المؤلفون: Steven Fried, L. Alexandra Wickham, Andrea D. Basso, Xinkang Wang, Lin Chu, Gary R. Sitko, Jason E. Imbriglio, Joseph M. Metzger, Karen Owens, Maria Maderia, Gino Castriota, Tian-Quan Cai, Maria Stranieri-Michener, Zhu Chen, Larry Handt

المصدر: Thrombosis Research. 145:133-139

مصطلحات موضوعية: 0301 basic medicine, Antagonist, Hemorrhage, Thrombosis, Hematology, 030204 cardiovascular system & hematology, Pharmacology, Biology, Platelet Activation, Macaca fascicularis, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Thrombin, In vivo, Hemostasis, cardiovascular system, medicine, Animals, Receptors, Thrombin, Platelet, Platelet activation, Receptor, Ex vivo, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22cc57d3496b4eef8d261c36432a307c
https://doi.org/10.1016/j.thromres.2016.06.007

المؤلفون: Lixia Jin, Shawn J. Stachel, Jacquelynn J. Cook, I. W. Chen, Marie A. Holahan, Steven M. Pitzenberger, Harold G. Selnick, Lou Anne Neilson, Debra S. Perlow, Craig A. Coburn, Melissa Egbertson, Beth Pietrak, John Swestock, Wenjin Yang, Georgia B. McGaughey, Ming Tain Lai, Maria Stranieri-Michener, James C. Barrow, Melody Mcwherter, Shaun R. Stauffer, Joseph P. Vacca, Shari Haugabook, Adam J. Simon, Samuel L. Graham, M. Katharine Holloway, Sethu Sankaranarayanan, Sanjeev Munshi, Zhi-Qiang Yang, Timothy Allison, Bruce Fahr, Katherine Tugusheva, Dennis Colussi

المصدر: Bioorganicmedicinal chemistry letters. 25(21)

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Methylation, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Aspartic Acid Endopeptidases, Humans, Receptor, Molecular Biology, biology, Dose-Response Relationship, Drug, Molecular Structure, Hydantoins, Organic Chemistry, Active site, Chemical modification, Ligand (biochemistry), Small molecule, Combinatorial chemistry, chemistry, biology.protein, Molecular Medicine, Piperidine, Amyloid Precursor Protein Secretases, Lead compound, Methyl group

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75108af66bf4e1bdc5122383cea324c
https://pubmed.ncbi.nlm.nih.gov/26195137

المؤلفون: Rominder Singh, K.J. Stauffer, S. Dale Lewis, Marie A. Holahan, Daniel R. McMasters, Youwei Yan, Harold G. Selnick, Rebecca B. White, Matthew M. Zrada, Peter D. Williams, Audrey A. Wallace, Joseph J. Lynch, Maria Stranieri-Michener, Beth Pietrak, Cynthia Miller-Stein, Bradley K. Wong, Yvonne M. Leonard, Julie A. Krueger, G. R. Sitko, Philippe G. Nantermet, Bobby J. Lucas, Jacquelyn J. Cook, Carl F. Homnick, Elizabeth A. Lyle, Christina L. Newton

المصدر: Journal of medicinal chemistry. 48(7)

مصطلحات موضوعية: Male, Models, Molecular, Proline, Stereochemistry, Administration, Oral, Biological Availability, In Vitro Techniques, Crystallography, X-Ray, Chemical synthesis, Rats, Sprague-Dawley, Structure-Activity Relationship, Thrombin, Dogs, Pharmacokinetics, Oral administration, In vivo, Drug Discovery, medicine, Potency, Animals, Humans, Fluorenes, biology, Chemistry, Stereoisomerism, Blood Proteins, Macaca mulatta, Rats, Enzyme inhibitor, biology.protein, Microsomes, Liver, Molecular Medicine, medicine.drug, Discovery and development of direct thrombin inhibitors, Half-Life, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3aca135659209619e69ed0f3ccd38b
https://pubmed.ncbi.nlm.nih.gov/15801822