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1دورية أكاديمية
المؤلفون: Yiolanda-Panayiota Christou, George A. Tanteles, Elena Kkolou, Annita Ormiston, Kostas Konstantopoulos, Maria Beconi, Randall D. Marshall, Horacio Plotkin, Kleopas A. Kleopa
المصدر: Case Reports in Neurological Medicine, Vol 2017 (2017)
مصطلحات موضوعية: Neurology. Diseases of the nervous system, RC346-429
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Jane S Sutcliffe, Vahri Beaumont, James M Watson, Chang Sing Chew, Maria Beconi, Daniel M Hutcheson, Celia Dominguez, Ignacio Munoz-Sanjuan
المصدر: PLoS ONE, Vol 9, Iss 7, p e102449 (2014)
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Maria Beconi, Omar Aziz, Kim Matthews, Lara Moumné, Catherine O'Connell, Dawn Yates, Steven Clifton, Hannah Pett, Julie Vann, Lynsey Crowley, Alan F Haughan, Donna L Smith, Ben Woodman, Gillian P Bates, Fred Brookfield, Roland W Bürli, George McAllister, Celia Dominguez, Ignacio Munoz-Sanjuan, Vahri Beaumont
المصدر: PLoS ONE, Vol 7, Iss 9, p e44498 (2012)
وصف الملف: electronic resource
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المؤلفون: Marieke Lamers, Jiffry Ismail, Kevin F. McGee, John Wityak, Gwen Wang, Jonathan Bard, Leticia Toledo-Sherman, Michele Luche, Mei Bai, Michael Conlon, W. Brent Clayton, Michael A. Lynch, Celia Dominguez, James C. Haber, Dawn Yates, Ryan Newell, Pat Wheelan, Ren Hua Song, Susan Deupree, Tania Mead, Macarena Irigoyen, Ignacio Munoz-Sanjuan, Douglas B. Kitchen, Emily Freeman, Kim L. Matthews, Jeff Webster, Bryan Cordell Duffy, IokTeng D. Kuok, Peter C. Michels, Alex S. Kiselyov, Steve Clifton, Lynette Ongeri, David D. Manning, Maria Beconi, Kathy Lyons, Yuri L. Khmelnitsky, Philip Leonard, Claire Wilson, Monica Hultman
المصدر: Journal of Medicinal Chemistry. 58:2967-2987
مصطلحات موضوعية: Pyrimidine, Drug Evaluation, Preclinical, Chemistry Techniques, Synthetic, Pharmacology, Crystallography, X-Ray, Madin Darby Canine Kidney Cells, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Pharmacokinetics, Mitogen-Activated Protein Kinase 10, Drug Discovery, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Protein Kinase Inhibitors, ADME, Molecular Structure, Chemistry, Cellular Assay, In vitro, Disease Models, Animal, Huntington Disease, Pyrimidines, Blood-Brain Barrier, Pharmacodynamics, Microsomes, Liver, Microsome, Pyrazoles, Molecular Medicine, Efflux, Half-Life
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5
المؤلفون: Kostas Konstantopoulos, Maria Beconi, Kleopas A. Kleopa, Elena Kkolou, George A. Tanteles, Randall D. Marshall, Annita Ormiston, Yiolanda-Panayiota Christou, Horacio Plotkin
المصدر: Case Reports in Neurological Medicine, Vol 2017 (2017)
Case Reports in Neurological Medicineمصطلحات موضوعية: 0301 basic medicine, Pediatrics, medicine.medical_specialty, Article Subject, Case Report, Disease, lcsh:RC346-429, 03 medical and health sciences, 0302 clinical medicine, medicine, lcsh:Neurology. Diseases of the nervous system, Dystonia, business.industry, Parkinsonism, Neurodegeneration, PANK2, medicine.disease, Symptomatic relief, 3. Good health, Surgery, Single patient, 030104 developmental biology, Open label, General Agricultural and Biological Sciences, business, 030217 neurology & neurosurgery
وصف الملف: text/xhtml
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المؤلفون: Junghyun Lim, Petr Vodicka, Hyunsun Park, Dana T. Williams, Zhenyu Yue, Marian DiFiglia, Kimberly B. Kegel, Kathy Lyons, Dawn Yates, Stephen Wilkinson, Maria Beconi, Neil Aronin, Celia Dominguez, Kathryn Chase, Deanna Marchionini, Tania Mead, Helen L. Birch
المصدر: Journal of Huntington's Disease. 3:159-174
مصطلحات موضوعية: Male, Huntingtin, Mice, Transgenic, Nerve Tissue Proteins, Pharmacology, Biology, Antimalarials, Mice, Cellular and Molecular Neuroscience, Chaperone-mediated autophagy, Western blot, In vivo, Chloroquine, Autophagy, medicine, Animals, Gene Knock-In Techniques, Receptor, Late endosome, Huntingtin Protein, medicine.diagnostic_test, Brain, Nuclear Proteins, rab7 GTP-Binding Proteins, Mice, Inbred C57BL, Disease Models, Animal, Huntington Disease, rab GTP-Binding Proteins, Neurology (clinical), Microtubule-Associated Proteins, Transcription Factor TFIIH, Transcription Factors, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fd8ec675205454aba95ca1433e297a
https://doi.org/10.3233/jhd-130081 -
7
المؤلفون: Sabine Schaertl, Celia Dominguez, Douglas Macdonald, Maria Beconi, Marie Li, Stephen Martin Courtney, Ignacio Munoz-Sanjuan, Sayeh Erfan, Richard W Marston, Frederick Arthur Brookfield, Darshan Gunvant Vaidya, Anna Pedret-Dunn, Michael Prime, Laura Reed, Peter Johnson, John Wityak, Siw F. Johnsen
المصدر: ACS Medicinal Chemistry Letters. 3:1024-1028
مصطلحات موضوعية: Dipeptide, biology, Tissue transglutaminase, business.industry, Organic Chemistry, Lysine, Pharmacology, medicine.disease, Biochemistry, In vitro, Polar surface area, chemistry.chemical_compound, chemistry, Huntington's disease, Acrylamide, Drug Discovery, biology.protein, medicine, business, ADME
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8
المؤلفون: Dawn Yates, Michael Prime, Dirk Winkler, Kathryn Lyons, Maria Beconi, Leticia Toledo-Sherman, Daryl Simon Walter, Ignacio Munoz-Sanjuan, Steve Clifton, Celia Dominguez, Tania Mead, Catherine M. O'Connell, Kim L. Matthews
المصدر: Drug Metabolism and Disposition. 40:2297-2306
مصطلحات موضوعية: Male, Metabolite, Pharmaceutical Science, Pharmacology, Cell Line, Madin Darby Canine Kidney Cells, Mice, chemistry.chemical_compound, Dogs, Pharmacokinetics, medicine, Animals, Humans, Prodrugs, Sulfonamides, Chemistry, Neurodegeneration, Tryptophan, Metabolism, Prodrug, medicine.disease, In vitro, Rats, Mice, Inbred C57BL, Thiazoles, Area Under Curve, Hepatocytes, Microsomes, Liver, Metabolic Detoxication, Phase I, Kynurenine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb46eb8292b21042ac77f7109f8e9241
https://doi.org/10.1124/dmd.112.046532 -
9
المؤلفون: Sabine Schaertl, Simon Gaines, Michael Prime, Celia Dominguez, Maria Beconi, John Wityak, Osamu Ichihara, Stephen Martin Courtney, Richard W Marston, Frederick Arthur Brookfield, Darshan Gunvant Vaidya, Leticia Toledo-Sherman, Anna Pedret-Dunn, Douglas Macdonald, Helen Williams, Marie Li, Laura Reed, Ignacio Munoz-Sanjuan
المصدر: ACS Medicinal Chemistry Letters. 3:731-735
مصطلحات موضوعية: biology, business.industry, Tissue transglutaminase, Organic Chemistry, Glutathione, Pharmacology, medicine.disease, Biochemistry, In vitro, chemistry.chemical_compound, Huntington's disease, chemistry, Acrylamide, Drug Discovery, 4-aminopiperidine, medicine, biology.protein, business, Conjugate, ADME
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10
المؤلفون: Robert K. Y. Cheng, Celia Dominguez, Osamu Ichihara, Douglas Macdonald, Ignacio Munoz-Sanjuan, Mark A. Brooks, Andreas Ebneth, Leticia Toledo-Sherman, Michael Prime, Ian Toogood-Johnson, Sayeh Erfan, John Wityak, Richard W Marston, Frederick Arthur Brookfield, Darshan Gunvant Vaidya, Stephen Martin Courtney, Peter Johnson, Anna Pedret-Dunn, Andreas Scheel, Dirk Winkler, Christopher John Yarnold, Sabine Schaertl, Ole A. Andersen, Shilpa Palan, Maria Beconi, Brunella Felicetti, Siw F. Johnsen, John J. Barker, Jordan J. Palfrey, Ina Sternberger
المصدر: Journal of Medicinal Chemistry. 55:1021-1046
مصطلحات موضوعية: Male, Models, Molecular, Cell Membrane Permeability, Pyridines, Tissue transglutaminase, Lysine, In Vitro Techniques, Piperazines, Mice, Structure-Activity Relationship, Huntington's disease, GTP-Binding Proteins, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Protein Glutamine gamma Glutamyltransferase 2, chemistry.chemical_classification, Acrylamides, Sulfonamides, Isopeptide bond, Transglutaminases, biology, medicine.disease, Molecular biology, In vitro, Rats, Glutamine, HEK293 Cells, Huntington Disease, Pyrimidines, Enzyme, Biochemistry, chemistry, Microsomes, Liver, biology.protein, Molecular Medicine, Caco-2 Cells