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1
المؤلفون: Bryan P. Kwan, Kirk J. Nelson, Grayson Hough, John T. Finn, Karen Joy Shaw, Mark Hilgers, Mark L. Cunningham, Thanh Lam, Michael Trzoss, Vickie Brown-Driver, Voon Ong
المصدر: Journal of Medicinal Chemistry. 57:651-668
مصطلحات موضوعية: Models, Molecular, Staphylococcus aureus, Benzimidazole, Stereochemistry, Microbial Sensitivity Tests, Cofactor, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Sepsis, Drug Resistance, Bacterial, Drug Discovery, Dihydrofolate reductase, Animals, Humans, Potency, Structure–activity relationship, chemistry.chemical_classification, biology, Wild type, Staphylococcal Infections, Anti-Bacterial Agents, Tetrahydrofolate Dehydrogenase, Streptococcus pneumoniae, Enzyme, chemistry, Quinazolines, biology.protein, Folic Acid Antagonists, Molecular Medicine, Benzimidazoles
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2
المؤلفون: Shahad Rahawi, Mark Hilgers, Juan J. Picazo, Jeffrey L. Stein, Jeffrey B. Locke, G C Kedar, Karen Joy Shaw, Gracia Morales
المصدر: ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)مصطلحات موضوعية: Ribosomal Proteins, Staphylococcus aureus, Micrococcaceae, Ribosomal Protein L3, Microbial Sensitivity Tests, Drug resistance, Biology, Microbiología, medicine.disease_cause, Microbiology, chemistry.chemical_compound, Anti-Infective Agents, Bacterial Proteins, Mechanisms of Resistance, Ribosomal protein, 23S ribosomal RNA, Acetamides, Drug Resistance, Bacterial, medicine, Pharmacology (medical), Oxazolidinones, Antibacterial agent, Pharmacology, Linezolid, Methyltransferases, Ribosomal RNA, biology.organism_classification, Infectious Diseases, chemistry, Mutation, Bacteriología
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4812ae11cea60f8da64f1db67eebebc5
https://doi.org/10.1128/aac.00714-10 -
3
المؤلفون: Shahad Rahawi, John Finn, Mark Hilgers, Juan J. Picazo, Weonbin Im, G C Kedar, Jeffrey L. Stein, Karen Joy Shaw, Jeffrey B. Locke, Gracia Morales
المصدر: ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)مصطلحات موضوعية: Staphylococcus aureus, Microbial Sensitivity Tests, Biology, Microbiología, medicine.disease_cause, Microbiology, Structure-Activity Relationship, chemistry.chemical_compound, Bacterial Proteins, Ribosomal protein, 23S ribosomal RNA, Acetamides, medicine, Pharmacology (medical), Ribosomal DNA, Oxazolidinones, Antibacterial agent, Pharmacology, Linezolid, Methyltransferases, Chemistry, Biosynthesis, Ribosomal RNA, Anti-Bacterial Agents, Infectious Diseases, Biochemistry, chemistry, Methyltransferase Gene, Mutation, Ribosomes, Bacteriología
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ce51ba992888de7ca742ba26f2d924
https://doi.org/10.1128/aac.00663-10 -
4
المؤلفون: Mark Hilgers, Jeffrey B. Locke, Karen Joy Shaw
المصدر: Antimicrobial Agents and Chemotherapy. 53:5275-5278
مصطلحات موضوعية: Ribosomal Proteins, Staphylococcus aureus, Peptidyl transferase, Ribosomal Protein L3, Staphylococcus, Tetrazoles, Biology, Staphylococcal infections, medicine.disease_cause, Protein Structure, Secondary, Microbiology, chemistry.chemical_compound, Mechanisms of Resistance, Ribosomal protein, Staphylococcus epidermidis, Acetamides, Drug Resistance, Bacterial, medicine, Pharmacology (medical), Oxazolidinones, Antibacterial agent, Pharmacology, Mutation, Binding Sites, Linezolid, Staphylococcal Infections, medicine.disease, biology.organism_classification, RNA, Ribosomal, 23S, Infectious Diseases, chemistry, biology.protein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d71f96bf4a1f1bdf0b416f02f93a343
https://doi.org/10.1128/aac.01032-09 -
5
المؤلفون: Mark Hilgers, Karen Joy Shaw, Jeffrey B. Locke
المصدر: Antimicrobial Agents and Chemotherapy. 53:5265-5274
مصطلحات موضوعية: Methicillin-Resistant Staphylococcus aureus, Ribosomal Proteins, Staphylococcus aureus, Ribosomal Protein L3, Tetrazoles, Microbial Sensitivity Tests, Drug resistance, Gene mutation, Biology, medicine.disease_cause, Microbiology, chemistry.chemical_compound, Mechanisms of Resistance, 23S ribosomal RNA, Acetamides, medicine, Pharmacology (medical), Escherichia coli, Oxazolidinones, Antibacterial agent, Pharmacology, Molecular Structure, Linezolid, Anti-Bacterial Agents, RNA, Ribosomal, 23S, Infectious Diseases, chemistry, Mutation, Tedizolid
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa727f0be454ca2b3a543c020c664b32
https://doi.org/10.1128/aac.00871-09 -
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المؤلفون: Mark Stidham, Daniel R. Reyes, Vickie Brown-Driver, G C Kedar, Robert Haselbeck, John T. Finn, Karen Joy Shaw, Mark Hilgers
المصدر: Antimicrobial Agents and Chemotherapy. 52:2009-2013
مصطلحات موضوعية: Mutagenesis (molecular biology technique), Microbial Sensitivity Tests, Fosfomycin, Microbiology, Inhibitory Concentration 50, Bacterial Proteins, Drug Resistance, Bacterial, Gene expression, medicine, RNA, Antisense, Pharmacology (medical), Mechanisms of Action: Physiological Effects, Gene, Pharmacology, Alkyl and Aryl Transferases, Bacillaceae, biology, biology.organism_classification, In vitro, Anti-Bacterial Agents, Bacillus anthracis, Infectious Diseases, Bacteria, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792cab45815141765055fcc25d63c63c
https://doi.org/10.1128/aac.01594-07 -
7
المؤلفون: G C Kedar, Daniel R. Reyes, Mark Stidham, Vickie Brown-Driver, Mark Hilgers, Karen Joy Shaw, Robert Haselbeck, John T. Finn
المصدر: Antimicrobial Agents and Chemotherapy. 51:1708-1718
مصطلحات موضوعية: Pharmacology, Genetics, Base Sequence, biology, Molecular Sequence Data, RNA, Methionine-tRNA Ligase, Reductase, biology.organism_classification, Anti-Bacterial Agents, Bacillus anthracis, Antisense RNA, Microbiology, Antisense Orientation, Infectious Diseases, Transcription (biology), Carbohydrate Dehydrogenases, RNA, Antisense, Pharmacology (medical), Mechanisms of Action: Physiological Effects, Gene, Antibacterial agent
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76959466862ccd46e9963ab481552e80
https://doi.org/10.1128/aac.01180-06 -
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المؤلفون: Mark L. Cunningham, Allen J. Borchardt, Grayson Hough, Mark Hilgers, Bryan P. Kwan, Karen J. Shaw, Jeffrey B. Locke, Sunny Abraham, Gregory Haley, John T. Finn, Min Teng, Courtney Hall
المصدر: Journal of medicinal chemistry. 56(4)
مصطلحات موضوعية: Models, Molecular, Burkholderia, Yersinia pestis, Mutant, Microbial Sensitivity Tests, medicine.disease_cause, Crystallography, X-Ray, Haemophilus influenzae, Substrate Specificity, Structure-Activity Relationship, Bacterial Proteins, Drug Discovery, Drug Resistance, Bacterial, medicine, Escherichia coli, Threonine-tRNA Ligase, Humans, Binding site, Binding Sites, biology, Burkholderia thailandensis, Molecular Structure, Chemistry, Escherichia coli Proteins, Substrate (chemistry), Stereoisomerism, biology.organism_classification, Antimicrobial, Anti-Bacterial Agents, Biochemistry, Mutation, Quinazolines, Molecular Medicine, Bacteria, Protein Binding
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المؤلفون: Xiaoming Li, Mark Hilgers, Mark Cunningham, Zhiyong Chen, Michael Trzoss, Junhu Zhang, Lucy Kohnen, Thanh Lam, Chris Creighton, Kedar GC, Kirk Nelson, Bryan Kwan, Mark Stidham, Vickie Brown-Driver, Karen J. Shaw, John Finn
المصدر: Bioorganicmedicinal chemistry letters. 21(18)
مصطلحات موضوعية: Drug, Models, Molecular, Staphylococcus aureus, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, medicine.disease_cause, Crystallography, X-Ray, Biochemistry, Microbiology, chemistry.chemical_compound, Structure-Activity Relationship, Antibiotic resistance, Drug Discovery, Dihydrofolate reductase, medicine, Potency, heterocyclic compounds, Enzyme Inhibitors, Molecular Biology, media_common, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Aryl, Organic Chemistry, Stereoisomerism, Trimethoprim, Anti-Bacterial Agents, Tetrahydrofolate Dehydrogenase, Drug Design, biology.protein, Quinazolines, Molecular Medicine, Antibacterial activity, medicine.drug
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10
المؤلفون: Mark Stidham, Mark Hilgers, G C Kedar, John T. Finn
المصدر: Bioorganicmedicinal chemistry letters. 18(14)
مصطلحات موضوعية: Staphylococcus aureus, Methionine—tRNA ligase, Molecular model, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Methionine-tRNA Ligase, Ligands, Biochemistry, Amino Acyl-tRNA Synthetases, chemistry.chemical_compound, Structure-Activity Relationship, Anti-Infective Agents, Drug Discovery, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Antibacterial agent, Virtual screening, Binding Sites, Molecular Structure, Chemistry, Aminoacyl tRNA synthetase, Organic Chemistry, Biological activity, Models, Chemical, Drug Design, Molecular Medicine, Pharmacophore