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1
المؤلفون: Richard Johnstone, Zhao Ren, Myung K. Shin, Maarten Hoek, Haihong Zhou, Anthony Kreamer, Mary-Jo Wildey, Jason E. Imbriglio, Stephen F. Previs, Xi Ai, Andrea M. Peier, Steve Cifelli, Lufei Hu, Ashmita Saigal, Josephine Johnson, Richard Visconti, Yanqing Kan, Lin-Lin Shiao, William T. McElroy, Jonathan W. Choy, Adam B. Weinglass, Ying Lei, Robert Ramos, Andy Liaw, Michelle Chen
المصدر: SLAS Discovery. 26:1225-1237
مصطلحات موضوعية: Apolipoprotein L2, Phenotypic screening, High-throughput screening, Cell, 030232 urology & nephrology, Biochemistry, Analytical Chemistry, law.invention, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, law, Drug Discovery, medicine, Humans, Viability assay, Cytotoxicity, 030304 developmental biology, 0303 health sciences, Podocytes, Chemistry, Drug discovery, Apolipoprotein L1, High-Throughput Screening Assays, Cell biology, medicine.anatomical_structure, Molecular Medicine, Suppressor, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4441c7993243e64c0eaf4458d6e4f2
https://doi.org/10.1177/24725552211026245 -
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المؤلفون: Xiujuan Wen, Kiersten Tovar, Gregory O'Donnell, Santhosh Satapati, Chang Liu, Lucien P. Ghislain, Steven J. Stout, Steven Cifelli, Vinit Shah, Kevin P. Bateman, Payal R. Sheth, Sammy S Datwani, David G. McLaren, Mary Jo Wildey, Thomas R. Covey
المصدر: Analytical chemistry. 93(15)
مصطلحات موضوعية: business.industry, Chemistry, High-throughput screening, Interface (computing), 010401 analytical chemistry, Phase (waves), Acoustics, 010402 general chemistry, 01 natural sciences, Bottleneck, 0104 chemical sciences, Analytical Chemistry, High-Throughput Screening Assays, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Direct coupling, Diacylglycerol O-Acyltransferase, Enzyme Inhibitors, business, Acoustic droplet ejection, Throughput (business), Computer hardware, Chromatography, Liquid
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3
المؤلفون: Sarah Souza, Steven Cifelli, Alice Struck, Richard Visconti, Mary Jo Wildey, Adam B. Weinglass, Brande Thomas-Fowlkes
المصدر: SLAS technology. 25(3)
مصطلحات موضوعية: 0303 health sciences, Reproducibility, Drug discovery, Chemistry, High-throughput screening, Cells, In vitro toxicology, Reproducibility of Results, Computational biology, 01 natural sciences, Small molecule, In vitro, 0104 chemical sciences, Computer Science Applications, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Medical Laboratory Technology, Automation, HEK293 Cells, Manual evacuation, Humans, Biological Assay, 030304 developmental biology, Cell based
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3535085903c19b1065ece49f6556b1da
https://pubmed.ncbi.nlm.nih.gov/32003291 -
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المؤلفون: Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez
المصدر: Toxicology and Applied Pharmacology
مصطلحات موضوعية: 0301 basic medicine, ICH, The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use, TN, True Negative, PPV, Positive Predictive Value, Pharmacology, TdP, Torsade de Pointes, Toxicology, Membrane Potentials, 0302 clinical medicine, HTS, High Throughput Screening, QTcVdW, Van de Water's Heart Rate QT-corrected Interval, In Silico modeling, Medicine, Translational PKPD modeling, NCEs, New Chemical Entities, CTD90, Ca2+-Transient Duration at 90% repolarization, education.field_of_study, Anesthetized Cardiovascular Guinea Pig, HR, Heart Rate, PNV, Predictive Negative Value, Safety pharmacology, ECG, Electrocardiogram, FIH, First in Human, IKr, rapidly-activating delayed rectifier potassium current, AP, Action Potential, QTc, Heart Rate corrected QT Interval, PX, PatchXpress®, 030220 oncology & carcinogenesis, Electrophysiologic Techniques, Cardiac, FP, False Positive, LVP, Left Ventricular Pressure, Anti-Arrhythmia Agents, In silico, Population, Guinea Pigs, QT interval, Models, Biological, Article, Ventricular action potential, Cell Line, CVGP, Cardiovascular Anesthetized Guinea Pig, GP, Guinea Pig, 03 medical and health sciences, hERG, Human Ether-a-go-go Related Gene, Pharmacokinetics, In vivo, Animals, Humans, Computer Simulation, education, QT corrected interval, BP, Blood Pressure, business.industry, M5P, M5 trees automated pruning model, tPKPD, thranslational pharmacokinetic/pharmacodynamic, FLIPR, Fluorescent Imaging Plate Reader, Arrhythmias, Cardiac, ORd, O'Hara Rudy model, Electrophysiological Phenomena, 030104 developmental biology, HEK293 Cells, Models, Chemical, Pharmacodynamics, Torsade de Pointes, EMw, Electromechanical window, FN, False Negative, TP, True Positive, Calcium, Calcium Channels, LOO, Leave-One-Out, business, APD90, Action Potential Duration at 90% repolarization
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المؤلفون: Christopher P. Austin, Rajarshi Guha, Madhu Lal-Nag, Bart Trawick, Michelle R. Arkin, Timothy L. Foley, Philip W. Iversen, Jonathan B. Baell, Thomas D.Y. Chung, Zhuyin Li, Eric W. Sayers, Neely Gal-Edd, James McGee, Owen B. McManus, Hanguan Liu, Nathan P. Coussens, Xin Xu, Viswanath Devanaryan, Marilu A. Hoeppner, Matthew D. Hall, Bruce E. Bejcek, Vance Lemmon, Kyle R. Brimacombe, Jeffrey R. Weidner, Jayme L. Dahlin, Andrew D. Napper, Steven D. Kahl, Anton Simeonov, James Inglese, Robert Pacifici, G. Sitta Sittampalam, Lisa Minor, William W. Chin, Abigail Grossman, Julie McVey, Sam Michael, Douglas S. Auld, Stacy Lathrop, Menghang Xia, Terry L. Riss, Mary Jo Wildey, Marcie A. Glicksman, Joseph V. Haas, Stephen C. Kales, O. Joseph Trask
المصدر: Clinical and Translational Science. 11:461-470
مصطلحات موضوعية: 0301 basic medicine, Extramural, Drug discovery, General Neuroscience, education, General Medicine, 01 natural sciences, Data science, General Biochemistry, Genetics and Molecular Biology, Quantitative biology, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, 030104 developmental biology, High-Throughput Screening Assays, General Pharmacology, Toxicology and Pharmaceutics
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المؤلفون: Meir Glick, Brian R. Lahue, Matthew Tudor, Janet Diratsouian, Mary Jo Wildey, Marybeth S. Burton, Robert Mazzola, Scott A. Johnson, Anne Mai Wassermann
المصدر: Bioorganic & Medicinal Chemistry. 28:115192
مصطلحات موضوعية: Drug Industry, Process (engineering), media_common.quotation_subject, Phenotypic screening, Clinical Biochemistry, Pharmaceutical Science, Chemist, 01 natural sciences, Biochemistry, Small Molecule Libraries, Drug Discovery, Molecular Biology, media_common, Pharmaceutical industry, Flexibility (engineering), 010405 organic chemistry, business.industry, Chemistry, Organic Chemistry, Data science, High-Throughput Screening Assays, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Portfolio, Identification (biology), business, Algorithms, Diversity (politics)
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المصدر: Journal of Chemical Information and Modeling. 55:231-238
مصطلحات موضوعية: Quantitative structure–activity relationship, Databases, Factual, Drug-Related Side Effects and Adverse Reactions, Computer science, General Chemical Engineering, Quantitative Structure-Activity Relationship, General Chemistry, Library and Information Sciences, computer.software_genre, Risk Assessment, Plot (graphics), High-Throughput Screening Assays, Computer Science Applications, Models, Chemical, Risk analysis (engineering), Drug development, Predictive Value of Tests, Drug Discovery, Data Mining, Data mining, Risk assessment, computer, Algorithms
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المؤلفون: Jonathan H. Connick, Anders Haunso, Matthew Tudor, Maria Webb, Mary Jo Wildey
مصطلحات موضوعية: 0301 basic medicine, Modalities, Computer science, Drug discovery, Process (engineering), business.industry, High-throughput screening, media_common.quotation_subject, Nanotechnology, Data science, Automation, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Informatics, Quality (business), business, media_common, Pharmaceutical industry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::25da8e82ef9957623f28062a1d2e791d
https://doi.org/10.1016/bs.armc.2017.08.004 -
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المؤلفون: Richard Johnstone, Sony Agrawal, Shree Agrawal, David Pechter, Richard Visconti, Tim Allison, Kevin Houle, Matthew Sills, Karen Lin, Jonathan Schneeweis, Alice Struck, Aida Rivera-Gines, Steven Cifelli, Mary Jo Wildey, Deborah A. Barbey, James A. Milligan
المصدر: Journal of laboratory automation. 21(1)
مصطلحات موضوعية: 0301 basic medicine, Accuracy and precision, Miniaturization, Chemistry, Drug discovery, High-throughput screening, Echo (computing), Biomedical Technology, Drug Evaluation, Preclinical, Acoustics, Real-Time Polymerase Chain Reaction, 01 natural sciences, 0104 chemical sciences, Computer Science Applications, Low volume, Solutions, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Medical Laboratory Technology, 030104 developmental biology, Real-time polymerase chain reaction, Acoustic droplet ejection, Biomedical engineering
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cb674440f3b5df2eee4606db49f4b5
https://pubmed.ncbi.nlm.nih.gov/26460107 -
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المؤلفون: Mary Jo Wildey, Weimin Tang
المصدر: SLAS Discovery. 9:607-613
مصطلحات موضوعية: 0301 basic medicine, Cell, Cystic Fibrosis Transmembrane Conductance Regulator, chemistry.chemical_element, Iodine, 01 natural sciences, Biochemistry, Analytical Chemistry, GABA Antagonists, 03 medical and health sciences, chemistry.chemical_compound, Chloride Channels, Tumor Cells, Cultured, medicine, Humans, GABA-A Receptor Antagonists, GABA Modulators, Receptor, gamma-Aminobutyric Acid, Forskolin, GABAA receptor, Bicuculline, Receptors, GABA-A, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, medicine.anatomical_structure, chemistry, Chloride channel, Biophysics, Molecular Medicine, Biological Assay, Colorimetry, Biotechnology, Picrotoxin, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6866d46525c1dedd7770bf45af3519
https://doi.org/10.1177/1087057104266740