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المؤلفون: Bin Ma, Urjana Poreci, Luisette Delva, Fengmei Zhang, Hao Tang, Tonika Bohnert, Patricia Schroeder, Richard Grater, Sudarshan Kapadnis, Kris King, Michael Mingueneau, Marc Hoemberger, Evelyne Polack, Brian T. Hopkins, Prince Robin, Chris Rowbottom, Robert Meissner, Eris Bame, Joseph C Santoro, Paramasivam Murugan, Allie M Roach, Claire M. Metrick, Kevin L. Otipoby, Eric Tien, Josh Johnson, Douglas Donaldson, Joseph P. Lyssikatos, Doug Burdette, Tom Magee, Carrie Boiselle, Chungang Gu, Mukesh Lulla, Bekim Bajrami, Jeremy C. Burns, Cheryl Black, Marx Isaac

المصدر: Journal of medicinal chemistry. 65(2)

مصطلحات موضوعية: Male, Phosphorylation sites, Multiple Sclerosis, Central nervous system, Inflammation, Unmet needs, Rats, Sprague-Dawley, Drug Discovery, medicine, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Animals, Tissue Distribution, Protein Kinase Inhibitors, biology, Chemistry, Multiple sclerosis, medicine.disease, Rats, Atp competitive, Macaca fascicularis, medicine.anatomical_structure, Tolerability, Cancer research, biology.protein, Molecular Medicine, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73da50c6f550d3e41002d416b5cebb6
https://pubmed.ncbi.nlm.nih.gov/34734694

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المؤلفون: Jing Zhu, Xiaomei Peng, Alex Pellerin, Brian T. Hopkins, Dipen Sangurdekar, Michael Mingueneau, Urjana Poreci, Eris Bame, Joseph C Santoro, Prince Robin, Katherine Riester, Mike Palte, Allie M Roach, Klaus Michelsen, Bin Ma, Hao Tang, Million Arefayene, Stephen J Rubino, Devangi Mehta, Fergal Casey, Patrick Cullen, Patrick Trapa, Bekim Bajrami, Thomas M. Carlile, Davide Gianni, Marx Isaac, Douglas Donaldson, Baohong Zhang, Jeremy C. Burns, Param Muragan, Alex Coppell, Shibeshih Belachew, Nathalie Franchimont, Matthew Scaramozza

المصدر: Clinical & Translational Immunology
Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)

مصطلحات موضوعية: 0301 basic medicine, Myeloid, Immunology, Antigen presentation, B-cell receptor, Fc receptor, multiple sclerosis, 03 medical and health sciences, 0302 clinical medicine, medicine, Immunology and Allergy, Bruton's tyrosine kinase, General Nursing, B cell, B cells, biology, B‐cell receptor, Chemistry, BTK inhibitor, Germinal center, Original Articles, RC581-607, 030104 developmental biology, medicine.anatomical_structure, myeloid cells, biology.protein, Cancer research, Original Article, Immunologic diseases. Allergy, Tyrosine kinase, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188cf6754afaaa237193991f00885497
https://doi.org/10.1002/cti2.1295

المؤلفون: May-Dracka, Tricia L., Fang Gao, Hopkins, Brian T., Xiaoping Hronowski, TeYu Chen, Chodaparambil, Jayanth V., Metrick, Claire M., Cullivan, Mike, Enyedy, Istvan, Kaliszczak, Maciej, Kankel, Mark W., Marx, Isaac, Michell-Robinson, Mackenzie A., Murugan, Param, Kumar, P. Rajesh, Rooney, Michael, Schuman, Eli, Sen, Anindya, Ti Wang, Tao Ye

المصدر: ACS Medicinal Chemistry Letters; 4/14/2022, Vol. 13 Issue 4, p665-673, 9p

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المؤلفون: Ella Negrou, Tracy J. Jenkins, Mark T. Cancilla, Douglas Marcotte, Minna Bui, Wenjin Yang, Brian T. Hopkins, Mukush Lulla, Daniel A. Erlanson, Eris Bame, Patrick Conlon, Stig Hansen, Elisabeth Mertsching, Tonika Bohnert, Noah Bell, Daniel Scott, Marx Isaac, Stacey A. Heumann, Junfa Fan, Ying Liu, Tarra Fuchs-Knotts, Laura Silvian, Chuck Gua, YuTing Liu, Jon K. Bowden-Verhoek, Michael J. Romanowski, Bob McDowell, Patrick Cullen, Min Zhong

المصدر: Bioorganic & Medicinal Chemistry. 44:116275

مصطلحات موضوعية: Drug, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Drug resistance, 01 natural sciences, Biochemistry, Structure-Activity Relationship, immune system diseases, In vivo, hemic and lymphatic diseases, Drug Discovery, Agammaglobulinaemia Tyrosine Kinase, Humans, Bruton's tyrosine kinase, Potency, Kinome, Protein Kinase Inhibitors, Molecular Biology, media_common, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, biology.protein, Cancer research, Molecular Medicine, Tyrosine kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08827c5ed0774a88dae1ef91956919b8
https://doi.org/10.1016/j.bmc.2021.116275

المؤلفون: Jurgen Schulz, Gao Fang, Brian T. Hopkins, Prince Robin, Jessica E. Pazienza, Marx Isaac

المصدر: The Journal of organic chemistry. 84(12)

مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Enantiopure drug, chemistry, Reagent, Diamine, Organic Chemistry, Hemiaminal, Lactam, Amine gas treating, Combinatorial chemistry, Aldehyde, Reductive amination

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b2c2b1a9e543cf6dce21fc7681b79f
https://pubmed.ncbi.nlm.nih.gov/31117567