dec 14; Vol. 60 (23), pp. 9599-9616. Date of Electronic Publication: 2017 Nov 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemistry , Antineoplastic Agents/*therapeutic use , Folic Acid Antagonists/*chemistry , Folic Acid Antagonists/*therapeutic use , Phosphoribosylaminoimidazolecarboxamide Formyltransferase/*antagonists & inhibitors , Triple Negative Breast Neoplasms/*drug therapy, Animals ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Breast/drug effects ; Breast/metabolism ; Breast/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Discovery ; Female ; Folic Acid Antagonists/pharmacokinetics ; Folic Acid Antagonists/pharmacology ; Humans ; Male ; Mice ; Mice, Nude ; Models, Molecular ; Phosphoribosylaminoimidazolecarboxamide Formyltransferase/metabolism ; Sulfonamides/chemistry ; Sulfonamides/pharmacokinetics ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Thiophenes/chemistry ; Thiophenes/pharmacokinetics ; Thiophenes/pharmacology ; Thiophenes/therapeutic use ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology

المؤلفون: Strelow JM; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA strelow_john_mark@lilly.com., Xiao M; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Cavitt RN; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Fite NC; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Margolis BJ; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Park KJ; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.

المصدر: Journal of biomolecular screening [J Biomol Screen] 2016 Sep; Vol. 21 (8), pp. 786-94. Date of Electronic Publication: 2016 Jul 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9612112 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-454X (Electronic) Linking ISSN: 10870571 NLM ISO Abbreviation: J Biomol Screen Subsets: MEDLINE

مواضيع طبية MeSH: High-Throughput Screening Assays/*methods , Histone-Lysine N-Methyltransferase/*metabolism , Nucleosomes/*genetics , Peptides/*isolation & purification, Adenosine/analogs & derivatives ; Adenosine/metabolism ; DNA Damage/genetics ; Histone-Lysine N-Methyltransferase/genetics ; Histones/genetics ; Humans ; Lysine/genetics ; Nucleosomes/metabolism ; PR-SET Domains/genetics ; Peptides/genetics ; Protein Binding ; Structure-Activity Relationship ; Substrate Specificity

المؤلفون: Gao C; Lilly Research Laboratories, Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Margolis BJ; Lilly Research Laboratories, Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Strelow JM; Lilly Research Laboratories, Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Vidler LR; Research and Development, Eli Lilly and Company Ltd. , Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom., Mader MM; Lilly Research Laboratories, Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Nov 19; Vol. 7 (2), pp. 156-61. Date of Electronic Publication: 2015 Nov 19 (Print Publication: 2016).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Liu S; Pfizer Inc., Pfizer Global Research and Development, Groton, CT 06340, United States. shenping.liu@pfizer.com, Babcock MS, Bode J, Chang JS, Fischer HD, Garlick RL, Gill GS, Lund ET, Margolis BJ, Mathews WR, Rogers BN, Wolfe M, Groppi V, Baldwin ET

المصدر: Protein expression and purification [Protein Expr Purif] 2011 Sep; Vol. 79 (1), pp. 102-10. Date of Electronic Publication: 2011 Jun 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0279 (Electronic) Linking ISSN: 10465928 NLM ISO Abbreviation: Protein Expr Purif Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Nicotinic/*genetics , Receptors, Nicotinic/*isolation & purification , Recombinant Fusion Proteins/*genetics , Recombinant Fusion Proteins/*isolation & purification, Amino Acid Sequence ; Animals ; Chromatography, Affinity ; HEK293 Cells ; Humans ; Mice ; Molecular Sequence Data ; Nicotinic Agonists/metabolism ; Nicotinic Antagonists/metabolism ; Protein Binding ; Receptors, Nicotinic/metabolism ; Recombinant Fusion Proteins/metabolism ; Ultracentrifugation ; alpha7 Nicotinic Acetylcholine Receptor

المؤلفون: Margolis BJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. margolis_brandon_j@lilly.com, Long KA, Laird DL, Ruble JC, Pulley SR

المصدر: The Journal of organic chemistry [J Org Chem] 2007 Mar 16; Vol. 72 (6), pp. 2232-5. Date of Electronic Publication: 2007 Feb 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-3263 (Print) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE

مواضيع طبية MeSH: Aminoquinolines/*chemical synthesis, Amines/chemistry ; Catalysis ; Methods ; Palladium/chemistry ; Quinolines/chemistry