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1
المؤلفون: Maria Rafalski, Wei Han, Swamy Yeleswaram, Charles F. Albright, Melody Diamond, George L. Trainor, Nilsa R. Graciani, Randine Dowling, Xiang-Jun Jiang, Zilun Hu, Steven P. Seitz, Eddy W. Yue, Robert Bruckner, Mingzhu Zhang, Shu-Yun Zhang
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:853-856
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, macromolecular substances, Matrix metalloproteinase, Biochemistry, Mice, Therapeutic index, In vivo, Cell Line, Tumor, Drug Discovery, polycyclic compounds, medicine, Animals, Humans, Prodrugs, Doxorubicin, Molecular Biology, Neprilysin, Chemistry, organic chemicals, Organic Chemistry, technology, industry, and agriculture, Prodrug, Xenograft Model Antitumor Assays, Matrix Metalloproteinases, carbohydrates (lipids), Cancer research, Molecular Medicine, HT1080, Ex vivo, medicine.drug
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2
المؤلفون: Yu-Wen Li, Harvey Wong, Allison B. Brenner, James E. Grace, Jianqing Li, Maria Rafalski, Nicholas J. Lodge, Macor John E, Ronald J. Mattson, Jonathan L. Ditta, Thaddeus F. Molski, Joanne J. Bronson, Vijay T. Ahuja, Robert Zaczek, Richard A. Hartz, Snjezana Lelas, Argyrios G. Arvanitis, Jeffrey A. Deskus, Kimberley A. Lentz, Richard E. Olson, Andrew P. Combs, William D. Schmitz, Eddy W. Yue, Derek J. Denhart
المصدر: Journal of Medicinal Chemistry. 52:4161-4172
مصطلحات موضوعية: Male, Metabolic Clearance Rate, Chemistry, Antagonist, Pharmacology, Receptors, Corticotropin-Releasing Hormone, Rats, Corticotropin-releasing hormone receptor 1, Bioavailability, Inhibitory Concentration 50, Biochemistry, Pharmacokinetics, In vivo, Oral administration, Pyrazines, Drug Discovery, Animals, Humans, Molecular Medicine, Receptor, IC50
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3
المؤلفون: Robert C. Bruckner, Andrew M. Stern, Anne Higley, Graciani Nilsa R, Sandya Mandlekar, Maria Rafalski, Melody Diamond, Ross L. Stein, Eddy W. Yue, Xiang Jiang, Pearl S. Huang, Randine Dowling, Dimeo Susan, Lisa C. Grimminger, Mingzhu Zhang, Zhihong Lai, Amy L. Musselman, Swamy Yeleswaram, Davette L. Behrens, Robert A. Copeland, Andrew P. Combs, Oliff Allen I, Wei Han, Shu-Yun Zhang, Rebecca Taub, Bruce Car, George L. Trainor, Charles F. Albright, Steve P. Seitz, Daniel Hu
المصدر: Molecular Cancer Therapeutics. 4:751-760
مصطلحات موضوعية: Cancer Research, Reticulocytes, Drug-Related Side Effects and Adverse Reactions, Matrix Metalloproteinases, Membrane-Associated, Fibrosarcoma, Transplantation, Heterologous, Pharmacology, Mice, Therapeutic index, Tumor Cells, Cultured, medicine, Animals, Humans, Prodrugs, Doxorubicin, Neprilysin, Chemistry, Metalloendopeptidases, Prodrug, medicine.disease, Peptide Fragments, In vitro, Transplantation, Matrix Metalloproteinase 9, Oncology, Matrix Metalloproteinase 2, HT1080, Drug Screening Assays, Antitumor, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45501a8fa2fc432573f20a1fa75bdc1c
https://doi.org/10.1158/1535-7163.mct-05-0006 -
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المؤلفون: Harvey Wong, Ge Zhang, John F. McElroy, Carolyn Diane Dzierba, Paul J. Gilligan, Yu-Wen Li, Andrew P. Combs, Thaddeus F. Molski, Snjezana Lelas, Yong Peng, Robert Zaczek, Maria Rafalski, Amy G. Takvorian, Padmaja Kasireddy-Polam, Rebecca Taub, George L. Trainor
المصدر: Journal of Medicinal Chemistry. 47:5783-5790
مصطلحات موضوعية: Male, medicine.medical_specialty, Pyridines, Administration, Oral, Anxiety, In Vitro Techniques, Binding, Competitive, Receptors, Corticotropin-Releasing Hormone, Corticotropin-releasing hormone receptor 1, Rats, Sprague-Dawley, Radioligand Assay, Structure-Activity Relationship, Dogs, In vivo, Internal medicine, Drug Discovery, Reaction Time, medicine, Animals, Structure–activity relationship, Receptor, IC50, Behavior, Animal, Chemistry, Antagonist, Small molecule, In vitro, Frontal Lobe, Rats, Endocrinology, Anti-Anxiety Agents, Pyrazines, Molecular Medicine, Half-Life
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5
المؤلفون: Douglas Guy Batt, William F. DeGrado, Arlene Rockwell, Prabhakar K. Jadhav, Joseph J. Petraitis, Shaker A. Mousa, Maria Rafalski, William J. Pitts
المصدر: Bioorganic & Medicinal Chemistry Letters. 9:937-942
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, medicine.drug_class, Carboxylic acid, Molecular Mimicry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Isoxazoles, Biochemistry, Chemical synthesis, Sulfonamide, Chain length, chemistry, Phase (matter), Drug Discovery, Structural isomer, medicine, Molecular Medicine, Receptors, Vitronectin, Oligopeptides, Molecular Biology
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6
المؤلفون: Andrew P. Combs, Maria Rafalski, Simon Saubern, Patrick Y.S. Lam
المصدر: Tetrahedron Letters. 40:1623-1626
مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Microwave heating, Organic Chemistry, Drug Discovery, Pyridine, Microwave irradiation, chemistry.chemical_element, Photochemistry, Biochemistry, Copper, Coupling reaction, Polymer supported
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7
المؤلفون: John Roderick, Chu-Biao Xue, Sharon A. Jackson, Richard E. Olson, Shaker A. Mousa, William F. DeGrado, Maria Rafalski, Arlene Rockwell
المصدر: Bioorganic & Medicinal Chemistry. 5:693-705
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Alkylation, Swine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Platelet Glycoprotein GPIIb-IIIa Complex, Benzoates, Biochemistry, Piperazines, Benzamidine, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, Drug Discovery, Aspartic acid, Animals, Humans, Structure–activity relationship, Moiety, Benzamide, Piperazine, Molecular Biology, Aspartic Acid, Sulfonamides, Alanine, Chemistry, Organic Chemistry, Esterases, Benzoic Acid, Benzamidines, Liver, Benzamides, beta-Alanine, Molecular Medicine, Platelet aggregation inhibitor, Carbamates, Glycoprotein IIb/IIIa, Oligopeptides, Platelet Aggregation Inhibitors
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8
المؤلفون: William F. DeGrado, John Roderick, Charles J. Eyermann, Shaker A. Mousa, Chu-Biao Xue, Maria Rafalski, Richard E. Olson
المصدر: Bioorganic & Medicinal Chemistry Letters. 6:339-344
مصطلحات موضوعية: chemistry.chemical_classification, Benzimidazole, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Peptide, Benzoxazole, Biochemistry, Benzamidine, Sulfonamide, chemistry.chemical_compound, chemistry, Glycoprotein IIb/IIIa inhibitors, Drug Discovery, medicine, Molecular Medicine, Moiety, Glycoprotein, Molecular Biology, medicine.drug
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9
المؤلفون: Maria Rafalski, Thais M. Sielecki, Bireshwar Dasgupta, Paul J. Gilligan, Padmaja Kasireddy-Polam, Thaddeus F. Molski, Argyrios G. Arvanitis, Nicholas J. Lodge, John E. Macor, Andrew P. Combs, Amy Galka, Shikha Vig, Amy G. Takvorian, Harvey Wong, George L. Trainor, Tricia L. Johnson, Carolyn Diane Dzierba, Joanne J. Bronson, Ge Zhang, Robert Zaczek
المصدر: Bioorganicmedicinal chemistry letters. 22(15)
مصطلحات موضوعية: medicine.medical_specialty, Chemistry, Pteridines, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Receptors, Corticotropin-Releasing Hormone, Rats, Structure-Activity Relationship, Endocrinology, Pharmacokinetics, Anti-Anxiety Agents, Internal medicine, Pyrazines, Drug Discovery, medicine, Molecular Medicine, Animals, Receptor, Molecular Biology, Half-Life
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10
المؤلفون: Yue-Zhong Shu, Macor John E, Richard A. Hartz, Richard E. Olson, Maria Rafalski, Yu-Wen Li, William D. Schmitz, Snjezana Lelas, Ronald J. Mattson, Gail K. Mattson, Joanne J. Bronson, Eddy W. Yue, Robert Zaczek, Yong Peng, Jingfang Qian-Cutrone, Nicholas J. Lodge, Frank W. Hobbs, Xiaoliang Zhuo, Argyrios G. Arvanitis, Andrew P. Combs, Vijay T. Ahuja, Kimberley A. Lentz, Jonathan L. Ditta, Jeffrey A. Deskus, Harvey Wong, Allison B. Brenner, Derek J. Denhart, James E. Grace, Joseph Payne, Thaddeus F. Molski
المصدر: Journal of medicinal chemistry. 52(14)
مصطلحات موضوعية: Male, Chemistry, medicine.drug_class, Antagonist, Pharmacology, Receptor antagonist, Receptors, Corticotropin-Releasing Hormone, In vitro, Rats, Rats, Sprague-Dawley, Macaca fascicularis, Structure-Activity Relationship, Pharmacokinetics, In vivo, Cell culture, Cell Line, Tumor, Pyrazines, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Animals, Humans, Receptor