المؤلفون: Alexander Safrygin, Petr Zhmurov, Dmitry Dar’in, Sergey Silonov, Mariia Kasatkina, Yulia Zonis, Maxim Gureev, Mikhail Krasavin

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1916-1921 (2021)

مصطلحات موضوعية: castagnoli-cushman reaction, 1-oxo-3,4-dihydroisoquinoline-4-carboxamides, poly(adp-ribose) polymerase, parp1/2 selectivity, nad+ mimetics, druglikeness, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/94cbe3267a764eb3b862deda4ce22495

المؤلفون: Alexander Safrygin, Petr Zhmurov, Dmitry Dar’in, Sergey Silonov, Mariia Kasatkina, Yulia Zonis, Maxim Gureev, Mikhail Krasavin

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1968-1983 (2021)

مصطلحات موضوعية: poly(adp-ribose) polymerase, parp1/2 selectivity, nad+ mimetics, 3,4-dihydroisoquinolone-4-carboxamides, castagnoli-cushman reaction, druglikeness, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/a5d24594dad4463bb818fc64b8151896

المؤلفون: Yulia Zonis, Dmitry Dar'in, Alexander Safrygin, Maxim Gureev, Mikhail Krasavin, Sergey Silonov, Mariia Kasatkina, Petr A. Zhmurov

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1916-1921 (2021)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record

مصطلحات موضوعية: Stereochemistry, Protein Conformation, Poly ADP ribose polymerase, Antineoplastic Agents, RM1-950, Acetates, Poly(ADP-ribose) Polymerase Inhibitors, Quinolones, Piperazines, Olaparib, chemistry.chemical_compound, Structure-Activity Relationship, PARP1, Drug Discovery, Humans, Amino Acid Sequence, poly(adp-ribose) polymerase, Polymerase, ADME, Pharmacology, Binding Sites, biology, 1-oxo-3,4-dihydroisoquinoline-4-carboxamides, Brief Report, General Medicine, NAD, parp1/2 selectivity, chemistry, PARP inhibitor, biology.protein, Phthalazines, druglikeness, Therapeutics. Pharmacology, Drug Screening Assays, Antitumor, Poly(ADP-ribose) Polymerases, Selectivity, Ammonium acetate, castagnoli-cushman reaction, nad+ mimetics, DNA Damage, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644be9e501a51538aba43fee94308b13
https://doaj.org/article/94cbe3267a764eb3b862deda4ce22495

المؤلفون: Maxim Gureev, Dmitry Dar'in, Yulia Zonis, Mikhail Krasavin, Sergey Silonov, Mariia Kasatkina, Petr A. Zhmurov, Alexander Safrygin

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1968-1983 (2021)

مصطلحات موضوعية: Models, Molecular, Poly ADP ribose polymerase, Antineoplastic Agents, RM1-950, Plasma protein binding, Poly(ADP-ribose) Polymerase Inhibitors, NAD+ mimetics, Olaparib, chemistry.chemical_compound, Structure-Activity Relationship, PARP1, Drug Discovery, Humans, Polymerase, ADME, Pharmacology, biology, Dose-Response Relationship, Drug, Molecular Structure, Poly(ADP-ribose) polymerase, Brief Report, General Medicine, Druglikeness, 3,4-dihydroisoquinolone-4-carboxamides, Combinatorial chemistry, PARP1/2 selectivity, chemistry, biology.protein, druglikeness, Therapeutics. Pharmacology, Poly(ADP-ribose) Polymerases, Lead compound, castagnoli-cushman reaction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f518868879f066e789c87c9bccbb4021