نتائج البحث - "Marina Fridlib"

1

دورية أكاديمية

Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF

المصدر: Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)

مصطلحات موضوعية: Transforming growth factor-β, Precision-cut lung slice, Antifibrotic, αv integrin, PLN-74809, Diseases of the respiratory system, RC705-779

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1465-993X

URL الوصول: https://doaj.org/article/f75a5266ef724db48db905d69406f78e

Find this article in full text from Springer Verlag.

Find this article in full text from ProQuest

Full Text Finder

2

دورية أكاديمية

FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression

المؤلفون: Timothy S. Heuer, Richard Ventura, Kasia Mordec, Julie Lai, Marina Fridlib, Douglas Buckley, George Kemble

المصدر: EBioMedicine, Vol 16, Iss C, Pp 51-62 (2017)

مصطلحات موضوعية: Fatty acid synthase, Inhibitor, Paclitaxel, Docetaxel, combination, Palmitoylation, Medicine, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396416305916; https://doaj.org/toc/2352-3964

URL الوصول: https://doaj.org/article/6f1c25fe440a4d5bb962bf5f6a378714

View record from ScienceDirect

Full Text via ClinicalKey

Full Text Finder

3

دورية أكاديمية

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression

المؤلفون: Richard Ventura, Kasia Mordec, Joanna Waszczuk, Zhaoti Wang, Julie Lai, Marina Fridlib, Douglas Buckley, George Kemble, Timothy S. Heuer

المصدر: EBioMedicine, Vol 2, Iss 8, Pp 808-824 (2015)

مصطلحات موضوعية: Fatty acid synthase, Inhibitor, Beta-catenin, MYC, KRAS, Lipid raft, Medicine, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396415300505; https://doaj.org/toc/2352-3964

URL الوصول: https://doaj.org/article/28834e3476c148f1a56469f98d334506

View record from ScienceDirect

Full Text via ClinicalKey

Full Text Finder

4

Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF

المصدر: Respiratory research, vol 22, iss 1
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)

مصطلحات موضوعية: Precision-cut lung slice, Respiratory System, αv integrin, alpha(v) integrin, Cardiorespiratory Medicine and Haematology, Inbred C57BL, Mice, Idiopathic pulmonary fibrosis, chemistry.chemical_compound, Receptors, Pulmonary fibrosis, Phosphorylation, alpha 1 Chain, Lung, biology, Transforming growth factor-β, Pirfenidone, Transforming growth factor-beta, medicine.anatomical_structure, 5.1 Pharmaceuticals, Respiratory, Nintedanib, Antifibrotic Agents, Development of treatments and therapeutic interventions, Cell activation, Type I collagen, Signal Transduction, medicine.drug, Integrin, Clinical Sciences, Collagen Type I, Cell Line, Diseases of the respiratory system, Bleomycin, Rare Diseases, medicine, Animals, Humans, Vitronectin, Smad3 Protein, PLN-74809, RC705-779, Integrin alpha6beta1, Animal, Epithelial Cells, Fibroblasts, medicine.disease, Coculture Techniques, Idiopathic Pulmonary Fibrosis, chemistry, Disease Models, Cancer research, biology.protein, Antifibrotic

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8943da51a8a3553a1e3711bc9a9ed07
https://escholarship.org/uc/item/5q12m0vq

5

FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression

المؤلفون: Douglas Buckley, Timothy S. Heuer, Julie Lai, George Kemble, Kasia Mordec, Richard Benn Abegania Ventura, Marina Fridlib

المصدر: EBioMedicine, Vol 16, Iss C, Pp 51-62 (2017)
EBioMedicine

مصطلحات موضوعية: 0301 basic medicine, DMEM, Dulbecco's modified Eagle medium, Carcinogenesis, NSCLC, Non-small-cell lung cancer, CS-FBS, Charcoal-filtered FBS—fetal bovine serum, lcsh:Medicine, medicine.disease_cause, Microtubules, Mice, chemistry.chemical_compound, 0302 clinical medicine, Tubulin, FITC, Fluorescein isothiocyante, gene symbols and common abbreviations such as DNA and RNA are not defined, Enzyme Inhibitors, Phosphorylation, beta Catenin, TGI, Tumor growth inhibition, Mice, Inbred BALB C, lcsh:R5-920, Microscopy, Confocal, Molecular Structure, biology, Reverse Transcriptase Polymerase Chain Reaction, LC-MS, Liquid chromatography–mass spectrometry, General Medicine, PBS, Phosphate-buffered saline, 3. Good health, Fatty Acid Synthase, Type I, Gene Expression Regulation, Neoplastic, Fatty acid synthase, Biochemistry, Paclitaxel, 030220 oncology & carcinogenesis, Female, Taxoids, lcsh:Medicine (General), Palmitoylation, Research Paper, Bridged-Ring Compounds, Inhibitor, Lipoylation, Blotting, Western, Mice, Nude, Antineoplastic Agents, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, Microtubule, Cell Line, Tumor, Nitriles, medicine, Animals, Humans, A549 cell, Docetaxel, combination, Taxane, IMDM, Iscove's modified Eagle medium, lcsh:R, MEM, Minimal essential media, Xenograft Model Antitumor Assays, 030104 developmental biology, chemistry, A549 Cells, FBS, Fetal bovine serum, biology.protein, Cancer research, Azetidines, Pyrazoles

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a802f596b8c80bcd58cda8b58cc926
http://www.sciencedirect.com/science/article/pii/S2352396416305916

View record from ScienceDirect

Full Text via ClinicalKey

6

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression

المؤلفون: Joanna Waszczuk, Marina Fridlib, Zhaoti Wang, Kasia Mordec, Douglas Buckley, Richard Benn Abegania Ventura, Julie Lai, George Kemble, Timothy S. Heuer

المصدر: EBioMedicine
EBioMedicine, Vol 2, Iss 8, Pp 808-824 (2015)

مصطلحات موضوعية: Cell, Palmitic Acid, lcsh:Medicine, Apoptosis, MYC, Neoplasms, Tumor Cells, Cultured, LC–MS, liquid chromatography–mass spectrometry, Enzyme Inhibitors, MEM, minimal essential media, lcsh:R5-920, TGI, tumor growth inhibition, biology, Fatty Acids, General Medicine, Neoplasm Proteins, 3. Good health, Fatty Acid Synthase, Type I, Gene Expression Regulation, Neoplastic, Fatty acid synthase, medicine.anatomical_structure, Liver, CRC, colorectal cancer, Original Article, FITC, fluorescein isothiocyanate, Signal transduction, lcsh:Medicine (General), Signal Transduction, Inhibitor, Antineoplastic Agents, NSCLC, non-small-cell lung cancer, Gene Expression Regulation, Enzymologic, General Biochemistry, Genetics and Molecular Biology, DMEM, Dulbecco's Modified Eagle's Medium, FBS, fetal bovine serum, PBS, phosphate buffered saline, Cell Line, Tumor, Lipid biosynthesis, medicine, HUVEC, human umbilical vein endothelial cells, KRAS, PTEN, Humans, RNA, Messenger, Cell growth, lcsh:R, Cell Membrane, NADPH, nicotinamide adenine dinucleotide phosphate, Tumor Cell Biology, Lipid raft, Tumor progression, Beta-catenin, biology.protein, Cancer research, Fatty Acid Synthases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580e0e766ed39e539cb71c538bdb6fe4
http://europepmc.org/articles/PMC4563160

View record from ScienceDirect

Full Text via ClinicalKey

7

Abstract LB-214: FASN inhibitor TVB-2640 shows pharmacodynamic effect and evidence of clinical activity in KRAS-mutant NSCLC patients in a phase I study

المؤلفون: Joanna Waszczuk, Marina Fridlib, Doug Buckley, William McCulloch, Richard Crowley, Marie O'Farrell, Claudia Rubio, Katharine Grimmer, Julie Lai, George Kemble, Richard Benn Abegania Ventura, Tim Heuer

المصدر: Cancer Research. 76:LB-214

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f83057e6e32f27edd75210ae9e587ca2
https://doi.org/10.1158/1538-7445.am2016-lb-214

8

Abstract 4446: Discovery of tumor types highly susceptible to FASN inhibition and biomarker candidates for clinical analysis

المؤلفون: Douglas Buckley, Timothy S. Heuer, Allan S. Wagman, Richard Benn Abegania Ventura, Lily W. Hu, Russell Johnson, Kasia Mordec, Julie Lai, Joanna Waszczuk, George Kemble, Marie O'Farrell, Marina Fridlib, Glenn Hammonds

المصدر: Cancer Research. 75:4446-4446

مصطلحات موضوعية: Cancer Research, biology, Wnt signaling pathway, Cancer, medicine.disease, Bioinformatics, Metastasis, Fatty acid synthase, Oncology, Tumor progression, In vivo, medicine, Cancer research, biology.protein, Biomarker (medicine), Signal transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9dc706c6d42468d7eb4142e02b9bc14c
https://doi.org/10.1158/1538-7445.am2015-4446

تنقيح النتائج