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المؤلفون: Geoffrey Chan, Mohammed Naveed Shaik, Tomoki Naoe, Yosuke Fujii, Wataru Munakata, Toshihiro Miyamoto, Adrian Woolfson, Goichi Yoshimoto, Yosuke Minami, Yukio Kobayashi, Xianxian Zheng, Chiho Ono, Mari Ikuta, Hironobu Minami, Masahiro Kobayashi, Yasushi Onishi
المصدر: Cancer Science
مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Cancer Research, Administration, Oral, Pharmacology, 0302 clinical medicine, Japan, Aged, 80 and over, biology, General Medicine, Middle Aged, Hedgehog signaling pathway, Gene Expression Regulation, Neoplastic, Treatment Outcome, 030220 oncology & carcinogenesis, Hematologic Neoplasms, Original Article, Female, medicine.symptom, medicine.medical_specialty, Maximum Tolerated Dose, Glasdegib, Antineoplastic Agents, Zinc Finger Protein GLI1, Drug Administration Schedule, 03 medical and health sciences, smoothened, Pharmacokinetics, GLI1, Clinical Research, Internal medicine, medicine, Humans, hedgehog signaling pathway, Adverse effect, Aged, Dose-Response Relationship, Drug, business.industry, Phenylurea Compounds, Original Articles, hematologic malignancies, Dysgeusia, Clinical trial, 030104 developmental biology, Pharmacodynamics, biology.protein, Japanese, Benzimidazoles, business, Smoothened
وصف الملف: application/pdf
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المؤلفون: James Hardwick, Xianzhi Mao, Constanine Kreatsoulas, Eileen S. Walsh, Sanjeev Munshi, Marc Abrams, George D. Hartman, Laura Sepp-Lorenzino, Mark E. Fraley, Rob Lobell, Kelly Hamilton, Lawrence Kuo, Carolyn A. Buser, Weikang Tao, Robert M. Garbaccio, Mari Ikuta, Keith W. Rickert, Edward S. Tasber, Bob Drakas, Steve Stirdivant, Stephen C. Beck, Shaei Huang, Youwei Yan
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:6280-6285
مصطلحات موضوعية: Models, Molecular, Photochemistry, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Apoptosis, Quinolones, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Residue (chemistry), Cell Line, Tumor, Drug Discovery, Humans, Transferase, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, Molecular Structure, biology, Organic Chemistry, Enzyme, chemistry, Enzyme inhibitor, Checkpoint Kinase 1, Lactam, biology.protein, Molecular Medicine, Amine gas treating, Protein Kinases
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المؤلفون: Keith Lee Spencer, Barbara Hanney, Eileen S. Walsh, George D. Hartman, Stephen C. Beck, Carolyn A. Buser, Weikang Tao, Robert B. Lobell, Youwei Yan, Lawrence C. Kuo, Kenneth L. Arrington, Edward J. Brnardic, Mari Ikuta, Sanjeev Munshi, Mark E. Fraley, Constantine Kreatsoulas, Justin T. Steen, Bob Drakas, Laura Sepp-Lorenzino, Kelly Hamilton, Yuntae Kim, Xianzhi Mao, James Hardwick, Steven M. Stirdivant, Keith W. Rickert
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:6049-6053
مصطلحات موضوعية: Models, Molecular, Indazoles, Stereochemistry, Clinical Biochemistry, Triazole, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Structure–activity relationship, Moiety, Potency, Hydroxymethyl, Protein Kinase Inhibitors, Molecular Biology, Indazole, Molecular Structure, biology, Cell Cycle, Organic Chemistry, chemistry, Enzyme inhibitor, Checkpoint Kinase 1, biology.protein, Molecular Medicine, Selectivity, Protein Kinases
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المؤلفون: Eileen S. Walsh, Steve Stirdivant, George D. Hartman, Kelly Hamilton, Marc Abrams, Robert M. Garbaccio, Laura Sepp-Lorenzino, Lawrence Kuo, Steve Beck, Joan Zugay Murphy, Constantine Kreatsoulas, Justin T. Steen, Sanjeev Munshi, Carolyn A. Buser, Weikang Tao, Shaei Huang, Youwei Yan, V V Sardana, Bob Drakas, Mari Ikuta, James Hardwick, Keith W. Rickert, Mark E. Fraley, Elizabeth Mahan, Xianzhi Mao, Rob Lobell, Michael Reilly
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:5907-5912
مصطلحات موضوعية: Indoles, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Quinolones, Crystallography, X-Ray, Biochemistry, Polar surface area, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Enzyme Inhibitors, Binding site, Molecular Biology, Cell potency, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, Active site, Enzyme, chemistry, Enzyme inhibitor, Drug Design, Checkpoint Kinase 1, biology.protein, Molecular Medicine, Hydrophobic and Hydrophilic Interactions, Protein Kinases
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المؤلفون: Nobuhiko Kawanishi, Jun Shibata, Tetsuya Sugimoto, Hiroshi Hirai, Mari Ikuta, Kaori Nakamura, Kouta Masutani
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:5122-5126
مصطلحات موضوعية: Macrocyclic Compounds, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Cyclin-dependent kinase, Quinoxalines, CDC2 Protein Kinase, Drug Discovery, CDC2-CDC28 Kinases, Animals, Humans, Structure–activity relationship, Molecular Biology, Binding Sites, Molecular Structure, biology, Chemistry, Cyclin-Dependent Kinase 2, Organic Chemistry, Cyclin-Dependent Kinase 4, Hydrogen Bonding, Cyclin-Dependent Kinase 6, Enzyme inhibitor, Drug Design, biology.protein, Lactam, Molecular Medicine, Cyclin-dependent kinase 6, biological phenomena, cell phenomena, and immunity, CDK inhibitor
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المؤلفون: Shinichi Kawaguchi, Mari Ikuta, Tsuneko Okazaki, Shuya Fukai, Hitoshi Kurumizaka, Osamu Nureki, Shigeyuki Yokoyama, Junji Iwahara, Yoshinori Tanaka
المصدر: The EMBO Journal. 20:6612-6618
مصطلحات موضوعية: Models, Molecular, Chromosomal Proteins, Non-Histone, Centromere, Molecular Sequence Data, Centromere protein B, Helix-turn-helix, Protein-DNA complex, Biology, Crystallography, X-Ray, Autoantigens, DNA-binding protein, Article, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Escherichia coli, Animals, Humans, Amino Acid Sequence, Molecular Biology, Binding Sites, Base Sequence, General Immunology and Microbiology, General Neuroscience, DNA, DNA-binding domain, Molecular biology, Chromatin, Recombinant Proteins, Protein Structure, Tertiary, DNA-Binding Proteins, chemistry, Helix, Biophysics, Nucleic Acid Conformation, lipids (amino acids, peptides, and proteins), Centromere Protein B, Protein Binding
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المؤلفون: Chinatsu Ikeura, Takashi Hayama, Hajime Morishima, Tetsuya Aoyama, Takumitsu Machida, Ikuko Suzuki-Takahashi, Toshiharu Iwama, Susumu Nishimura, Teruki Honma, Kyoko Hayashi, Kazuhiro Fukasawa, Noriaki Hashimoto, Mari Ikuta, Yoshikazu Iwasawa
المصدر: Journal of Medicinal Chemistry. 44:4615-4627
مصطلحات موضوعية: Models, Molecular, Library design, Scaffold, Magnetic Resonance Spectroscopy, Molecular model, Pyridines, Stereochemistry, Design strategy, Isoindoles, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Structure-Activity Relationship, Proto-Oncogene Proteins, Drug Discovery, CDC2-CDC28 Kinases, Combinatorial Chemistry Techniques, Urea, Structure–activity relationship, Homology modeling, Enzyme Inhibitors, Binding site, Fluorenes, Chemistry, Cyclin-Dependent Kinase 2, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinases, Docking (molecular), Drug Design, Molecular Medicine, biological phenomena, cell phenomena, and immunity, Protein Binding
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المؤلفون: Teruki Honma, Takumitsu Machida, Ikuko Suzuki-Takahashi, Hiroshi Hirai, Kazuhiro Fukasawa, Mari Ikuta, Kenji Kamata, Susumu Nishimura, Takashi Hayama
المصدر: Journal of Biological Chemistry. 276:27548-27554
مصطلحات موضوعية: Models, Molecular, endocrine system diseases, Molecular Conformation, Substituent, Biology, Crystallography, X-Ray, Biochemistry, chemistry.chemical_compound, Cyclin-dependent kinase, Proto-Oncogene Proteins, Transferase, Enzyme Inhibitors, neoplasms, Molecular Biology, Cyclin, integumentary system, Kinase, Cyclin-dependent kinase 4, Cyclin-dependent kinase 2, Cyclin-Dependent Kinase 4, Genetic Alteration, Hydrogen Bonding, Cell Biology, Cyclin-Dependent Kinases, enzymes and coenzymes (carbohydrates), Crystallography, chemistry, biology.protein, biological phenomena, cell phenomena, and immunity
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280b37a1bf28a7fa253be9c3a8a06130
https://doi.org/10.1074/jbc.m102060200 -
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المؤلفون: Noel Byrne, Sanjeev Munshi, Sujata Sharma, Kaoru Funabashi, Sangita B. Patel, Mari Ikuta, Tomoko Sunami, Yoshikazu Iwasawa, Ronald E. Diehl, Joan Zugay-Murphy, Kevin J. Lumb, Jennifer M. Shipman, Robert F. Smith, Ikuko Takahashi, Dawn L. Hall
المصدر: The Journal of biological chemistry. 285(7)
مصطلحات موضوعية: Materials science, P70-S6 Kinase 1, Plasma protein binding, Crystallography, X-Ray, Biochemistry, Polymerase Chain Reaction, Protein Structure, Secondary, Ribosomal s6 kinase, Protein structure, medicine, Glucose homeostasis, Staurosporine, Humans, Phosphorylation, Molecular Biology, biology, Ribosomal Protein S6 Kinases, 70-kDa, Cell Biology, Cell biology, Protein kinase domain, Protein Structure and Folding, biology.protein, Chromatography, Gel, Protein Multimerization, Ultracentrifugation, medicine.drug, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad9662dff264b9ac1ee8e95fb821017
https://pubmed.ncbi.nlm.nih.gov/19864428 -
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المؤلفون: Hidehito Kotani, Mari Ikuta, Maria Kornienko, Noel Byrne, Shinji Mizuarai, John C. Reid, Sanjeev Munshi
المصدر: Protein science : a publication of the Protein Society. 16(12)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Protein Conformation, Amino Acid Motifs, Mitogen-activated protein kinase kinase, Crystallography, X-Ray, Ligands, Biochemistry, Ribosomal Protein S6 Kinases, 90-kDa, Protein Structure, Secondary, Article, MAP2K7, Adenosine Triphosphate, Catalytic Domain, Humans, c-Raf, Molecular Biology, Serine/threonine-specific protein kinase, Binding Sites, biology, Cyclin-dependent kinase 2, Staurosporine, Protein Structure, Tertiary, Purines, Cyclin-dependent kinase complex, biology.protein, Cyclin-dependent kinase 9, Casein kinase 2, Hydrophobic and Hydrophilic Interactions