المؤلفون: James G. Macfarlane, David A. Dorward, Marie-Hélène Ruchaud-Sparagano, Jonathan Scott, Christopher D. Lucas, Adriano G. Rossi, A. John Simpson

المصدر: Journal of Inflammation, Vol 17, Iss 1, Pp 1-12 (2020)

مصطلحات موضوعية: Dasatinib, Src kinases, Neutrophil, Acute lung injury, acute respiratory distress syndrome, Pneumonia, Phagocytosis, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12950-020-00261-5; https://doaj.org/toc/1476-9255

URL الوصول: https://doaj.org/article/265f8bb518ed4ed1996f119e15528116

المؤلفون: Wendy Funston, Marie-Hélène Ruchaud-Sparagano, Jonathan Scott, Jason Powell, Faye A H Cooles, Lauren Shelmerdine, Cliona McDowell, Denis O'Leary, Karen L Booth, Stephen C Clark, Simon J Ledingham, Anthony J Rostron, John H Dark, A John Simpson

المصدر: PLoS ONE, Vol 17, Iss 7, p e0271958 (2022)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/2aa19e5197294224bd7a878b503c8168

المؤلفون: Marie-Hélène Ruchaud-Sparagano, Sabrina Mühlen, Paul Dean, Brendan Kenny

المصدر: PLoS Pathogens, Vol 7, Iss 12, p e1002414 (2011)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22144899/pdf/?tool=EBI; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

URL الوصول: https://doaj.org/article/60416883997542438378929f55d7f720

المؤلفون: Gary Reynolds, Ian Forrest, Jonathan Scott, Kile Green, Sarah Wiscombe, David McDonald, Andrew Filby, Matthew Collin, Marie-Hélène Ruchaud-Sparagano, Laura Jardine, A. John Simpson, Muzlifah Haniffa, Andrew Fuller

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications

مصطلحات موضوعية: Lipopolysaccharides, 0301 basic medicine, Lipopolysaccharide, Science, General Physics and Astronomy, Inflammation, 02 engineering and technology, Article, Monocytes, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, Macrophages, Alveolar, medicine, Humans, Acute inflammation, lcsh:Science, Monocytes and macrophages, Respiratory tract diseases, Multidisciplinary, Innate immune system, medicine.diagnostic_test, business.industry, Monocyte, Dendritic Cells, General Chemistry, Dendritic cell, Mononuclear phagocyte system, respiratory system, 021001 nanoscience & nanotechnology, Acquired immune system, 030104 developmental biology, medicine.anatomical_structure, Bronchoalveolar lavage, chemistry, Immunology, Mucosal immunology, Cytokines, lcsh:Q, medicine.symptom, 0210 nano-technology, business, Bronchoalveolar Lavage Fluid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4adc6a527666b99237705008bc22fae
https://doaj.org/article/11e52c2ba9844e3281cec25ae0efb925

المؤلفون: Leena Habiballa, David Dolan, Anthony B. Lagnado, Madison L. Doolittle, Jodie Birch, Daniel Geh, Helen L. Reeves, Marie-Hélène Ruchaud-Sparagano, Shane A. Evans, Nicola Neretti, Amy L Collins, Sushma Nagaraja Grellscheid, João F. Passos, Derek A. Mann, Thomas von Zglinicki, Sanjay Pandanaboyana, Colin H Wilson, Claudio Akio Masuda, Diana Jurk, Caroline L. Wilson, Tamar Tchkonia, Adam Hruby, Suchira Gallage, Maria Grazia Vizioli, Stella Victorelli, Petra Hirsova, Jack Leslie, Kevin D. Pavelko, Hanna Salmonowicz, Mathias Heikenwalder, Gabriele Saretzki, James Chapman, Sundeep Khosla, Mikolaj Ogrodnik, Bernadette Carroll, James L. Kirkland, Fiona Oakley

المصدر: The EMBO Journal
e106048
The EMBO Journal, 2021, Vol.40(9), pp.e106048 [Peer Reviewed Journal]
EMBO Journal
Lagnado, A, Carroll, B, Passos, J F & al., E 2021, ' Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner ', EMBO Journal, vol. 40, no. 9, e106048 . https://doi.org/10.15252/embj.2020106048

مصطلحات موضوعية: Senescence, 0303 health sciences, senescence, Cell cycle checkpoint, General Immunology and Microbiology, General Neuroscience, aging, Biology, telomeres, medicine.disease, Phenotype, General Biochemistry, Genetics and Molecular Biology, In vitro, Cell biology, Telomere, 03 medical and health sciences, Liver disease, Paracrine signalling, 0302 clinical medicine, neutrophils, medicine, Molecular Biology, 030217 neurology & neurosurgery, Ex vivo, 030304 developmental biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7ecf05c62cdbe0563c81d2d28fa0fa

المؤلفون: A. John Simpson, Jonathan Scott, David A. Dorward, Marie-Hélène Ruchaud-Sparagano, James G. Macfarlane, Adriano G. Rossi, Christopher D. Lucas

المصدر: Journal of Inflammation (London, England)
MacFarlane, J G, Dorward, D A, Ruchaud-Sparagano, M-H, Scott, J, Lucas, C D, Rossi, A G & Simpson, A J 2020, ' Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury ', Journal of inflammation . https://doi.org/10.1186/s12950-020-00261-5
Journal of Inflammation, Vol 17, Iss 1, Pp 1-12 (2020)

مصطلحات موضوعية: 0301 basic medicine, Phagocytosis, Clinical Biochemistry, Dasatinib, Inflammation, Lung injury, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, medicine, business.industry, Research, lcsh:RM1-950, Neutrophil, Degranulation, Chemotaxis, Cell Biology, Pneumonia, Acute lung injury, acute respiratory distress syndrome, 3. Good health, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, 030220 oncology & carcinogenesis, Neutrophil degranulation, Cancer research, medicine.symptom, Src kinases, business, Infection, medicine.drug, Proto-oncogene tyrosine-protein kinase Src

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926bfcaf5e28d6d4f744ef45dbcb777a
http://europepmc.org/articles/PMC7597020

المؤلفون: David K. Menon, Charlotte Summers, Edwin R. Chilvers, Alexander J.T. Wood, Carmelo Zinnato, A. John Simpson, Jonathan Scott, Kamal Kishore, Carmen Gonzalez-Tejedo, Andrew Conway Morris, Clive D'Santos, Klaus Okkenhaug, Marie-Hélène Ruchaud-Sparagano, Arlette Vassallo

المساهمون: Kishore, Kamal [0000-0002-4650-8745], Menon, David [0000-0002-3228-9692], Summers, Charlotte [0000-0002-7269-2873], Okkenhaug, Klaus [0000-0002-9432-4051], Apollo - University of Cambridge Repository

المصدر: JCI Insight

مصطلحات موضوعية: 0301 basic medicine, Staphylococcus aureus, Proteome, Endosome, Neutrophils, Phagocytosis, Critical Illness, Immunology, Complement, Complement C5a, chemical and pharmacologic phenomena, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Immune system, Bacterial infections, Phagosomes, medicine, Humans, Protein phosphorylation, PI3K/AKT/mTOR pathway, Infectious disease, Chemistry, Critically ill, FOS: Clinical medicine, hemic and immune systems, General Medicine, Staphylococcal Infections, Phosphoproteins, 3. Good health, Cell biology, 030104 developmental biology, 030220 oncology & carcinogenesis, Case-Control Studies, Signal transduction, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b99e14b0f0a845fe0443f1914a1190
http://hdl.handle.net/10044/1/81729

المؤلفون: Kathryn M. Musgrave, Stephen E Wright, Anthony J. Rostron, John D. Perry, Jonathan M. Scott, Alistair I Roy, Marie-Hélène Ruchaud-Sparagano, A. John Simpson, Andrew Conway Morris

المصدر: Journal of immunology (Baltimore, Md. : 1950). 207(7)

مصطلحات موضوعية: Adult, Male, Risk, RHOA, Class I Phosphatidylinositol 3-Kinases, Neutrophils, Phagocytosis, Critical Illness, Immunology, Sepsis, 3-Phosphoinositide-Dependent Protein Kinases, Bacteriolysis, Intensive care, Immunology and Allergy, Medicine, Humans, Protein kinase A, Cells, Cultured, Aged, Phosphoinositide-3 Kinase Inhibitors, Aged, 80 and over, Phosphoinositide 3-kinase, biology, business.industry, SARS-CoV-2, COVID-19, Pneumonia, Middle Aged, medicine.disease, Cyclic AMP-Dependent Protein Kinases, Bacterial Load, Blood pressure, biology.protein, Phosphorylation, Female, business, Respiratory Insufficiency

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ef14e94eb03267e76cbb84573713b6
https://pubmed.ncbi.nlm.nih.gov/34497151

المؤلفون: Klaus Okkenhaug, Clive D'Santos, Charlotte Summers, Marie-Hélène Ruchaud-Sparagano, Jonathan M. Scott, Andrew Conway Morris, A. John Simpson, David K. Menon, Arlette Vassallo, Alex J. Wood, Carmelo Zinnato, Kamal Kishore, Edwin R. Chilvers, Carmen Gonzalez-Tejedo

مصطلحات موضوعية: 0303 health sciences, Endosome, Phagocytosis, hemic and immune systems, chemical and pharmacologic phenomena, Complement C5a, medicine.disease_cause, Cell biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, chemistry, Staphylococcus aureus, medicine, Neutrophil dysfunction, Protein phosphorylation, Phosphatidylinositol, 030304 developmental biology, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bd2e2ed979112e1edf50b0dee6b0a7
https://doi.org/10.1101/2020.01.17.907618

المؤلفون: Marie-Hélène Ruchaud-Sparagano, Stephen E Wright, Michael W. Mather, Stephen Cummings, Janet A. Wilson, Faye A. H. Cooles, Jon Scott, Bernard Verdon, John D. Perry, Andrew Nelson, Jason Powell, Chris Ward, James P. Garnett, A. John Simpson, K Jiwa, Jeffrey P. Pearson

مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, Glottis, Neutrophils, Mucoproteins, Critical Illness, Phagocytosis, B100, Critical Care and Intensive Care Medicine, Microbiology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Colonization, Prospective Studies, Aged, Inflammation, Host (biology), business.industry, Mucin, Mucins, Ventilator-associated pneumonia, 030208 emergency & critical care medicine, C500, Middle Aged, A300, bacterial infections and mycoses, medicine.disease, Respiration, Artificial, Immunity, Innate, respiratory tract diseases, Pneumonia, 030228 respiratory system, Female, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34d2c68604fb15c5c9614863f6f4531