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1دورية أكاديمية
المؤلفون: Ellen L. Berg, Mark A. Polokoff, Alison O'Mahony, Dat Nguyen, Xitong Li
المصدر: International Journal of Molecular Sciences, Vol 16, Iss 1, Pp 1008-1029 (2015)
مصطلحات موضوعية: thrombosis, toxicity, primary human cells, endothelial cells, inflammation, cholesterol, aryl hydrocarbon receptor, nutrient sensing, pathway, tissue factor, bacterial sensing, hypoxia, Biology (General), QH301-705.5, Chemistry, QD1-999
وصف الملف: electronic resource
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2
المؤلفون: Richard I. Feldman, Gary Phillips, Marc Adler, Daguang Zhu, Elena Ho, Wheeseong Lee, Mark A. Polokoff, Hongyi Yu, Dao Lentz, Marc Whitlow, Arnaiz Damian O, Kochanny Monica, Babu Subramanyam, Imadul Islam, James M. Wu, Judi Bryant, Yuo-Ling Chou
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:3814-3818
مصطلحات موضوعية: Models, Molecular, Indoles, animal structures, Clinical Biochemistry, Pharmaceutical Science, Protein Serine-Threonine Kinases, Biochemistry, Chemical synthesis, 3-Phosphoinositide-Dependent Protein Kinases, Drug Discovery, Transferase, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, Molecular Structure, biology, Chemistry, Organic Chemistry, Biological activity, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Signal transduction, Phosphoinositide-dependent kinase-1
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3
المؤلفون: Marc Adler, Wei Xu, Sunil K. Koovakkat, Eric Pham, Marc Whitlow, Qinglan Huang, David D. Davey, John Parkinson, Gary Phillips, Shendong Yuan, Mark A. Polokoff
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:2505-2508
مصطلحات موضوعية: Molecular model, Stereochemistry, Chemistry, Pharmaceutical, Dimer, Clinical Biochemistry, Molecular Conformation, Nitric Oxide Synthase Type II, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Nitric oxide, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, Rational design, Nitric oxide synthase, Enzyme, Models, Chemical, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Crystallization, Dimerization
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4
المؤلفون: Jih-Lie Tseng, David D. Davey, Mark A. Polokoff, Gary Phillips, Raju Mohan, Marc Whitlow, Shendong Yuan, Marc Adler, Robert G. Wei, Elena Ho, Wei Xu
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:2499-2504
مصطلحات موضوعية: Nitric Oxide Synthase Type III, Molecular model, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Molecular Conformation, Nitric Oxide Synthase Type II, Pharmaceutical Science, Nitric Oxide Synthase Type I, Nitric Oxide, Biochemistry, Nitric oxide, Inhibitory Concentration 50, Mice, chemistry.chemical_compound, Piperidines, Cell Line, Tumor, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Imidazoles, Nitric oxide synthase, Monomer, Enzyme, Models, Chemical, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Piperidine, Selectivity, Dimerization
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5
المؤلفون: Damian Arnaiz, Gary Phillips, Shawn David Erickson, Marc Whitlow, Margaret Kenrick, James J. Devlin, Gonghua Pan, Cecile Santos, William J. Guilford, Robert G. Wei, Marc Adler, Kurt W. Saionz, Bin Ye, Ron Vergona, John Parkinson, Zuchun Spring Zhao, David D. Davey, Michael Ohlmeyer, Babu Subramanyam, Vidyadhar M. Paradkar, Mark A. Polokoff, Keith A. Eagen, Michael M. Morrissey
المصدر: Journal of Medicinal Chemistry. 50:1146-1157
مصطلحات موضوعية: Male, Models, Molecular, Gene isoform, Nitric Oxide Synthase Type II, Crystallography, X-Ray, Chemical synthesis, Cell Line, Nitric oxide, chemistry.chemical_compound, Oxidoreductase, Chlorocebus aethiops, Drug Discovery, Animals, Benzodioxoles, Binding site, chemistry.chemical_classification, biology, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Imidazoles, Biological activity, Arthritis, Experimental, Rats, Nitric oxide synthase, Pyrimidines, Enzyme, Biochemistry, Rats, Inbred Lew, biology.protein, Molecular Medicine, Dimerization
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6
المؤلفون: Dao Lentz, Marc Whitlow, Zheng Chang, Harald Dinter, Mike Ferrer, Silke Finster, Marc Adler, Daguang Zhu, Sandra L. Biroc, Richard I. Feldman, Bruno Alicke, Monica Kochanny, Judi Bryant, Brad O. Buckman, Mark A. Polokoff, Arnaiz Damian O, James M. Wu, Shendong Yuan
المصدر: Journal of Biological Chemistry. 280:19867-19874
مصطلحات موضوعية: Models, Molecular, Lung Neoplasms, animal structures, Drug Evaluation, Preclinical, Melanoma, Experimental, Mice, Nude, Antineoplastic Agents, In Vitro Techniques, Protein Serine-Threonine Kinases, Biology, Biochemistry, 3-Phosphoinositide-Dependent Protein Kinases, Mice, chemistry.chemical_compound, Catalytic Domain, Cell Line, Tumor, Proto-Oncogene Proteins, Animals, Humans, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Molecular Structure, Kinase, Akt/PKB signaling pathway, Cell Biology, Xenograft Model Antitumor Assays, Cell biology, Kinetics, Pyrimidines, chemistry, Cell culture, Cancer cell, Female, Growth inhibition, Proto-Oncogene Proteins c-akt, Cell Division, HeLa Cells, Signal Transduction, Phosphoinositide-dependent kinase-1
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5088ddc20f2394f04c36606bd1d432b
https://doi.org/10.1074/jbc.m501367200 -
7
المؤلفون: Amy Liang, Kathryn V. Dunn, Peter J. Kretschmer, Lan Trinh, Richard Spann, David Senator, Jason Kondracki, John Morser, Michael M. Morrissey, Samuel E. Lipson, Mark A. Polokoff, Wei Zheng, John Loughlin, James J. Devlin
المصدر: Drug Development Research. 37:80-85
مصطلحات موضوعية: chemistry.chemical_classification, biology, Drug discovery, High capacity, Nitric oxide, Matrix (chemical analysis), chemistry.chemical_compound, Enzyme, chemistry, Biochemistry, Active compound, Enzyme inhibitor, Drug Discovery, biology.protein, Bioassay
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bf6eeb64f936a1665682b999a3ad508b
https://doi.org/10.1002/(sici)1098-2299(199602)37:2<80::aid-ddr3>3.0.co;2-h -
8
المصدر: Journal of Medicinal Chemistry. 38:2119-2129
مصطلحات موضوعية: chemistry.chemical_classification, biology, Chemistry, Stereochemistry, Metalloendopeptidases, Bronchi, Muscle, Smooth, Endothelin-Converting Enzymes, Hydroxamic Acids, Chemical synthesis, Amino acid, chemistry.chemical_compound, Malonate, Enzyme, Enzyme inhibitor, Thermolysin, Drug Discovery, Succinates, biology.protein, Aspartic Acid Endopeptidases, Humans, Molecular Medicine, Neprilysin, Cells, Cultured
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9
المصدر: ChemInform. 26
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, General Medicine, In vitro, Amino acid, chemistry.chemical_compound, Malonate, Enzyme, chemistry, Biochemistry, Thermolysin, Succinates, Neprilysin, Isopropyl
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10
المؤلفون: Deborah Chen, Damian O. Arnaiz, Wei-Wei Li, Feldman Richard, James M. Wu, Marc Whitlow, Shendong Yuan, Mike Ferrer, Brad Buckman, Judi Bryant, Mark A. Polokoff, Daguang Zhu, Bob Mintzer, Zheng Chang, Kumar Emayan, Sandra L. Biroc, Harald Dinter, Xue Snow Ge, Jih-Lie Tseng, Marc Adler, Jian-Ming Gu, Takashi Sato, Jun Shen
المصدر: Chemical biologydrug design. 74(1)
مصطلحات موضوعية: Cell signaling, Lactams, Macrocyclic, Transplantation, Heterologous, Mice, Nude, Pharmacology, Crystallography, X-Ray, Biochemistry, Metastasis, Mice, Heat shock protein, Cell Line, Tumor, Drug Discovery, medicine, Benzoquinones, Animals, Humans, Computer Simulation, HSP90 Heat-Shock Proteins, biology, Cell growth, Ansamycin, Organic Chemistry, Triazoles, medicine.disease, Small molecule, Hsp90, Xenograft Model Antitumor Assays, Cancer cell, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, HT29 Cells