يعرض 1 - 10 نتائج من 53 نتيجة بحث عن '"Martin Frotscher"', وقت الاستعلام: 1.32s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Hydroxybenzothiazoles as new nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1).

    المؤلفون: Alessandro Spadaro, Matthias Negri, Sandrine Marchais-Oberwinkler, Emmanuel Bey, Martin Frotscher

    المصدر: PLoS ONE, Vol 7, Iss 1, p e29252 (2012)

    مصطلحات موضوعية: Medicine, Science

    وصف الملف: electronic resource

    Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22242164/?tool=EBI; https://doaj.org/toc/1932-6203

    URL الوصول: https://doaj.org/article/8b5b42ff1bff47bcaee02bfde7a2d7c2

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  2. 2
    دورية أكاديمية
    Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation.

    المؤلفون: Tobias Klein, Claudia Henn, Matthias Negri, Martin Frotscher

    المصدر: PLoS ONE, Vol 6, Iss 8, p e22990 (2011)

    مصطلحات موضوعية: Medicine, Science

    وصف الملف: electronic resource

    Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21857977/?tool=EBI; https://doaj.org/toc/1932-6203

    URL الوصول: https://doaj.org/article/45cc11ccb04c4095995648f3d3a5c1df

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  3. 3
    Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis

    المؤلفون: Abdelrahman Mohamed, Mohamed Salah, Mariam Tahoun, Manuel Hawner, Ahmed S. Abdelsamie, Martin Frotscher

    المصدر: Journal of medicinal chemistry. 65(17)

    مصطلحات موضوعية: Structure-Activity Relationship, 17-Hydroxysteroid Dehydrogenases, Phenols, Drug Discovery, Endometriosis, Molecular Medicine, Humans, Female, Prodrugs, Steryl-Sulfatase, Enzyme Inhibitors

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16cdeffc24d89f049400a1ed565610da
    https://pubmed.ncbi.nlm.nih.gov/35993890

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  4. 4
    17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer

    المؤلفون: Rolf W. Hartmann, Chris J. van Koppen, Matthias W. Laschke, Giuseppe Felice Mangiatordi, Ahmed S. Abdelsamie, Martin Frotscher, Orazio Nicolotti, Abdelrahman Mohamed, Angelo Carotti, Arcangela Mazzini, Hanna Drzewiecka, Emanuele M. Gargano, Paweł P. Jagodziński, Sandrine Marchais-Oberwinkler

    المساهمون: HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.

    المصدر: ACS medicinal chemistry letters
    United States
    ACS Med Chem Lett
    ACS medicinal chemistry letters (2021). doi:10.1021/acsmedchemlett.1c00462
    info:cnr-pdr/source/autori:Emanuele M. Gargano, Abdelrahman Mohamed, Ahmed S. Abdelsamie, Giuseppe F. Mangiatordi, Hanna Drzewiecka, Pawe? P. Jagodzi?ski, Arcangela Mazzini, Chris J. van Koppen, Matthias W. Laschke, Orazio Nicolotti, Angelo Carotti, Sandrine Marchais-Oberwinkler, Rolf W. Hartmann, and Martin Frotscher/titolo:17?-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer/doi:10.1021%2Facsmedchemlett.1c00462/rivista:ACS medicinal chemistry letters/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume

    مصطلحات موضوعية: business.industry, Organic Chemistry, Treatment options, medicine.disease, Biochemistry, Docking, respiratory tract diseases, Drug Discovery, Cancer research, Medicine, Non small cell, Hydroxysteroid dehydrogenase, business, Lung cancer, hormones, hormone substitutes, and hormone antagonists

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b72b1eb9a0d3948ea61df325c6e341e
    https://hdl.handle.net/10033/623149

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  5. 5
    Highly Potent 17β-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy

    المؤلفون: Lorenz Siebenbuerger, Sandrine Marchais-Oberwinkler, Michael D. Menger, Martin Frotscher, Ahmed S. Abdelsamie, Carsten Boerger, Rolf W. Hartmann, Victor Hernandez-Olmos, Claudia Scheuer, Chris J. van Koppen, Matthias W. Laschke

    المصدر: Journal of Medicinal Chemistry. 61:10724-10738

    مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Pharmacology, 01 natural sciences, Targeted therapy, Estradiol Dehydrogenases, Mice, 03 medical and health sciences, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Potency, Tissue Distribution, Enzyme Inhibitors, Hydroxysteroid dehydrogenase, chemistry.chemical_classification, 010405 organic chemistry, Water, In vitro, 0104 chemical sciences, 030104 developmental biology, Enzyme, Solubility, S9 fraction, chemistry, Drug Design, Osteoporosis, Molecular Medicine, Female, Intracellular

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a7ff0cde1f64d87d00e9445907fc28
    https://doi.org/10.1021/acs.jmedchem.8b01373

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  6. 6
    A Hybrid In Silico/In Vitro Target Fishing Study to Mine Novel Targets of Urolithin A and B: A Step Towards a Better Comprehension of Their Estrogenicity

    المؤلفون: Margherita Interlandi, Angela Falco, Paola Puccini, Benedetta Riccardi, Chiara Dall'Asta, Abdelrahman Mohamed, Martin Frotscher, Daniele Del Rio, Marco Milioli, Luca Dellafiora, Gianni Galaverna

    المصدر: Molecular nutritionfood research. 64(16)

    مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, 17-Hydroxysteroid Dehydrogenases, In silico, Cell, Computational biology, Molecular Dynamics Simulation, Ligands, Estradiol Dehydrogenases, 03 medical and health sciences, chemistry.chemical_compound, Molecular level, Coumarins, medicine, Humans, Computer Simulation, Estrogen Sulfotransferase, Enzyme Inhibitors, Beneficial effects, 030109 nutrition & dietetics, Cell-Free System, Chemistry, Proteins, In vitro, Urolithin, Molecular Docking Simulation, 030104 developmental biology, medicine.anatomical_structure, MCF-7 Cells, Sulfotransferases, Food Science, Biotechnology, Ellagic acid

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e38d730a0c40db8edbf0a574574976
    https://pubmed.ncbi.nlm.nih.gov/32640069

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  7. 7
    First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases

    المؤلفون: Ahmed S. Abdelsamie, Mohamed Salah, Martin Frotscher

    المصدر: Journal of Medicinal Chemistry. 60:4086-4092

    مصطلحات موضوعية: 0301 basic medicine, 17-Hydroxysteroid Dehydrogenases, Membrane permeability, medicine.drug_class, Endometriosis, Estrogen receptor, Breast Neoplasms, Ligands, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, medicine, Steroid sulfatase, Humans, Enzyme Inhibitors, Hydroxysteroid dehydrogenase, Cell Proliferation, chemistry.chemical_classification, Chemistry, Ligand, Cell growth, 030104 developmental biology, Enzyme, Biochemistry, Estrogen, 030220 oncology & carcinogenesis, Molecular Medicine, Female, Steryl-Sulfatase, hormones, hormone substitutes, and hormone antagonists

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab7539bb25c3ef750bb4e58e019a8ef
    https://doi.org/10.1021/acs.jmedchem.7b00062

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  8. 8
    Synthesis, anti-17β-HSD and antiproliferative activity of new substituted 5-nitrosopyrimidine analogs

    المؤلفون: Najim A. Al-Masoudi, Nabeel A. Abdul-Rida, Martin Frotscher, Tiba I. Mohammed

    المصدر: Medicinal Chemistry Research. 26:830-840

    مصطلحات موضوعية: 010405 organic chemistry, Organic Chemistry, 010402 general chemistry, Chloroacetyl chloride, 01 natural sciences, 0104 chemical sciences, Solvent, chemistry.chemical_compound, chemistry, Nucleophilic aromatic substitution, Nucleophilic substitution, Dimethylformamide, Organic chemistry, General Pharmacology, Toxicology and Pharmaceutics, Triethylamine, Acetamide, Dichloromethane

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7e3bba056fadf765e4322b5af8d44d76
    https://doi.org/10.1007/s00044-017-1795-z

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  9. 9
    Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC 50 for a proof-of-principle study

    المؤلفون: Emmanuel Bey, Chris J. van Koppen, Matthias W. Laschke, Mohamed Salah, Carsten Börger, Martin Frotscher, Ahmed S. Abdelsamie, Lorenz Siebenbürger, Michael D. Menger

    المصدر: European Journal of Medicinal Chemistry. 127:944-957

    مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, Cell, Estrogen receptor, Estrone, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, medicine, IC50, chemistry.chemical_classification, Pregnane X receptor, biology, Chemistry, Organic Chemistry, General Medicine, 030104 developmental biology, Enzyme, medicine.anatomical_structure, Estrogen, Enzyme inhibitor, 030220 oncology & carcinogenesis, biology.protein, hormones, hormone substitutes, and hormone antagonists

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::681b60c43a98312f9761a0d03b45cfb3
    https://doi.org/10.1016/j.ejmech.2016.11.004

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  10. 10
    Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis

    المؤلفون: Martin Frotscher, Ahmed S. Abdelsamie, Rolf W. Hartmann, Sebastian Müller, Sandrine Marchais-Oberwinkler, Chris J. van Koppen, Matthias W. Laschke, Lorenz Siebenbürger, Mohamed Salah, Ahmed Merabet, Claudia Scheuer, Oliver Zierau, Michael D. Menger, Günter Vollmer

    المصدر: Journal of medicinal chemistry. 62(15)

    مصطلحات موضوعية: medicine.drug_class, Osteoporosis, Estrogen receptor, Administration, Oral, Pharmacology, 01 natural sciences, Bone resorption, Estradiol Dehydrogenases, 03 medical and health sciences, Mice, Drug Delivery Systems, Drug Discovery, medicine, Animals, Humans, Hydroxysteroid dehydrogenase, Enzyme Inhibitors, Rats, Wistar, IC50, Testosterone, 030304 developmental biology, 0303 health sciences, Bone Density Conservation Agents, Chemistry, medicine.disease, In vitro, 0104 chemical sciences, Rats, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Estrogen, Drug Design, Molecular Medicine, Female

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab02369095497d2b4ea68f6ffabf214
    https://pubmed.ncbi.nlm.nih.gov/31343176

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