المؤلفون: Gabriela Ispas, Anil Koul, Johan Verbeeck, Jennifer Sheehan, Brigitte Sanders-Beer, Dirk Roymans, Koen Andries, Marie-Claude Rouan, Sandra De Jonghe, Jean-François Bonfanti, Marc Vanstockem, Kenneth Simmen, Rene Verloes

المصدر: PLoS ONE, Vol 10, Iss 5, p e0126959 (2015)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/f305416d7c6540b8927222167c47ba8d

المؤلفون: Sandy Thijssen, Sofie Starckx, Adriana Looszova, Geert Mannens, Ilham Smyej, Sandra De Jonghe, Tom Verhaeghe, Marie-Claude Rouan, Ann Lampo

المصدر: Toxicologic pathology. 45(5)

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, medicine.drug_class, Metabolite, 030106 microbiology, Antibiotics, Antitubercular Agents, Administration, Oral, Pharmacology, Toxicology, Pathology and Forensic Medicine, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Pharmacokinetics, Internal medicine, medicine, Animals, Tissue Distribution, Diarylquinolines, Adverse effect, Muscle, Skeletal, Molecular Biology, Pancreas, Phospholipids, Phospholipidosis, business.industry, Stomach, Myocardium, Cell Biology, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Toxicity, Female, Bedaquiline, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925cefd774175f9c4f8da214b2717b26
https://pubmed.ncbi.nlm.nih.gov/28789609

المؤلفون: Maxwell D. Cummings, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan, Katie Amssoms, Stefaan Last, Benoit Devogelaere, Marie-Claude Rouan, Leen Vijgen, Jan Martin Berke, Pascale Dehertogh, Els Fransen, Erna Cleiren, Liesbet van der Helm, Gregory Fanning, Origène Nyanguile, Kenny Simmen, Pieter Van Remoortere, Pierre Raboisson, Sandrine Vendeville

المصدر: Journal of Medicinal Chemistry. 57:1880-1892

مصطلحات موضوعية: Models, Molecular, Simeprevir, Magnetic Resonance Spectroscopy, Hepatitis C virus, Drug Evaluation, Preclinical, Viral Nonstructural Proteins, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Mass Spectrometry, Virus, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Potency, Enzyme Inhibitors, Polymerase, Sulfonamides, biology, Chemistry, Virology, In vitro, Rats, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a739d81f60a1fc5d33b63d73ddc9a32b
https://doi.org/10.1021/jm401396p

المؤلفون: Wim Bert Griet Schepens, Judith Eva Baumeister, Tim H. M. Jonckers, Geerwin Yvonne Paul Haché, Sabine Hallenberger, Marie-Claude Rouan, Jennifer C. Sasaki

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:4998-5002

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Pharmacokinetics, Amide, Drug Discovery, medicine, Animals, Cytochrome P-450 CYP3A, Humans, HIV Protease Inhibitor, Benzothiazoles, Molecular Biology, ADME, Benzoxazoles, CYP3A4, Organic Chemistry, HIV Protease Inhibitors, Benzoxazole, Amides, Rats, chemistry, Benzothiazole, HIV-1, Cytochrome P-450 CYP3A Inhibitors, Molecular Medicine, Ritonavir, Caco-2 Cells, Half-Life, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2d88d0d5d3ea91fb98899e19d056b0
https://doi.org/10.1016/j.bmcl.2012.06.022

المؤلفون: Sandrine Vendeville, Tse-I. Lin, Lili Hu, Abdellah Tahri, David McGowan, Maxwell D. Cummings, Katie Amssoms, Maxime Canard, Stefaan Last, Iris Van den Steen, Benoit Devogelaere, Marie-Claude Rouan, Leen Vijgen, Jan Martin Berke, Pascale Dehertogh, Els Fransen, Erna Cleiren, Liesbet van der Helm, Gregory Fanning, Kristof Van Emelen, Origène Nyanguile, Kenny Simmen, Pierre Raboisson

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:4437-4443

مصطلحات موضوعية: Indoles, Macrocyclic Compounds, Stereochemistry, Hepatitis C virus, Clinical Biochemistry, Allosteric regulation, Drug Evaluation, Preclinical, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Virus Replication, Ring (chemistry), medicine.disease_cause, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Biochemistry, Rats, Sprague-Dawley, Structure-Activity Relationship, Allosteric Regulation, Pharmacokinetics, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Potency, Enzyme Inhibitors, Molecular Biology, Indole test, Sulfonamides, Chemistry, Organic Chemistry, Rats, Liver, Cell culture, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdda9d43e14137e73732d76cab0062d
https://doi.org/10.1016/j.bmcl.2012.04.113

المؤلفون: Ron Gilissen, Lieve Dillen, Tom Gevers, Nancer Lounis, Araz Raoof, Koen Andries, Marie-Claude Rouan

المصدر: Antimicrobial agents and chemotherapy

مصطلحات موضوعية: Male, Metabolite, Antitubercular Agents, Colony Count, Microbial, Microbial Sensitivity Tests, Pharmacology, Drug Administration Schedule, Mycobacterium tuberculosis, Mice, chemistry.chemical_compound, Bacterial Proteins, Pharmacokinetics, Oral administration, Animals, Humans, Medicine, Drug Dosage Calculations, Pharmacology (medical), Dosing, Diarylquinolines, Lung, Tuberculosis, Pulmonary, Biotransformation, biology, business.industry, Pharmacology. Therapy, Drug Administration Routes, Half-life, Desmethyl, biology.organism_classification, ATP Synthetase Complexes, Disease Models, Animal, Infectious Diseases, chemistry, Area Under Curve, Pharmacodynamics, Quinolines, Female, business, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218a2580892f26d9ce1c8f2e48a60e85
https://doi.org/10.1128/aac.00720-11

المؤلفون: D Sawant, Dirk Roymans, R. Verloes, Koen Andries, P Sowinski, B Wang, Anil Koul, Marc Vanstockem, B Van Kerckhove, D Nauwelaers, Marie-Claude Rouan, Peter J. M. Openshaw, F Van Velsen, M De Meulder, P Van Remoortere, C Schnoeller, Wieslawa Olszewska, G Ispas, Jean-François Bonfanti, T Van de Casteele

المصدر: European Respiratory Journal. 38:401-408

مصطلحات موضوعية: Lung Diseases, Pulmonary and Respiratory Medicine, Palivizumab, Pyridines, medicine.drug_class, Respiratory Syncytial Virus Infections, Virus Replication, Antiviral Agents, Mice, chemistry.chemical_compound, In vivo, medicine, Animals, Mononegavirales, Lung, Mice, Inbred BALB C, medicine.diagnostic_test, biology, business.industry, Ribavirin, Viral Load, Virus Internalization, biology.organism_classification, medicine.disease, Virology, Respiratory Syncytial Viruses, Treatment Outcome, Bronchoalveolar lavage, chemistry, Bronchiolitis, Immunology, Benzimidazoles, Female, Antiviral drug, business, Bronchoalveolar Lavage Fluid, Viral load, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86870442d480a236e604b1db14574811
https://doi.org/10.1183/09031936.00005610

المؤلفون: Guy Van den Mooter, Liesbeth Grooten, Gerben Albert Eleutherius Van 'T Klooster, Elke Van Gyseghem, Jan Rosier, Laurent Schueller, Herman de Kock, Marie-Claude Rouan, Lieven Baert, Voorspoels Jody Firmin Marceline, Pieter Van Remoortere

المصدر: European Journal of Pharmaceutical Sciences. 41:193-200

مصطلحات موضوعية: Sulfonamides, Chromatography, Chemistry, Pharmaceutical, Sodium lauryl sulphate, Pharmaceutical Science, HIV Protease Inhibitors, Polyethylene glycol, Pharmacology, chemistry.chemical_compound, Dogs, Pharmacokinetics, Pharmaceutical technology, chemistry, Drug delivery, Plasma concentration, medicine, Animals, Darunavir, Tablets, medicine.drug, Co administration

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e4035aa15a1d25e1f567c11c129df2
https://doi.org/10.1016/j.ejps.2010.05.017

المؤلفون: Daniele Alberti, Romain Sechaud, Renzo Galanello, Antonio Piga, Hilde Bigler, Marie-Claude Rouan

المصدر: The Journal of Clinical Pharmacology. 43:565-572

مصطلحات موضوعية: Pharmacology, business.industry, Deferasirox, Cmax, Pharmacokinetics, Tolerability, Oral administration, Pharmacodynamics, Blood plasma, Toxicity, Immunology, Medicine, Pharmacology (medical), business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a4bf08d64bc9434e01b81923065fae
https://doi.org/10.1177/0091270003253350

المؤلفون: David McGowan, Sandrine Vendeville, Tse-I Lin, Abdellah Tahri, Lili Hu, Maxwell D. Cummings, Katie Amssoms, Jan Martin Berke, Maxime Canard, Erna Cleiren, Pascale Dehertogh, Stefaan Last, Els Fransen, Elisabeth Van Der Helm, Iris Van den Steen, Leen Vijgen, Marie-Claude Rouan, Gregory Fanning, Origène Nyanguile, Kristof Van Emelen, Kenneth Simmen, Pierre Raboisson

المصدر: Bioorganicmedicinal chemistry letters. 22(13)

مصطلحات موضوعية: Indoles, Stereochemistry, Clinical Biochemistry, Allosteric regulation, Drug Evaluation, Preclinical, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Ring (chemistry), Virus Replication, Biochemistry, Antiviral Agents, Ns5b polymerase, Rats, Sprague-Dawley, chemistry.chemical_compound, Structure-Activity Relationship, Allosteric Regulation, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Potency, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Cell potency, Indole test, Chemistry, Organic Chemistry, Rats, Microsomes, Liver, Molecular Medicine, Bioisostere

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f464255080be25fce83db8bd04aefdd
https://pubmed.ncbi.nlm.nih.gov/22542193