المؤلفون: Arianna Giusti, Xuan-Bac Nguyen, Stanislav Kislyuk, Mélanie Mignot, Cecilia Ranieri, Johan Nicolaï, Marlies Oorts, Xiao Wu, Pieter Annaert, Noémie De Croze, Marc Léonard, Annelii Ny, Deirdre Cabooter, Peter de Witte

المصدر: International Journal of Molecular Sciences, Vol 20, Iss 7, p 1712 (2019)

مصطلحات موضوعية: drug discovery, toxicity, microsomes, metabolism, zebrafish eleuthero embryos, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1422-0067/20/7/1712; https://doaj.org/toc/1422-0067

URL الوصول: https://doaj.org/article/8477ae5478d348fbbb6e72bd31d6b1a7

المؤلفون: Mathieu Vinken, Pieter Annaert, Sagnik Chatterjee, Axelle Cooreman, Lysiane Richert, Pieter Van Brantegem, Erwin Dreesen, Neel Deferm, Marlies Oorts

المساهمون: Pharmaceutical and Pharmacological Sciences, Faculty of Medicine and Pharmacy, Experimental in vitro toxicology and dermato-cosmetology

مصطلحات موضوعية: Glycocholic acid, Pharmacology, Bile Acids and Salts, chemistry.chemical_compound, Cholestasis, Chenodeoxycholic acid, Glycochenodeoxycholic acid, medicine, Extracellular, Humans, Antihypertensive Agents, Cells, Cultured, Dose-Response Relationship, Drug, Bosentan, Extracellular Fluid, medicine.disease, Culture Media, respiratory tract diseases, chemistry, S9 fraction, Glycine, Hepatocytes, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c217992b234cbd7bc6a7d4f08e3d953b
https://hdl.handle.net/20.500.14017/e05ae3dd-cdd5-4a09-8f8a-4cf98ecbca80

المؤلفون: Thomas Dufour, Greet Van den Berghe, Sarah Vander Perre, Sarah Derde, Marlies Oorts, Marc Jenniskens, Fabian Güiza, Steven Thiessen, Pieter Annaert, Lies Langouche

المصدر: Shock (Augusta, Ga.)

مصطلحات موضوعية: 0301 basic medicine, Time Factors, ALT, Critical Care and Intensive Care Medicine, intensive care unit, gGT, law.invention, sepsis, Mice, 0302 clinical medicine, aspartate aminotransferase, law, CYP27A1, Gene expression, Angiogenic Proteins, Cholesterol 7-alpha-Hydroxylase, nutrient restriction, Cholestasis, Bile acid, Intensive care unit, 3. Good health, FXR, Emergency Medicine, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Cholestanetriol 26-Monooxygenase, Female, bilirubin, Multidrug Resistance-Associated Proteins, CRP, alkaline phosphatase, medicine.medical_specialty, medicine.drug_class, alanine aminotransferase, RXR, Cholesterol 7 alpha-hydroxylase, liver, BA, Gene Expression Regulation, Enzymologic, C-reactive protein, Farnesoid-X-Receptor, Sepsis, Bile Acids and Salts, 03 medical and health sciences, Internal medicine, Severity of illness, medicine, critical illness, Animals, AST, Caloric Restriction, business.industry, retinoid-X-receptor, Basic Science Aspects, 030208 emergency & critical care medicine, medicine.disease, Bile acids, Disease Models, Animal, 030104 developmental biology, Endocrinology, gamma-glutamyltranspeptidase, ICU, ALP, business

وصف الملف: Print

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67989a8d126ff04a1ac7780ffe96c70
http://europepmc.org/articles/PMC6039378

المؤلفون: Vera Rogiers, Agapios Sachinidis, Umesh Chaudhari, Pieter Annaert, René P. Zahedi, Albert Sickmann, Xiaoqi Jiang, Marlies Oorts, Hector C. Keun, Eva Gijbels, Laxmikanth Kollipara, Eef Hoeben, Annette Kopp-Schneider, Jan G. Hengstler, Mathieu Vinken, Joery De Kock, Tamara Vanhaecke, Robim Marcelino Rodrigues

المساهمون: Pharmaceutical and Pharmacological Sciences, Faculty of Medicine and Pharmacy, Experimental in vitro toxicology and dermato-cosmetology, Connexin Signalling Research Group, Vriendenkring VUB, Liver Connexin and Pannexin Research Group

المصدر: Archives of Toxicology. 92:1939-1952

مصطلحات موضوعية: Proteomics, 0301 basic medicine, Health, Toxicology and Mutagenesis, Receptors, Cytoplasmic and Nuclear, Pharmacology, Toxicology, HEPATOCYTES, transcriptomics, 0302 clinical medicine, ATP Binding Cassette Transporter, Subfamily B, Member 11, Liver injury, BILE-ACIDS, Cholestasis, Bile acid, SAMPLE PREPARATION, General Medicine, adverse outcome pathway, Liver, BSEP, 030220 oncology & carcinogenesis, LIVER-INJURY, HepaRG, Life Sciences & Biomedicine, FARNESOID-X-RECEPTOR, medicine.drug, Cell Survival, medicine.drug_class, Adverse outcome pathway, INHIBITION, Biology, Article, MECHANISMS, Bile Acids and Salts, 03 medical and health sciences, Metabolomics, Cell Line, Tumor, medicine, Humans, dverse outcome pathway, Transcriptomics, Science & Technology, IDENTIFICATION, Dose-Response Relationship, Drug, DRUG-INDUCED CHOLESTASIS, Gene Expression Profiling, Bosentan, medicine.disease, Bile Salt Export Pump, SALT EXPORT PUMP, Oxidative Stress, 030104 developmental biology, 1115 Pharmacology And Pharmaceutical Sciences, Farnesoid X receptor, cholestasis, Transcriptome

وصف الملف: Print-Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0922659e4897f7f7ed55511e7e1d06
https://doi.org/10.1007/s00204-018-2214-z

المؤلفون: Nico Holmstock, Marlies Oorts, Pieter Annaert, Jan Snoeys

المصدر: Drug Metabolism and Disposition. 46:697-703

مصطلحات موضوعية: Male, 0301 basic medicine, Pharmaceutical Science, 030226 pharmacology & pharmacy, law.invention, 03 medical and health sciences, 0302 clinical medicine, Confocal microscopy, law, medicine, Animals, Humans, HIV Protease Inhibitor, Drug Interactions, Rats, Wistar, Cells, Cultured, Darunavir, Pharmacology, Microscopy, Confocal, Chemistry, Multidrug resistance-associated protein 2, Membrane Transport Proteins, Biological Transport, HIV Protease Inhibitors, Fluoresceins, Multidrug Resistance-Associated Protein 2, Rats, 030104 developmental biology, Nelfinavir, Liver, Biochemistry, Hepatocytes, Efflux, Multidrug Resistance-Associated Proteins, Tipranavir, Saquinavir, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a571eb5464e4ecf9b253f381f7049f
https://doi.org/10.1124/dmd.117.079467

المؤلفون: Pieter Annaert, Patrick Augustijns, Robin Adriaensen, Janneke Keemink, Marlies Oorts, Neel Deferm, Lysiane Richert

المصدر: Journal of Pharmacological and Toxicological Methods. 90:31-38

مصطلحات موضوعية: Male, 0301 basic medicine, Glucuronosyltransferase, Cellular differentiation, Cell, Cell Culture Techniques, Toxicology, Extracellular matrix, 03 medical and health sciences, Bile canaliculi, Methods, medicine, Animals, Bile, Rats, Wistar, Cells, Cultured, Pharmacology, biology, Cell Differentiation, Metabolism, Phenotype, Extracellular Matrix, Rats, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Liver, Biochemistry, Cell culture, Toxicity, Hepatocytes, biology.protein, Hepatic drug disposition, Collagen, Sandwich-cultured hepatocytes

وصف الملف: Print-Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ad39654ac827fb686c784bade46381
https://doi.org/10.1016/j.vascn.2017.10.007

المؤلفون: Marie Mardal, Marlies Oorts, Pieter Annaert, Kristian Linnet, Carolina Noble

المصدر: Journal of Pharmaceutical and Biomedical Analysis. 149:296-307

مصطلحات موضوعية: Male, medicine.medical_treatment, Metabolite, Primary Cell Culture, Clinical Biochemistry, Pharmaceutical Science, Tandem mass spectrometry, 030226 pharmacology & pharmacy, 01 natural sciences, Analytical Chemistry, Divalent, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Tandem Mass Spectrometry, Drug Discovery, medicine, Animals, Bile, Humans, Rats, Wistar, Cells, Cultured, Chromatography, High Pressure Liquid, Spectroscopy, chemistry.chemical_classification, Cannabinoids, 010401 analytical chemistry, Metabolism, In vitro, Rats, 0104 chemical sciences, Hepatobiliary Elimination, chemistry, Biochemistry, Hepatocytes, Microsomes, Liver, Microsome, Cannabinoid, Efflux

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efa11180c2a4fc5b8491423a857846d
https://doi.org/10.1016/j.jpba.2017.11.027

المؤلفون: Anton Pohanka, Pieter Annaert, Dirk Kuypers, Jan de Hoon, Thomas Vanhove, Hylke de Jonge, Marlies Oorts, Henriette de Loor

مصطلحات موضوعية: Adult, Male, Genotype, Itraconazole, cytochrome P450, Midazolam, Metabolite, Pharmaceutical Science, chemical and pharmacologic phenomena, Pharmacology, Kidney, Polymorphism, Single Nucleotide, 030226 pharmacology & pharmacy, Tacrolimus, Cohort Studies, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, metabolite disposition, medicine, Cytochrome P-450 CYP3A, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, CYP3A5, Aged, Aged, 80 and over, CYP3A4, business.industry, Kidney metabolism, Middle Aged, Kidney Transplantation, Healthy Volunteers, drug toxicity, surgical procedures, operative, chemistry, 030220 oncology & carcinogenesis, Toxicity, Female, clinical pharmacology, business, Immunosuppressive Agents, medicine.drug

وصف الملف: Print-Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b80f0f3319b6fb426acd687b56bda95
https://lirias.kuleuven.be/handle/123456789/627987

المؤلفون: Johan Nicolaï, Annelii Ny, Pieter Annaert, Arianna Giusti, Xuan-Bac Nguyen, Deirdre Cabooter, Stanislav Kislyuk, Cecilia Ranieri, Peter de Witte, Marc Léonard, Marlies Oorts, Mélanie Mignot, Xiao Wu, Noémie De Croze

المساهمون: Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Laboratoire de Photonique Quantique et Moléculaire (LPQM), École normale supérieure - Cachan (ENS Cachan)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Lab Pharmacotechnology and Biopharmacy, L'Oréal recherche et innovation, L'Oréal, Laboratory of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences Lueven Belgium, ChromaFish, an individual fellowship from H2020-Marie Skłodowska-Curie Actions (MSCA post-doc), project number 799806

المصدر: International Journal of Molecular Sciences
Volume 20
Issue 7
International Journal of Molecular Sciences, MDPI, 2019, 20 (7), pp.1712. ⟨10.3390/ijms20071712⟩
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1712 (2019)

مصطلحات موضوعية: 0301 basic medicine, Embryo, Nonmammalian, Chemistry, Multidisciplinary, 030226 pharmacology & pharmacy, lcsh:Chemistry, ACTIVATION, chemistry.chemical_compound, 0302 clinical medicine, microsomes, lcsh:QH301-705.5, Zebrafish, ComputingMilieux_MISCELLANEOUS, Spectroscopy, biology, Chemistry, General Medicine, METHYL-PARATHION, DEVELOPMENTAL TOXICITY, 3. Good health, Computer Science Applications, embryonic structures, Physical Sciences, Toxicity, Malathion, Microsomes, Liver, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, animal structures, Article, Catalysis, drug discovery, zebrafish eleuthero embryos, Inorganic Chemistry, 03 medical and health sciences, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, In vivo, HUMAN LIVER, ALTERNATIVE MODEL, Animals, MALATHION, Physical and Theoretical Chemistry, Molecular Biology, Science & Technology, DRUG TOXICITY, Chromatography, Parathion, Organic Chemistry, toxicity, Metabolism, biology.organism_classification, In vitro, Chloramphenicol, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Microsome, RAT, CHLORAMPHENICOL, Xenobiotic, metabolism, SYSTEM, Chromatography, Liquid

وصف الملف: Electronic; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d612e6f9fd53638a78e5fd1a75e4e6
https://doi.org/10.3390/ijms20071712

المؤلفون: Pieter Annaert, Philippe Bachellier, Lysiane Richert, Bruno Heyd, Thomas Zacharias, Audrey Baze, Marlies Oorts

المصدر: Toxicology in vitro : an international journal published in association with BIBRA. 34

مصطلحات موضوعية: 0301 basic medicine, Drug, medicine.medical_specialty, media_common.quotation_subject, Cmax, Pharmacology, Fialuridine, Toxicology, Risk Assessment, Bile Acids and Salts, 03 medical and health sciences, 0302 clinical medicine, Diclofenac, Cholestasis, medicine, Humans, Urea, Cells, Cultured, media_common, Tolcapone, business.industry, Troglitazone, General Medicine, medicine.disease, Surgery, 030104 developmental biology, Perhexiline, Cyclosporine, Hepatocytes, Chemical and Drug Induced Liver Injury, business, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec88456517f82683eafa3b9f12371d14
https://pubmed.ncbi.nlm.nih.gov/27046439