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المؤلفون: Xidong Feng, Ye Che, Adam M. Gilbert, Reto Horst, Kris A. Borzilleri, Matthew Merrill Hayward, Carolyn A. Leverett, James Schiemer, Yilin Meng, Justin I. Montgomery, Matthew F. Calabrese, Mark C. Noe, Daniel P. Uccello, Stephen P. Brown, Matthew Frank Brown, Yingrong Xu
المصدر: Nature Chemical Biology. 17:152-160
مصطلحات موضوعية: 0303 health sciences, biology, Chemistry, Drug discovery, 030302 biochemistry & molecular biology, Ubiquitin-Protein Ligases, Cell Biology, Protein degradation, Ubiquitin ligase, 03 medical and health sciences, Protein structure, biology.protein, Biophysics, Bruton's tyrosine kinase, Ternary operation, Molecular Biology, Ternary complex, 030304 developmental biology
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المؤلفون: James, Schiemer, Reto, Horst, Yilin, Meng, Justin I, Montgomery, Yingrong, Xu, Xidong, Feng, Kris, Borzilleri, Daniel P, Uccello, Carolyn, Leverett, Stephen, Brown, Ye, Che, Matthew F, Brown, Matthew M, Hayward, Adam M, Gilbert, Mark C, Noe, Matthew F, Calabrese
المصدر: Nature chemical biology. 17(2)
مصطلحات موضوعية: Models, Molecular, Spectrometry, Mass, Electrospray Ionization, Protein Conformation, Ubiquitin-Protein Ligases, Ubiquitination, Inhibitor of Apoptosis Proteins, Kinetics, Cross-Linking Reagents, X-Ray Diffraction, Proteolysis, Agammaglobulinaemia Tyrosine Kinase, Chromatography, Gel, Humans, Nuclear Magnetic Resonance, Biomolecular
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المؤلفون: Adam M. Gilbert, Veerabahu Shanmugasundaram, Ye Che, Mark C. Noe
المصدر: Bioorganic & Medicinal Chemistry Letters. 28:2585-2592
مصطلحات موضوعية: 0301 basic medicine, Enzyme function, Clinical Biochemistry, Allosteric regulation, Receptors, Cytoplasmic and Nuclear, Pharmaceutical Science, Drug action, Ligands, 01 natural sciences, Biochemistry, Protein–protein interaction, 03 medical and health sciences, Contact surfaces, Allosteric Regulation, Adhesives, Drug Discovery, Humans, Binding site, Molecular Biology, Biological Products, 010405 organic chemistry, Chemistry, Organic Chemistry, Small molecule, 0104 chemical sciences, Cell biology, 030104 developmental biology, Proteolysis, Proteome, Molecular Medicine, Protein Binding
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المؤلفون: Suman Luthra, Graham M. West, Jeremy T. Starr, Matthew Frank Brown, Matthew F. Calabrese, Jinshan Chen, Hongyao Zhu, Xiayang Qiu, Daniel P. Uccello, Matthew Merrill Hayward, Jeanne S. Chang, Jotham Wadsworth Coe, Kathleen A. Farley, Kris A. Borzilleri, Mark C. Noe, Justin I. Montgomery, Adam M. Gilbert, Veerabahu Shanmugasundaram, Lara C. Czabaniuk, Robert M. Oliver, Carmen N. Garcia-Irrizary, Brandon P. Schuff, Chuong Nguyen, Yingrong Xu, James Schiemer, Jaymin C. Shah, Xidong Feng, Mark Niosi, Jennifer A. Young, WeiDong Ding, Ayman El-Kattan, Adelajda Zorba, James F. Smith
مصطلحات موضوعية: 0301 basic medicine, Ubiquitin-Protein Ligases, Cooperativity, Ligands, 03 medical and health sciences, hemic and lymphatic diseases, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Animals, Polyubiquitin, Cells, Cultured, Multidisciplinary, biology, Chemistry, Cereblon, Proteolysis targeting chimera, Ubiquitination, Protein-Tyrosine Kinases, Ubiquitin ligase, Cell biology, Rats, 030104 developmental biology, Proteasome, PNAS Plus, Proteolysis, biology.protein, Thermodynamics, Target protein, Tyrosine kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf434de63be490efb6416cf59a222839
https://europepmc.org/articles/PMC6077745/ -
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المؤلفون: Daniel P. Uccello, Jeremy T. Starr, Matthew Merrill Hayward, R. Scott Obach, Mark C. Noe, Adam M. Gilbert, Justin I. Montgomery, Mark Edward Flanagan, Veerabahu Shanmugasundaram, Dennis P. Anderson, Ann Aulabaugh, Ye Che, Matthew Frank Brown, Michael J. Shapiro, Chao Li, Tim F. Ryder, Stacey R. Oppenheimer, Laurence Philippe, Gregory S. Walker, Yan Wu, Brandon P. Schuff, Joseph A. Abramite, Jinshan M. Chen, Justin G. Stroh, Upendra P. Dahal
المصدر: Journal of Medicinal Chemistry. 57:10072-10079
مصطلحات موضوعية: chemistry.chemical_classification, Chemistry, Stereochemistry, Kinetics, food and beverages, Glutathione, Mass Spectrometry, chemistry.chemical_compound, Enzyme, Pharmaceutical Preparations, Nucleophile, Covalent bond, Drug Design, Drug Discovery, Electrophile, Humans, Molecular Medicine, Reactivity (chemistry), Enzyme Inhibitors, Selectivity, Nuclear Magnetic Resonance, Biomolecular
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المؤلفون: Adam M. Gilbert, Mark C. Noe
المصدر: Medicinal Chemistry Reviews ISBN: 9780996293235
Medicinal Chemistry ReviewsURL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e9c5d56a2b09b501b32c1e0a509a148b
https://doi.org/10.29200/acsmedchemrev-v51.ch21 -
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المؤلفون: Rose Barham, Thuy Hoang, Jeremy T. Starr, Jennifer A. Young, M. Megan Lemmon, Joseph Penzien, Mark J. Mitton-Fry, Thomas M. Harris, Antonia A. Nikitenko, Brian S. Gerstenberger, Sandra P. McCurdy, Veerabahu Shanmugasundaram, Lisa Mullins, Joel R. Hardink, Jeffrey M. Casavant, Eric S. Marr, Jian Lin, Seungil Han, Joel T. Arcari, John P. Mueller, Brandon P. Schuff, Mark S. Plummer, Craig J. McPherson, Michael D. Huband, Mark C. Noe, Manjinder S. Lall, Richard P. Zaniewski, Chao Li, Matthew Frank Brown, Jianmin Sun, Eric B. McElroy, Andrew P. Tomaras
المصدر: Journal of Medicinal Chemistry. 56:5541-5552
مصطلحات موضوعية: Male, Gram-negative bacteria, Pyridones, Klebsiella pneumoniae, Microbial Sensitivity Tests, Plasma protein binding, medicine.disease_cause, Microbiology, Inhibitory Concentration 50, Gram-Negative Bacteria, Drug Discovery, Escherichia coli, medicine, Animals, Monobactam, Rats, Wistar, Molecular Structure, biology, Pseudomonas aeruginosa, Chemistry, biology.organism_classification, In vitro, Anti-Bacterial Agents, Rats, Biochemistry, Molecular Medicine, Antibacterial activity, Monobactams, medicine.drug
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المؤلفون: Magee Thomas Victor, Thuy-Trinh Nguyen, Joseph A. Abramite, Yue Shen, Jian Lin, Jiri Aubrecht, Fadia Dib-Hajj, Jeremy T. Starr, Alita A. Miller, Matthew Frank Brown, Shawn H. MacVane, Michael D. Huband, Li Zhang, Karl Granskog, Bryan Li, Jinshan Michael Chen, James M. McKim, John P. O'Donnell, Karen L. Leach, Paul C. Wilga, David P. Nicolau, Sandra P. McCurdy, Mark Edward Flanagan, Antonia F. Stepan, Andrew P. Tomaras, Mark C. Noe, Michael Kuhn, Scott B. Seibel, Rebecca Irvine, Jinfeng Xu, David C. Ackley, David R. Luke, Jared L. Crandon, Joel R. Hardink, Andrew Butler
المصدر: Journal of Medicinal Chemistry. 56:5079-5093
مصطلحات موضوعية: Male, medicine.drug_class, Polymyxin, Microbial Sensitivity Tests, medicine.disease_cause, Microbiology, Dogs, Therapeutic index, In vivo, Gram-Negative Bacteria, Drug Discovery, medicine, Animals, Humans, Polymyxins, Cross Infection, biology, Chemistry, Pseudomonas aeruginosa, biology.organism_classification, Antimicrobial, Drug Resistance, Multiple, Anti-Bacterial Agents, Rats, Acinetobacter baumannii, Multiple drug resistance, beta-Alanine, Molecular Medicine, Female, Polymyxin B, medicine.drug
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المؤلفون: Kuang Tongtao, Wang Zhibo, Yuanqiang Long, Jian Li, Xin Ran, Jinshan Chen, David W. Piotrowski, Hua Yi, Cristiano Ruch Werneck Guimarães, Chonggang Liu, Frank Rong, Shai Li, Heather N. Frost, Guoyun Bai, Junwei Shen, Jieyang Tan, James Federico, Hua Yu, Kexin Xu, Li Chen, Liu Bo, Ai Chaowu, Yingfu Li, Chen Yuanwei, Zhilong Jiang, Geng Xi, Hongyun Qiao, Carrie Whitney-Pickett, Magee Thomas Victor, Bo Shan, Kai Wu, Matthew D. Troutman, Mark C. Noe, Dale Gordon Mcleod, Youpei Chen, Jing Du, Gilles H. Goetz, Dapeng Zhao, Qiu Gao, Li Xiaoyong, Changqing Shi
المصدر: Tetrahedron Letters. 54:3298-3301
مصطلحات موضوعية: Solvent, Template, Hydrogen bond, Chemistry, Stereochemistry, Intramolecular force, Organic Chemistry, Drug Discovery, Diastereomer, Biochemistry, Combinatorial chemistry
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المؤلفون: Lisa Mullins, Daniel P. Uccello, Justin I. Montgomery, Ye Che, John P. O'Donnell, Mark S. Plummer, Joseph A. Abramite, Seung Won Chung, Loren M. Price, Mark C. Noe, Laura A. McAllister, Rose Barham, Mark J. Mitton-Fry, Andrew P. Tomaras, Usa Reilly, Matthew Frank Brown, Jinshan M. Chen, Joseph Penzien, Carol A. Menard, Veerabahu Shanmugasundaram, Robert M. Oliver
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:6832-6838
مصطلحات موضوعية: Gram-negative bacteria, Klebsiella pneumoniae, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Hydroxamic Acids, Biochemistry, Amidohydrolases, Structure-Activity Relationship, chemistry.chemical_compound, Heterocyclic Compounds, Gram-Negative Bacteria, Drug Discovery, Structure–activity relationship, Sulfones, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Hydroxamic acid, biology, Organic Chemistry, biology.organism_classification, Anti-Bacterial Agents, Enzyme, chemistry, Pseudomonas aeruginosa, Molecular Medicine, Antibacterial activity, Bacterial outer membrane, Bacteria