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المؤلفون: Robert Francis Kester, Linda Marcus, Marek M. Kabat, Lida Qi, Wang Ka, Michael Pignatello, Wendy Lea Corbett, Cheryl Spence, Franz M. Matschinsky, Lisa M. Garofalo, Roumen Nikolaev Radinov, Ramakanth Sarabu, David J Moore, Yi Ren, Nancy-Ellen Haynes, Zhenmin Liang, Fred Thomas Bizzarro, Darryl W. Hilliard, John Tengi, Wanping Geng, Stanley D. Hutchings, Thomas G. Steele, Joseph Grimsby, Mark T. Dvorozniak, Joseph F. Grippo, Kevin Richard Guertin, Paige Erin Mahaney, Jagdish Kumar Racha
المصدر: Journal of Medicinal Chemistry. 55:7021-7036
مصطلحات موضوعية: Male, medicine.medical_specialty, Metabolite, medicine.medical_treatment, Benzeneacetamides, Enzyme Activators, Type 2 diabetes, Lipidoses, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, In vivo, Internal medicine, Glucokinase, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Rats, Wistar, Thiazole, Insulin, Stereoisomerism, Postprandial Period, medicine.disease, Rats, Mice, Inbred C57BL, Macaca fascicularis, Glucose, Endocrinology, Postprandial, Diabetes Mellitus, Type 2, Liver, chemistry, Toxicity, Molecular Medicine, Female, Rabbits
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المؤلفون: Ramakanth Sarabu, Jianping Lou, Achyutharao Sidduri, David J Moore, Jagdish Kumar Racha, Joseph Grimsby, Wendy Lea Corbett, Cheryl Spence, Robert Francis Kester, Linda Marcus, Mark T. Dvorozniak, Joseph F. Grippo
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5673-5676
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Benzeneacetamides, Pharmaceutical Science, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Glucokinase, Drug Discovery, Glucokinase activator, Animals, Hypoglycemic Agents, Sulfones, Rats, Wistar, Molecular Biology, Alkyl, chemistry.chemical_classification, Acrylamides, Chemistry, Organic Chemistry, In vitro, Rats, Enzyme, Acrylamide, Molecular Medicine
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المؤلفون: Joseph Grimsby, Robert Francis Kester, Aruna Railkar, Cheryl Spence, Nancy-Ellen Haynes, Kevin Richard Guertin, Paige Erin Mahaney, Lida Qi, John Tengi, Wendy Lea Corbett, Fred Thomas Bizzarro, Mark T. Dvorozniak, George W. Holland, Joseph F. Grippo, Franz M. Matschinsky, Darryl W. Hilliard, Ramakanth Sarabu
المصدر: Journal of Medicinal Chemistry. 53:3618-3625
مصطلحات موضوعية: Blood Glucose, Male, medicine.medical_treatment, Allosteric regulation, Carbohydrate metabolism, Cell Line, Mice, Structure-Activity Relationship, Pharmacokinetics, Glucokinase, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Insulin, Structure–activity relationship, Glucose homeostasis, Sulfones, Dose-Response Relationship, Drug, Cytotoxins, Chemistry, Drug discovery, Thiazoles, Diabetes Mellitus, Type 2, Biochemistry, Molecular Medicine
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المؤلفون: J Douglas Larigan, Kuo-Sen Huang, Mark T. Dvorozniak, Rebecca Taub, Yimin Qian, Charles H. Reynolds, Nancy-Ellen Haynes, Bruce L. Banner, Sherrie Lynn Pietranico-Cole, Kelly Martha, Jefferson Wright Tilley, Irwin Klein, Nathan Robert Scott, Frank Mennona, Kshitij Chhabilbhai Thakkar, Sung-Sau So, Sara Danzi, Karin Conde-Knape, John Vermeulen
المصدر: Journal of medicinal chemistry. 57(10)
مصطلحات موضوعية: Agonist, Male, medicine.medical_specialty, medicine.drug_class, Pharmacology, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Bone Density, Internal medicine, Drug Discovery, medicine, Potency, Animals, Humans, Uracil, Dyslipidemias, Clinical Trials as Topic, Thyroid hormone receptor, Chemistry, Thyroid, Thyroid Hormone Receptors beta, medicine.disease, Hypothalamic–pituitary–thyroid axis, Rats, Mice, Inbred C57BL, Pyridazines, medicine.anatomical_structure, Endocrinology, Molecular Medicine, Dyslipidemia, Isopropyl, Hormone
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المؤلفون: Cheryl Janson, Martin Weisel, Barry Goggin, Liang Weiling, Adrian J. Fretland, Robert Francis Kester, Christine Lukacs, Edmund Lee, Jennifer Lo, J. Heather Hogg, Xiaochun Han, Kyoungja Hong, Stacy Remiszewski, Shirley Li, Ann Polonskaia, John Anthony Moliterni, Kang Le, Lin Gao, Nam T. Le, Christophe Michoud, A. Schutt, Shahid Tannu, Andrew F. Donnell, Shaoqing Chen, Louis J. Lombardo, Steven Gregory Mischke, Mark T. Dvorozniak, Yan Lou, Christine Tardell, Kenneth Carey Rupert, Doug Aguilar, Dave S. Solis
المصدر: Journal of medicinal chemistry. 56(20)
مصطلحات موضوعية: Models, Molecular, Cell Survival, Ubiquitin-Protein Ligases, Blotting, Western, Mice, Nude, Apoptosis, X-Linked Inhibitor of Apoptosis Protein, Inhibitor of apoptosis, Crystallography, X-Ray, Inhibitor of Apoptosis Proteins, Mice, Heterocyclic Compounds, Cell Line, Tumor, Drug Discovery, Animals, Humans, Caspase, Caspase-9, Caspase 7, Benzodiazepinones, Alanine, biology, Molecular Structure, Chemistry, Caspase 3, Xenograft Model Antitumor Assays, In vitro, Cell biology, XIAP, Protein Structure, Tertiary, Models, Chemical, Cell culture, Cancer cell, biology.protein, Molecular Medicine, Female
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المؤلفون: Joseph Grimsby, Wanping Geng, Navita L. Mallalieu, Mark T. Dvorozniak, Wendy Lea Corbett, Nancy-Ellen Haynes, Jagdish Kumar Racha, Yimin Qian, David J Moore, Kevin Richard Guertin, Nathan Robert Scott, Robert Francis Kester, Steven Joseph Berthel, Roumen Nikolaev Radinov, Francis A. Mennona, Ramakanth Sarabu, Duk Soon Choi, Paul Gillespie
المصدر: ACS medicinal chemistry letters. 4(4)
مصطلحات موضوعية: Drug, Ligand efficiency, Safety studies, business.industry, media_common.quotation_subject, Metabolite, Organic Chemistry, Metabolism, Type 2 diabetes, Pharmacology, medicine.disease, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Glucokinase activator, Medicine, business, Redox cycling, media_common
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المؤلفون: Michael J. Brunda, Mark T. Dvorozniak, Jill A. Hendrzak, Anthony Aglione, Rosemary B. Wright, Palleroni Alicia Vallejo, Leopoldo Luistro, Leonid Rumennik, Jon M. Wigginton, Robert H. Wiltrout
المصدر: Cancer Chemotherapy and Pharmacology. 38:S16-S21
مصطلحات موضوعية: Interleukin 2, Cancer Research, medicine.medical_treatment, Pharmacology, Toxicology, Immune system, Interferon, Antimetastatic Agent, Tumor Cells, Cultured, medicine, Animals, Humans, Pharmacology (medical), Interferon alfa, Chemotherapy, business.industry, Neoplasms, Experimental, Interleukin-12, Cytokine, Oncology, Interleukin 12, Interleukin-2, Drug Screening Assays, Antitumor, business, medicine.drug
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المؤلفون: Lida Qi, John Tengi, Robert Francis Kester, Kevin Richard Guertin, Linda Marcus, Cheryl Spence, Nancy-Ellen Haynes, Fred Thomas Bizzarro, Paige Erin Mahaney, Joseph Grimsby, Mark A. Magnuson, Mark T. Dvorozniak, Franz M. Matschinsky, Wendy Lea Corbett, Chang An Chu, Joseph F. Grippo, John W. Coffey, Ramakanth Sarabu, Darryl W. Hilliard
المصدر: Science (New York, N.Y.). 301(5631)
مصطلحات موضوعية: Blood Glucose, Male, medicine.medical_treatment, Drug Evaluation, Preclinical, Mice, Obese, Mice, Glucokinase, Insulin Secretion, Glucose homeostasis, Homeostasis, Insulin, Glucose tolerance test, Multidisciplinary, medicine.diagnostic_test, Glucokinase regulatory protein, Intracellular Signaling Peptides and Proteins, Stereoisomerism, Keto Acids, Recombinant Proteins, medicine.anatomical_structure, Liver, medicine.medical_specialty, Enzyme Activators, Biology, Islets of Langerhans, Allosteric Regulation, Internal medicine, Diabetes mellitus, medicine, Animals, Humans, Hypoglycemic Agents, Rats, Wistar, Adaptor Proteins, Signal Transducing, Dose-Response Relationship, Drug, Pancreatic islets, Type 2 Diabetes Mellitus, Proteins, Glucose Tolerance Test, medicine.disease, Liver Glycogen, Rats, Enzyme Activation, Mice, Inbred C57BL, Thiazoles, Endocrinology, Glucose, Diabetes Mellitus, Type 2, biology.protein, Carrier Proteins
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المؤلفون: Satbir Kaur, Joseph F. Grippo, Chiyo Shiota, Jeanne Magram, Franz M. Matschinsky, Guizhu Li, Mark A. Magnuson, John W. Coffey, Joseph Grimsby, Mark T. Dvorozniak
المصدر: The Journal of biological chemistry. 275(11)
مصطلحات موضوعية: medicine.medical_specialty, Heterozygote, Biochemistry, Islets of Langerhans, Mice, Internal medicine, Gene expression, Glucokinase, medicine, Animals, Homeostasis, Insulin, Enzyme Inhibitors, Molecular Biology, Adaptor Proteins, Signal Transducing, Mice, Knockout, Glucose tolerance test, Glucokinase regulatory protein, biology, medicine.diagnostic_test, Homozygote, Age Factors, Intracellular Signaling Peptides and Proteins, Gene targeting, Proteins, Heterozygote advantage, Cell Biology, Metabolism, Glucose Tolerance Test, Endocrinology, Glucose, Liver, Mutagenesis, Knockout mouse, Gene Targeting, biology.protein, Carrier Proteins
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8892c21f6d7c1e388bb07e77efde8c
https://pubmed.ncbi.nlm.nih.gov/10713097 -
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المصدر: Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 18(6)
مصطلحات موضوعية: chemistry.chemical_classification, biology, medicine.diagnostic_test, Immunology, Substrate (chemistry), Alpha interferon, Interferon-alpha, Reproducibility of Results, Cell Biology, Molecular biology, Immunoglobulin G, Antibodies, Immunoenzyme Techniques, Enzyme, chemistry, Antigen, Virology, Immunoassay, biology.protein, medicine, Antibody, Peroxidase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0e2c1ecf186055b7d0d478cb387243
https://pubmed.ncbi.nlm.nih.gov/9660241
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