نتائج البحث - "Maria A. Sartori da Silva"

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research, Gastroenterology & Hepatology, Center of Experimental and Molecular Medicine, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Gastroenterology and Hepatology, Amsterdam institute for Infection and Immunity

المصدر: Stem Cells and Development, 21(17), 3091-3103. Mary Ann Liebert Inc.
Stem cells and development, 21(17), 3091-3103. Mary Ann Liebert Inc.

مصطلحات موضوعية: Blastomeres, Embryo, Nonmammalian, Satellite Cells, Skeletal Muscle, Cellular differentiation, Cell Count, Suppressor of Cytokine Signaling Proteins, Muscle Development, Transfection, Mice, Original Research Reports, Animals, Regeneration, Compartment (development), RNA, Messenger, Progenitor cell, Muscle, Skeletal, Zebrafish, Alleles, Cells, Cultured, Germ-Line Mutation, Cell Proliferation, Progenitor, Regulation of gene expression, biology, Myogenesis, asb11 ubiquitin myogenesis, Gene Expression Regulation, Developmental, PAX7 Transcription Factor, Cell Differentiation, Cell Biology, Hematology, Zebrafish Proteins, biology.organism_classification, Immunohistochemistry, Molecular biology, Cell biology, Models, Animal, PAX7, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c41c4d8bcf3883a933914c624caa429
https://doi.org/10.1089/scd.2012.0123

5

d-Asb11 is an essential mediator of canonical Delta–Notch signalling

المؤلفون: Maikel P. Peppelenbosch, Anke Brouwers, Jan-Luuk Hillebrands, Ajay B. Chitnis, Danica Zivkovic, Sander H. Diks, Carina van Rooijen, Henri H. Versteeg, Robert J. Bink, Maria A. Sartori da Silva

المساهمون: Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), Groningen Institute for Organ Transplantation (GIOT), Hubrecht Institute for Developmental Biology and Stem Cell Research

المصدر: Nature Cell Biology, 10(10), 1190-1198. Nature Publishing Group

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54e4b664a0938e3e907d428737ffe05
https://doi.org/10.1038/ncb1779

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6

Genetically Modified Lactococcus lactis for Delivery of Human Interleukin-10 to Dendritic Cells

المؤلفون: Maria A. Sartori da Silva, Maikel P. Peppelenbosch, Martien L. Kapsenberg, Henri Braat, Sander J. H. van Deventer, Sebatian A. Zaat, IL Huibregtse

المساهمون: Gastroenterology & Hepatology, AII - Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, Cell Biology and Histology, Other departments

المصدر: Gastroenterology Research and Practice
Gastroenterology Research and Practice, Vol 2012 (2012)
Gastroenterology Research and Practice. Hindawi Publishing Corporation
Gastroenterology research and practice, 2012. Hindawi Publishing Corporation
STARTPAGE=-;TITLE=Gastroenterology Research and Practice

وصف الملف: application/pdf; text/xhtml

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5989d58826d11f565ac6c992211c93c4
http://europepmc.org/articles/PMC3146989

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7

Zebrafish as a Suitable Model for Evaluating Nanocosmetics and Nanomedicines

المؤلفون: Maria A. Sartori-da-Silva, Giselle Z. Justo, Carmen Veríssima Ferreira

المصدر: Nanocosmetics and Nanomedicines ISBN: 9783642197918

مصطلحات موضوعية: Skin care, biology, ved/biology, ved/biology.organism_classification_rank.species, Visual assessment, Danio, Optical transparency, Biological database, Computational biology, biology.organism_classification, Model organism, Zebrafish, Phenotype

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6dc04b17ea33eda676b1504a4cee9c56
https://doi.org/10.1007/978-3-642-19792-5_12

8

Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo

المؤلفون: Maikel P. Peppelenbosch, Anke Brouwers, Judith T.M.L. Paridaen, Vincent Runtuwene, Sander H. Diks, Danica Zivkovic, Maria A. Sartori da Silva, Jin-Ming Tee, Daniele Guardavaccaro

المساهمون: Molecular Neuroscience and Ageing Research (MOLAR), Stem Cell Aging Leukemia and Lymphoma (SALL), Hubrecht Institute for Developmental Biology and Stem Cell Research, Gastroenterology & Hepatology

المصدر: PLoS ONE, 5(11):14023. PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 5, Iss 11, p e14023 (2010)
PLoS One, 5(11). Public Library of Science
PLoS One (print), 5(11). Public Library of Science
PLoS ONE

مصطلحات موضوعية: Embryo, Nonmammalian, lcsh:Medicine, Suppressor of Cytokine Signaling Proteins, 0302 clinical medicine, Receptors, Developmental Biology/Developmental Molecular Mechanisms, Basic Helix-Loop-Helix Transcription Factors, UBIQUITIN LIGASES, an Elongin BC adaptor and a cullin (Cul2 or Cul5) scaffold which interacts with the RING protein. In vitro studies have shown that the conserved amino acid sequence of the cullin box in SOCS-box proteins is required for complex formation and function. However, Developmental, lcsh:Science, Non-U.S. Gov't, PHOSPHORYLATION, Zebrafish, Animals, Binding Sites, Cell Proliferation, Cullin Proteins, Gene Expression Regulation, Developmental, Green Fluorescent Proteins, Immunoblotting, In Situ Hybridization, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Microscopy, Confocal, Mutation, Neurons, Receptors, Notch, Reverse Transcriptase Polymerase Chain Reaction, Zebrafish Proteins, Signal Transduction, NEUROGENIN1, Microscopy, 0303 health sciences, Nonmammalian, Multidisciplinary, biology, Research Support, Non-U.S. Gov't, CUL5-RBX2 MODULES, ANKYRIN REPEAT, Cell biology, Notch proteins, we isolated a zebrafish mutant lacking the Cul5 box (Asb11Cul). We found that homozygous zebrafish mutants for this allele were defective in Notch signaling as indicated by the impaired expression of Notch target genes. Importantly, Embryo, proper cell fate specification within the neurogenic regions of the zebrafish embryo was impaired. In addition, Confocal, embryonic structures, PROTEIN-SYNTHESIS, asb11Cul fish were not capable to degrade the Notch ligand DeltaA during embryogenesis, CUL5, Cullin, Research Article, ECS (Elongin BC-Cul2/Cul5-SOCS-box protein) ubiquitin ligases recruit substrates to E2 ubiquitin-conjugating enzymes through a SOCS-box protein substrate receptor, an Elongin BC adaptor and a cullin (Cul2 or Cul5) scaffold which interacts with the RING protein. In vitro studies have shown that the conserved amino acid sequence of the cullin box in SOCS-box proteins is required for complex formation and function. However, the in vivo importance of cullin boxes has not been addressed. To explore the biological functions of the cullin box domain of ankyrin repeat and SOCS-box containing protein 11 (d-Asb11), a key mediator of canonical Delta-Notch signaling, we isolated a zebrafish mutant lacking the Cul5 box (Asb11Cul). We found that homozygous zebrafish mutants for this allele were defective in Notch signaling as indicated by the impaired expression of Notch target genes. Importantly, asb11Cul fish were not capable to degrade the Notch ligand DeltaA during embryogenesis, a process essential for the initiation of Notch signaling during neurogenesis. Accordingly, proper cell fate specification within the neurogenic regions of the zebrafish embryo was impaired. In addition, Asb11Cul mRNA was defective in the ability to transactivate a her4::gfp reporter DNA when injected in embryos. Thus, our study reporting the generation and the characterization of a metazoan organism mutant in the conserved cullin binding domain of the SOCS-box demonstrates a hitherto unrecognized importance of the SOCS-box domain for the function of this class of cullin-RING ubiquitin ligases and establishes that the d-Asb11 cullin box is required for both canonical Notch signaling and proper neurogenesis, EXPRESSION, Notch, our study reporting the generation and the characterization of a metazoan organism mutant in the conserved cullin binding domain of the SOCS-box demonstrates a hitherto unrecognized importance of the SOCS-box domain for the function of this class of cullin-RING ubiquitin ligases and establishes that the d-Asb11 cullin box is required for both canonical Notch signaling and proper neurogenesis, Cell Biology/Developmental Molecular Mechanisms, Notch signaling pathway, SOCS-BOX, Cell fate determination, Asb11Cul mRNA was defective in the ability to transactivate a her4::gfp reporter DNA when injected in embryos. Thus, Research Support, 03 medical and health sciences, Journal Article, 030304 developmental biology, the in vivo importance of cullin boxes has not been addressed. To explore the biological functions of the cullin box domain of ankyrin repeat and SOCS-box containing protein 11 (d-Asb11), a process essential for the initiation of Notch signaling during neurogenesis. Accordingly, lcsh:R, fungi, ZEBRAFISH EMBRYOS, Chemical Biology/Chemical Biology of the Cell, biology.organism_classification, GENE, ECS (Elongin BC-Cul2/Cul5-SOCS-box protein) ubiquitin ligases recruit substrates to E2 ubiquitin-conjugating enzymes through a SOCS-box protein substrate receptor, a key mediator of canonical Delta-Notch signaling, Gene Expression Regulation, biology.protein, lcsh:Q, Ankyrin repeat, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee680c8d0064a7b76c045954e41c10cf
https://doi.org/10.1371/journal.pone.0014023

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9

دورية أكاديمية

Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo.

المؤلفون: Maria A Sartori da Silva, Jin-Ming Tee, Judith Paridaen, Anke Brouwers, Vincent Runtuwene, Danica Zivkovic, Sander H Diks, Daniele Guardavaccaro, Maikel P Peppelenbosch

المصدر: PLoS ONE, Vol 5, Iss 11, p e14023 (2010)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC2988792?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/fc06b93860674e68a01af6ddf697a006

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