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المؤلفون: Bernard Evers, Inge A. M. de Graaf, Ivan Vokral, Ming Li, Marina H. de Jager, Geny M. M. Groothuis
المساهمون: Nanomedicine & Drug Targeting, Biopharmaceuticals, Discovery, Design and Delivery (BDDD)
المصدر: European Journal of Pharmaceutical Sciences, 121, 65-73. ELSEVIER SCIENCE BV
مصطلحات موضوعية: Male, 0301 basic medicine, TAUROCHOLATE, Simvastatin, Pharmaceutical Science, 030226 pharmacology & pharmacy, Jejunum, chemistry.chemical_compound, Adenosine Triphosphate, 0302 clinical medicine, ILEAL, Human and rat precision-cut intestinal slices, ABSORPTION, Symporters, Bile acid, Chemistry, Deoxycholic acid, Middle Aged, SUBSTRATE-SPECIFICITY, medicine.anatomical_structure, Biochemistry, Female, Apical sodium-dependent bile acid transporter, Taurocholic Acid, Bile acid uptake kinetics, medicine.drug_class, INHIBITION, Organic Anion Transporters, Sodium-Dependent, Ileum, In Vitro Techniques, P-GP ACTIVITY, METABOLISM, Bile Acids and Salts, 03 medical and health sciences, medicine, Animals, Humans, Rats, Wistar, Fluvastatin, PHYSIOLOGY, DRUG-DRUG INTERACTIONS, Aged, Cholic acid, Biological Transport, IN-VITRO, Apical membrane, Taurocholic acid, Small intestine, Ex vivo, 030104 developmental biology, Intestinal Absorption
وصف الملف: application/pdf
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المؤلفون: Eduard Post, Corry-Anke Brandsma, René Lutter, Barbro N. Melgert, Linsey E. S. de Groot, Ken R. Bracke, Irene H. Heijink, Maarten van den Berge, T. Anienke van der Veen, Mirjam P. Roffel, Tania Maes, Marina H. de Jager, Ilse M. Boudewijn
المساهمون: Groningen Research Institute for Asthma and COPD (GRIAC), Molecular Pharmacology, Nanomedicine & Drug Targeting, Biopharmaceuticals, Discovery, Design and Delivery (BDDD)
المصدر: European Respiratory Journal, 54. EUROPEAN RESPIRATORY SOC JOURNALS LTD
مصطلحات موضوعية: business.industry, Copd exacerbation, Immunology, Macrophage polarization, Medicine, Dysfunctional family, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ba936d3255170c3e2e0fd347a4ba4b
https://hdl.handle.net/11370/26eaf657-4dbe-4dd2-8fa9-821737eb444f -
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المؤلفون: Ming Li, Evita van de Steeg, Inge A. M. de Graaf, Geny M. M. Groothuis, Marina H. de Jager
المساهمون: Nanomedicine & Drug Targeting, Groningen Research Institute of Pharmacy, Biopharmaceuticals, Discovery, Design and Delivery (BDDD)
المصدر: Toxicology in Vitro, 40, 26-33. PERGAMON-ELSEVIER SCIENCE LTD
مصطلحات موضوعية: Male, 0301 basic medicine, CYP3A4, Metabolite, PROTEIN, Pharmacology, Toxicology, 030226 pharmacology & pharmacy, Jejunum, chemistry.chemical_compound, 0302 clinical medicine, Cytochrome P-450 CYP3A, Interplay, Drug Interactions, P-glycoprotein, Aged, 80 and over, PRECISION-CUT SLICES, biology, GLYCOPROTEIN, General Medicine, Middle Aged, Quinidine, Ketoconazole, medicine.anatomical_structure, Selective P-gp inhibitor, Female, Intracellular, medicine.drug, Adult, EXPRESSION, Colon, Cyclosporins, Ileum, In Vitro Techniques, METABOLISM, 03 medical and health sciences, FEMALE RATS, medicine, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, ORAL ATORVASTATIN, Precision-cut intestinal slice, ENTIRE LENGTH, Aged, CYTOCHROME-P450 3A, IN-VITRO, Isoquinolines, Ex vivo, 030104 developmental biology, Verapamil, chemistry, Quinazolines, biology.protein, Cytochrome P-450 CYP3A Inhibitors
وصف الملف: application/pdf
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المؤلفون: Marina H. de Jager, Geny M. M. Groothuis, Ming Li, Inge A. M. de Graaf
المصدر: Biopharmaceutics & Drug Disposition. 38:127-138
مصطلحات موضوعية: Pharmacology, biology, Pharmaceutical Science, Ileum, General Medicine, 030226 pharmacology & pharmacy, Rhodamine 123, In vitro, Jejunum, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, biology.protein, medicine, Duodenum, Pharmacology (medical), IC50, Ex vivo, P-glycoprotein
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المؤلفون: Marina H. de Jager, René Lutter, Barbro N. Melgert, Linsey E. S. de Groot, Eduard Post, T. Anienke van der Veen
المصدر: Airway Cell Biology and Immunopathology.
مصطلحات موضوعية: CD64, COPD, Immune system, business.industry, CD68, Immunology, Antigen presentation, Macrophage polarization, Macrophage, CD11c, Medicine, business, medicine.disease
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::306bd298680e93ec92672c2c93720452
https://doi.org/10.1183/23120541.lungscienceconference-2019.pp219 -
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المؤلفون: Ming Li, Geny M. M. Groothuis, Marina H. de Jager, Sanna Siissalo, Annie van Dam, Inge A. M. de Graaf
المساهمون: Nanomedicine & Drug Targeting, Analytical Biochemistry, Biopharmaceuticals, Discovery, Design and Delivery (BDDD)
المصدر: Drug Metabolism and Disposition, 44(5), 683-691. AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
مصطلحات موضوعية: Male, 0301 basic medicine, CYP3A, Metabolite, Pharmaceutical Science, Cyclosporins, Ileum, Pharmacology, 030226 pharmacology & pharmacy, Intestinal absorption, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cytochrome P-450 CYP3A, medicine, Animals, Drug Interactions, ATP Binding Cassette Transporter, Subfamily B, Member 1, Rats, Wistar, P-glycoprotein, biology, Valine, Quinidine, Rats, Jejunum, Ketoconazole, 030104 developmental biology, medicine.anatomical_structure, Intestinal Absorption, Pharmaceutical Preparations, Verapamil, Biochemistry, chemistry, biology.protein, Valspodar, Ex vivo
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6580c3b60431179d51e66d59aba9b3
https://doi.org/10.1124/dmd.115.068684 -
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المؤلفون: Marina H de Jager, Raditya Iswandana, Marina Ika Irianti, H. S. Hofker, Dorenda Oosterhuis, Marjolijn T Merema, Henricus Am Mutsaers, Peter Olinga
المصدر: Iswandana, R, Irianti, M I, Oosterhuis, D, Hofker, H S, Merema, M T, de Jager, M H, Mutsaers, H A M & Olinga, P 2018, ' Regional Differences in Human Intestinal Drug Metabolism ', Drug Metabolism and Disposition, vol. 46, no. 12, pp. 1879-1885 . https://doi.org/10.1124/dmd.118.083428
مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Colon, Metabolite, Pharmaceutical Science, Ileum, In Vitro Techniques, 03 medical and health sciences, chemistry.chemical_compound, Internal medicine, medicine, Humans, Testosterone, Androstenedione, Umbelliferones, Pharmacology, chemistry.chemical_classification, Sex Characteristics, Chemistry, Metabolic Detoxication, Phase II, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Enzyme, Female, Metabolic Detoxication, Phase I, Glucuronide, Drug metabolism, Sex characteristics
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9aaf07ead619a0e6477dd81e7cc0bcf
https://pubmed.ncbi.nlm.nih.gov/30275119 -
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المؤلفون: Natalia Estrada-Ortiz, Chiara Gabbiani, Angela Casini, Marina H. de Jager, Geny M. M. Groothuis, Federica Guarra, Lorella Marchetti, Inge A. M. de Graaf
المساهمون: Nanomedicine & Drug Targeting, Groningen Research Institute of Pharmacy, Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Medicinal Chemistry and Bioanalysis (MCB)
المصدر: ChemMedChem, 12(17), 1429-1435. WILEY-V C H VERLAG GMBH
مصطلحات موضوعية: Male, Stereochemistry, DNA-BINDING, gold NHC complexes, Antineoplastic Agents, 010402 general chemistry, Kidney, 01 natural sciences, Biochemistry, MEDICINAL INORGANIC-CHEMISTRY, CISPLATIN, chemistry.chemical_compound, Heterocyclic Compounds, Cell Line, Tumor, Neoplasms, Drug Discovery, Moiety, Animals, Humans, QD, General Pharmacology, Toxicology and Pharmaceutics, Rats, Wistar, AGENTS, Cytotoxicity, BIOLOGICAL-PROPERTIES, precision-cut kidney slices, PLATINUM, SLICES, Pharmacology, 010405 organic chemistry, Ligand, Organic Chemistry, CANCER, In vitro, 0104 chemical sciences, chemistry, PALLADIUM(II), Cell culture, Cancer cell, alkynyl compounds, cytotoxicity, Molecular Medicine, GOLD(III) COMPLEXES, Carbene, Methane, Organogold Compounds, Ex vivo, organometallics
وصف الملف: application/pdf
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المؤلفون: Angela Casini, Pierre Le Gendre, Michel Picquet, Ewen Bodio, Elena Warmerdam, Marina H. de Jager, David Monchaud, Marc Pirrotta, Geny M. M. Groothuis, Loic Stefan, Philippe Richard, Benoît Bertrand
المساهمون: UMR - Interactions Plantes Microorganismes Environnement (UMR IPME), Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Conception, synthèse et vectorisation de biomolécules. (CSVB), Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Journaliste, AFP, Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze [Firenze], Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Nanomedicine & Drug Targeting, Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Medicinal Chemistry and Bioanalysis (MCB)
المصدر: Inorganic Chemistry
Inorganic Chemistry, American Chemical Society, 2014, 53 (4), pp.2296-2303. ⟨10.1021/ic403011h⟩
Inorganic Chemistry, 53(4), 2296-2303. AMER CHEMICAL SOCمصطلحات موضوعية: Stereochemistry, Antineoplastic Agents, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, Ligands, Xanthine, Cell Line, Inorganic Chemistry, Inhibitory Concentration 50, chemistry.chemical_compound, Heterocyclic Compounds, Caffeine, Cell Line, Tumor, Biological property, Animals, Humans, Molecule, Physical and Theoretical Chemistry, ComputingMilieux_MISCELLANEOUS, Cell Proliferation, Molecular Structure, Chemistry, In vitro, 3. Good health, Förster resonance energy transfer, Cell culture, Gold, Selectivity, Methane, Ex vivo
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المؤلفون: Ming, Li, Inge A M, de Graaf, Marina H, de Jager, Geny M M, Groothuis
المصدر: Biopharmaceuticsdrug disposition. 38(2)
مصطلحات موضوعية: Adult, Male, Dose-Response Relationship, Drug, Colon, Duodenum, Biological Transport, In Vitro Techniques, Middle Aged, Kinetics, Jejunum, Ileum, Membrane Transport Modulators, Intestine, Small, Humans, Female, Rhodamine 123, ATP Binding Cassette Transporter, Subfamily B, Member 1, Aged, Fluorescent Dyes
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