يعرض 1 - 2 نتائج من 2 نتيجة بحث عن '"Maria Maccecchini"', وقت الاستعلام: 0.74s تنقيح النتائج
  1. 1
    دورية أكاديمية
    A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer’s Disease

    المؤلفون: Douglas Galasko, Martin R. Farlow, Brendan P. Lucey, Lawrence S. Honig, Donald Elbert, Randall Bateman, Jeremiah Momper, Ronald G. Thomas, Robert A. Rissman, Judy Pa, Vahan Aslanyan, Archana Balasubramanian, Tim West, Maria Maccecchini, Howard H. Feldman

    المصدر: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-15 (2024)

    مصطلحات موضوعية: Alzheimer’s disease, Amyloid beta protein, APP, Pharmacodynamics, Clinical trial, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/1758-9193

    URL الوصول: https://doaj.org/article/e42d62be4d5d45feab248f4b5d8078a5

    Find this article in full text from Springer Verlag. Find this article in full text from ProQuest Full Text Finder
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  2. 2
    Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model

    المؤلفون: Xu-Qiao Chen, Phuong Nguyen, William C. Mobley, Maria Maccecchini, Alexander M. Kleschevnikov, Matthew L. Pearn, Ahmad Salehi, Cassia R. Overk

    المصدر: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 17, iss 2
    Alzheimer's & Dementia

    مصطلحات موضوعية: 0301 basic medicine, early endosome, Aging, Posiphen, Epidemiology, Physostigmine, Down syndrome, Tropomyosin receptor kinase B, Neurodegenerative, Alzheimer's Disease, Mice, Amyloid beta-Protein Precursor, 0302 clinical medicine, Amyloid precursor protein, Ts65Dn mouse, 2.1 Biological and endogenous factors, Phosphorylation, Aetiology, Neurons, education.field_of_study, biology, Kinase, Health Policy, Theoretical Article, Alzheimer's disease, Cell biology, neurotrophin signaling, Psychiatry and Mental health, Phenotype, Neurological, Signal transduction, Amyloid beta, Intellectual and Developmental Disabilities (IDD), Population, Clinical Sciences, Endosomes, CREB, 03 medical and health sciences, Cellular and Molecular Neuroscience, Developmental Neuroscience, Alzheimer Disease, mental disorders, Acquired Cognitive Impairment, Genetics, Animals, Humans, education, Protein kinase B, Amyloid beta-Peptides, Animal, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Disease Models, Animal, 030104 developmental biology, Geriatrics, Disease Models, biology.protein, Dementia, Neurology (clinical), Cholinesterase Inhibitors, Geriatrics and Gerontology, APP, 030217 neurology & neurosurgery

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691143f65dfced6635b43343f8af2cf7
    https://escholarship.org/uc/item/4d04n1ns

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