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1
المؤلفون: D. Vijay Kumar, Daniel M. Cimbora, Kraig M. Yager, Brandi L. Williams, Matthew Gregory Bursavich, Mark D. Shenderovich, David M Dastrup
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:6829-6833
مصطلحات موضوعية: Models, Molecular, Purine, Clinical Biochemistry, Pharmaceutical Science, Cell Cycle Proteins, Protein Serine-Threonine Kinases, Scaffold hopping, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Quinazoline, Humans, Pyrroles, Protein kinase A, Purine metabolism, Protein Kinase Inhibitors, Molecular Biology, Cell Proliferation, Kinase, Organic Chemistry, Protein-Tyrosine Kinases, HCT116 Cells, Pyrimidines, chemistry, Purines, Drug Design, Quinazolines, Molecular Medicine, Protein Binding
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2
المؤلفون: Damon I. Papac, Rena McKinnon, Ashok C. Bajji, Vijay Baichwal, Rosann Robinson, Richard Trovato, Daniel Wettstein, Paul L. Bartel, Rajendra P. Tangallapally, Kraig M. Yager, Daniel M. Cimbora, Robert O. Carlson, Se-Ho Kim, Mark D. Shenderovich, Benjamin Markovitz
المصدر: Journal of Medicinal Chemistry. 55:7480-7501
مصطلحات موضوعية: Models, Molecular, Purine, Stereochemistry, Adenine, Cellular homeostasis, In vitro, Hsp90 inhibitor, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, In vivo, Sulfanyl, Drug Discovery, Animals, Molecular Medicine, Moiety, Benzodioxoles, HSP90 Heat-Shock Proteins, Piperidine, Chromatography, High Pressure Liquid
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3
المؤلفون: Daniel Feodore Zigar, J. Jay Boniface, Ryan T. Terry-Lorenzo, Jeremy Green, Paul M. Slattum, Mark D. Shenderovich, Tracey C. Fleischer, Zhong-hua Gao, Jeffrey W. Lockman, J. Adam Willardsen, Kirill Ostanin, Brett Murphy, Rena McKinnon, Weston R Judd
المصدر: Journal of Medicinal Chemistry. 53:8734-8746
مصطلحات موضوعية: Models, Molecular, chemistry.chemical_classification, Stereochemistry, Nicotinamide phosphoribosyltransferase, Substituent, Antineoplastic Agents, Electrophilic aromatic substitution, HCT116 Cells, Structure-Activity Relationship, chemistry.chemical_compound, Enzyme, chemistry, Benzamides, Drug Discovery, Quinazolines, Humans, Molecular Medicine, Potency, Drug Screening Assays, Antitumor, Nicotinamide Phosphoribosyltransferase, Cytotoxicity, Benzamide
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4
المؤلفون: Weiquan Zhu, Alan L. Mueller, Ashok C. Bajji, Jackson R. Richards, Mark D. Shenderovich, Dean Y. Li, Lise K. Sorensen, Tara M. Mleynek, Dallas Shi, Kirill Ostanin, J. William Harbour, Jacob M. Winter, Jie Zhu, Kirk R. Thomas, Scott E. Woodman, Shannon J. Odelberg, Christine Dunn, Aaron Rogers, Jae Hyuk Yoo, Allie H. Grossmann, Zon g Zhong Tong
المصدر: Cancer cell. 29(6)
مصطلحات موضوعية: 0301 basic medicine, Uveal Neoplasms, Cancer Research, Cytoplasm, Beta-catenin, Uveal Neoplasm, Article, Small Molecule Libraries, 03 medical and health sciences, Mice, Heterotrimeric G protein, Cell Line, Tumor, Animals, Humans, Small GTPase, Melanoma, beta Catenin, Cell Proliferation, Cell Nucleus, biology, ADP-Ribosylation Factors, Cell Membrane, Transport protein, Cell biology, Protein Transport, 030104 developmental biology, Oncology, Gq alpha subunit, ADP-Ribosylation Factor 6, biology.protein, GTP-Binding Protein alpha Subunits, Gq-G11, Signal transduction, GNAQ, Neoplasm Transplantation, Signal Transduction
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المؤلفون: Mark D. Shenderovich, Cindy L. Fisher, Vladimir Tseitin, Michael J. Dudek, S. McDonald, Muthuchidambaram Prabhakaran, Kal Ramnarayan, Shankari Mylvaganam, R. Kodandapani, Jian Hua Zheng, G. Raghunathan
المصدر: Current Proteomics. 2:233-258
مصطلحات موضوعية: business.industry, Computer science, media_common.quotation_subject, Protein structure prediction, Machine learning, computer.software_genre, Biochemistry, Key (cryptography), Quality (business), Artificial intelligence, Data mining, Homology modeling, business, Molecular Biology, computer, media_common
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0140d2dfb44651a02baa4d86595d13cd
https://doi.org/10.2174/157016405774641156 -
6
المصدر: Protein Science. 14:1870-1878
مصطلحات موضوعية: Models, Molecular, Genotype, Protein Conformation, Stereochemistry, medicine.medical_treatment, Mutant, Pyrimidinones, Biochemistry, Article, Lopinavir, HIV Protease, HIV-1 protease, Drug Resistance, Viral, medicine, Humans, HIV Protease Inhibitor, Molecular Biology, Saquinavir, Protease, Molecular Structure, biology, Wild type, HIV Protease Inhibitors, Protease inhibitor (biology), Kinetics, Phenotype, Mutation, HIV-1, biology.protein, Protein Binding, medicine.drug
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7
المصدر: Protein Science. 12:1706-1718
مصطلحات موضوعية: Models, Molecular, Anti-HIV Agents, Protein Conformation, Mutant, Drug resistance, Biochemistry, Article, Structure-Activity Relationship, HIV Protease, HIV-1 protease, Drug Resistance, Viral, Genotype, HIV Protease Inhibitor, Binding site, Molecular Biology, IC50, biology, HIV Protease Inhibitors, Ligand (biochemistry), Virology, Molecular biology, Phenotype, Drug Design, HIV-1, biology.protein, Algorithms
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8
المصدر: Drug Discovery Today. 7:1214-1220
مصطلحات موضوعية: Models, Molecular, Pharmacology, Drug, Anti-HIV Agents, business.industry, Drug discovery, media_common.quotation_subject, Drug resistance, Biology, Competitive advantage, Biotechnology, Efficacy, Clinical trial, Drug Resistance, Multiple, Viral, Models, Chemical, Risk analysis (engineering), Pharmacogenetics, Drug Design, Pharmacogenomics, Drug Discovery, Animals, Humans, business, media_common
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9
المؤلفون: S. Liao, Mark D. Shenderovich, Frank Porreca, Peg Davis, Victor J. Hruby, Z. Zhang, Keiko Hosohata, Katalin E. Kövér, Henry I. Yamamura
المصدر: The Journal of Peptide Research. 57:257-276
مصطلحات موضوعية: chemistry.chemical_classification, Molecular model, Chemistry, Stereochemistry, Peptidomimetic, Deltorphin I, Peptide, Biochemistry, Combinatorial chemistry, Amino acid, chemistry.chemical_compound, Residue (chemistry), Endocrinology, Deltorphin, Opioid peptide
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10
المؤلفون: Subo Liao, Mark D. Shenderovich, Xinhua Qian, Victor J. Hruby
المصدر: Biopolymers. 53:565-580
مصطلحات موضوعية: chemistry.chemical_classification, Molecular model, Chemistry, Stereochemistry, Ligand, Organic Chemistry, Biophysics, Peptide, Aromaticity, General Medicine, Biochemistry, Biomaterials, chemistry.chemical_compound, Side chain, Isoquinoline, Pharmacophore, Conformational isomerism
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::15b4d7f97578e20790c21cf6eb410cbf
https://doi.org/10.1002/(sici)1097-0282(200006)53:7<565::aid-bip4>3.0.co;2-5