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1
المؤلفون: Timothy P. Spicer, Marie-Therese Schaeffer, Peter Hodder, Hugh Rosen, Xuemei Peng, Peter Chase, Steven D. Brown, Ramulu Poddutoori, Mariangela Urbano, Miguel Guerrero, Edward Roberts
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:6346-6349
مصطلحات موضوعية: Azoles, Models, Molecular, Agonist, Molecular model, medicine.drug_class, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Mutagenesis (molecular biology technique), Ligands, Biochemistry, Article, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Receptor, Molecular Biology, Chemistry, Organic Chemistry, Rational design, Ligand (biochemistry), Amides, High-Throughput Screening Assays, Receptors, Lysosphingolipid, Molecular Medicine, Immunosuppressive Agents, Function (biology), Protein Binding
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2
المؤلفون: Mariangela Urbano, Olivier Civelli, Subash Velaparthi, Hugh Rosen, Marie-Therese Schaeffer, Steven D. Brown, Zhiwei Wang, Peter Hodder, Miguel Guerrero, Edward Roberts, S. Adrian Saldanha, Peter Chase, Jian Zhao
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:7135-7141
مصطلحات موضوعية: Receptors, Neuropeptide, Clinical Biochemistry, Pharmaceutical Science, Plasma protein binding, Pharmacology, Biochemistry, Article, Receptors, G-Protein-Coupled, Small Molecule Libraries, Structure-Activity Relationship, In vivo, Drug Discovery, Humans, Structure–activity relationship, Receptor, Molecular Biology, Chemistry, Organic Chemistry, Antagonist, Inflammatory pain, Small molecule, Pyridazines, Drug Design, Molecular Medicine, Protein Binding
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3
المؤلفون: Mariangela Urbano, Hugh Rosen, Melissa Crisp, Miguel Guerrero, Peter Hodder, Edward Roberts, Jian Zhao, Peter Chase, Marie-Therese Schaeffer, Steven D. Brown
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:537-542
مصطلحات موضوعية: Agonist, medicine.drug_class, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Small molecule, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Sphingosine-1-phosphate, Receptor, Molecular Biology
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4
المؤلفون: Jian Zhao, Mariangela Urbano, Miguel Guerrero, Hugh Rosen, Subash Velaparthi, Edward Roberts, Marie-Therese Schaeffer, Steven J. Brown
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5470-5474
مصطلحات موضوعية: Stereochemistry, Chemistry, Megakaryocyte differentiation, Sphingosine-1-phosphate receptor, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Small molecule, chemistry.chemical_compound, In vivo, Drug Discovery, Molecular Medicine, Structure–activity relationship, Moiety, Sphingosine-1-phosphate, Receptor, Molecular Biology
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5
المؤلفون: Junying Wang, Jing Chen Xiao, D. Sloan Stribling, Marie-Therese Schaeffer, Alison M. Strack, Lauren P. Shearman, Cathy C. R.-R. Huang, D. Euan MacIntyre, Thomas F. Walsh, Christina B. Madsen-Duggan, Chun-Pyn Shen, John S. Debenham, Jeffrey J. Hale, Tung M. Fong, Julie Lao, Xinchun Tong
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:2591-2594
مصطلحات موضوعية: Cannabinoid receptor, Chemistry, Pharmaceutical, medicine.medical_treatment, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Chemical synthesis, Receptor, Cannabinoid, CB2, Inhibitory Concentration 50, Structure-Activity Relationship, Receptor, Cannabinoid, CB1, Drug Discovery, medicine, Animals, Humans, Inverse agonist, Structure–activity relationship, Obesity, Receptor, Molecular Biology, Cannabinoid Receptor Agonists, Cannabinoids, Chemistry, Organic Chemistry, Biological activity, Protein Structure, Tertiary, Rats, Pyrimidines, Drug Design, Molecular Medicine, Cannabinoid
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6
المؤلفون: Timothy P. Spicer, Peter Hodder, Pedro J. Gonzalez-Cabrera, Steven J. Brown, Peter Chase, Jacqueline Chapman, Hugh Rosen, Marie Therese Schaeffer, Euijung Jo, Stephan C. Schürer
المصدر: ACS Chemical Biology. 3:486-498
مصطلحات موضوعية: Models, Molecular, Agonist, Protein Conformation, medicine.drug_class, Sphingosine-1-phosphate receptor, Biosensing Techniques, CHO Cells, Biology, Ligands, Biochemistry, Article, Structure-Activity Relationship, chemistry.chemical_compound, Cricetulus, Cricetinae, medicine, Animals, Cluster Analysis, Sphingosine-1-phosphate, Phosphorylation, Binding site, Receptor, Oxadiazoles, Binding Sites, General Medicine, Ligand (biochemistry), Receptors, Lysosphingolipid, chemistry, Docking (molecular), Molecular Probes, Biophysics, Molecular Medicine, Calcium, 5-HT1 receptor, Protein Binding
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7
المؤلفون: Mark T. Goulet, Christina B. Madsen-Duggan, Yue Feng, George A. Doss, Jing Chen Xiao, John S. Debenham, Cathy R.-R.C. Huang, Lex H.T. Van der Ploeg, Alison M. Strack, Chun-Pyn Shen, Marie-Therese Schaeffer, Donald J. Marsh, Junying Wang, D. Euan MacIntyre, Julie Lao, Tung M. Fong, D. Sloan Stribling, Lauren P. Shearman, Thomas F. Walsh, Xinchun Tong
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:681-685
مصطلحات موضوعية: Cannabinoid receptor, medicine.medical_treatment, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Chemical synthesis, Eating, Mice, Receptor, Cannabinoid, CB1, Oral administration, In vivo, Drug Discovery, medicine, Animals, Inverse agonist, Naphthyridines, Molecular Biology, Mice, Knockout, Binding Sites, Chemistry, Organic Chemistry, In vitro, Models, Chemical, nervous system, Knockout mouse, Molecular Medicine, lipids (amino acids, peptides, and proteins), Cannabinoid
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8
المؤلفون: Sander G. Mills, Xinchun Tong, Christopher W. Plummer, Chun-Pyn Shen, Jing Chen, Paul E. Finke, D. Sloan Stribling, Lex H.T. Van der Ploeg, George A. Doss, Junying Wang, Alison M. Strack, Lauren P. Shearman, Tung M. Fong, Julie Z. Lao, Marie-Therese Schaeffer
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:1441-1446
مصطلحات موضوعية: Food intake, Cannabinoid receptor, medicine.medical_treatment, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Body weight, Binding, Competitive, Biochemistry, Chemical synthesis, Eating, Structure-Activity Relationship, chemistry.chemical_compound, Receptor, Cannabinoid, CB1, Oral administration, Amide, Drug Discovery, medicine, Animals, Humans, Inverse agonist, Obesity, Molecular Biology, Molecular Structure, Chemistry, Body Weight, Organic Chemistry, Imidazoles, Rats, Disease Models, Animal, Area Under Curve, Molecular Medicine, Cannabinoid
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9
المؤلفون: Xiao-Ming Guan, Lex H.T. Van der Ploeg, Marie-Therese Schaeffer, Jie Liu, Tung M. Fong, Zhege J. Lao, Michael M. Jiang, Jiaping Zhang
المصدر: Biochemistry. 41:8954-8960
مصطلحات موضوعية: Agonist, medicine.drug_class, Stereochemistry, Molecular Sequence Data, Restriction Mapping, Peptide, Biology, Polymerase Chain Reaction, Biochemistry, Mice, medicine, Extracellular, Animals, Humans, Potency, Amino Acid Sequence, Cloning, Molecular, Receptor, DNA Primers, chemistry.chemical_classification, Base Sequence, Sequence Homology, Amino Acid, fungi, Ligand (biochemistry), Molecular biology, Rats, Bombesin receptor, Receptors, Bombesin, chemistry, Bombesin Receptor Subtype-3, Bombesin, Sequence Alignment
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10
المؤلفون: Pedro J. Gonzalez-Cabrera, Fiona Scott, Bryan Clemons, Marie-Therese Schaeffer, Gor Sarkisyan, Hugh Rosen, Liming Huang, Nhan Nguyen, Stuart M. Cahalan, Adam Richard Yeager
المصدر: Nature chemical biology
مصطلحات موضوعية: Agonist, Multiple Sclerosis, Time Factors, medicine.drug_class, Lymphocyte, Green Fluorescent Proteins, Down-Regulation, Biology, Article, Green fluorescent protein, 03 medical and health sciences, Mice, 0302 clinical medicine, Gene knockin, medicine, Animals, Endothelium, Gene Knock-In Techniques, Lymphocytes, Receptor, Molecular Biology, 030304 developmental biology, Fluorescent Dyes, 0303 health sciences, Cell Biology, Flow Cytometry, Molecular biology, 3. Good health, Receptors, Lysosphingolipid, medicine.anatomical_structure, 030217 neurology & neurosurgery, Receptor degradation