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1دورية أكاديمية
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2دورية أكاديمية
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3دورية أكاديمية
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4دورية أكاديمية
المؤلفون: Acker BA; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Badescu VO; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Berkenpas MB; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Groppi VE; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Hajós M; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Higdon NR; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Hurst RS; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Jon Jacobsen E; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Margolis BJ; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., McWhorter WW; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Myers JK; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Piotrowski DW; Pfizer Worldwide Research & Development, Groton, CT 06340, USA. Electronic address: david.w.piotrowski@comcast.net., Rogers BN; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Sarapa D; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Vetman TN; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Walker DP; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Wall TM; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Wilhite DM; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Wishka DG; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Xu W; Pfizer Worldwide Research & Development, Groton, CT 06340, USA., Yates KM; Pfizer Worldwide Research & Development, Groton, CT 06340, USA.
المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Sep 01; Vol. 93, pp. 129433. Date of Electronic Publication: 2023 Aug 07.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
مواضيع طبية MeSH: alpha7 Nicotinic Acetylcholine Receptor* , Receptors, Nicotinic*, Rats ; Animals ; Hippocampus ; Phenylurea Compounds/chemistry ; Isoxazoles/pharmacology ; Isoxazoles/chemistry ; Allosteric Regulation
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5دورية أكاديمية
المؤلفون: Vidler LR; Research and Development, Eli Lilly and Company, Ltd., Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom., Watson IA; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Margolis BJ; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Cummins DJ; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Brunavs M; Research and Development, Eli Lilly and Company, Ltd., Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom.
المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Jul 10; Vol. 9 (8), pp. 792-796. Date of Electronic Publication: 2018 Jul 10 (Print Publication: 2018).
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
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6دورية أكاديمية
المؤلفون: Fales KR; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Njoroge FG; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Brooks HB; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Thibodeaux S; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Torrado A; Centro de Investigación Lilly , S. A., Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain., Si C; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Toth JL; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Mc Cowan JR; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Roth KD; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Thrasher KJ; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Frimpong K; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Lee MR; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Dally RD; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Shepherd TA; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Durham TB; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Margolis BJ; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Wu Z; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Wang Y; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Atwell S; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Wang J; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Hui YH; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Meier TI; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Konicek SA; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Geeganage S; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States.
المصدر: Journal of medicinal chemistry [J Med Chem] 2017 Dec 14; Vol. 60 (23), pp. 9599-9616. Date of Electronic Publication: 2017 Nov 09.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
مواضيع طبية MeSH: Antineoplastic Agents/*chemistry , Antineoplastic Agents/*therapeutic use , Folic Acid Antagonists/*chemistry , Folic Acid Antagonists/*therapeutic use , Phosphoribosylaminoimidazolecarboxamide Formyltransferase/*antagonists & inhibitors , Triple Negative Breast Neoplasms/*drug therapy, Animals ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Breast/drug effects ; Breast/metabolism ; Breast/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Discovery ; Female ; Folic Acid Antagonists/pharmacokinetics ; Folic Acid Antagonists/pharmacology ; Humans ; Male ; Mice ; Mice, Nude ; Models, Molecular ; Phosphoribosylaminoimidazolecarboxamide Formyltransferase/metabolism ; Sulfonamides/chemistry ; Sulfonamides/pharmacokinetics ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Thiophenes/chemistry ; Thiophenes/pharmacokinetics ; Thiophenes/pharmacology ; Thiophenes/therapeutic use ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology
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7دورية أكاديمية
المؤلفون: Strelow JM; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA strelow_john_mark@lilly.com., Xiao M; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Cavitt RN; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Fite NC; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Margolis BJ; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Park KJ; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.
المصدر: Journal of biomolecular screening [J Biomol Screen] 2016 Sep; Vol. 21 (8), pp. 786-94. Date of Electronic Publication: 2016 Jul 01.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9612112 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-454X (Electronic) Linking ISSN: 10870571 NLM ISO Abbreviation: J Biomol Screen Subsets: MEDLINE
مواضيع طبية MeSH: High-Throughput Screening Assays/*methods , Histone-Lysine N-Methyltransferase/*metabolism , Nucleosomes/*genetics , Peptides/*isolation & purification, Adenosine/analogs & derivatives ; Adenosine/metabolism ; DNA Damage/genetics ; Histone-Lysine N-Methyltransferase/genetics ; Histones/genetics ; Humans ; Lysine/genetics ; Nucleosomes/metabolism ; PR-SET Domains/genetics ; Peptides/genetics ; Protein Binding ; Structure-Activity Relationship ; Substrate Specificity
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8دورية أكاديمية
المؤلفون: Gao C; Lilly Research Laboratories, Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Margolis BJ; Lilly Research Laboratories, Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Strelow JM; Lilly Research Laboratories, Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Vidler LR; Research and Development, Eli Lilly and Company Ltd. , Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom., Mader MM; Lilly Research Laboratories, Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States.
المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Nov 19; Vol. 7 (2), pp. 156-61. Date of Electronic Publication: 2015 Nov 19 (Print Publication: 2016).
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
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9دورية أكاديمية
المؤلفون: Liu S; Pfizer Inc., Pfizer Global Research and Development, Groton, CT 06340, United States. shenping.liu@pfizer.com, Babcock MS, Bode J, Chang JS, Fischer HD, Garlick RL, Gill GS, Lund ET, Margolis BJ, Mathews WR, Rogers BN, Wolfe M, Groppi V, Baldwin ET
المصدر: Protein expression and purification [Protein Expr Purif] 2011 Sep; Vol. 79 (1), pp. 102-10. Date of Electronic Publication: 2011 Jun 02.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0279 (Electronic) Linking ISSN: 10465928 NLM ISO Abbreviation: Protein Expr Purif Subsets: MEDLINE
مواضيع طبية MeSH: Receptors, Nicotinic/*genetics , Receptors, Nicotinic/*isolation & purification , Recombinant Fusion Proteins/*genetics , Recombinant Fusion Proteins/*isolation & purification, Amino Acid Sequence ; Animals ; Chromatography, Affinity ; HEK293 Cells ; Humans ; Mice ; Molecular Sequence Data ; Nicotinic Agonists/metabolism ; Nicotinic Antagonists/metabolism ; Protein Binding ; Receptors, Nicotinic/metabolism ; Recombinant Fusion Proteins/metabolism ; Ultracentrifugation ; alpha7 Nicotinic Acetylcholine Receptor
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10دورية أكاديمية
المؤلفون: Margolis BJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. margolis_brandon_j@lilly.com, Long KA, Laird DL, Ruble JC, Pulley SR
المصدر: The Journal of organic chemistry [J Org Chem] 2007 Mar 16; Vol. 72 (6), pp. 2232-5. Date of Electronic Publication: 2007 Feb 13.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-3263 (Print) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE
مواضيع طبية MeSH: Aminoquinolines/*chemical synthesis, Amines/chemistry ; Catalysis ; Methods ; Palladium/chemistry ; Quinolines/chemistry