المؤلفون: Erin M. Duffy, Nadia R. Cohen, Su L. Chiang, Ed T. Buurman, Maria Uria-Nickelsen, Richard A. Alm

المصدر: ACS Infectious Diseases. 7:2043-2049

مصطلحات موضوعية: 0303 health sciences, Research groups, Modalities, Bacteria, 030306 microbiology, Microbiota, Anti-Bacterial Agents, 3. Good health, Unmet needs, 03 medical and health sciences, Infectious Diseases, Biopharmaceutical, General partnership, Drug Discovery, Drug Resistance, Bacterial, Portfolio, Business, Microbiome, Marketing, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495d91af336e507954cc87812d30b5ef
https://doi.org/10.1021/acsinfecdis.1c00331

المؤلفون: Michael Boehnke, Anke R. Hammerschlag, Stavroula Kanoni, Nilesh J. Samani, Stefan Blankenberg, Arpana Agrawal, Ersin Yavas, Chris Hsu, Dominique Arveiler, Giovanni Veronesi, Sarah E. Harris, Guillaume Lettre, Leah Wetherill, Helen R. Warren, M Samuel, Manav Kapoor, Praveen Surendran, Mengzhen Liu, Massimo Mangino, Abdulla Al Shafi Majumder, Chiara Batini, Jeff Haessler, Anton J. M. De Craen, Matt McGue, Laura J. Bierut, Yi Ling Chou, Markku Laakso, Ian J. Deary, Rebecca Rohde, Nhung Le, David Schlessinger, J. Dylan Weissenkampen, Claudia Langenberg, Tim D. Spector, Paul W. Franks, John P. Rice, Philippe M. Frossard, Hanieh Yaghootkar, Janie Corley, Frank Kee, J. Wouter Jukema, Pim van der Harst, Dermot F. Reily, Jenny Chang-Claude, Nicholas G. Martin, Tatiana Foroud, Sune F. Nielsen, Charles Kooperberg, Rudolf A. de Boer, Francesco Cucca, Paul D.P. Pharoah, Alex P. Reiner, Daniel R. Barnes, Anders Mälarstig, Jonathan Marten, Henry Völzke, Yu Jiang, Jukka Kontto, J Danesh, Antonis C. Antoniou, Andrew C. Heath, Nicholas J. Wareham, Joanna M. M. Howson, Alison Goate, Olov Rolandsson, Frida Renström, Chu Chen, Vinicius Tragante, Matt J. Neville, Kathleen Stirrups, Clemens Baumbach, Colin N. A. Palmer, Adam S. Butterworth, William G. Iacono, Naveed Sattar, Ian P. Hall, Daniel O. Stram, Giorgio Pistis, Jan-Håkan Jansson, Jaakko Kaprio, David R. Weir, David P. Strachan, Martin D. Tobin, Folkert W. Asselbergs, John M. Starr, Stefan Weiss, Thomas F. Vogt, Riccardo E. Marioni, Maarten Hoek, Jessica Tyrrell, Hilary A. Tindle, Alison M. Dunning, Anu Loukola, Joe Dennis, Victoria E. Jackson, Louise V. Wain, Eleftheria Zeggini, Weihua Zhang, Yaming Shao, Kari Kuulasmaa, Elisabeth Altmaier, Jean-Claude Tardif, Jian Gong, A. Mesut Erzurumluoglu, Andries R. van der Leij, Kari E. North, Anna F. Dominiczak, Martina Müller-Nurasyid, Scott I. Vrieze, Sarah Bertelsen, Markus Perola, Evangelos Evangelou, Chris J. Packard, Gonçalo R. Abecasis, Robert A. Scott, S. Trompet, Jennifer A. Smith, H. Steven Scholte, Timothy M. Frayling, Danielle Posthuma, Ian Ford, Douglas F. Easton, Børge Grønne Nordestgaard, Michiel L. Bots, Charles B. Eaton, Sharon L.R. Kardia, Dewan S. Alam, Xiaowei Zhan, Sean P. David, Maria Uria-Nickelsen, Dongbing Lai, Ilonca Vaartjes, Mark J. Caulfield, Valérie Turcot, Jean Ferrières, Emanuele Di Angelantonio, Robin Young, Pamela A. F. Madden, Tibor V. Varga, Asif Rasheed, Peter van der Meer, Dajiang J. Liu, Ioanna Tachmazidou, Panos Deloukas, Danish Saleheen, Evelin Mihailov, Caroline Hayward, Patricia B. Munroe, Beenish Qaiser, Jessica D. Faul, John C. Chambers, Matthias Nauck, Niek Verweij, Jordan M. Hughey, Christopher A. Haiman, Hans J. Grabe, Muriel Caslake, Saima Afaq, Jaspal S. Kooner, Tinca J. C. Polderman, Philippe Amouyel, Wei Zhao, Göran Hallmans, Andres Metspalu, Jarmo Virtamo, Carl A. Melbourne, Kaixin Zhou, Christiaan de Leeuw, Peter S. Sever, Eirini Marouli, Neil Poulter, Rajiv Chowdhury, Jian'an Luan, Deborah J. Thompson, F Karpe, Kyriaki Michailidou, David M. Brazel, Heather M. Stringham

المساهمون: Brein en Cognitie (Psychologie, FMG), Psychology Other Research (FMG), Human genetics, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Reproduction & Development (AR&D), Cardiovascular Centre (CVC), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), Graduate School, Experimental Vascular Medicine, ACS - Diabetes & metabolism, Amsterdam Cardiovascular Sciences, ACS - Atherosclerosis & ischemic syndromes, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, Laboratory Genetic Metabolic Diseases, Gastroenterology and Hepatology, Experimental Immunology, Radiotherapy, Cardiology, HUSLAB, Institute for Molecular Medicine Finland, Department of Public Health, Genetic Epidemiology, Barnes, Daniel [0000-0002-3781-7570], Erzurumluoglu, Mesut [0000-0003-1322-8138], Apollo - University of Cambridge Repository, Biological Psychology, Complex Trait Genetics

المصدر: Biological Psychiatry, 85(11), 946-955. Elsevier
Biological Psychiatry, 85(11), 946-955. Elsevier USA
Biological Psychiatry, 85(11), 946-955. ELSEVIER SCIENCE INC
Brazel, D M, Jiang, Y, Hughey, J M, Turcot, V, Zhan, X, Gong, J, Batini, C, Weissenkampen, J D, Liu, M, Barnes, D R, Bertelsen, S, Chou, Y-L, Erzurumluoglu, A M, Faul, J D, Haessler, J, Hammerschlag, A R, Hsu, C, Kapoor, M, Lai, D, Le, N, de Leeuw, C A, Loukola, A, Mangino, M, Melbourne, C A, Pistis, G, Qaiser, B, Rohde, R, Shao, Y, Stringham, H, Wetherill, L, Zhao, W, Agrawal, A, Bierut, L, Chen, C, Eaton, C B, Goate, A, Haiman, C, Heath, A, Iacono, W G, Martin, N G, Polderman, T J, Reiner, A, Rice, J, Schlessinger, D, Scholte, H S, Smith, J A, Tardif, J-C, Tindle, H A, van der Leij, A R, Boehnke, M, Chang-Claude, J, Cucca, F, David, S P, Foroud, T, Howson, J M M, Kardia, S L R, Kooperberg, C, Laakso, M, Lettre, G, Madden, P, Mcgue, M, North, K, Posthuma, D, Spector, T, Stram, D, Tobin, M D, Weir, D R, Kaprio, J, Abecasis, G R, Liu, D J, Vrieze, S, Surendran, P, Young, R, Barnes, D R, Nielsen, S F, Rasheed, A, Samuel, M, Zhao, W, Kontto, J, Perola, M, Caslake, M, de Craen, A J M, Trompet, S, Uria-Nickelsen, M, Malarstig, A, Reily, D F, Hoek, M, Vogt, T, Jukema, J W, Sattar, N, Ford, I, Packard, C J, Alam, D S, Majumder, A A S, Di Ange-Lantonio, E, Chowdhury, R, Amouyel, P, Arveiler, D, Blankenberg, S, Ferrieres, J, Kee, F, Kuulasmaa, K, Mueller-Nurasyid, M, Veronesi, G, Virtamo, J, Frossard, P, Nordestgaard, B G, Saleheen, D, Danesh, J, Butterworth, A S, Howson, J M M, Erzurumluoglu, A M, Jackson, V E, Melbourne, C A, Varga, T V, Warren, H R, Tragante, V, Tachmazidou, I, Harris, S E, Evangelou, E, Marten, J, Zhang, W, Altmaier, E, Luan, J, Langenberg, C, Scott, R A, Yaghootkar, H, Stirrups, K, Kanoni, S, Marouli, E, Karpe, F, Dominiczak, A F, Sever, P, Poulter, N, Rolandsson, O, Baumbach, C, Afaq, S, Chambers, J C, Kooner, J S, Wareham, N J, Renstrom, F, Hallmans, G, Marioni, R E, Corley, J, Starr, J M, Verweij, N, de Boer, R A, van der Meer, P, Yavas, E, Vaartjes, I, Bots, M L, Asselbergs, F W, Grabe, H J, Volzke, H, Nauck, M, Weiss, S, Pharoah, P D P, Dunning, A M, Dennis, J G, Thompson, D J, Michailidou, K, Easton, D F, Antoniou, A C, Tyrrell, J, Mihailov, E, Samani, N J, Zhou, K, Neville, M J, Metspalu, A, Palmer, C N A, Hall, I P, Strachan, D P, Deary, I J, Frayling, T M, Hayward, C, van der Harst, P, Zeggini, E, Munroe, P B, Jansson, J-H, Franks, P W, Deloukas, P, Caulfield, M J, Wain, L V & Tobin, M D 2019, ' Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use ', Biological Psychiatry, vol. 85, no. 11, pp. 946-955 . https://doi.org/10.1016/j.biopsych.2018.11.024
Biological Psychiatry, 85(11), 946. Elsevier USA
Brazel, D M, Jiang, Y, Hughey, J M, Turcot, V, Zhan, X, Gong, J, Batini, C, Weissenkampen, J D, Liu, M, Surendran, P, Young, R, Barnes, D R, Nielsen, S F, Rasheed, A, Samuel, M, Zhao, W, Kontto, J, Perola, M, Caslake, M, de Craen, A J M, Trompet, S, Uria-Nickelsen, M, Malarstig, A, Reily, D F, Hoek, M, Vogt, T, Jukema, J W, Sattar, N, Ford, I, Packard, C J, Alam, D S, Majumder, A A S, di Angelantonio, E, Chowdhury, R, Amouyel, P, Arveiler, D, Blankenberg, S, Ferrières, J, Kee, F, Kuulasmaa, K, Müller-Nurasyid, M, Veronesi, G, Virtamo, J, EPIC-CVD Consortium, Frossard, P, Nordestgaard, B R G, Saleheen, D, Danesh, J, Hammerschlag, A R, Posthuma, D, Spector, T, Stram, D O, Tobin, M D, Weir, D R, Kaprio, J, Abecasis, G R, Liu, D J, Vrieze, S & CHD Exome+ Consortium 2019, ' Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use ', Biological Psychiatry, vol. 85, no. 11, pp. 946-955 . https://doi.org/10.1016/j.biopsych.2018.11.024
Biological psychiatry. Elsevier USA
CHD Exome+ Consortium & Consortium for Genetics of Smoking Behaviour 2019, ' Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use ', Biological Psychiatry, vol. 85, no. 11, pp. 946-955 . https://doi.org/10.1016/j.biopsych.2018.11.024

مصطلحات موضوعية: 0301 basic medicine, Nonsynonymous substitution, Genome-wide association study, 3124 Neurology and psychiatry, 0302 clinical medicine, DEPENDENCE, Genotype, Databases, Genetic, SEQUENCE VARIANTS, GWAS, Exome, Non-U.S. Gov't, Oligonucleotide Array Sequence Analysis, Genetics, RISK, HERITABILITY, Research Support, Non-U.S. Gov't, Smoking, ASSOCIATION, 3. Good health, ADH1B, Phenotype, Behavioral genetics, LOW-FREQUENCY, Alcohol, Heritability, Nicotine, Tobacco, Alcohol Drinking, Non-P.H.S, Single-nucleotide polymorphism, Biology, Research Support, Polymorphism, Single Nucleotide, N.I.H, 03 medical and health sciences, Research Support, N.I.H., Extramural, SDG 3 - Good Health and Well-being, Genetic variation, Journal Article, Humans, Genetic Predisposition to Disease, COMMON, Biological Psychiatry, 3112 Neurosciences, Genetic Variation, Extramural, MISSENSE VARIANTS, R1, Genetic architecture, 030104 developmental biology, U.S. Gov't, 030217 neurology & neurosurgery, Research Support, U.S. Gov't, Non-P.H.S, Genome-Wide Association Study

وصف الملف: application/pdf; text/plain; application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4c6686918e3fb0cec91a0a7423b4f4
https://dare.uva.nl/personal/pure/en/publications/exome-chip-metaanalysis-fine-maps-causal-variants-and-elucidates-the-genetic-architecture-of-rare-coding-variants-in-smoking-and-alcohol-use(5b2dcbfd-0c32-47f3-869f-1ff60f676314).html

المؤلفون: John M, Gregson, Daniel F, Freitag, Praveen, Surendran, Nathan O, Stitziel, Rajiv, Chowdhury, Stephen, Burgess, Stephen, Kaptoge, Pei, Gao, James R, Staley, Peter, Willeit, Sune F, Nielsen, Muriel, Caslake, Stella, Trompet, Linda M, Polfus, Kari, Kuulasmaa, Jukka, Kontto, Markus, Perola, Stefan, Blankenberg, Giovanni, Veronesi, Francesco, Gianfagna, Satu, Männistö, Akinori, Kimura, Honghuang, Lin, Dermot F, Reilly, Mathias, Gorski, Vladan, Mijatovic, Patricia B, Munroe, Georg B, Ehret, Alex, Thompson, Maria, Uria-Nickelsen, Anders, Malarstig, Abbas, Dehghan, Thomas F, Vogt, Taishi, Sasaoka, Fumihiko, Takeuchi, Norihiro, Kato, Yoshiji, Yamada, Frank, Kee, Martina, Müller-Nurasyid, Jean, Ferrières, Dominique, Arveiler, Philippe, Amouyel, Veikko, Salomaa, Eric, Boerwinkle, Simon G, Thompson, Ian, Ford, J, Wouter Jukema, Naveed, Sattar, Chris J, Packard, Abdulla Al, Shafi Majumder, Dewan S, Alam, Panos, Deloukas, Heribert, Schunkert, Nilesh J, Samani, Sekar, Kathiresan, Børge G, Nordestgaard, Danish, Saleheen, Joanna Mm, Howson, Emanuele, Di Angelantonio, Adam S, Butterworth, John, Danesh

المصدر: European journal of preventive cardiology. 24(5)

مصطلحات موضوعية: Adult, Male, Genotype, Phospholipase A2 Inhibitors, Reproducibility of Results, Coronary Disease, Middle Aged, Polymorphism, Single Nucleotide, Risk Assessment, Treatment Outcome, Gene Expression Regulation, Reference Values, Benzaldehydes, Case-Control Studies, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Oximes, Humans, Female, Molecular Targeted Therapy, Alleles, Aged, Randomized Controlled Trials as Topic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::42865f42e94e84613152c8d214a26980
https://pubmed.ncbi.nlm.nih.gov/28121171

المؤلفون: Dewan S. Alam, Martina Müller-Nurasyid, Pei Gao, Akinori Kimura, Danish Saleheen, Emanuele Di Angelantonio, Stefan Blankenberg, Taishi Sasaoka, Jean Ferrières, Børge G. Nordestgaard, Panos Deloukas, Abbas Dehghan, Eric Boerwinkle, Maria Uria-Nickelsen, Simon G. Thompson, Markus Perola, Chris J. Packard, Giovanni Veronesi, Dominique Arveiler, Dermot F. Reilly, Patricia B. Munroe, Stephen Burgess, Rajiv Chowdhury, Philippe Amouyel, J. Wouter Jukema, Alex Thompson, Francesco Gianfagna, Satu Männistö, Honghuang Lin, Nathan O. Stitziel, Heribert Schunkert, Naveed Sattar, Vladan Mijatovic, Abdulla Al Shafi Majumder, Nilesh J. Samani, Daniel F. Freitag, Stephen Kaptoge, Sekar Kathiresan, Stella Trompet, Peter Willeit, Jukka Kontto, John Danesh, Georg Ehret, Veikko Salomaa, Adam S. Butterworth, Joanna M. M. Howson, Ian Ford, Mathias Gorski, Kari Kuulasmaa, Yoshiji Yamada, Norihiro Kato, John M. Gregson, Frank Kee, Fumihiko Takeuchi, Praveen Surendran, James R Staley, Linda M. Polfus, Sune F. Nielsen, Anders Mälarstig, Thomas F. Vogt, Muriel J. Caslake

المساهمون: CKDGen consortium, International Consortium for Blood Pressure, CHARGE inflammation working group, MICAD Exome consortium, EPIC-CVD consortium and the CHD Exome+ consortium, Epidemiology, Surendran, Praveen [0000-0002-4911-6077], Chowdhury, Rajiv [0000-0003-4881-5690], Burgess, Stephen [0000-0001-5365-8760], Kaptoge, Stephen [0000-0002-1155-4872], Thompson, Simon [0000-0002-5274-7814], Howson, Joanna [0000-0001-7618-0050], Di Angelantonio, Emanuele [0000-0001-8776-6719], Butterworth, Adam [0000-0002-6915-9015], Danesh, John [0000-0003-1158-6791], Apollo - University of Cambridge Repository, Institute for Molecular Medicine Finland, University of Helsinki, Quantitative Genetics

المصدر: European Journal of Preventive Cardiology, 24(5), 492-504
Gregson, J M, Freitag, D F, Surendran, P, Stitziel, N O, Chowdhury, R, Burgess, S, Kaptoge, S, Gao, P, Staley, J R, Willeit, P, Nielsen, S F, Caslake, M, Trompet, S, Polfus, L M, Kuulasmaa, K, Kontto, J, Perola, M, Blankenberg, S, Veronesi, G, Gianfagna, F, Männistö, S, Kimura, A, Lin, H, Reilly, D F, Gorski, M, Mijatovic, V, Munroe, P B, Ehret, G B, Thompson, A, Uria-Nickelsen, M, Malarstig, A, Dehghan, A, Vogt, T F, Sasaoka, T, Takeuchi, F, Kato, N, Yamada, Y, Kee, F, Müller-Nurasyid, M, Ferrières, J, Arveiler, D, Amouyel, P, Salomaa, V, Boerwinkle, E, Thompson, S G, Ford, I, Wouter Jukema, J, Sattar, N, Packard, C J, Shafi Majumder, A A, Alam, D S, Deloukas, P, Schunkert, H, Samani, N J, Kathiresan, S, Nordestgaard, B G, Saleheen, D, Howson, J M, Di Angelantonio, E, Butterworth, A S & Danesh, J 2017, ' Genetic invalidation of Lp-PLA 2 as a therapeutic target : Large-scale study of five functional Lp-PLA 2-lowering alleles ', European Journal of Preventive Cardiology, vol. 24, no. 5, pp. 492-504 . https://doi.org/10.1177/2047487316682186
European journal of preventive cardiology, vol. 24, no. 5, pp. 492-504
European Journal of Preventive Cardiology, 24(5), 492-504. SAGE Publications Ltd
Gregson, J M, Freitag, D F, Surendran, P, Stitziel, N O, Chowdhury, R, Burgess, S, Stephen, K, Gao, P, Staley, J R, Willeit, P, Nielsen, S F, Caslake, M, Trompet, S, Polfus, L M, Kuulasmaa, K, Kontto, J, Perola, M, Blankenberg, S, Veronesi, G, Gianfagna, F, Mannisto, S, Kimura, A, Lin, H, Reilly, D F, Gorski, M, Mijatovic, V, CKDGen consortium, Munroe, P B, Ehret, G B, International Consortium for Blood Pressure, Thompson, A, Uria-Nickelsen, M, Malarstig, A, Dehghan, A, CHARGE inflammation working group, Vogt, T F, Sasaoka, T, Takeuchi, F, Kato, N, Yamada, Y, Kee, F, Muller-Nurasyid, M, Ferrieres, J, Arveiler, D, Amouyel, P, Salomaa, V, Boerwinkle, E, Thompson, S G, Ford, I, Jukema, J W, Sattar, N, Packard, C J, Majumder, A A S, Alam, D S, Deloukas, P, Schunkert, H, Samani, N J, Kathiresan, S, MICAD Exome consortium, Nordestgaard, B G, Saleheen, D, Howson, J M M, Di Angelantonio, E, Butterworth, A S, Danesh, J, EPIC-CVD consortium & CHD Exome+ consortium 2017, ' Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles ', European Journal of Preventive Cardiology, vol. 24, no. 5, pp. 492-504 . https://doi.org/10.1177/2047487316682186

مصطلحات موضوعية: 0301 basic medicine, Pathology, Epidemiology, 030204 cardiovascular system & hematology, VARIANTS, Gastroenterology, law.invention, CHARGE inflammation working group, 0302 clinical medicine, Randomized controlled trial, Human genetics, law, Medicine, ARTERY-DISEASE, RISK, 1184 Genetics, developmental biology, physiology, 3. Good health, CARDIOVASCULAR-DISEASE, International Consortium for Blood Pressure, MICAD Exome consortium, lipids (amino acids, peptides, and proteins), Cardiology and Cardiovascular Medicine, medicine.medical_specialty, coronary heart disease, darapladib, lipoprotein-associated phospholipase A2, target validation, ACTIVATING-FACTOR ACETYLHYDROLASE, EVENTS, 03 medical and health sciences, Internal medicine, Darapladib, health services administration, lipoprotein-associated phospholipase A(2), CORONARY-HEART-DISEASE, Allele, Risk factor, GENOME-WIDE ASSOCIATION, Genotyping, PHOSPHOLIPASE A(2) ACTIVITY, business.industry, Lipoprotein-associated phospholipase A2, EPIC-CVD consortium and the CHD Exome+ consortium, R1, 030104 developmental biology, CKDGen consortium, Relative risk, 3121 General medicine, internal medicine and other clinical medicine, 1-Alkyl-2-acetylglycerophosphocholine Esterase/drug effects, 1-Alkyl-2-acetylglycerophosphocholine Esterase/genetics, Adult, Aged, Alleles, Benzaldehydes/therapeutic use, Case-Control Studies, Coronary Disease/diagnosis, Coronary Disease/drug therapy, Coronary Disease/genetics, Female, Gene Expression Regulation, Genotype, Humans, Male, Middle Aged, Molecular Targeted Therapy, Oximes/therapeutic use, Phospholipase A2 Inhibitors/therapeutic use, Polymorphism, Single Nucleotide, Randomized Controlled Trials as Topic, Reference Values, Reproducibility of Results, Risk Assessment, Treatment Outcome, 3111 Biomedicine, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b2ff2015d30a1017632842598090d2
http://hdl.handle.net/10044/1/54554

المؤلفون: Ruth Illingworth, P. Ann Boriack-Sjodin, Gregory S. Basarab, Shanta Bist, Shubha Sriram, Maria Uria-Nickelsen, Brian Sherer, Brian Dangel, John I. Manchester, Ann E. Eakin

المصدر: Journal of Medicinal Chemistry. 56:8712-8735

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Topoisomerase IV, Microbial Sensitivity Tests, DNA gyrase, Mice, Structure-Activity Relationship, Adenosine Triphosphate, Drug Discovery, Animals, Topoisomerase II Inhibitors, Urea, Asparagine, Bacteria, Dose-Response Relationship, Drug, Molecular Structure, biology, DNA synthesis, Chemistry, Topoisomerase, Hit to lead, Staphylococcal Infections, Anti-Bacterial Agents, Disease Models, Animal, DNA Topoisomerases, Type II, Biochemistry, biology.protein, Molecular Medicine, Antibacterial activity, Type II topoisomerase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1742db4c3423159858a80e562db9f9c
https://doi.org/10.1021/jm401208b

المؤلفون: Shubha Sriram, John I. Manchester, Georg Neckermann, Dan Carcanague, Maria Uria-Nickelsen, Beth Andrews, Suzanne Stokes, Kenneth Gregory Hull

المصدر: International Journal of Antimicrobial Agents. 41:363-371

مصطلحات موضوعية: DNA Topoisomerase IV, Models, Molecular, Microbiology (medical), Topoisomerase Inhibitors, medicine.drug_class, Microbial Sensitivity Tests, Biology, medicine.disease_cause, Haemophilus influenzae, Microbiology, Moraxella catarrhalis, Mice, In vivo, Gram-Negative Bacteria, Streptococcus pneumoniae, medicine, Animals, Humans, Topoisomerase II Inhibitors, Pharmacology (medical), Mode of action, General Medicine, Pneumonia, Pneumococcal, biology.organism_classification, Anti-Bacterial Agents, Gram-Positive Cocci, Disease Models, Animal, Treatment Outcome, Infectious Diseases, Staphylococcus aureus, Female, Topoisomerase-II Inhibitor, Topoisomerase inhibitor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04fe22df520c66550ed3e570f4fa319
https://doi.org/10.1016/j.ijantimicag.2012.12.001

المؤلفون: April E. Blodgett, Ann E. Eakin, Heather Kamp, Maria Uria-Nickelsen, Brian Sherer, Oluyinka Green

المصدر: International Journal of Antimicrobial Agents. 41:28-35

مصطلحات موضوعية: Microbiology (medical), Meticillin, Microbial Sensitivity Tests, Gram-Positive Bacteria, medicine.disease_cause, DNA gyrase, Microbiology, Haemophilus influenzae, Moraxella catarrhalis, Minimum inhibitory concentration, Drug Resistance, Bacterial, Gram-Negative Bacteria, Streptococcus pneumoniae, medicine, Humans, Topoisomerase II Inhibitors, Pyrroles, Pharmacology (medical), Enzyme Inhibitors, Mode of action, biology, General Medicine, biology.organism_classification, Amides, Anti-Bacterial Agents, Infectious Diseases, Staphylococcus aureus, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651e321ef377ba85ec8fe973475721fd
https://doi.org/10.1016/j.ijantimicag.2012.08.017

المؤلفون: Kevin J. Embrey, Julie Demeritt, Joanna Bryant, Beth Andrews, George B. Mullen, Ning Gao, Lawrence Macpherson, James T. Loch, Ken Hull, Bryan Prince, Brian Sherer, Alok Singh, P. Ann Boriack-Sjodin, Sheila Irene Hauck, Oluyinka Green, Ann E. Eakin, Haihong Ni, Ruth Illingworth, Dave Timms, Maria Uria-Nickelsen, Grant K. Walkup, Neil James Hales, Alexander L. Breeze, April E. Blodgett, Shanta Bist

المصدر: Antimicrobial Agents and Chemotherapy. 56:1240-1246

مصطلحات موضوعية: Models, Molecular, Staphylococcus aureus, Magnetic Resonance Spectroscopy, Mutant, Microbial Sensitivity Tests, Biology, Crystallography, X-Ray, medicine.disease_cause, DNA gyrase, DNA sequencing, Inhibitory Concentration 50, Mice, Nuclear magnetic resonance, Drug Resistance, Bacterial, medicine, Animals, Humans, Topoisomerase II Inhibitors, Pyrroles, Experimental Therapeutics, Pharmacology (medical), Enzyme Inhibitors, Binding site, Pharmacology, chemistry.chemical_classification, Mutation, Binding Sites, DNA synthesis, Staphylococcal Infections, Amides, Molecular biology, Anti-Bacterial Agents, Streptococcus pneumoniae, Infectious Diseases, Enzyme, chemistry, Biochemistry, DNA Gyrase, Antibacterial activity, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b8b08a77f0d6262fe9dd591b0c4d6a
https://doi.org/10.1128/aac.05485-11

المؤلفون: David E. Ehmann, Mark Zambrowski, Adam B. Shapiro, Pratik R. Bhagunde, Beesan Tan, Kerry E. Murphy-Benenato, Li Sha, Olga Quiroga, Vincent Galullo, Hajnalka E. Davis, M. R. Manjunatha, Holia Hatoum-Mokdad, Mark Sylvester, Aryun Kim, Haris Jahic, Shannon X. Zhao, Ye Wu, April Chen, Andy S. Tsai, Jennifer J. Harris, Sara A. Patey, Michael T. Rooney, Erika L. Manyak, Thomas F. Durand-Reville, Maria Uria-Nickelsen, John P. Mueller

المصدر: Journal of medicinal chemistry. 58(5)

مصطلحات موضوعية: Male, Siderophore, Siderophores, Pharmacology, medicine.disease_cause, beta-Lactamases, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Potency, Structure–activity relationship, Animals, Humans, Pseudomonas Infections, Rats, Wistar, Chemistry, Pseudomonas aeruginosa, Drug discovery, In vitro, Anti-Bacterial Agents, Rats, Free fraction, Molecular Medicine, Monobactams

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9c8bc8fc6fed09ccc99de4eda7e65b
https://pubmed.ncbi.nlm.nih.gov/25658376

المؤلفون: Daniel Robert Carcanague, Mark A. Wuonola, Camil Joubran, Thomas C Kühler, Maria Uria-Nickelsen, Joseph K. Abedi, Youe-Kong Shue, Jeanette Jones

المصدر: Journal of Medicinal Chemistry. 45:4300-4309

مصطلحات موضوعية: Benzimidazole, Colony Count, Microbial, Microbial Sensitivity Tests, Microbiology, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Clarithromycin, Drug Resistance, Bacterial, Drug Discovery, medicine, Animals, Pathogen, Antibacterial agent, Helicobacter pylori, biology, biology.organism_classification, Antimicrobial, Anti-Bacterial Agents, Mice, Inbred C57BL, Kinetics, Metronidazole, chemistry, Molecular Medicine, Benzimidazoles, Female, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a198546fc5cef3bc445126443bdf7bbd
https://doi.org/10.1021/jm020868v