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المؤلفون: Tim Esbenshade, Martin D. Brand, Ramzi F. Sweis, Simon Melov, Vojtech Mezera, Bryan McKibben, Pratiksha A. Dighe, Marina A. Pliushchev, Akos A. Gerencser, Zhi Wang, Stephan Riedmaier, Hoi Shan Wong
المصدر: Free Radical Biology and Medicine. 164:223-232
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, medicine.medical_specialty, Reactive oxygen species, biology, Superoxide, Succinate dehydrogenase, SOD2, Mitochondrion, medicine.disease, Biochemistry, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Endocrinology, chemistry, In vivo, Physiology (medical), Internal medicine, medicine, biology.protein, Steatosis, 030217 neurology & neurosurgery
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المؤلفون: Kathy Sarris, Ying Wang, Gary G. Chiang, Yupeng He, Mikkel Algire, Ramzi F. Sweis, Huan-Qiu Li, Marina A. Pliushchev, Zhiqin Ji, Paul L. Richardson, Maricel Torrent, Bailin Shaw, Richard F. Clark, Michael L. Curtin, Justin D. Dietrich, Clarissa G. Jakob, Chaohong Sun, Sujatha Selvaraju, Haizhong Zhu, Hongyu Zhao, Michael R. Michaelides
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1576-1583
مصطلحات موضوعية: 0301 basic medicine, Pyrrolidines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Stereoisomerism, macromolecular substances, Plasma protein binding, Ligands, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Mouse xenograft, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, PRC2 complex, Molecular Biology, Indole test, Sulfonamides, biology, Novel protein, Chemistry, Organic Chemistry, Polycomb Repressive Complex 2, Xenograft Model Antitumor Assays, 030104 developmental biology, 030220 oncology & carcinogenesis, Microsomes, Liver, biology.protein, Molecular Medicine, PRC2, Protein Binding
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المؤلفون: Nirupama B. Soni, Anil Vasudevan, Jun Guo, Marina A. Pliushchev, Julie L. Wilsbacher, H. Robin Heyman, Michael R. Michaelides, Kathy Sarris, Bryan K. Sorensen, Richard F. Clark, Noah Tu, Min Cheng, George Doherty, Alla Korepanova, Anurupa Shrestha, Michael L. Curtin, Mikkel Algire, Badagnani Ilaria, Kenton L. Longenecker, Chris Tse, Diana Raich, Woller Kevin R, Robin R. Frey, Violeta L. Marin, Gary G. Chiang, T. Matthew Hansen, Ana L. Aguirre, F. Greg Buchanan, Peter Kovar, David Maag, Dong Cheng, Paul L. Richardson, Ramzi F. Sweis
المصدر: Bioorganicmedicinal chemistry letters. 27(15)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Clinical Biochemistry, Nicotinamide phosphoribosyltransferase, Pharmaceutical Science, Antineoplastic Agents, Isoindoles, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cell Line, Tumor, Neoplasms, Drug Discovery, Structure–activity relationship, Animals, Humans, Urea, Enzyme Inhibitors, Nicotinamide Phosphoribosyltransferase, Molecular Biology, Cell Proliferation, Antitumor activity, Drug discovery, Cell growth, Organic Chemistry, Substrate (chemistry), Isoindoline, 030104 developmental biology, chemistry, Molecular Medicine, Cytokines
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المؤلفون: Kenneth M. Comess, Steven Kennedy, Donald J. Osterling, Michael L. Curtin, Masoud Vedadi, Ramzi F. Sweis, Guillermo Senisterra, Mikkel Algire, Evelyne Lima-Fernandes, Dalia Barsyte-Lovejoy, Justin D. Dietrich, William N. Pappano, Bailin Shaw, David Maag, Dong Cheng, Cheryl H. Arrowsmith, Fengling Li, Marina A. Pliushchev, Kelly L Klinge, Jun Guo, Chaohong Sun, Andrew M. Petros, Gary G. Chiang, Magdalena M. Szewczyk, Huan-Qiu Li, Maricel Torrent, Scott Galasinski, Sujatha Selvaraju, Yupeng He, David Lindley, Clarissa G. Jakob, Sanjay C. Panchal, Wenqing Gao, Lance J Bigelow, Haizhong Zhu, Fritz G. Buchanan, Qin Wu
المصدر: Nature chemical biology. 13(4)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Cell Survival, Protein subunit, Allosteric regulation, Antineoplastic Agents, macromolecular substances, Protein–protein interaction, 03 medical and health sciences, Histone H3, Structure-Activity Relationship, 0302 clinical medicine, Cell Line, Tumor, Tumor Cells, Cultured, Gene silencing, Humans, Epigenetics, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Sulfonamides, biology, Dose-Response Relationship, Drug, Molecular Structure, Polycomb Repressive Complex 2, Cell Biology, 030104 developmental biology, Enzyme, Biochemistry, chemistry, 030220 oncology & carcinogenesis, Indans, biology.protein, Drug Screening Assays, Antitumor, PRC2, Protein Binding
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المؤلفون: Hovis M. Imade, Hing L. Sham, Liping Pan, Linda E. Chovan, Heidi S. Camp, Bryan K. Sorensen, Rodger F. Henry, Jiahong Wang, Atul Ramaiya, Mark M. Mullally, Rohde Jeffrey J, J.T. Link, William J. Chiou, Katina Monzon, Peer B. Jacobson, Thomas A. Fey, Kennan C. Marsh, Xiaoqing Deng, David W A Beno, DeAnne Stolarik, Brian A. Droz, Steven Fung, Michael E. Brune, Ernst U. Frevert, Marina A. Pliushchev, Qi Shuai, Dariusz Wodka
المصدر: Journal of Medicinal Chemistry. 50:149-164
مصطلحات موضوعية: Adamantane, Dehydrogenase, In Vitro Techniques, Piperazines, Cell Line, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, 11β-hydroxysteroid dehydrogenase type 1, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, Animals, Humans, Structure–activity relationship, Tissue Distribution, chemistry.chemical_classification, biology, Chemistry, Stereoisomerism, Rats, Enzyme, Biochemistry, Enzyme inhibitor, Microsomes, Liver, biology.protein, Molecular Medicine, Ex vivo
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المؤلفون: Daisy Pireh, Stevan W. Djuric, Richard J. Sciotti, David Madar, Paul E. Wiedeman, Marina A. Pliushchev, Jonathan Pease, Hana Kopecka
المصدر: Tetrahedron Letters. 42:3681-3684
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Aryl, Organic Chemistry, Drug Discovery, chemistry.chemical_element, Biochemistry, Combinatorial chemistry, Coupling reaction, Antibacterial agent, Catalysis, Palladium
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المؤلفون: Gary G. Chiang, Masoud Vedadi, Michael R. Michaelides, William N. Pappano, Nirupama B. Soni, Jun Guo, David Maag, Andrew M. Petros, Chris Tse, Fengling Li, Marina A. Pliushchev, Ramzi F. Sweis, Peter Brown
المصدر: ACS medicinal chemistry letters. 5(2)
مصطلحات موضوعية: Genetics, Methyltransferase, Histone deacetylase 2, Organic Chemistry, EZH2, Lysine, Methylation, Biology, complex mixtures, Biochemistry, Histone H3, Histone methyltransferase, Drug Discovery, bacteria, Epigenetics
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المؤلفون: Marina A. Pliushchev, Angela M. Nilius, Paul E. Wiedeman, Robert A. Jolly, Darlene J. Balli, DeAnne Stolarik, Robert K. Flamm, Roger G. Ulrich, Richard J. Sciotti, Stevan W. Djuric, Kennan C. Marsh
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:2121-2123
مصطلحات موضوعية: Molecular Structure, Stereochemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Linezolid, Pharmaceutical Science, Gram-Positive Bacteria, Antimicrobial, Biochemistry, Chemical synthesis, Anti-Bacterial Agents, Rats, Structure-Activity Relationship, chemistry.chemical_compound, Acetamides, Drug Discovery, Animals, Molecular Medicine, Pharmacophore, Molecular Biology, Oxazolidinones, Biological evaluation, Antibacterial agent
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المؤلفون: Richard J. Sciotti, Marina A. Pliushchev, Paul E. Wiedeman, David Madar, Stevan W. Djuric, Jonathan Pease, Hana Kopecka, Daisy Pireh
المصدر: ChemInform. 32
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Aryl, chemistry.chemical_element, Organic chemistry, General Medicine, Combinatorial chemistry, Coupling reaction, Palladium, Catalysis, Antibacterial agent
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المؤلفون: David W A Beno, Wenying Qin, J.T. Link, Jiahong Wang, Liping Pan, M. Winn, Peer B. Jacobson, Francis A. J. Kerdesky, Seble Wagaw, Michael E. Brune, Hing L. Sham, Jyoti R. Patel, Russell A. Judge, DeAnne Stolarik, Linda E. Chovan, Jürgen Dinges, Steven Fung, Hovis M. Imade, Qi Shuai, Kenton L. Longenecker, Kenneth M. Engstrom, Katina Monzon, Marina A. Pliushchev, William J. Chiou
المصدر: Bioorganicmedicinal chemistry letters. 17(3)
مصطلحات موضوعية: Models, Molecular, endocrine system, animal structures, Hydrogenase, Alkylation, Stereochemistry, Adamantane, Clinical Biochemistry, Pharmaceutical Science, Ether, Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Mice, Drug Discovery, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Animals, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Mice, Knockout, biology, Dose-Response Relationship, Drug, Organic Chemistry, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Microsomes, Liver, Molecular Medicine, Indicators and Reagents, Selectivity, Ex vivo, Ethers, Half-Life
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