المؤلفون: Mahat DB; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Tippens ND; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Martin-Rufino JD; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Waterton SK; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Stanford University, Stanford, CA, USA., Fu J; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Interdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, IL, USA., Blatt SE; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Exact Sciences, Madison, WI, USA., Sharp PA; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. sharppa@mit.edu.

المصدر: Nature [Nature] 2024 Jul; Vol. 631 (8019), pp. 216-223. Date of Electronic Publication: 2024 Jun 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Enhancer Elements, Genetic*/genetics , Gene Expression Regulation*/genetics , Promoter Regions, Genetic*/genetics , RNA*/analysis , RNA*/biosynthesis , RNA*/genetics , Sequence Analysis, RNA*/methods , Single-Cell Gene Expression Analysis*/methods , Transcription, Genetic*, Animals ; Humans ; Mice ; Cell Cycle/genetics ; Click Chemistry/methods ; DNA-Directed RNA Polymerases/analysis ; DNA-Directed RNA Polymerases/metabolism ; Histones/metabolism ; Time Factors

المؤلفون: Weng C; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Yu F; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, P.R. China., Yang D; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Molecular Pharmacology and Therapeutics, Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Poeschla M; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Liggett LA; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jones MG; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Dermatology, Stanford University, Stanford, CA, USA.; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA., Qiu X; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Genetics and Computer Science, BASE Research Initiative, Betty Irene Moore Children's Heart Center, Stanford University, Stanford, CA, USA., Wahlster L; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Caulier A; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hussmann JA; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Schnell A; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Yost KE; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Koblan LW; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Martin-Rufino JD; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Min J; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Hammond A; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ssozi D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA., Bueno R; Division of Thoracic and Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA., Mallidi H; Division of Thoracic and Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA., Kreso A; Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA, USA., Escabi J; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Rideout WM 3rd; Koch Institute For Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA., Jacks T; Koch Institute For Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA., Hormoz S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., van Galen P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA., Weissman JS; Whitehead Institute for Biomedical Research, Cambridge, MA, USA. weissman@wi.mit.edu.; Department of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA. weissman@wi.mit.edu.; Koch Institute For Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA. weissman@wi.mit.edu., Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. sankaran@broadinstitute.org.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. sankaran@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. sankaran@broadinstitute.org.; Harvard Stem Cell Institute, Cambridge, MA, USA. sankaran@broadinstitute.org.

المصدر: Nature [Nature] 2024 Mar; Vol. 627 (8003), pp. 389-398. Date of Electronic Publication: 2024 Jan 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cell Lineage* , Hematopoiesis* , Hematopoietic Stem Cells*/classification , Hematopoietic Stem Cells*/cytology , Hematopoietic Stem Cells*/metabolism, Humans ; Chromatin/genetics ; Chromatin/metabolism ; Clone Cells/classification ; Clone Cells/cytology ; Clone Cells/metabolism ; DNA, Mitochondrial/genetics ; Mutation ; Single-Cell Analysis ; Transcription, Genetic ; Aging

المؤلفون: Mahat DB; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139., Tippens ND; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139., Martin-Rufino JD; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Waterton SK; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.; Current address: Department of Biology, Stanford University, Stanford, CA 94305., Fu J; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.; Current address: Interdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, IL 60208., Blatt SE; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.; Current address: Exact Sciences Corporation, Madison, WI 53719., Sharp PA; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.; Lead Contact.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 19. Date of Electronic Publication: 2023 Sep 19.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Martin-Rufino JD; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; PhD Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA., Castano N; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Pang M; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard-MIT Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA., Grody EI; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Joubran S; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Chemical Biology PhD Program, Harvard Medical School, Boston, MA 02115, USA., Caulier A; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wahlster L; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Li T; Department of Pharmacology and Yale Cancer Biology Institute, Yale University School of Medicine, New Haven, CT 06510, USA., Qiu X; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Riera-Escandell AM; Independent Researcher, now at Google, Zurich, Switzerland., Newby GA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA., Al'Khafaji A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Chaudhary S; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Black S; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Weng C; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Munson G; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Liu DR; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA., Wlodarski MW; Department of Hematology, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Sims K; St. Jude Affiliate Clinic at Our Lady of the Lake Children's Health, Baton Rouge, LA 70809, USA., Oakley JH; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30322, USA., Fasano RM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30322, USA., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Department of Molecular Biology, and Center for the Study of Inflammatory Bowel Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Klein DE; Department of Pharmacology and Yale Cancer Biology Institute, Yale University School of Medicine, New Haven, CT 06510, USA., Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: sankaran@broadinstitute.org.

المصدر: Cell [Cell] 2023 May 25; Vol. 186 (11), pp. 2456-2474.e24. Date of Electronic Publication: 2023 May 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Gene Editing* , Hematopoietic Stem Cells*/metabolism, Humans ; Cell Differentiation ; CRISPR-Cas Systems ; Genome ; Hematopoiesis ; Genetic Engineering ; Single-Cell Analysis

المؤلفون: Gupta A; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115., Martin-Rufino JD; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115.; Dana-Farber Cancer Institute, Boston, MA 02215., Jones TR; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Subramanian V; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Qiu X; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; HHMI, Massachusetts Institute of Technology, Cambridge, MA 02139., Grody EI; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Bloemendal A; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Weng C; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115.; Dana-Farber Cancer Institute, Boston, MA 02215.; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Niu SY; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Min KH; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139., Mehta A; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Dana-Farber Cancer Institute, Boston, MA 02215.; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114., Zhang K; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Siraj L; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Al' Khafaji A; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Sankaran VG; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115.; Dana-Farber Cancer Institute, Boston, MA 02215., Raychaudhuri S; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115., Cleary B; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Grossman S; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142.; Department of Systems Biology, Harvard Medical School, Boston, MA 02115.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Aug 23; Vol. 119 (34), pp. e2207392119. Date of Electronic Publication: 2022 Aug 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation* , Models, Biological* , Transcription Factors*/genetics , Transcription Factors*/metabolism, Computer Simulation ; Gene Regulatory Networks

المؤلفون: Qiu X; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: xqiu@wi.mit.edu., Zhang Y; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA; Joint CMU-Pitt Ph.D. Program in Computational Biology, University of Pittsburgh, Pittsburgh, PA, USA., Martin-Rufino JD; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Weng C; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Hosseinzadeh S; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Yang D; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Pogson AN; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Hein MY; Chan Zuckerberg Biohub, 499 Illinois St, San Francisco, CA 94158, USA., Hoi Joseph Min K; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Wang L; Department of Mathematics, University of Texas at Arlington, Arlington, TX, USA., Grody EI; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shurtleff MJ; Lycia Therapeutics, South San Francisco, San Francisco, CA, USA., Yuan R; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA., Xu S; Microsoft, Redmond, WA, USA., Ma Y; Halıcıoğlu Data Science Institute, University of California San Diego, San Diego, CA, USA., Replogle JM; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA; Medical Scientist Training Program, University of California, San Francisco, CA, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Systems Biology Harvard Medical School, Boston, MA 02125, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Darmanis S; Genentech Inc., South San Francisco, CA, USA., Bahar I; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA; Joint CMU-Pitt Ph.D. Program in Computational Biology, University of Pittsburgh, Pittsburgh, PA, USA., Sankaran VG; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Xing J; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA; Joint CMU-Pitt Ph.D. Program in Computational Biology, University of Pittsburgh, Pittsburgh, PA, USA; UPMC-Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA; Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: xing1@pitt.edu., Weissman JS; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA; Koch Institute For Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA. Electronic address: weissman@wi.mit.edu.

المصدر: Cell [Cell] 2022 Feb 17; Vol. 185 (4), pp. 690-711.e45. Date of Electronic Publication: 2022 Feb 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Single-Cell Analysis*, Transcriptome/*genetics, Algorithms ; Female ; Gene Expression Regulation ; HL-60 Cells ; Hematopoiesis/genetics ; Hematopoietic Stem Cells/metabolism ; Humans ; Kinetics ; Models, Biological ; RNA, Messenger/metabolism ; Staining and Labeling

المؤلفون: Martin-Rufino JD; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard., Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard.; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.

المصدر: Current opinion in hematology [Curr Opin Hematol] 2021 Jul 01; Vol. 28 (4), pp. 269-276.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Lippincott Williams And Wilkins Country of Publication: United States NLM ID: 9430802 Publication Model: Print Cited Medium: Internet ISSN: 1531-7048 (Electronic) Linking ISSN: 10656251 NLM ISO Abbreviation: Curr Opin Hematol Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Developmental* , Genetic Heterogeneity* , Genomics*/methods , Single-Cell Analysis*/methods, Cell Differentiation/*genetics , Hematopoiesis/*genetics , Hematopoietic Stem Cells/*metabolism, Animals ; Gene Expression Profiling/methods ; Hematopoietic Stem Cells/cytology ; Humans ; In Situ Hybridization, Fluorescence ; Transcriptome

المؤلفون: Martin-Rufino JD; Unidad de Terapia Celular, Servicio de Hematología, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain.; Facultad de Medicina, Universidad de Salamanca, Salamanca, Spain., Espinosa-Lara N; Unidad de Terapia Celular, Servicio de Hematología, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain., Osugui L; Unidad de Terapia Celular, Servicio de Hematología, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain., Sanchez-Guijo F; Unidad de Terapia Celular, Servicio de Hematología, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain.; Facultad de Medicina, Universidad de Salamanca, Salamanca, Spain.; Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León, Salamanca, Spain.

المصدر: Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2019 Nov 05; Vol. 7, pp. 308. Date of Electronic Publication: 2019 Nov 05 (Print Publication: 2019).

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101632513 Publication Model: eCollection Cited Medium: Print ISSN: 2296-4185 (Print) Linking ISSN: 22964185 NLM ISO Abbreviation: Front Bioeng Biotechnol Subsets: PubMed not MEDLINE

المؤلفون: Martin-Rufino JD; Department of Hematology, Cell Therapy Unit, IBSAL-Hospital Universitario de Salamanca, Paseo de San Vicente 58-182, 37007, Salamanca, Spain.; Faculty of Medicine, Universidad de Salamanca, Salamanca, Spain., Lozano FS; Department of Angiology and Vascular Surgery, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain.; Faculty of Medicine, Universidad de Salamanca, Salamanca, Spain., Redondo AM; Department of Hematology, Cell Therapy Unit, IBSAL-Hospital Universitario de Salamanca, Paseo de San Vicente 58-182, 37007, Salamanca, Spain.; Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y Leon, Salamanca, Spain., Villaron EM; Department of Hematology, Cell Therapy Unit, IBSAL-Hospital Universitario de Salamanca, Paseo de San Vicente 58-182, 37007, Salamanca, Spain.; Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y Leon, Salamanca, Spain., Rueda R; Department of Radiology, Hospital de Leon, Leon, Spain., Fernandez-Samos R; Department of Angiology and Vascular Surgery, Hospital de Leon, Leon, Spain., Sanchez-Guijo F; Department of Hematology, Cell Therapy Unit, IBSAL-Hospital Universitario de Salamanca, Paseo de San Vicente 58-182, 37007, Salamanca, Spain. ferminsg@usal.es.; Faculty of Medicine, Universidad de Salamanca, Salamanca, Spain. ferminsg@usal.es.; Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y Leon, Salamanca, Spain. ferminsg@usal.es.

المصدر: Stem cell research & therapy [Stem Cell Res Ther] 2018 May 30; Vol. 9 (1), pp. 150. Date of Electronic Publication: 2018 May 30.

نوع المنشور: Case Reports; Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE

مواضيع طبية MeSH: Mesenchymal Stem Cell Transplantation/*methods , Thromboangiitis Obliterans/*therapy , Transplantation, Homologous/*methods, Administration, Intravenous ; Adult ; Humans ; Male ; Mesenchymal Stem Cells ; Thromboangiitis Obliterans/pathology ; Treatment Outcome