المؤلفون: Matt Soars, Lisa M. Kopcho, Carolyn A. Weigelt, Shilpa Demes, Gregory D. Vite, Mary J. Harner, Rohit Malik, Guo Li, David G. Harden, Charles F. Voliva, Kevin O’Malley, Zheming Ruan, Lan-Ying Qin, Brian J. Arey, Peter K. Park, Jennifer Price, Steven Sheriff, Gerald J. Duke, Ashvinikumar V. Gavai, JIngjing Deng, Brian E. Fink, Christopher M. Barbieri, Max Ruzanov, Muge Celiktas, Mark R. Witmer, Yuval Blat, William D. Schmitz, Joseph G. Naglich, Iyoncy Rodrigo

المصدر: Cancer Research. 81:1140-1140

مصطلحات موضوعية: Cancer Research, Gene knockdown, Chemistry, Protein arginine methyltransferase 5, Cancer, medicine.disease, Molecular biology, In vitro, law.invention, Oncology, CDKN2A, In vivo, law, Cancer cell, medicine, Suppressor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::769a298e5dedd6469a5cf85008a3a619
https://doi.org/10.1158/1538-7445.am2021-1140

المؤلفون: William J. Metzler, Luciano Mueller, Yaqun Zhang, Mian Gao, Nicolas Szapiel, Mark R. Witmer, David Hedin, Deepa Calambur, Dianlin Xie, Hui Wei, Frank Marsilio, Andrew E Douglas, Ping Zhang

المصدر: Journal of Biomolecular NMR. 68:237-247

مصطلحات موضوعية: 0301 basic medicine, Spodoptera, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Stable isotope labeling by amino acids in cell culture, Sf9 Cells, Animals, Amino Acids, Nuclear Magnetic Resonance, Biomolecular, Spectroscopy, chemistry.chemical_classification, Carbon Isotopes, Growth medium, Chromatography, Nitrogen Isotopes, 030102 biochemistry & molecular biology, Insect cell culture, Yeast, Culture Media, Amino acid, 030104 developmental biology, chemistry, Focal Adhesion Kinase 1, Isotope Labeling, Protein Biosynthesis, Reagent, Yield (chemistry), CD4 Antigens, Fermentation, Baculoviridae

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c242af38cb96b9b62862b64bf418f26
https://doi.org/10.1007/s10858-017-0117-6

المؤلفون: Katherine A. Grant-Young, Andrew Nickel, Rajesh Onkardas Bora, Prakash Anjanappa, Bender John A, Kevin Kish, Kap-Sun Yeung, Dawn D. Parker, Joseph Raybon, Mark R. Witmer, Karen Rigat, Matthew G. Soars, Steven Sheriff, Yue-Zhong Shu, Kenneth S. Santone, Prashantha Gunaga, Kyle Parcella, Nicholas A. Meanwell, Jay O. Knipe, Susan B. Roberts, Alicia Ng, Michael Sinz, Kathy Mosure, Ying-Kai Wang, Brett R. Beno, Mengping Liu, Elizabeth Colston, Dennis M. Grasela, John F. Kadow, Qi Gao, Min Gao, Umesh Hanumegowda, Roy Haskell, Julie A. Lemm, Xiaoliang Zhuo, Changhong Wan, Kumaravel Selvakumar

المصدر: Journal of Medicinal Chemistry. 60:4369-4385

مصطلحات موضوعية: Male, 0301 basic medicine, Hepatitis C virus, Allosteric regulation, RNA-dependent RNA polymerase, Hepacivirus, Viral Nonstructural Proteins, medicine.disease_cause, Antiviral Agents, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Allosteric Regulation, Drug Discovery, medicine, Animals, Humans, Benzofuran, NS5B, Benzofurans, Ligand efficiency, 010405 organic chemistry, Chemistry, Drug discovery, Haplorhini, Hepatitis C, Rats, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Biochemistry, Benzothiadiazine, Molecular Medicine, Allosteric Site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e500f8c2cd73d6873f1280c193d753
https://doi.org/10.1021/acs.jmedchem.7b00328

المؤلفون: Hua Fang, Kevin Kish, Mark R. Witmer, Matthew G. Soars, Kyle Parcella, Brett R. Beno, Ying-Kai Wang, Prakash Anjanappa, Julie A. Lemm, Karen Rigat, Katherine A. Grant-Young, Kap-Sun Yeung, Kathy Mosure, Steven Sheriff, Kenneth S. Santone, Jeffrey Tredup, Dawn D. Parker, John F. Kadow, Rajesh Onkardas Bora, Mengping Liu, Nicholas A. Meanwell, Susan B. Roberts, Adam G. Jardel, Rudolph G. Krause, Juliang Zhu, Kumaravel Selvakumar, Roy Haskell

مصطلحات موضوعية: Membrane permeability, 010405 organic chemistry, Hydrogen bond, Chemistry, Organic Chemistry, Transporter, 01 natural sciences, Biochemistry, 0104 chemical sciences, Polar surface area, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Intramolecular force, Drug Discovery, Biophysics, Molecule, Efflux, NS5B

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b87c17f58394ad90d7b8ea7bef1817f
https://europepmc.org/articles/PMC6295864/

المؤلفون: Stephen R. Johnson, Dianlin Xie, Lihong Cheng, Yang Hong, John S. Tokarski, Adriana Zupa-Fernandez, Jodi K. Muckelbauer, Mark R. Witmer, Sophie Wu, Chiehying Chang, Donna L. Pedicord, Suzanne C. Edavettal, David S. Weinstein, William J. Pitts, Yuval Blat, James R. Burke, Lisa Elkin, Kristen Pike, Jeffrey Tredup

المصدر: Journal of Biological Chemistry. 290:11061-11074

مصطلحات موضوعية: Models, Molecular, T-Lymphocytes, Allosteric regulation, Biology, Crystallography, X-Ray, Biochemistry, TYK2 Kinase, Enzyme Stability, Functional selectivity, Humans, Molecular Biology, Janus kinase 1, Janus kinase 3, Janus Kinase 3, Receptors, Interleukin-2, Janus Kinase 1, Cell Biology, Protein Structure, Tertiary, Cell biology, Tyrosine kinase 2, Signal transduction, Janus kinase, Receptors, Thrombopoietin, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9176c99caf70572ecd7615a142c06a
https://doi.org/10.1074/jbc.m114.619502

المؤلفون: Joseph E. Myers, Javed Khan, Daniel Meyers, Ginger Chao, Doree F. Sitkoff, Fred Lo, Katie A. Russo, Hossain Monshizadegan, Tracy S. Mitchell, Mark R. Witmer, Rex A. Parker, Bowman Miao, Mian Gao, Denhez Fabienne M, Gerald J. Duke, Dibella Rose A, Simon Low, Siew Peng Ho

المصدر: Journal of Pharmacology and Experimental Therapeutics. 350:412-424

مصطلحات موضوعية: Transgene, Molecular Sequence Data, Mice, Transgenic, Pharmacology, Biology, Polyethylene Glycols, Mice, chemistry.chemical_compound, Species Specificity, Pharmacokinetics, Animals, Humans, Amino Acid Sequence, Receptor, Cholesterol, Anticholesteremic Agents, PCSK9, Cholesterol, HDL, Serine Endopeptidases, Proteins, Proprotein convertase, Rats, Lipoproteins, LDL, Mice, Inbred C57BL, Macaca fascicularis, Receptors, LDL, chemistry, Biochemistry, Low-density lipoprotein, Molecular Medicine, Female, Proprotein Convertases, Proprotein Convertase 9, Crystallization, Lipoprotein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e5075ea30b90a342b6d689f6c54c63
https://doi.org/10.1124/jpet.114.214221

المؤلفون: Zhong Yang, Jay O. Knipe, Susan B. Roberts, Yong Tu, Paul E. Morin, Ying-Kai Wang, John Wan, Andrew Nickel, Katharine A. Grant-Young, Piyasena Hewawasam, Sam T. Chao, Xiaoliang Zhuo, Bergstrom Carl P, Brett R. Beno, Qi Gao, Dianlin Xie, Chong-Hwan Chang, Dawn D. Parker, Mian Gao, Alicia Regueiro-Ren, Mengping Liu, Umesh Hanumegowda, Richard J. Colonno, Kathy Mosure, Nicholas A. Meanwell, Min Ding, Lenore A. Pelosi, John F. Kadow, Xiaofan Zheng, Steven Sheriff, Voss Stacey A, Alicia Ng, Kenneth S. Santone, Mark R. Witmer, Jung-Hui Sun, Robert G. Gentles, Bender John A, Min Gao, Yi Wang, Jeff Tredup, Daniel M. Camac, Scott W. Martin, Thomas W. Hudyma, Julie A. Lemm, Kap-Sun Yeung, Karen Rigat

المصدر: Journal of Medicinal Chemistry. 57:1855-1879

مصطلحات موضوعية: Models, Molecular, Indoles, Magnetic Resonance Spectroscopy, Membrane permeability, Hepatitis C virus, Allosteric regulation, Viral Nonstructural Proteins, Pharmacology, medicine.disease_cause, Antiviral Agents, Mass Spectrometry, Structure-Activity Relationship, chemistry.chemical_compound, Transactivation, Dogs, Allosteric Regulation, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, Beclabuvir, Pregnane X receptor, Drug discovery, Benzazepines, Rats, Biochemistry, chemistry, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef74807d123b8140c1724c36314db30
https://doi.org/10.1021/jm4016894

المؤلفون: Jing Yang, Mary Ellen Cvijic, Huaping Tang, Mark R. Witmer, Sophie Wu, Mian Gao, Yaqun Zhang, Litao Zhang, Brian Carpenter, Deepa Calambur, Ding Ren Shen, Keith Constantine

المصدر: ASSAY and Drug Development Technologies. 12:80-86

مصطلحات موضوعية: Lung Neoplasms, Cell, Drug Evaluation, Preclinical, Receptor tyrosine kinase, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Proto-Oncogene Proteins, Image Interpretation, Computer-Assisted, Drug Discovery, medicine, Humans, Receptor, Protein Kinase Inhibitors, Dose-Response Relationship, Drug, biology, AXL receptor tyrosine kinase, Kinase, GAS6, Cell growth, Receptor Protein-Tyrosine Kinases, Axl Receptor Tyrosine Kinase, High-Throughput Screening Assays, Molecular Imaging, Cell biology, medicine.anatomical_structure, Microscopy, Fluorescence, Drug Design, biology.protein, Molecular Medicine, Biological Assay, Signal transduction, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e74076c1993d77fad803179872424e7
https://doi.org/10.1089/adt.2013.540

المؤلفون: Kevin Kish, Tianle Li, Shuqun Lin, Yi Fan, Alaric J. Dyckman, John H. Dodd, Murray McKinnon, Rosemary Zhang, John S. Sack, Katerina Leftheris, John S. Tokarski, T. G. Murali Dhar, Gary L. Schieven, Susan E. Kiefer, Arthur M. Doweyko, Joel C. Barrish, Mark R. Witmer, Stephen T. Wrobleski, Sidney Pitt, John A. Newitt

المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4120-4126

مصطلحات موضوعية: Gene isoform, Clinical Biochemistry, Pharmaceutical Science, Peptide, Molecular Dynamics Simulation, Crystallography, X-Ray, Biochemistry, Mitogen-Activated Protein Kinase 14, Structure-Activity Relationship, Drug Discovery, Humans, Protein Isoforms, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Kinase, Chemistry, Organic Chemistry, Rational design, Hydrogen Bonding, Protein Structure, Tertiary, Flip, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Cyclin-dependent kinase 9, Kinase binding, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f28c8e396ac76e6111c1f403141f812
https://doi.org/10.1016/j.bmcl.2013.05.047

المؤلفون: Richard Doyle, Robert M. Johnston, Wei Ding, Yeoun jin Kim, Changhong Wan, Yeung Y. Chan, Mian Gao, Olav Lyngberg, James William Bryson, Deepa Calambur, Mark R. Witmer, Stanley R. Krystek, Ronald L. Hanson, Ehrlic Lo, Steven H. Chan, Animesh Goswami, Nuria de Mas, Steven L. Goldberg, Antonio Ramirez

المصدر: Bioconjugate chemistry. 27(5)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Leucine zipper, Biomedical Engineering, Pharmaceutical Science, Bioengineering, Peptide, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Escherichia coli, Amino Acid Sequence, Disulfides, Protein Structure, Quaternary, Peptide sequence, Pharmacology, chemistry.chemical_classification, Oligopeptide, business.industry, Organic Chemistry, Combinatorial chemistry, Fusion protein, Biotechnology, Amino acid, 030104 developmental biology, S-tag, chemistry, Protein Multimerization, business, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f2c9a4bdec7035d8f9d6121167956d
https://pubmed.ncbi.nlm.nih.gov/27098672