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1
المؤلفون: Thomas R. Malek, Alicia Santos Savio, Connor J. Dwyer, Jenny Xie, Aixin Yu, Rosmely Hernandez, Mary Struthers, Liping Yu, Jen Bon Lui, Natasha C. Ward, Sunnie Hsiung
المصدر: Diabetes
مصطلحات موضوعية: 0301 basic medicine, Recombinant Fusion Proteins, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, T cell, Mice, Inbred Strains, chemical and pharmacologic phenomena, 030209 endocrinology & metabolism, Immune tolerance, Mice, 03 medical and health sciences, 0302 clinical medicine, T-Lymphocyte Subsets, Diabetes Mellitus, Internal Medicine, medicine, Animals, Humans, IL-2 receptor, Autoantibodies, NOD mice, Type 1 diabetes, business.industry, Interleukin-2 Receptor alpha Subunit, Autoantibody, Receptors, Interleukin-2, hemic and immune systems, Immunotherapy, medicine.disease, 030104 developmental biology, Cytokine, medicine.anatomical_structure, Immunology, Interleukin-2, Female, Immunology and Transplantation, business, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15bfdfe95b7de2b2a96cf36840be32d4
https://doi.org/10.2337/db20-0186 -
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المؤلفون: Yifan Zhang, Shailesh Dudhgaonkar, Luisa Salter-Cid, Anjuman Rudra, Mary Struthers, Xiadi Zhou, Thomas R. Malek, Elizabeth M. Heimrich, Paul R. Mangan, Jenny Xie, Martine Loubeau, Priyanka Apurva Madia, Siva Subramani, James Young, Michael L. Doyle, Christian Tovar
المصدر: Journal of immunology (Baltimore, Md. : 1950). 207(1)
مصطلحات موضوعية: Mice, Inbred MRL lpr, Regulatory T cell, Immunology, Lupus nephritis, chemical and pharmacologic phenomena, CD8-Positive T-Lymphocytes, T-Lymphocytes, Regulatory, Proinflammatory cytokine, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, immune system diseases, Mice, Inbred NOD, medicine, Immunology and Allergy, Animals, Humans, Lupus Erythematosus, Systemic, IL-2 receptor, skin and connective tissue diseases, NOD mice, business.industry, Interleukin-2 Receptor alpha Subunit, FOXP3, hemic and immune systems, Forkhead Transcription Factors, medicine.disease, medicine.anatomical_structure, Interleukin-2, business, CD8, 030215 immunology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a25dd99976fb5dfa07ae1070822931
https://pubmed.ncbi.nlm.nih.gov/34935627 -
3
المؤلفون: Luisa Salter-Cid, Jian Pang, Vangipuram S. Rangan, Huadong Sun, Xiaoxia Yang, Richard A. Westhouse, Wendy Sun, Jenny Xie, Shrikant Deshpande, Mary Struthers, Taeg Kim, Jinhong Wang, Mary Ellen Cvijic, Huaping Tang, Yunling Song, Timothy V Olah, Hongwei Zhang, Qihong Zhao
المصدر: Journal of Leukocyte Biology. 102:1271-1280
مصطلحات موضوعية: Male, 0301 basic medicine, Chemokine, Receptors, CXCR3, Primary Cell Culture, Immunology, Inflammation, Adaptive Immunity, CXCR3, Interleukin-23, p38 Mitogen-Activated Protein Kinases, Inflammatory bowel disease, Monocytes, Proinflammatory cytokine, Interferon-gamma, Mice, 03 medical and health sciences, Crohn Disease, medicine, Animals, Humans, Immunology and Allergy, CXCL10, CD40 Antigens, Mice, Inbred BALB C, biology, Monocyte, Cell Biology, Colitis, medicine.disease, Acquired immune system, Antibodies, Neutralizing, Interleukin-12, Immunity, Innate, I-kappa B Kinase, Chemokine CXCL10, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, biology.protein, Colitis, Ulcerative, Female, medicine.symptom, Signal Transduction
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4
المؤلفون: Joe Clemas, Jerry Andrew Taylor, Feroze Ujjainwalla, Jim Tata, Doris F. Cully, Tom Wisniewski, Wei Tang, Charlene Bopp, Clare London, Andreas Verras, Scott B. Hoyt, Andrea Sok, Elaine Tung, Douglas J. MacNeil, Gaochao Zhou, Amjad Ali, Qing Chen, Gino Salituro, Yusheng Xiong, Daniel R. McMasters, Mary Struthers, Ning Ren, Ruth A. Duffy
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2384-2388
مصطلحات موضوعية: Male, 0301 basic medicine, Aldosterone synthase, Indazoles, Clinical Biochemistry, High selectivity, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, Cell Line, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Cricetulus, Pharmacokinetics, Cytochrome P-450 CYP2D6 Inhibitors, Drug Discovery, Animals, Cytochrome P-450 CYP11B2, Humans, Molecular Biology, Antihypertensive Agents, Indazole, biology, Aromatase Inhibitors, Chemistry, Organic Chemistry, Stereoisomerism, Hit to lead, Macaca mulatta, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Hypertension, biology.protein, Steroid 11-beta-Hydroxylase, Molecular Medicine
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5
المؤلفون: Hiroshi Nagabukuro, Sean M. Smith, Richard A. Berger, Melissa Costa, Nam Fung Kar, Bart Harper, Karen H. Dingley, Gino Salituro, Liping Wang, Jerry Di Salvo, Scott D. Edmondson, Bing Li, Xiaofang Li, Cheng Zhu, Christopher Moyes, Stephen D. Goble, Sookhee Ha, Mary Struthers, Jeffrey J. Hale, Amanda L. Hurley, Randy R. Miller
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1094-1098
مصطلحات موضوعية: medicine.medical_specialty, Clinical Biochemistry, Pharmaceutical Science, Adrenergic beta-3 Receptor Agonists, Pharmacology, 030226 pharmacology & pharmacy, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Drug Discovery, medicine, Potency, Structure–activity relationship, Benzamide, Receptor, Molecular Biology, biology, Organic Chemistry, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Piperazine, Endocrinology, Overactive bladder, chemistry, Norepinephrine transporter, biology.protein, Molecular Medicine
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6
المؤلفون: Brent R. Whitehead, Michael M.-C. Lo, Amjad Ali, Min K. Park, Scott B. Hoyt, Yusheng Xiong, Jiaqiang Cai, Emma Carswell, Andrew Cooke, John MacLean, Paul Ratcliffe, John Robinson, D. Jonathan Bennett, Joseph A. Clemas, Tom Wisniewski, Mary Struthers, Doris Cully, Douglas J. MacNeil
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:143-146
مصطلحات موضوعية: Male, Aldosterone synthase, medicine.medical_specialty, Pyridines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Cricetulus, Internal medicine, Drug Discovery, medicine, Animals, Cytochrome P-450 CYP11B2, Humans, Rats, Wistar, Molecular Biology, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Imidazoles, Macaca mulatta, humanities, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Endocrinology, Microsomes, Liver, biology.protein, Steroid 11-beta-Hydroxylase, Molecular Medicine
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7
المؤلفون: Jonathan H. Davis, Alejandro Moro, Aaron P. Yamniuk, Martine Loubeau, Yuguang Ban, Thomas R. Malek, Aixin Yu, Jaren M. Arbanas, Anil Thankappan, Sunnie Hsiung, Xi Chen, James Keegan, Mary Struthers, Natasha C. Ward
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Recombinant Fusion Proteins, Immunology, Context (language use), chemical and pharmacologic phenomena, medicine.disease_cause, T-Lymphocytes, Regulatory, Article, Immune tolerance, Autoimmunity, Cell Line, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, Mice, Inbred NOD, medicine, Diabetes Mellitus, Immune Tolerance, Immunology and Allergy, Animals, IL-2 receptor, NOD mice, Mice, Inbred BALB C, Chemistry, Interleukin-2 Receptor alpha Subunit, hemic and immune systems, Immunotherapy, Fusion protein, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, Interleukin-2, Female, 030215 immunology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb78e3d1a456ad2bd65ff1f98b1779bb
https://europepmc.org/articles/PMC6200646/ -
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المؤلفون: Cheng Zhu, Mary Struthers, Jerry Di Salvo, Bing Li, Jeffrey J. Hale, Ann E. Weber, Xiaofang Li, Randy R. Miller, Scott D. Edmondson, Melissa Costa, Nam Fung Kar, Sookhee Ha, Karen H. Dingley, Amanda L. Hurley, Gino Salituro
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:55-59
مصطلحات موضوعية: Agonist, Stereochemistry, medicine.drug_class, Clinical Biochemistry, hERG, Pharmaceutical Science, Adrenergic beta-3 Receptor Agonists, 01 natural sciences, Biochemistry, Pyrrolidine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Structure–activity relationship, Benzamide, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Drug discovery, Organic Chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Receptors, Adrenergic, beta-3, Benzamides, biology.protein, Molecular Medicine, Bioisostere
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9
المؤلفون: Chris J. van Koppen, Scott B. Hoyt, Gino Salituro, Elaine Tung, Jim Tata, Joe Clemas, Mark Rosenbach, Jack Gibson, Daphne Szeto, Wei Tang, Andreas Verras, Lee-Yuh Pai, Ning Ren, Carrie Ann Maxwell, Joe Metzger, Jose Castro-Perez, Qing Chen, Lina Yin, Daniel R. McMasters, Yusheng Xiong, Rolf W. Hartmann, Mary Struthers, Gui-Bai Liang, Charlene Bopp, Xiuying Ma, Gaochao Zhou, Richard Hajdu, Tom Wisniewski, Mike E. Lassman, Nicole Buist, Clare London, Andrea Sok, Gail Forrest, Sloan Stribling, Theresa McLaughlin, Qingzhong Hu, Tian-Quan Cai, Whitney Lane Petrilli
المصدر: ACS Medicinal Chemistry Letters. 6:861-865
مصطلحات موضوعية: Aldosterone synthase, medicine.medical_specialty, Aldosterone, Organic Chemistry, Triazole, Hit to lead, Biology, Pharmacology, Biochemistry, chemistry.chemical_compound, Endocrinology, chemistry, Pharmacokinetics, In vivo, Pharmacodynamics, Internal medicine, Drug Discovery, medicine, biology.protein, Cortisol level
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10
المؤلفون: Rochelle Thomas, Andrea L. Tatum, Mary Struthers, Linhui Julie Su, Pete Z. Cotter, Qihong Zhao, Paul R. Mangan, Ruchira Das Gupta, Irvith M. Carvajal, Zheng Lin, Victoria Jenny, Jenny Xie, Caryn Picarillo, Brigitte Devaux, Noah Ditto, Elizabeth M. Heimrich, Xiaoxia Yang, Luisa Salter-Cid, Kim W. McIntyre, Stacey Skala, Yunling Song, David J. Shuster, Virna Borowski
المصدر: Journal of Pharmacology and Experimental Therapeutics. 354:152-165
مصطلحات موضوعية: Encephalomyelitis, Autoimmune, Experimental, medicine.medical_treatment, Autoimmunity, Pharmacology, medicine.disease_cause, Interleukin-23, Myelin oligodendrocyte glycoprotein, Mice, Random Allocation, In vivo, medicine, Interleukin 23, Animals, Humans, Mice, Inbred BALB C, biology, business.industry, Interleukin-17, Experimental autoimmune encephalomyelitis, Antibodies, Monoclonal, Interleukin, medicine.disease, Coculture Techniques, Mice, Inbred C57BL, HEK293 Cells, Cytokine, NIH 3T3 Cells, biology.protein, Molecular Medicine, Female, Interleukin 17, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c561a111ea25819a76674ff10040206
https://doi.org/10.1124/jpet.115.224246